BR9908156A - Processo para efetuar uma cristalização em estado sólido de um composto orgânico molecular alotrópico em uma partìcula de tamanho e forma definidos,partìcula estável na estocagem, e, processo para efetuar uma cristalização em estado sólido de uma mistura contendo pelo menos um composto orgânico alotrópico molecular. - Google Patents
Processo para efetuar uma cristalização em estado sólido de um composto orgânico molecular alotrópico em uma partìcula de tamanho e forma definidos,partìcula estável na estocagem, e, processo para efetuar uma cristalização em estado sólido de uma mistura contendo pelo menos um composto orgânico alotrópico molecular.Info
- Publication number
- BR9908156A BR9908156A BR9908156-3A BR9908156A BR9908156A BR 9908156 A BR9908156 A BR 9908156A BR 9908156 A BR9908156 A BR 9908156A BR 9908156 A BR9908156 A BR 9908156A
- Authority
- BR
- Brazil
- Prior art keywords
- allotropic
- solid state
- particle
- state crystallization
- stable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Abstract
"PROCESSO PARA EFETUAR UMA CRISTALIZAçãO EM ESTADO SóLIDO DE UM COMPOSTO ORGâNICO MOLECULAR ALOTRóPICO EM UMA PARTìCULA DE TAMANHO E FORMA DEFINIDOS, PARTìCULA ESTáVEL NA ESTOCAGEM, E, PROCESSO PARA EFETUAR UMA CRISTALIZAçãO EM ESTADO SóLIDO DE UMA MISTURA CONTENDO PELO MENOS UM COMPOSTO ORGâNICO ALOTRóPICO MOLECULAR". A presente invenção proporciona partículas moldadas estáveis em estocagem, de compostos orgânicos alotrópicos. As partículas da presente invenção podem ser moldadas de acordo com a aplicação desejada. As formas preferidas de tais partículas são microsferas, particularmente aquelas que têm diâmetros de aproximadamente 1 a aproximadamente 1.000 microns. As partículas estáveis moldadas da presente invenção são particularmente bem adaptadas para a fabricação de formulações farmacêuticas, particularmente onde a liberação retardada e a biodisponibilidade uniforme são desejadas. As partículas estáveis em estocagem são formadas por uma cristalização em estado sólido de compostos orgânicos alotrópicos. O processo de cristalização em estado sólido da presente invenção fornece um meio para atingir uma forma cristalina estável em estocagem do citado composto alotrópico sem perda ou deterioração das dimensões da partícula original.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/030,388 US6287693B1 (en) | 1998-02-25 | 1998-02-25 | Stable shaped particles of crystalline organic compounds |
| PCT/IB1999/000233 WO1999043304A1 (en) | 1998-02-25 | 1999-02-10 | Stable shaped particles of crystalline organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908156A true BR9908156A (pt) | 2000-10-31 |
Family
ID=21853984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908156-3A BR9908156A (pt) | 1998-02-25 | 1999-02-10 | Processo para efetuar uma cristalização em estado sólido de um composto orgânico molecular alotrópico em uma partìcula de tamanho e forma definidos,partìcula estável na estocagem, e, processo para efetuar uma cristalização em estado sólido de uma mistura contendo pelo menos um composto orgânico alotrópico molecular. |
Country Status (35)
| Country | Link |
|---|---|
| US (7) | US6287693B1 (pt) |
| EP (4) | EP2085075B1 (pt) |
| JP (2) | JP4885357B2 (pt) |
| KR (1) | KR100726315B1 (pt) |
| CN (2) | CN1146407C (pt) |
| AR (3) | AR018107A1 (pt) |
| AT (2) | ATE427102T1 (pt) |
| AU (1) | AU747779B2 (pt) |
| BR (1) | BR9908156A (pt) |
| CA (1) | CA2319176C (pt) |
| CL (1) | CL2010001333A1 (pt) |
| CY (1) | CY1118522T1 (pt) |
| CZ (1) | CZ301042B6 (pt) |
| DE (2) | DE69940684D1 (pt) |
| DK (3) | DK1056444T3 (pt) |
| EE (1) | EE05019B1 (pt) |
| ES (3) | ES2324366T3 (pt) |
| HK (2) | HK1036017A1 (pt) |
| HU (1) | HUP0101271A3 (pt) |
| ID (1) | ID26523A (pt) |
| IL (2) | IL137970A0 (pt) |
| MY (1) | MY138375A (pt) |
| NO (1) | NO331804B1 (pt) |
| NZ (1) | NZ505987A (pt) |
| PE (1) | PE20000393A1 (pt) |
| PL (1) | PL196369B1 (pt) |
| PT (1) | PT2085075T (pt) |
| RU (1) | RU2225708C2 (pt) |
| SA (1) | SA99200098B1 (pt) |
| TR (1) | TR200002462T2 (pt) |
| TW (1) | TWI256308B (pt) |
| UA (1) | UA73470C2 (pt) |
| UY (1) | UY25404A1 (pt) |
| WO (1) | WO1999043304A1 (pt) |
| ZA (1) | ZA991058B (pt) |
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| US20040028747A1 (en) * | 2002-08-06 | 2004-02-12 | Tucker Christopher J. | Crystalline drug particles prepared using a controlled precipitation process |
| EA018356B1 (ru) * | 2003-06-13 | 2013-07-30 | Джон Клод Савуар | Микросферы эстрадиола и холестерина |
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| US20050048127A1 (en) * | 2003-07-22 | 2005-03-03 | Larry Brown | Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof |
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1998
- 1998-02-25 US US09/030,388 patent/US6287693B1/en not_active Expired - Lifetime
-
1999
- 1999-02-10 ES ES06022834T patent/ES2324366T3/es not_active Expired - Lifetime
- 1999-02-10 EE EEP200000492A patent/EE05019B1/xx unknown
- 1999-02-10 DK DK99902729T patent/DK1056444T3/da active
- 1999-02-10 ZA ZA9901058A patent/ZA991058B/xx unknown
- 1999-02-10 EP EP09156268.6A patent/EP2085075B1/en not_active Expired - Lifetime
- 1999-02-10 AU AU22936/99A patent/AU747779B2/en not_active Expired
- 1999-02-10 BR BR9908156-3A patent/BR9908156A/pt not_active Application Discontinuation
- 1999-02-10 TR TR2000/02462T patent/TR200002462T2/xx unknown
- 1999-02-10 AT AT06022834T patent/ATE427102T1/de active
- 1999-02-10 JP JP2000533103A patent/JP4885357B2/ja not_active Expired - Fee Related
- 1999-02-10 KR KR1020007009352A patent/KR100726315B1/ko not_active IP Right Cessation
- 1999-02-10 DE DE69940684T patent/DE69940684D1/de not_active Expired - Lifetime
- 1999-02-10 DE DE69934099T patent/DE69934099T2/de not_active Expired - Lifetime
- 1999-02-10 CA CA002319176A patent/CA2319176C/en not_active Expired - Fee Related
- 1999-02-10 ES ES99902729T patent/ES2275334T3/es not_active Expired - Lifetime
- 1999-02-10 AT AT99902729T patent/ATE345779T1/de active
- 1999-02-10 EP EP99902729A patent/EP1056444B1/en not_active Expired - Lifetime
- 1999-02-10 PT PT91562686T patent/PT2085075T/pt unknown
- 1999-02-10 CN CNB998032794A patent/CN1146407C/zh not_active Expired - Fee Related
- 1999-02-10 CN CNB2004100076469A patent/CN100528140C/zh not_active Expired - Fee Related
- 1999-02-10 IL IL13797099A patent/IL137970A0/xx active IP Right Grant
- 1999-02-10 NZ NZ505987A patent/NZ505987A/en not_active IP Right Cessation
- 1999-02-10 HU HU0101271A patent/HUP0101271A3/hu unknown
- 1999-02-10 CZ CZ20003047A patent/CZ301042B6/cs not_active IP Right Cessation
- 1999-02-10 DK DK06022834T patent/DK1772141T3/da active
- 1999-02-10 EP EP06022834A patent/EP1772141B1/en not_active Expired - Lifetime
- 1999-02-10 DK DK09156268.6T patent/DK2085075T3/en active
- 1999-02-10 PL PL343170A patent/PL196369B1/pl unknown
- 1999-02-10 EP EP10183811A patent/EP2319497B1/en not_active Expired - Lifetime
- 1999-02-10 WO PCT/IB1999/000233 patent/WO1999043304A1/en active IP Right Grant
- 1999-02-10 ES ES09156268.6T patent/ES2609284T3/es not_active Expired - Lifetime
- 1999-02-10 ID IDW20001723A patent/ID26523A/id unknown
- 1999-02-10 RU RU2000124327/15A patent/RU2225708C2/ru not_active IP Right Cessation
- 1999-02-12 MY MYPI99000491A patent/MY138375A/en unknown
- 1999-02-17 PE PE1999000141A patent/PE20000393A1/es not_active IP Right Cessation
- 1999-02-23 AR ARP990100728A patent/AR018107A1/es not_active Application Discontinuation
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- 1999-03-12 TW TW088103853A patent/TWI256308B/zh not_active IP Right Cessation
- 1999-05-05 SA SA99200098A patent/SA99200098B1/ar unknown
- 1999-10-02 UA UA2000095446A patent/UA73470C2/uk unknown
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2000
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2001
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2002
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2003
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2010
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2011
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2016
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