JPS5799562A - Preparation of microcrystal - Google Patents
Preparation of microcrystalInfo
- Publication number
- JPS5799562A JPS5799562A JP17618080A JP17618080A JPS5799562A JP S5799562 A JPS5799562 A JP S5799562A JP 17618080 A JP17618080 A JP 17618080A JP 17618080 A JP17618080 A JP 17618080A JP S5799562 A JPS5799562 A JP S5799562A
- Authority
- JP
- Japan
- Prior art keywords
- thd
- polymorph
- solvent
- resultant
- dihydroabietamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain a microcrystal capable of exhibiting a remarkably high cholesterol-lowering action in blood by the oral administration, by forming a polymorph from N-(2,6-dimethylphenyl)-Δ3-dihydroabietamide (THD) with a specific solvent, and finely dividing the resultant polymorph.
CONSTITUTION: The polymorph of N-(2,6-Dimethylphenyl)-Δ3-dihydroabietamide (THD) is prepared by the following methods: (A) THD is dissolved in a solvent selected from a halogenated hydrocarbon, e.g. methylene chloride, a cyclic saturated hydrocarbon, e.g. cyclohexane, and chain or cyclic ethereal organic solvent, e.g. ethyl ether, and the crystal is then separated from the resultant solution. (B) THD is wetted by the solvent and allowed to stand. (C) THD is allowed to stand in the solvent vapor. The resultant polymorph of THD is then mechanically and finely divided to give the crystal of THD having an average particle diameter of 2W4μ.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17618080A JPS5799562A (en) | 1980-12-12 | 1980-12-12 | Preparation of microcrystal |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17618080A JPS5799562A (en) | 1980-12-12 | 1980-12-12 | Preparation of microcrystal |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5799562A true JPS5799562A (en) | 1982-06-21 |
Family
ID=16009048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17618080A Pending JPS5799562A (en) | 1980-12-12 | 1980-12-12 | Preparation of microcrystal |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5799562A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999043304A1 (en) * | 1998-02-25 | 1999-09-02 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
US7589082B2 (en) | 2003-06-13 | 2009-09-15 | Skendi Finance Ltd | Pharmaceutical formulation for contraception and hormone-replacement therapy |
-
1980
- 1980-12-12 JP JP17618080A patent/JPS5799562A/en active Pending
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999043304A1 (en) * | 1998-02-25 | 1999-09-02 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
US6287693B1 (en) | 1998-02-25 | 2001-09-11 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
AU747779B2 (en) * | 1998-02-25 | 2002-05-23 | Skendi Finance Ltd. | Stable shaped particles of crystalline organic compounds |
US6528094B1 (en) | 1998-02-25 | 2003-03-04 | John-Claude Savoir | Stable shaped particles of crystalline organic compounds |
US6737081B2 (en) | 1998-02-25 | 2004-05-18 | John-Claude Savoir | Stable shaped particles of crystalline organic compounds |
US7427413B2 (en) | 1998-02-25 | 2008-09-23 | Skendi Finance Ltd. | Stable shaped particles of crystalline organic compounds |
EP2085075A1 (en) * | 1998-02-25 | 2009-08-05 | Skendi Finance, Ltd. | Stable shaped particles of crystalline organic compounds |
US7589082B2 (en) | 2003-06-13 | 2009-09-15 | Skendi Finance Ltd | Pharmaceutical formulation for contraception and hormone-replacement therapy |
US8163722B2 (en) | 2003-06-13 | 2012-04-24 | Skendi Finance Ltd. | Pharmaceutical formulation for contraception and hormone-replacement therapy |
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