JPS5799562A - Preparation of microcrystal - Google Patents

Preparation of microcrystal

Info

Publication number
JPS5799562A
JPS5799562A JP17618080A JP17618080A JPS5799562A JP S5799562 A JPS5799562 A JP S5799562A JP 17618080 A JP17618080 A JP 17618080A JP 17618080 A JP17618080 A JP 17618080A JP S5799562 A JPS5799562 A JP S5799562A
Authority
JP
Japan
Prior art keywords
thd
polymorph
solvent
resultant
dihydroabietamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP17618080A
Other languages
Japanese (ja)
Inventor
Masanobu Kawamata
Hisashi Yamaguchi
Hiroshi Enomoto
Yoshiaki Yoshikuni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP17618080A priority Critical patent/JPS5799562A/en
Publication of JPS5799562A publication Critical patent/JPS5799562A/en
Pending legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain a microcrystal capable of exhibiting a remarkably high cholesterol-lowering action in blood by the oral administration, by forming a polymorph from N-(2,6-dimethylphenyl)-Δ3-dihydroabietamide (THD) with a specific solvent, and finely dividing the resultant polymorph.
CONSTITUTION: The polymorph of N-(2,6-Dimethylphenyl)-Δ3-dihydroabietamide (THD) is prepared by the following methods: (A) THD is dissolved in a solvent selected from a halogenated hydrocarbon, e.g. methylene chloride, a cyclic saturated hydrocarbon, e.g. cyclohexane, and chain or cyclic ethereal organic solvent, e.g. ethyl ether, and the crystal is then separated from the resultant solution. (B) THD is wetted by the solvent and allowed to stand. (C) THD is allowed to stand in the solvent vapor. The resultant polymorph of THD is then mechanically and finely divided to give the crystal of THD having an average particle diameter of 2W4μ.
COPYRIGHT: (C)1982,JPO&Japio
JP17618080A 1980-12-12 1980-12-12 Preparation of microcrystal Pending JPS5799562A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17618080A JPS5799562A (en) 1980-12-12 1980-12-12 Preparation of microcrystal

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17618080A JPS5799562A (en) 1980-12-12 1980-12-12 Preparation of microcrystal

Publications (1)

Publication Number Publication Date
JPS5799562A true JPS5799562A (en) 1982-06-21

Family

ID=16009048

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17618080A Pending JPS5799562A (en) 1980-12-12 1980-12-12 Preparation of microcrystal

Country Status (1)

Country Link
JP (1) JPS5799562A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043304A1 (en) * 1998-02-25 1999-09-02 John Claude Savoir Stable shaped particles of crystalline organic compounds
US7589082B2 (en) 2003-06-13 2009-09-15 Skendi Finance Ltd Pharmaceutical formulation for contraception and hormone-replacement therapy

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043304A1 (en) * 1998-02-25 1999-09-02 John Claude Savoir Stable shaped particles of crystalline organic compounds
US6287693B1 (en) 1998-02-25 2001-09-11 John Claude Savoir Stable shaped particles of crystalline organic compounds
AU747779B2 (en) * 1998-02-25 2002-05-23 Skendi Finance Ltd. Stable shaped particles of crystalline organic compounds
US6528094B1 (en) 1998-02-25 2003-03-04 John-Claude Savoir Stable shaped particles of crystalline organic compounds
US6737081B2 (en) 1998-02-25 2004-05-18 John-Claude Savoir Stable shaped particles of crystalline organic compounds
US7427413B2 (en) 1998-02-25 2008-09-23 Skendi Finance Ltd. Stable shaped particles of crystalline organic compounds
EP2085075A1 (en) * 1998-02-25 2009-08-05 Skendi Finance, Ltd. Stable shaped particles of crystalline organic compounds
US7589082B2 (en) 2003-06-13 2009-09-15 Skendi Finance Ltd Pharmaceutical formulation for contraception and hormone-replacement therapy
US8163722B2 (en) 2003-06-13 2012-04-24 Skendi Finance Ltd. Pharmaceutical formulation for contraception and hormone-replacement therapy

Similar Documents

Publication Publication Date Title
JPS56100714A (en) Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane
AU512448B2 (en) The use of cyclic carbonic acid esters as solvents for poly-(b-hydroxy butric acid
JPS5225013A (en) Insulin pharmaceutical for nasal administration
JPS5427520A (en) Purification of crude acrylic acid
ES535798A0 (en) PROCESS FOR THE MANUFACTURE OF SPYRO-HYDANTOIN COMPOUNDS.
JPS5799562A (en) Preparation of microcrystal
JPS52108028A (en) Remedies for dysacousis
JPS5433278A (en) Separating method for liquid mixture
JPS5489A (en) Polymerization of diolefins
JPS55122715A (en) Antidiabetic agent
FR2274331A1 (en) PERFECTED PROCESS FOR CONTINUOUS SEPARATION, BY SORPTION AND DESORPTION, OF THE CONSTITUENTS OF A LIQUID MIXTURE
JPS549183A (en) Adsorbent for blood purification
JPS543019A (en) Preparation of 4-nitrosodiphenylamine hydrochliride
JPS6450817A (en) Agent for reducing blood viscosity
JPS5432597A (en) Purification of high molecular weight alkylene oxide polymer
JPS51140789A (en) Method of measurement of electron spin resonance absorption
JPS549184A (en) Method of separation organic compound adsorbed by protein
JPS57175124A (en) Antitumor drug
JPS5498339A (en) Carcinostatic agent
JPS53112023A (en) Display unit for cathode ray tube unit
JPS52111488A (en) Ozonizer
JPS51127676A (en) Fluorescent indicator and its manufacturing process
JPS5241210A (en) Method of making insulin preparations for rectal administration
JPS5223067A (en) Novel synthesis of 2-aminomethyl-1- ethylpyrrolidine
JPS5365867A (en) Preparation of chenodeoxycholic acid crystal