JPS56100714A - Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane - Google Patents

Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane

Info

Publication number
JPS56100714A
JPS56100714A JP252280A JP252280A JPS56100714A JP S56100714 A JPS56100714 A JP S56100714A JP 252280 A JP252280 A JP 252280A JP 252280 A JP252280 A JP 252280A JP S56100714 A JPS56100714 A JP S56100714A
Authority
JP
Japan
Prior art keywords
mucous membrane
pharmaceutical
adhering
drug
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP252280A
Other versions
JPS6323964B2 (en
Inventor
Masami Ishida
Ryoji Machida
Tsuneji Nagai
Naoki Nanbu
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP55002522A priority Critical patent/JPS6323964B2/ja
Publication of JPS56100714A publication Critical patent/JPS56100714A/en
Publication of JPS6323964B2 publication Critical patent/JPS6323964B2/ja
Application status is Expired legal-status Critical

Links

Abstract

PURPOSE: The titled pharmaceutical, capable of being absorbed from the mucous membrane well, and prepared by placing a drug layer containing particularly a drug which will not be absorbed orally in a coating layer adhering to the mucous membrane unevenly.
CONSTITUTION: A pharmaceutical adhering to the oral or nasal mucous membrane prepared by placing a drug layer consisting of an ointment base containing a drug, particularly insulin which can be administered only by the injection at present and a surfactant unevenly in a coating layer adhering to the mucous membrane, and consisting of a cellulose ether and/or an acrylic acid polymer or a salt thereof, e.g. hydroxypropyl cellulose and carbopol in a 1:2 mixture base. The pharmaceutical adhered to the oral or nasal mucous membrane permits the efficient absorption of insulin from the mucous membrane with a high absorption efficiency for a long time without using injection giving pain to a patient.
COPYRIGHT: (C)1981,JPO&Japio
JP55002522A 1980-01-16 1980-01-16 Expired JPS6323964B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55002522A JPS6323964B2 (en) 1980-01-16 1980-01-16

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55002522A JPS6323964B2 (en) 1980-01-16 1980-01-16

Publications (2)

Publication Number Publication Date
JPS56100714A true JPS56100714A (en) 1981-08-12
JPS6323964B2 JPS6323964B2 (en) 1988-05-18

Family

ID=11531701

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55002522A Expired JPS6323964B2 (en) 1980-01-16 1980-01-16

Country Status (1)

Country Link
JP (1) JPS6323964B2 (en)

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58174307A (en) * 1982-04-06 1983-10-13 Teikoku Seiyaku Kk Edible drug for attaching to oral cavity
JPS58213709A (en) * 1982-06-05 1983-12-12 Teikoku Seiyaku Kk Application agent for gum mucosa
JPS5989619A (en) * 1982-10-05 1984-05-23 Sandoz Ag Calcitonin composition and use
JPS59232552A (en) * 1983-06-16 1984-12-27 Nitto Electric Ind Co Mucous membrane bandage
JPS59232553A (en) * 1983-06-16 1984-12-27 Nitto Electric Ind Co Mucous membrane bandage
US4517173A (en) * 1980-09-26 1985-05-14 Nippon Soda Co. Ltd. Mucous membrane-adhering film preparation and process for its preparation
US4569837A (en) * 1983-06-01 1986-02-11 Teijin Limited Pharmaceutical preparation for remedy of periodontal disease and process for production thereof
US4572832A (en) * 1982-10-07 1986-02-25 Grelan Pharmaceutical Co., Ltd. Soft buccal
JPS61282320A (en) * 1985-06-04 1986-12-12 Sandoz Ag Nasal medicinal composition
JPS63310818A (en) * 1987-06-12 1988-12-19 Sato Seiyaku Kk Sheet preparation to be applied to oral mucosa
JPH01279839A (en) * 1988-04-30 1989-11-10 Nitto Denko Corp Water-soluble physiologically active protein preparation
JPH02262526A (en) * 1982-10-05 1990-10-25 Sandoz Ag Calcitonin composition and its use
US5122127A (en) * 1985-05-01 1992-06-16 University Of Utah Apparatus and methods for use in administering medicaments by direct medicament contact to mucosal tissues
US5132114A (en) * 1985-05-01 1992-07-21 University Of Utah Research Foundation Compositions and methods of manufacture of compressed powder medicaments
US5364634A (en) * 1991-11-08 1994-11-15 Southwest Research Institute Controlled-release PH sensitive capsule and adhesive system and method
US5800832A (en) * 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
US5955097A (en) * 1996-10-18 1999-09-21 Virotex Corporation Pharmaceutical preparation applicable to mucosal surfaces and body tissues
WO2000001416A1 (en) * 1998-07-07 2000-01-13 Yissum Research Developing Company Of The Hebrew University Of Jerusalem Pharmaceutical compositions containing low-melting waxes
US6103266A (en) * 1998-04-22 2000-08-15 Tapolsky; Gilles H. Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues
EP1123696A4 (en) * 1998-09-25 2002-02-06 Kao Corp Compositions for oral cavity
US6432415B1 (en) 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces
JP2009535304A (en) * 2006-04-13 2009-10-01 オラヘルス コーポレーション Mouth patch containing salt of glycyrrhetinic acid which is water soluble at mouth temperature
JP4632499B2 (en) * 1999-08-26 2011-02-23 武田薬品工業株式会社 Nasal mucosa adhesion matrix
US8173113B1 (en) 1989-11-03 2012-05-08 3M Innovative Properties Company Bioadhesive composition and patch
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8906277B2 (en) 2001-10-12 2014-12-09 Monosol Rx, Llc Process for manufacturing a resulting pharmaceutical film
JP2015519403A (en) * 2012-06-14 2015-07-09 エントレガ,インコーポレイテッド Mucoadhesive devices for active agent delivery
US9108340B2 (en) 2001-10-12 2015-08-18 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US9597288B2 (en) 2006-07-21 2017-03-21 Biodelivery Sciences International, Inc. Transmucosal delivery devices with enhanced uptake
US9855221B2 (en) 2001-10-12 2018-01-02 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
US9931305B2 (en) 2001-10-12 2018-04-03 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US10272607B2 (en) 2010-10-22 2019-04-30 Aquestive Therapeutics, Inc. Manufacturing of small film strips
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions

Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517173A (en) * 1980-09-26 1985-05-14 Nippon Soda Co. Ltd. Mucous membrane-adhering film preparation and process for its preparation
JPS58174307A (en) * 1982-04-06 1983-10-13 Teikoku Seiyaku Kk Edible drug for attaching to oral cavity
JPH057368B2 (en) * 1982-04-06 1993-01-28 Teikoku Seiyaku Kk
JPS58213709A (en) * 1982-06-05 1983-12-12 Teikoku Seiyaku Kk Application agent for gum mucosa
JPH057369B2 (en) * 1982-06-05 1993-01-28 Teikoku Seiyaku Kk
JPS5989619A (en) * 1982-10-05 1984-05-23 Sandoz Ag Calcitonin composition and use
JPH0354647B2 (en) * 1982-10-05 1991-08-20
JPH02262526A (en) * 1982-10-05 1990-10-25 Sandoz Ag Calcitonin composition and its use
US4572832A (en) * 1982-10-07 1986-02-25 Grelan Pharmaceutical Co., Ltd. Soft buccal
US4569837A (en) * 1983-06-01 1986-02-11 Teijin Limited Pharmaceutical preparation for remedy of periodontal disease and process for production thereof
JPH0458989B2 (en) * 1983-06-16 1992-09-21 Nitsuto Denko Kk
JPH0458988B2 (en) * 1983-06-16 1992-09-21 Nitsuto Denko Kk
JPS59232553A (en) * 1983-06-16 1984-12-27 Nitto Electric Ind Co Mucous membrane bandage
JPS59232552A (en) * 1983-06-16 1984-12-27 Nitto Electric Ind Co Mucous membrane bandage
US5122127A (en) * 1985-05-01 1992-06-16 University Of Utah Apparatus and methods for use in administering medicaments by direct medicament contact to mucosal tissues
US5132114A (en) * 1985-05-01 1992-07-21 University Of Utah Research Foundation Compositions and methods of manufacture of compressed powder medicaments
JPS61282320A (en) * 1985-06-04 1986-12-12 Sandoz Ag Nasal medicinal composition
JPH044296B2 (en) * 1987-06-12 1992-01-27
JPS63310818A (en) * 1987-06-12 1988-12-19 Sato Seiyaku Kk Sheet preparation to be applied to oral mucosa
JPH01279839A (en) * 1988-04-30 1989-11-10 Nitto Denko Corp Water-soluble physiologically active protein preparation
US8173113B1 (en) 1989-11-03 2012-05-08 3M Innovative Properties Company Bioadhesive composition and patch
US5364634A (en) * 1991-11-08 1994-11-15 Southwest Research Institute Controlled-release PH sensitive capsule and adhesive system and method
US5800832A (en) * 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
US5955097A (en) * 1996-10-18 1999-09-21 Virotex Corporation Pharmaceutical preparation applicable to mucosal surfaces and body tissues
US6159498A (en) * 1996-10-18 2000-12-12 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds of mucosal surfaces
US6290984B1 (en) 1996-10-18 2001-09-18 Virotex Corporation Pharmaceutical preparation applicable to mucosal surfaces and body tissues
US7579019B2 (en) 1996-10-18 2009-08-25 Arius Two, Inc. Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
US6103266A (en) * 1998-04-22 2000-08-15 Tapolsky; Gilles H. Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues
WO2000001416A1 (en) * 1998-07-07 2000-01-13 Yissum Research Developing Company Of The Hebrew University Of Jerusalem Pharmaceutical compositions containing low-melting waxes
EP1123696A4 (en) * 1998-09-25 2002-02-06 Kao Corp Compositions for oral cavity
JP4632499B2 (en) * 1999-08-26 2011-02-23 武田薬品工業株式会社 Nasal mucosa adhesion matrix
US6432415B1 (en) 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces
US9931305B2 (en) 2001-10-12 2018-04-03 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8906277B2 (en) 2001-10-12 2014-12-09 Monosol Rx, Llc Process for manufacturing a resulting pharmaceutical film
US9855221B2 (en) 2001-10-12 2018-01-02 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US9108340B2 (en) 2001-10-12 2015-08-18 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US10111810B2 (en) 2002-04-11 2018-10-30 Aquestive Therapeutics, Inc. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
JP2009535304A (en) * 2006-04-13 2009-10-01 オラヘルス コーポレーション Mouth patch containing salt of glycyrrhetinic acid which is water soluble at mouth temperature
US9597288B2 (en) 2006-07-21 2017-03-21 Biodelivery Sciences International, Inc. Transmucosal delivery devices with enhanced uptake
US9655843B2 (en) 2006-07-21 2017-05-23 Biodelivery Sciences International, Inc. Transmucosal delivery devices with enhanced uptake
US10272607B2 (en) 2010-10-22 2019-04-30 Aquestive Therapeutics, Inc. Manufacturing of small film strips
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
JP2015519403A (en) * 2012-06-14 2015-07-09 エントレガ,インコーポレイテッド Mucoadhesive devices for active agent delivery

Also Published As

Publication number Publication date
JPS6323964B2 (en) 1988-05-18

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