CY1118522T1 - Σταθερα μορφοποιημενα σωματιδια κρυσταλλικων οργανικων ενωσεων - Google Patents
Σταθερα μορφοποιημενα σωματιδια κρυσταλλικων οργανικων ενωσεωνInfo
- Publication number
- CY1118522T1 CY1118522T1 CY20161101356T CY161101356T CY1118522T1 CY 1118522 T1 CY1118522 T1 CY 1118522T1 CY 20161101356 T CY20161101356 T CY 20161101356T CY 161101356 T CY161101356 T CY 161101356T CY 1118522 T1 CY1118522 T1 CY 1118522T1
- Authority
- CY
- Cyprus
- Prior art keywords
- particles
- organic compounds
- present
- allotropic
- stable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει σταθερά κατά την αποθήκευση, μορφοποιημένα σωματίδια αλλοτροπικών οργανικών ενώσεων. Τα σωματίδια της παρούσας εφεύρεσης μπορεί να μορφοποιηθούν ανάλογα με την επιθυμητή εφαρμογή. Προτιμητέα σχήματα τέτοιων σωματιδίων είναι οι μικροσφαίρες, ειδικότερα εκείνες οι οποίες έχουν διαμέτρους από περίπου 1 έως περίπου 1000 μικρόμετρα. Τα σταθερά μορφοποιημένα σωματίδια της παρούσας εφεύρεσης είναι ιδιαίτερα καλά προσαρμοσμένα για την κατασκευή φαρμακευτικών σκευασμάτων, ειδικότερα όπου παρατεταμένη απελευθέρωση και ομοιόμορφη βιοδιαθεσιμότητα είναι επιθυμητές. Τα σταθερά κατά την αποθήκευση σωματίδια σχηματίζονται από μια στερεάς κατάστασης κρυστάλλωση αλλοτροπικών οργανικών ενώσεων. Η διαδικασία στερεάς κατάστασης κρυστάλλωσης της παρούσας εφεύρεσης παρέχει ένα μέσο για επίτευξη μιας σταθερής κατά την αποθήκευση κρυσταλλικής μορφής της εν λόγω αλλοτροπικής ένωσης χωρίς απώλεια ή φθορά των αρχικών διαστάσεων των σωματιδίων.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/030,388 US6287693B1 (en) | 1998-02-25 | 1998-02-25 | Stable shaped particles of crystalline organic compounds |
EP99902729A EP1056444B1 (en) | 1998-02-25 | 1999-02-10 | Stable shaped particles of crystalline organic compounds |
EP06022834A EP1772141B1 (en) | 1998-02-25 | 1999-02-10 | Method for effecting solid state crystallization |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118522T1 true CY1118522T1 (el) | 2017-07-12 |
Family
ID=21853984
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161101356T CY1118522T1 (el) | 1998-02-25 | 2016-12-28 | Σταθερα μορφοποιημενα σωματιδια κρυσταλλικων οργανικων ενωσεων |
Country Status (35)
Country | Link |
---|---|
US (7) | US6287693B1 (el) |
EP (4) | EP1056444B1 (el) |
JP (2) | JP4885357B2 (el) |
KR (1) | KR100726315B1 (el) |
CN (2) | CN1146407C (el) |
AR (3) | AR018107A1 (el) |
AT (2) | ATE427102T1 (el) |
AU (1) | AU747779B2 (el) |
BR (1) | BR9908156A (el) |
CA (1) | CA2319176C (el) |
CL (1) | CL2010001333A1 (el) |
CY (1) | CY1118522T1 (el) |
CZ (1) | CZ301042B6 (el) |
DE (2) | DE69934099T2 (el) |
DK (3) | DK2085075T3 (el) |
EE (1) | EE05019B1 (el) |
ES (3) | ES2609284T3 (el) |
HK (2) | HK1036017A1 (el) |
HU (1) | HUP0101271A3 (el) |
ID (1) | ID26523A (el) |
IL (2) | IL137970A0 (el) |
MY (1) | MY138375A (el) |
NO (1) | NO331804B1 (el) |
NZ (1) | NZ505987A (el) |
PE (1) | PE20000393A1 (el) |
PL (1) | PL196369B1 (el) |
PT (1) | PT2085075T (el) |
RU (1) | RU2225708C2 (el) |
SA (1) | SA99200098B1 (el) |
TR (1) | TR200002462T2 (el) |
TW (1) | TWI256308B (el) |
UA (1) | UA73470C2 (el) |
UY (1) | UY25404A1 (el) |
WO (1) | WO1999043304A1 (el) |
ZA (1) | ZA991058B (el) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6287693B1 (en) | 1998-02-25 | 2001-09-11 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
US6667344B2 (en) | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
PT2767539T (pt) | 2002-05-16 | 2017-08-28 | Janssen Sciences Ireland Uc | Formas pseudopolimórficas de um inibidor de protease de hiv |
US20040028746A1 (en) * | 2002-08-06 | 2004-02-12 | Sonke Svenson | Crystalline drug particles prepared using a controlled precipitation (recrystallization) process |
US20040028747A1 (en) * | 2002-08-06 | 2004-02-12 | Tucker Christopher J. | Crystalline drug particles prepared using a controlled precipitation process |
ATE454885T1 (de) * | 2003-06-13 | 2010-01-15 | Skendi Finance Ltd | Mikrosphären von estradiol und cholesterol |
TWI359675B (en) | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
EP1646354A4 (en) * | 2003-07-22 | 2010-03-17 | Baxter Int | SMALL SPHERICAL PARTICLES OF LOW MOLECULAR WEIGHT MOLECULES AND PROCESSES FOR THEIR PREPARATION AND USE |
RU2331410C2 (ru) * | 2003-12-04 | 2008-08-20 | Пфайзер Продактс Инк. | Способ получения фармацевтических мультичастиц |
SI2351555T1 (sl) * | 2004-02-23 | 2017-01-31 | Euro-Celtique S.A. | Naprava za transdermalno dajanje opioida, varna pred zlorabo |
RU2008100543A (ru) * | 2005-06-17 | 2009-07-27 | БАСФ Акциенгезельшафт (DE) | Способ получения усилителей эффекта отбеливания |
US20090246265A1 (en) * | 2008-03-26 | 2009-10-01 | Alltranz Inc. | Abuse deterrent transdermal formulations of opiate agonists and agonist-antagonists |
WO2009128692A1 (es) * | 2008-04-14 | 2009-10-22 | Posi Visionary Solutions Llp | Método y composición farmacéutica para lograr niveles plasmáticos de progesterona requeridos para diferentes indicaciones terapéuticas |
FR2939326B1 (fr) * | 2008-12-10 | 2011-04-01 | Univ Joseph Fourier | Procede et dispositif de controle d'une cristallisation. |
BR112012008317A2 (pt) | 2009-09-17 | 2016-03-22 | Upsher Smith Lab Inc | produto de liberação sustentada compreendendo uma combinação de uma amina não-opioide e uma droga anti-inflamatória não-esteroidal |
UY33103A (es) * | 2009-12-15 | 2011-07-29 | Techsphere S A De C V | Formulacion farmaceutica parenteral en suspension, de liberacion sostenida, en dosis baja y ultra baja, en terapia hormonal en el sindrome climaterico |
KR101708528B1 (ko) * | 2010-03-19 | 2017-02-20 | 다이이찌 산쿄 가부시키가이샤 | 디아민 유도체의 결정 및 그 제조 방법 |
US9351924B2 (en) | 2011-03-11 | 2016-05-31 | Snu R&Db Foundation | Drug delivery system including laminated structure |
KR101314126B1 (ko) | 2011-03-11 | 2013-10-04 | 서울대학교산학협력단 | 다면체 형상의 약물 전달 시스템 |
MX365818B (es) | 2011-11-23 | 2019-05-30 | Therapeuticsmd Inc | Formulaciones y terapias de reemplazo hormonal de combinacion naturales. |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
AU2014228175B2 (en) | 2013-03-15 | 2018-05-31 | Incyte Holdings Corporation | Tricyclic heterocycles as BET protein inhibitors |
WO2015095492A1 (en) | 2013-12-19 | 2015-06-25 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
MX2016013851A (es) | 2014-04-23 | 2017-07-14 | Incyte Corp | 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet). |
US10206932B2 (en) | 2014-05-22 | 2019-02-19 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
ITUB20153652A1 (it) * | 2015-09-16 | 2017-03-16 | Fatro Spa | Microsfere contenenti lattoni macrociclici antielminitici |
WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
AU2017239645A1 (en) | 2016-04-01 | 2018-10-18 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
BR112018076486A2 (pt) | 2016-06-20 | 2019-04-09 | Incyte Corporation | formas sólidas cristalinas de um inibidor de bet |
PL236889B1 (pl) * | 2017-10-03 | 2021-02-22 | Univ Warszawski Medyczny | Nowa forma krystaliczna bezwodnego 17-β-estradiolu, sposób jej otrzymywania oraz kompozycja farmaceutyczna zawierająca nową formę krystaliczną bezwodnego 17-β-estradiolu i jej zastosowanie |
EP3542786A1 (en) * | 2018-03-21 | 2019-09-25 | ITF Research Pharma, S.L.U. | Progesterone intravaginal devices |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2447362A (en) | 1945-11-01 | 1948-08-17 | Rca Corp | Production of crystals |
US3800038A (en) * | 1972-04-21 | 1974-03-26 | Biolog Concepts Inc | Uterine administraton of eutectic solid solutions of steroid hormones in a steroidal lipid carrier |
US4230621A (en) * | 1978-05-01 | 1980-10-28 | E. R. Squibb & Sons, Inc. | Steroid derivatives and their use in radioimmunoassays |
DE2843963A1 (de) * | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
IL63968A (en) | 1980-10-01 | 1985-10-31 | Glaxo Group Ltd | Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it |
JPS5799562A (en) | 1980-12-12 | 1982-06-21 | Nippon Shinyaku Co Ltd | Preparation of microcrystal |
DE3049196A1 (de) | 1980-12-24 | 1982-07-29 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von granulaten aus organischen in form einer schmelze vorliegenden stoffen |
US4447426A (en) * | 1982-01-18 | 1984-05-08 | E. R. Squibb & Sons, Inc. | Steroid monohydrates, formulations containing same and method |
JPS58143832A (ja) | 1982-02-22 | 1983-08-26 | Yoshiaki Kawashima | 結晶性化学物質の球状化再結晶法 |
DE3213025C2 (de) | 1982-04-02 | 1997-06-12 | Fischer Karl Ind Gmbh | Verfahren zur Nachkondensation von Polykondensaten |
GB8618847D0 (en) * | 1986-08-01 | 1986-09-10 | Smith Kline French Lab | Pharmaceutical formulations |
JPH0714625B2 (ja) | 1987-03-30 | 1995-02-22 | 呉羽化学工業株式会社 | 高結晶化ポリアリ−レンチオエ−テル成形物 |
US4897307A (en) | 1987-08-11 | 1990-01-30 | The Dow Chemical Company | Process for the solvent-induced crystallization of amorphous poly(etheretherketone)-type polymers and the article formed thereby |
DE3850384T2 (de) | 1987-09-28 | 1995-02-23 | Asahi Chemical Ind | Verfahren zur herstellung von kristallinem aromatischem polykarbonat und so hergestellte aromatische polykarbonate. |
US4919899A (en) | 1988-02-29 | 1990-04-24 | Herrmann Frederick T | Crystal growth apparatus |
YU120988A (en) * | 1988-06-23 | 1990-06-30 | Lek Tovarna Farmacevtskih | Process for preparing new dispersion pills of cimetidine |
IT1230566B (it) | 1988-10-17 | 1991-10-28 | Vectorpharma Int | Farmaci poco solubili supportati su sostanze polimeriche in forma atta all'aumento della velocita' di dissoluzione |
US5360478A (en) | 1989-10-16 | 1994-11-01 | Phasex Corporation | Gas anti-solvent recrystallization process |
FR2663224B1 (fr) * | 1990-06-14 | 1995-01-20 | Applicationes Farmaceuticas Sa | Forme galenique parenterale. |
FR2663223B1 (fr) * | 1990-06-14 | 1994-12-02 | Af Aplicaciones Far Lab | Forme galenique parenterale. |
JPH04305226A (ja) | 1991-01-25 | 1992-10-28 | Senichi Masuda | ガス中窒素酸化物の低減方法 |
SE9302777D0 (sv) * | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
US5874063A (en) * | 1991-04-11 | 1999-02-23 | Astra Aktiebolag | Pharmaceutical formulation |
SE9101090D0 (sv) | 1991-04-11 | 1991-04-11 | Astra Ab | Process for conditioning of water-soluble substances |
US5391810A (en) | 1991-05-23 | 1995-02-21 | Ajinomoto Co., Inc. | Method of crystallizing α-L-aspartyl-L-phenylalanine methyl ester |
DE4130173A1 (de) | 1991-09-11 | 1993-03-18 | Bayer Ag | Pharmazeutische zubereitungen mit einer speziellen kristallmodifikation des 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridindicarbonsaeure-isopropyl-(2-methoxyethyl)-esters |
DE4218929C1 (el) | 1992-06-10 | 1993-09-09 | Deutsche Bundesbahn, Vertreten Durch Das Bundesbahn-Zentralamt Minden (Westf.), 4950 Minden, De | |
US5290913A (en) | 1992-10-08 | 1994-03-01 | Carrier Vibrating Equipment, Inc. | Method and apparatus for the heat treatment of material |
US5558678A (en) | 1992-11-13 | 1996-09-24 | Karl Fischer Industrieanlagen Gmbh | Process and apparatus for continuous crystallization of plastic granules |
US5643595A (en) | 1992-11-24 | 1997-07-01 | Alkermes Controlled Therapeutics Inc. Ii | Growth promoters for animals |
WO1994020116A1 (en) * | 1993-03-10 | 1994-09-15 | University Of Alabama Research Foundation | Artificial primers for glycogen synthesis |
US5409605A (en) * | 1993-08-05 | 1995-04-25 | Chemical Lime Company | Apparatus and method for treating waste sludge |
JPH0757558A (ja) * | 1993-08-09 | 1995-03-03 | Showa Electric Wire & Cable Co Ltd | 耐熱絶縁電線 |
DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
US5849651A (en) * | 1995-06-01 | 1998-12-15 | Kabushiki Kaisha Toshiba | Reversible thermal recording medium |
JPH0957558A (ja) * | 1995-08-18 | 1997-03-04 | Nabeya Iron & Tool Works Ltd | スライド装置 |
JPH09227558A (ja) * | 1996-02-28 | 1997-09-02 | Fujisawa Pharmaceut Co Ltd | チアゾール化合物の安定な結晶およびその製造方法 |
US6287693B1 (en) * | 1998-02-25 | 2001-09-11 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
JP2000143832A (ja) | 1998-11-10 | 2000-05-26 | Toppan Printing Co Ltd | 高剛性を有するフィルムまたはシート |
-
1998
- 1998-02-25 US US09/030,388 patent/US6287693B1/en not_active Expired - Lifetime
-
1999
- 1999-02-10 CN CNB998032794A patent/CN1146407C/zh not_active Expired - Fee Related
- 1999-02-10 PT PT91562686T patent/PT2085075T/pt unknown
- 1999-02-10 DE DE69934099T patent/DE69934099T2/de not_active Expired - Lifetime
- 1999-02-10 PL PL343170A patent/PL196369B1/pl unknown
- 1999-02-10 NZ NZ505987A patent/NZ505987A/en not_active IP Right Cessation
- 1999-02-10 EP EP99902729A patent/EP1056444B1/en not_active Expired - Lifetime
- 1999-02-10 BR BR9908156-3A patent/BR9908156A/pt not_active Application Discontinuation
- 1999-02-10 KR KR1020007009352A patent/KR100726315B1/ko not_active IP Right Cessation
- 1999-02-10 EE EEP200000492A patent/EE05019B1/xx unknown
- 1999-02-10 RU RU2000124327/15A patent/RU2225708C2/ru not_active IP Right Cessation
- 1999-02-10 AT AT06022834T patent/ATE427102T1/de active
- 1999-02-10 CA CA002319176A patent/CA2319176C/en not_active Expired - Fee Related
- 1999-02-10 DE DE69940684T patent/DE69940684D1/de not_active Expired - Lifetime
- 1999-02-10 HU HU0101271A patent/HUP0101271A3/hu unknown
- 1999-02-10 EP EP10183811A patent/EP2319497B1/en not_active Expired - Lifetime
- 1999-02-10 AU AU22936/99A patent/AU747779B2/en not_active Expired
- 1999-02-10 JP JP2000533103A patent/JP4885357B2/ja not_active Expired - Fee Related
- 1999-02-10 ES ES09156268.6T patent/ES2609284T3/es not_active Expired - Lifetime
- 1999-02-10 IL IL13797099A patent/IL137970A0/xx active IP Right Grant
- 1999-02-10 TR TR2000/02462T patent/TR200002462T2/xx unknown
- 1999-02-10 ES ES99902729T patent/ES2275334T3/es not_active Expired - Lifetime
- 1999-02-10 DK DK09156268.6T patent/DK2085075T3/en active
- 1999-02-10 EP EP06022834A patent/EP1772141B1/en not_active Expired - Lifetime
- 1999-02-10 ID IDW20001723A patent/ID26523A/id unknown
- 1999-02-10 EP EP09156268.6A patent/EP2085075B1/en not_active Expired - Lifetime
- 1999-02-10 ES ES06022834T patent/ES2324366T3/es not_active Expired - Lifetime
- 1999-02-10 ZA ZA9901058A patent/ZA991058B/xx unknown
- 1999-02-10 CN CNB2004100076469A patent/CN100528140C/zh not_active Expired - Fee Related
- 1999-02-10 WO PCT/IB1999/000233 patent/WO1999043304A1/en active IP Right Grant
- 1999-02-10 AT AT99902729T patent/ATE345779T1/de active
- 1999-02-10 DK DK06022834T patent/DK1772141T3/da active
- 1999-02-10 CZ CZ20003047A patent/CZ301042B6/cs not_active IP Right Cessation
- 1999-02-10 DK DK99902729T patent/DK1056444T3/da active
- 1999-02-12 MY MYPI99000491A patent/MY138375A/en unknown
- 1999-02-17 PE PE1999000141A patent/PE20000393A1/es not_active IP Right Cessation
- 1999-02-23 AR ARP990100728A patent/AR018107A1/es not_active Application Discontinuation
- 1999-02-24 UY UY25404A patent/UY25404A1/es not_active Application Discontinuation
- 1999-03-12 TW TW088103853A patent/TWI256308B/zh not_active IP Right Cessation
- 1999-05-05 SA SA99200098A patent/SA99200098B1/ar unknown
- 1999-10-02 UA UA2000095446A patent/UA73470C2/uk unknown
-
2000
- 2000-07-12 US US09/615,061 patent/US6537580B1/en not_active Expired - Lifetime
- 2000-08-20 IL IL137970A patent/IL137970A/en not_active IP Right Cessation
- 2000-08-24 NO NO20004241A patent/NO331804B1/no not_active IP Right Cessation
-
2001
- 2001-05-23 US US09/862,723 patent/US6528094B1/en not_active Expired - Lifetime
- 2001-10-04 HK HK01106985A patent/HK1036017A1/xx not_active IP Right Cessation
-
2002
- 2002-01-15 US US10/045,148 patent/US6638536B2/en not_active Expired - Lifetime
- 2002-05-29 US US10/156,079 patent/US6663895B2/en not_active Expired - Lifetime
-
2003
- 2003-02-26 US US10/373,088 patent/US6737081B2/en not_active Expired - Lifetime
- 2003-02-26 US US10/372,897 patent/US7427413B2/en not_active Expired - Fee Related
-
2010
- 2010-03-17 AR ARP100100844A patent/AR077167A2/es not_active Application Discontinuation
- 2010-03-17 AR ARP100100845A patent/AR077168A2/es not_active Application Discontinuation
- 2010-12-02 CL CL2010001333A patent/CL2010001333A1/es unknown
-
2011
- 2011-07-22 JP JP2011161017A patent/JP2011241220A/ja not_active Withdrawn
- 2011-09-14 HK HK11109693.8A patent/HK1155384A1/xx not_active IP Right Cessation
-
2016
- 2016-12-28 CY CY20161101356T patent/CY1118522T1/el unknown
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