CH639422A5 - Process for the preparation of novel compounds C-076 - Google Patents

Process for the preparation of novel compounds C-076 Download PDF

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Publication number
CH639422A5
CH639422A5 CH477177A CH477177A CH639422A5 CH 639422 A5 CH639422 A5 CH 639422A5 CH 477177 A CH477177 A CH 477177A CH 477177 A CH477177 A CH 477177A CH 639422 A5 CH639422 A5 CH 639422A5
Authority
CH
Switzerland
Prior art keywords
compounds
hydroxy
dashed line
formula
fractions
Prior art date
Application number
CH477177A
Other languages
German (de)
English (en)
Inventor
Georg Albers-Schonberg
Richard William Burg
Thomas William Miller
Robert Eugene Ormond
Hyman Wallick
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24722350&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CH639422(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH639422A5 publication Critical patent/CH639422A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
CH477177A 1976-04-19 1977-04-18 Process for the preparation of novel compounds C-076 CH639422A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67832876A 1976-04-19 1976-04-19

Publications (1)

Publication Number Publication Date
CH639422A5 true CH639422A5 (en) 1983-11-15

Family

ID=24722350

Family Applications (1)

Application Number Title Priority Date Filing Date
CH477177A CH639422A5 (en) 1976-04-19 1977-04-18 Process for the preparation of novel compounds C-076

Country Status (40)

Country Link
US (1) US4310519A (enExample)
JP (1) JPS52151197A (enExample)
AR (1) AR215000A1 (enExample)
AT (1) AT357503B (enExample)
AU (1) AU513641B2 (enExample)
BE (1) BE853702A (enExample)
BG (1) BG35900A3 (enExample)
CA (1) CA1098063A (enExample)
CH (1) CH639422A5 (enExample)
CS (1) CS207397B2 (enExample)
CY (1) CY1114A (enExample)
DD (1) DD137727A5 (enExample)
DE (1) DE2717040C2 (enExample)
DK (1) DK146514C (enExample)
ES (1) ES457932A1 (enExample)
FI (1) FI57781C (enExample)
FR (1) FR2348970A1 (enExample)
GB (1) GB1573955A (enExample)
GR (1) GR63128B (enExample)
GT (1) GT197746150A (enExample)
HK (1) HK38481A (enExample)
HU (1) HU179041B (enExample)
IE (1) IE44822B1 (enExample)
IL (1) IL51854A (enExample)
IT (1) IT1106424B (enExample)
KE (1) KE3141A (enExample)
LU (1) LU77152A1 (enExample)
MY (1) MY8200087A (enExample)
NL (3) NL188859C (enExample)
NO (1) NO148856C (enExample)
NZ (1) NZ183847A (enExample)
OA (1) OA05638A (enExample)
PL (1) PL108004B1 (enExample)
PT (1) PT66445B (enExample)
RO (1) RO71785A (enExample)
SE (1) SE434277B (enExample)
SU (1) SU716524A3 (enExample)
YU (1) YU40814B (enExample)
ZA (1) ZA772345B (enExample)
ZM (1) ZM3677A1 (enExample)

Families Citing this family (271)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ186851A (en) * 1977-04-11 1984-12-14 Merck & Co Inc Glycosyloxy derivatives of milbemycin and parasiticidal compositions
US4093629A (en) * 1977-04-11 1978-06-06 Merck & Co., Inc. Derivatives of antibiotic substance milbemycin and processes therefor
PH15982A (en) 1977-10-03 1983-05-18 Merck & Co Inc Selective hydrogenation producta of c-076 compounds and derivatives thereof
NZ188459A (en) * 1977-10-03 1982-09-07 Merck & Co Inc Derivatives of c-076 compounds and pesticidal compositions
US4206205A (en) * 1977-10-03 1980-06-03 Merck & Co., Inc. Monosaccharide and aglycone derivatives of C-076
PH16612A (en) * 1977-12-19 1983-11-28 Merck & Co Inc 13-halo and 13-deoxy derivatives of c-076 compounds
US4203976A (en) * 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
US4263168A (en) * 1979-01-10 1981-04-21 Imperial Chemical Industries Limited Olefine polymerization catalyst
US4550160A (en) * 1979-08-13 1985-10-29 Merck & Co., Inc. Processes for the interconversion of C-076 compounds
JPS5632481A (en) 1979-08-23 1981-04-01 Sankyo Co Ltd Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
US4285963A (en) * 1980-08-07 1981-08-25 Merck & Co., Inc. Novel derivatives of C-076 compounds
US4385065A (en) 1980-10-23 1983-05-24 Merck & Co., Inc. Novel substances and process for their production
US4378353A (en) 1981-02-17 1983-03-29 Merck & Co., Inc. Novel C-076 compounds
US4333925A (en) 1981-05-11 1982-06-08 Merck & Co., Inc. Derivatives of C-076 compounds
US4399274A (en) 1981-07-02 1983-08-16 Merck & Co., Inc. Isolation of non-ionic lipophilic materials on macroreticular polymeric absorbents
US4412991A (en) * 1981-08-28 1983-11-01 Merck & Co., Inc. 22-Hydroxy derivatives of C-076 compounds, pharmaceutical compositions and method of use
US4457920A (en) * 1981-09-03 1984-07-03 Merck & Co., Inc. 4a-Substituted avermectin compounds
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
US4423211A (en) * 1981-12-21 1983-12-27 Merck & Co., Inc. Process for the whole broth extraction of avermectin
US4423209A (en) * 1982-02-26 1983-12-27 Merck & Co., Inc. Processes for the interconversion of avermectin compounds
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
NZ204074A (en) * 1982-05-10 1986-05-09 Merck & Co Inc Synergistic compositions containing avermectins
US4430329A (en) 1982-05-17 1984-02-07 Merck & Co., Inc. Synergistic treatment of adult canine heartworm with thiacetarsamide and ivermectin
DE3372693D1 (en) * 1982-07-22 1987-09-03 Ici Plc Methods and compositions of combating pests
US4469682A (en) * 1983-01-28 1984-09-04 Merck & Co., Inc. Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use
EP0125155A1 (en) * 1983-04-07 1984-11-14 Merck & Co. Inc. Novel synergistic agricultural insecticidal, pesticidal and acaricidal combinations
NZ207655A (en) * 1983-04-07 1986-09-10 Merck & Co Inc Synergistic veterinary compositions containing an avermectin compound and clorsulon
US4530921A (en) * 1983-10-03 1985-07-23 Merck & Co., Inc. Avermectin epoxide derivatives and method of use
US4560677A (en) * 1984-01-31 1985-12-24 Merck & Co., Inc. Synergistic avermectin combination for treating plant pests
US5169956A (en) * 1984-06-05 1992-12-08 American Cyanamid Company Macrolide antibiotic compounds
US4579864A (en) * 1984-06-11 1986-04-01 Merck & Co., Inc. Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
HU197046B (en) * 1984-09-14 1989-02-28 Glaxo Group Ltd Process for producing macrolide compounds with antiparasitic effect, pharmaceuticals comprising them and plant protectives comprising the same
US5182207A (en) * 1984-09-14 1993-01-26 American Cyanamid Company Strains of streptomyces thermoarchaensis
US4587247A (en) * 1985-02-25 1986-05-06 Merck & Co., Inc. Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use
US4666937A (en) * 1985-03-04 1987-05-19 Merck & Co., Inc. Avermectin bioconversion products
US4789684A (en) * 1985-05-02 1988-12-06 Merck & Co., Inc. Anthelmintic fermentation products of microorganisms
NZ215917A (en) 1985-05-02 1989-10-27 Merck & Co Inc 22-oh milbemycin derivatives and parasiticidal compositions
US4678774A (en) * 1985-06-06 1987-07-07 Merck & Co., Inc. Novel synergistic compositions
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
US4668696A (en) * 1985-07-29 1987-05-26 Merck & Co., Inc. Novel averonectin fermentation product of a microorganism with anthelmintic activity
US4766112A (en) * 1985-07-29 1988-08-23 Merck & Co. Inc. Anthelmintic fermentation products of a microorganism
NZ216908A (en) 1985-07-29 1989-06-28 Merck & Co Inc Avermectin derivatives
US4622313A (en) * 1985-08-01 1986-11-11 Merck & Co., Inc. O-sulfate derivatives of avermectins and milbemycins having improved water solubility
ES8605582A1 (es) * 1985-12-11 1986-03-16 Antibioticos Sa Un procedimiento para la preparacion de avermectinas
GB8606120D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
GB8606116D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
EP0240274A3 (en) * 1986-04-03 1990-03-14 Merck & Co. Inc. Avermectins as growth promotant agents
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
JP2587241B2 (ja) * 1986-07-24 1997-03-05 ビ−チヤム・グル−プ・ピ−エルシ− 新規化合物、その製法及びそれを含む医薬組成物
US4833168A (en) * 1986-10-03 1989-05-23 Merck & Co., Inc. Avermectin reformatsky adducts
US5077398A (en) * 1986-11-18 1991-12-31 Merck & Co., Inc. Process for isolation of avermectin B1 components with improved purity and subsequent isolaton of B2 components
IN167980B (enExample) * 1987-01-23 1991-01-19 Pfizer
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
DE3883408T2 (de) * 1987-01-23 1993-12-09 Pfizer Verfahren zur Herstellung von Avermectinen und die verwendeten Kulturen.
US5077278A (en) * 1987-01-23 1991-12-31 Pfizer Inc. Non-natural demethylavermectins compositions and method of use
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
US4831017A (en) * 1987-06-29 1989-05-16 Merck & Co., Inc. Increased litter size in monogastric domestic animals after treatment in mid-gestation of gravid female with avermectin or milbemycin compound
US4847243A (en) * 1987-10-08 1989-07-11 Merck & Co., Inc. Treatment for fescue toxicosis in grazing animals
EP0313297B1 (en) * 1987-10-23 1993-05-19 Pfizer Inc. Process for production of avermectin aglycones and cultures therefor
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
ATE87926T1 (de) * 1987-11-09 1993-04-15 Pfizer Ethylierte avermectine.
US4963667A (en) * 1987-11-10 1990-10-16 Merck & Co., Inc. Ivermectin derivative compounds and process for preparing the same
GB8726730D0 (en) 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
US4895837A (en) * 1988-01-29 1990-01-23 Merck & Co., Inc. Avermectin derivatives
GB8804440D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Antiparasitic agents
US4918097A (en) * 1988-03-11 1990-04-17 Ciba-Geigy Corporation Insecticides and parasiticides
GB8815967D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Antiparasitic agents
US5015662A (en) * 1988-10-18 1991-05-14 Merck & Co., Inc. Anthelmintic bioconversion products
US5120646A (en) * 1988-10-18 1992-06-09 Chen Shieh Shung T Process for the preparation of anthelmintive bioconversion products
US5015630A (en) * 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
US4897383A (en) * 1989-02-13 1990-01-30 Merck & Co., Inc. Avermectin derivatives
NZ232422A (en) * 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
ATE129286T1 (de) * 1989-03-31 1995-11-15 Merck & Co Inc Klonierung von streptomyces avermitilis genen zur biosynthese von avermectin und verfahren zu ihrer verwendung.
US5030622A (en) * 1989-06-02 1991-07-09 Merck & Co., Inc. Avermectin derivatives
US5023241A (en) * 1989-07-31 1991-06-11 Merck & Co., Inc. Avermectin derivatives
US5055454A (en) * 1989-10-30 1991-10-08 Merck & Co., Inc. 13-epi-avermectin derivatives useful as antiparasitic agents
US5830875A (en) * 1989-10-30 1998-11-03 Merck & Co., Inc. 24-and 25-substituted avermectin and milbemycin derivatives
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
US5114930A (en) * 1990-05-14 1992-05-19 Merck & Co., Inc. Avermectin derivatives with a spacer inserted between the disaccharide and the aglycone useful as antiparasitic agents
US5188944A (en) * 1990-06-22 1993-02-23 Merck & Co., Inc. Process for the glycosylation of avermectin agylcones
US5070015A (en) * 1990-10-15 1991-12-03 Merck & Co., Inc. Novel avermectins are produced from known microorganisms
US5192546A (en) * 1991-01-15 1993-03-09 Mycogen Corporation Synergistic pesticidal compositions
US5346698A (en) * 1991-01-15 1994-09-13 Mycogen Corporation Synergistic pesticidal compositions
US5177063A (en) * 1991-03-11 1993-01-05 Merck & Co., Inc. Avermectin compounds with a 6,5-spiroketal ring system
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
US5189026A (en) * 1991-06-07 1993-02-23 Fractal Laboratories, Inc. Treatment of human diseases involving dysregulation or dysfunction of the nervous system
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
US5192671A (en) * 1991-06-26 1993-03-09 Merck & Co., Inc. Process for the glycosylation of avermectin compounds
EP0524686A1 (en) * 1991-07-23 1993-01-27 Merck & Co. Inc. A process for the 14a-hydroxylation of avermectin compounds
EP0524687A1 (en) * 1991-07-23 1993-01-27 Merck & Co. Inc. A process for the glycosylation of avermectin compounds at the 14a-position
US5240915A (en) * 1991-10-15 1993-08-31 Merck & Co., Inc. Avermectin derivatives
US5171742A (en) * 1991-10-15 1992-12-15 Merck & Co., Inc. Avermectin compounds with a 6,5-spiroketal ring system ad a 23-acyl substituent
US5248669A (en) * 1991-12-17 1993-09-28 Samir Amer Inhibition of anoxia or hypoxia-induced, endothelium-mediated vasospasm with avermectins
GB9205007D0 (en) * 1992-03-07 1992-04-22 Pfizer Ltd Antiparasitic agents
US5162363A (en) * 1992-03-18 1992-11-10 Merck & Co., Inc. 23-nor-23-thia avermectin analogs are active anthelmintic agents
US5244879A (en) * 1992-03-18 1993-09-14 Merck & Co., Inc. 23-nor-23-oxa avermectin analogs are active anthelmintic agents
DE69329821T2 (de) * 1992-03-23 2001-07-19 Merck & Co., Inc. Ein streptomyces avermitilis-stamm glykosyliert avermectin-verbindungen
US5312753A (en) * 1992-03-23 1994-05-17 Merck & Co., Inc. Strain of streptomyces avermitilis capable of glycosylating avermectin compounds at the 13- and 14A positions
US5229415A (en) * 1992-03-24 1993-07-20 Merck & Co., Inc. Alkylthio alkyl avermectins are active antiparasitic agents
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
IT1255135B (it) * 1992-05-05 1995-10-20 Principio attivo a base di avermectine, ceppo e procedimento per la sua preparazione e composizione veterinaria che lo contiene.
US5248678A (en) * 1992-06-30 1993-09-28 Fractal Laboratories, Inc. Methods for increasing arousal and alertness and for the amelioration of comatose states
US5241083A (en) * 1992-07-01 1993-08-31 Merck & Co., Inc. Process for converting the 13-α-hydroxy group of avermectin aglycones
US5547955A (en) * 1992-10-22 1996-08-20 The Clorox Company High fructose insecticide bait compositions
US6162825A (en) * 1992-10-22 2000-12-19 The Clorox Company High fructose insecticide bait compositions
US5292647A (en) * 1992-11-30 1994-03-08 Eli Lilly And Company Strain of streptomyces for producing avermectins and processes therewith
US5411946A (en) * 1993-02-24 1995-05-02 Merck & Co., Inc. Avermectin derivatives
PL174488B1 (pl) * 1993-05-10 1998-08-31 Merck & Co Inc Preparat do zwalczania pasożytów zwierząt oraz sposób wytwarzania preparatu do zwalczania pasożytów zwierząt
US5602107A (en) * 1993-05-10 1997-02-11 Merck & Co., Inc. Pour-on formulations consisting of gylcols, glycerides and avermectin compounds
WO1995003419A1 (en) * 1993-07-23 1995-02-02 Pfizer Inc. Method for precipitating natural avermectins
CN1041523C (zh) * 1993-08-19 1999-01-06 麦克公司 结晶态取代的阿佛曼菌素苯甲酸盐及其制备方法与应用
US5478929A (en) * 1993-09-15 1995-12-26 Merck & Co., Inc. Bioconversion products of 27-hydroxy avermectin
US5380838A (en) * 1993-10-08 1995-01-10 Merck & Co. Inc. Stable solvates of avermectin compounds
US5399582A (en) * 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
TW327125B (en) * 1994-02-07 1998-02-21 Merck & Co Inc Composition and method for protecting against pine exhausted
GB9402916D0 (en) * 1994-02-16 1994-04-06 Pfizer Ltd Antiparasitic agents
US5578581A (en) * 1994-04-26 1996-11-26 Merck & Co., Inc. Active avermectin analogue
US5550153A (en) * 1994-11-14 1996-08-27 Kerz; Phillip D. Method for treating heartworm-infected canines
DE69612088T2 (de) 1995-02-24 2001-08-30 Novartis Ag, Basel Zusammensetzung zur bekämpfung von parasiten
AU691424B2 (en) * 1995-03-20 1998-05-14 Merck Sharp & Dohme Corp. Nodulisporic acid derivatives
DE19520275A1 (de) * 1995-06-02 1996-12-05 Bayer Ag Endoparasitizide Mittel
US6124359A (en) * 1995-10-20 2000-09-26 Mycogen Corporation Materials and methods for killing nematodes and nematode eggs
US5674897A (en) * 1995-10-20 1997-10-07 Mycogen Corporation Materials and methods for controlling nematodes
DE19613972A1 (de) * 1996-04-09 1997-10-16 Bayer Ag Injektionsformulierungen von Avermectinen und Milbemycinen auf Basis von Rizinusöl
AUPN933396A0 (en) * 1996-04-17 1996-05-09 Pfizer Pty Limited Non-aqueuos oral-drench compositions containing avermectin compounds
AU728221B2 (en) 1996-06-05 2001-01-04 Ashmont Holdings Limited Injectable compositions
US6114376A (en) * 1997-04-30 2000-09-05 Mcgill University Methods for using macrocyclic lactone compounds as multidrug resistance reversing agents in tumor and other cells
US6403308B1 (en) * 1997-04-30 2002-06-11 Mcgill University Methods for detecting and reversing resistance to macrocyclic lactone compounds
PL192651B1 (pl) * 1997-12-03 2006-11-30 Merck & Co Inc Preparaty iniekcyjne o długotrwałym działaniu
PL194270B1 (pl) * 1998-02-13 2007-05-31 Pfizer Prod Inc Wyizolowana cząsteczka polinukleotydowa, cząsteczka oligonukleotydowa, zrekombinowany wektor, komórka gospodarza, wyizolowany produkt genu AveC S. avermitilis, wyizolowany produkt homologu genu AveC S. hygroscopicus, sposób wytwarzania zrekombinowanego produktu genu AveC, sposób wytwarzania zrekombinowanego produktu homologu genu AveC, cząsteczka polinukleotydowa, wektor do zastępowania genu, sposób identyfikowania mutacji otwartej ramki odczytuAveC, sposób wytwarzania nowych szczepów S. avermitilis, szczep S. avermitilis i sposób wytwarzaniaawermektyn
ES2359973T3 (es) 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
GB9825402D0 (en) 1998-11-19 1999-01-13 Pfizer Ltd Antiparasitic formulations
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
DE10013914A1 (de) 2000-03-21 2001-09-27 Bayer Ag Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
US7897559B2 (en) * 2000-06-29 2011-03-01 Parks L Dean Dermatological composition and kit containing avermectin compound for treating dermatological conditions
US6399651B1 (en) * 2000-06-29 2002-06-04 L. Dean Parks Method of treating dermatoses using avermectin compound
DE10055941A1 (de) 2000-11-10 2002-05-23 Bayer Ag Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
DE10059606A1 (de) 2000-12-01 2002-06-06 Bayer Ag Wirkstoffkombinationen
AR036872A1 (es) 2001-08-13 2004-10-13 Du Pont Compuesto de antranilamida, composicion que lo comprende y metodo para controlar una plaga de invertebrados
DE10203688A1 (de) * 2002-01-31 2003-08-07 Bayer Cropscience Ag Synergistische insektizide Mischungen
EP2050815B1 (en) 2002-02-12 2011-10-26 Pfizer Products Inc. Streptomyces Avermitilis gene directing the ratio of B2:B1 avermectins
DE10207241A1 (de) * 2002-02-21 2003-09-04 Bayer Cropscience Ag Synergistische insektizide Mischungen
GB2386066A (en) * 2002-02-28 2003-09-10 Norbrook Lab Ltd Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species
US7001889B2 (en) * 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
US20060205681A1 (en) * 2002-06-21 2006-09-14 Maryam Moaddeb Homogenous paste formulations
US6764999B2 (en) 2002-07-11 2004-07-20 Stephen E. Bachman Nasal delivery of parasiticides
US20040077703A1 (en) * 2002-10-02 2004-04-22 Soll Mark D. Nodulisporic acid derivative spot-on formulations for combating parasites
DE10248257A1 (de) * 2002-10-16 2004-04-29 Bayer Cropscience Ag Wirkstoffkombinationen im insektiziden und akariziden Eigenschaften
GB0229804D0 (en) * 2002-12-20 2003-01-29 Syngenta Participations Ag Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
GB0316377D0 (en) 2003-07-12 2003-08-13 Norbrook Lab Ltd Parasiticidal composition
DE10353281A1 (de) 2003-11-14 2005-06-16 Bayer Cropscience Ag Wirkstoffkombination mit insektiziden und akariziden Eigenschaften
US7531186B2 (en) 2003-12-17 2009-05-12 Merial Limited Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
US7671034B2 (en) 2003-12-19 2010-03-02 Merial Limited Stabilized formulation of ivermectin feed premix with an extended shelf life
US7666444B2 (en) 2004-02-02 2010-02-23 Wyeth Antiparasitic composition
US7493609B2 (en) * 2004-08-30 2009-02-17 International Business Machines Corporation Method and apparatus for automatic second-order predictive commoning
KR20070054691A (ko) 2004-09-23 2007-05-29 쉐링-프라우 리미티드 신규한 트리플루오로메탄설폰아미드 옥심 에테르 유도체를사용하여 동물의 기생충 방제
DE102004053964A1 (de) * 2004-11-09 2006-05-11 Bayer Healthcare Ag Mittel gegen Demodikose
CA2587495A1 (en) * 2004-11-19 2006-05-26 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
GB0501220D0 (en) * 2005-01-21 2005-03-02 Norbrook Lab Ltd Anthelmintic composition
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US20080027011A1 (en) * 2005-12-20 2008-01-31 Hassan Nached Homogeneous paste and gel formulations
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
EP1849363A1 (en) * 2006-03-09 2007-10-31 Cheminova A/S Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
TWI422328B (zh) 2006-06-19 2014-01-11 Univ California 結合有殺線蟲之種子塗覆物的生物控制劑
DK2035390T3 (en) 2006-07-05 2016-01-04 Merial Inc 1-aryl-5-alkylpyrazolderivatforbindelser, methods of making and methods of use thereof
DE102007007750A1 (de) * 2006-08-17 2008-02-21 Bayer Cropscience Ag Avermectinderivate
FR2906468B1 (fr) * 2006-09-28 2012-09-21 Galderma Sa Utilisation de composes de la famille des avermectines pour le traitement de desordres dermatologiques
US8044230B2 (en) * 2006-12-13 2011-10-25 Intervet Inc. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
CN101605756A (zh) * 2006-12-13 2009-12-16 先灵-普劳有限公司 氟苯尼考及其类似物的水溶性前药
US8901163B2 (en) 2007-01-03 2014-12-02 Galderma S.A. Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound
BR122018010599B1 (pt) 2007-05-15 2019-05-14 Merial, Inc. Compostos de arilazol-2-il cianoetilamino, processos para fazê-los e uso dos mesmos
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
ES2666187T3 (es) 2007-06-27 2018-05-03 E. I. Du Pont De Nemours And Company Procedimiento de control de plagas en animales
EP2008517A1 (de) 2007-06-29 2008-12-31 Bayer CropScience AG Akarizide Wirkstoffkombinationen
AU2007251891B8 (en) 2007-06-29 2014-03-06 Y-Tex Corporation Pesticidal ear tag
US8425925B2 (en) 2007-06-29 2013-04-23 Y-Tex Corporation Pesticidal tag
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
EP2039248A1 (de) * 2007-09-21 2009-03-25 Bayer CropScience AG Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
DE102007045922A1 (de) 2007-09-26 2009-04-02 Bayer Cropscience Ag Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
ES2693696T3 (es) 2007-11-26 2018-12-13 Merial, Inc. Sistemas de disolventes para formulaciones de unción dorsal continua para combatir parásitos
AU2008340434B2 (en) 2007-12-21 2014-02-06 Boehringer Ingelheim Animal Health USA Inc. The use of 6-halogeno-[1,2,4]-triazolo-[1,5-a]-pyrimidine compounds for combating pests in and on animals
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
EP2127522A1 (de) 2008-05-29 2009-12-02 Bayer CropScience AG Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
US20100022469A1 (en) * 2008-06-24 2010-01-28 Majid Razzak Anthelminthic formulations
KR20110038723A (ko) * 2008-07-30 2011-04-14 인터벳 인터내셔널 비.브이. 플로르페니콜에 대한 중간체로서 유용한 옥사졸린-보호된 아미노디올 화합물의 제조 방법
CA2675093A1 (en) * 2008-08-08 2010-02-08 Michael L. Corrado Treatment of bed mite and bed bug infestations
AU2009313920B2 (en) 2008-11-14 2014-10-23 Boehringer Ingelheim Animal Health USA Inc. Enantiomerically enriched aryloazol- 2 -yl cyanoethylamino paraciticidal compounds
US8683346B2 (en) * 2008-11-17 2014-03-25 Sap Portals Israel Ltd. Client integration of information from a supplemental server into a portal
US9173728B2 (en) 2008-11-19 2015-11-03 Merial Inc. Multi-cavity container having offset indentures for dispensing fluids
CN102271672B (zh) * 2008-11-19 2015-02-04 梅里亚有限公司 用于治疗寄生物感染的包含单独的或与甲脒组合的1-芳基吡唑的组合物
CN102282154B (zh) 2008-12-04 2015-07-01 梅瑞尔公司 二聚的阿佛菌素和米尔倍霉素衍生物
EP2227951A1 (de) 2009-01-23 2010-09-15 Bayer CropScience AG Verwendung von Enaminocarbonylverbindungen zur Bekämpfung von durch Insekten übertragenen Viren
CN102355891A (zh) 2009-03-17 2012-02-15 英特威国际有限公司 大环内酯药物递送系统
KR101735605B1 (ko) 2009-03-25 2017-05-15 바이엘 인텔렉쳐 프로퍼티 게엠베하 피리딜에틸 벤즈아미드와 살충제를 포함하는 살선충, 살충 및 살비 활성성분 배합물
AU2010278948B2 (en) 2009-07-30 2015-04-23 Boehringer Ingelheim Animal Health USA Inc. Insecticidal 4-Amino-thieno(2,3-d)-pyrimidine compounds and methods of their use
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
US20120122679A1 (en) 2009-08-05 2012-05-17 E. I. Du Pont De Nemours And Company Mesoionic pesticides
IN2012DN00838A (enExample) 2009-08-05 2015-06-26 Du Pont
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
EP2485725A2 (en) * 2009-10-07 2012-08-15 Wyeth LLC Compositions comprising adjuvant, macrolide and proteinaceous antigen and methods of use thereof
EP2327410A1 (en) 2009-10-28 2011-06-01 Consiglio Nazionale Delle Ricerche - Infm Istituto Nazionale Per La Fisica Della Materia Avermectins and milbemycins for the treatment of flavivirus infections
MX2012006366A (es) 2009-12-04 2012-06-27 Basf Se Compuesto de bis-organoazufre plaguicidas.
WO2011075592A1 (en) 2009-12-17 2011-06-23 Merial Limited Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
HUE029006T2 (en) 2009-12-17 2017-02-28 Merial Inc Antiparasitic dihydroazole compounds and compositions comprising same
BR112012018108A2 (pt) 2010-01-22 2015-10-20 Bayer Ip Gmbh combinações acaricidas e/ou inseticidas de ingredientes ativos
UY33282A (es) 2010-03-25 2011-09-30 Novartis Ag Composiciones endoparasiticidas
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
EP2382865A1 (de) 2010-04-28 2011-11-02 Bayer CropScience AG Synergistische Wirkstoffkombinationen
SI2568980T1 (sl) 2010-05-12 2016-02-29 Merial, Inc. Injekcijske paraziticidne formulacije levamizola in makrocikličnih laktonov
MA34247B1 (fr) 2010-05-27 2013-05-02 Du Pont Forme cristalline du 4-[5-[3-chloro-5-(trifluorométhyl) phényl] -4,5-dihydro-5-(trifluorométhyl)-3-isoxazolyl]-n-[2-oxo-2-[(2, 2,2-trifluoroéthyl) amino] éthyl]-1-naphtalènecarboxamide
AR081970A1 (es) 2010-06-24 2012-10-31 Intervet Int Bv Formulacion inyectable de una lactona macrociclica y levamisol, formulacion y uso veterinario
WO2012001083A2 (en) 2010-06-29 2012-01-05 Ceva Sante Animale Sa Novel eprinomectin injectable compositions
CA2811926A1 (en) 2010-10-20 2012-04-26 Galderma S.A. Method of treating otitis externa using macrocyclic lactone compound
EP2629772B1 (en) 2010-10-20 2016-05-18 Galderma S.A. Ivermectin for use in the treatment of hemorrhoids
AU2011328948B2 (en) 2010-11-16 2016-08-04 Centre National De La Recherche Scientifique (Cnrs) Novel monensin derivatives for the treatment and prevention of protozoal infections
AU2011338573B2 (en) 2010-12-07 2016-07-28 Boehringer Ingelheim Animal Health USA Inc. Topical combination formulations of macrocyclic lactones with synthetic pyrethroids
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
GB201021836D0 (en) 2010-12-21 2011-02-02 Norbrook Lab Ltd Topical Composition
CA2832710C (en) 2011-04-15 2021-05-04 Palle Pedersen Method for controlling nematode pests
WO2013003505A1 (en) 2011-06-27 2013-01-03 Merial Limited Amido-pyridyl ether compounds and compositions and their use against parasites
WO2013003168A1 (en) 2011-06-27 2013-01-03 Merial Limited Novel insect-repellent coumarin derivatives, syntheses, and methods of use
CN102356769A (zh) * 2011-09-02 2012-02-22 魏振东 一种含有机质的可湿性粉剂农药
TR201903499T4 (tr) 2011-09-12 2019-04-22 Merial Inc Bi̇r i̇zoksazoli̇n akti̇f maddesi̇ni̇ i̇çeren parazi̇ti̇si̇dal bi̇leşi̇mler, bunlarin yöntemleri̇ ve kullanimlari
WO2013044118A2 (en) 2011-09-23 2013-03-28 Merial Limited Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods
EP2780008B1 (en) 2011-11-17 2017-07-05 Merial, Inc. Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof
ES2978407T3 (es) 2011-12-02 2024-09-12 Boehringer Ingelheim Vetmedica Gmbh Formulaciones de moxidectina inyectables de acción prolongada
HU231098B1 (hu) 2012-02-06 2020-08-28 Boehringer Ingelheim Animal Health USA Inc. Szisztémás hatóanyagokat tartalmazó, parazitaellenes hatású, orális állatgyógyászati készítmények, eljárások és alkalmazásuk
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CA3059936A1 (en) 2012-04-20 2013-10-24 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof
LT2922845T (lt) 2012-11-20 2018-09-10 Merial, Inc. Antihelmintiniai junginiai ir kompozicijos ir jų naudojimo būdai
SMT201800309T1 (it) 2013-01-31 2018-07-17 Merial Inc Metodo per trattare e curare leishmaniosi utilizzando fexinidazolo
NZ712345A (en) 2013-04-12 2016-04-29 Zoetis Services Llc Composition of macrocyclic lactones, levamisole, an amino sugar and an additional antiparasitic agent
US9447084B2 (en) 2013-11-01 2016-09-20 Merial, Inc. Antiparisitic and pesticidal isoxazoline compounds
EP2886640A1 (en) 2013-12-18 2015-06-24 Riga Technical University Process for isolation of milbemycins A3 and A4
US10857121B2 (en) 2014-04-17 2020-12-08 Merial Inc. Use of malononitrile compounds for protecting animals from parasites
JP6616786B2 (ja) 2014-05-19 2019-12-04 メリアル インコーポレイテッド 駆虫性化合物
MX383300B (es) 2014-06-19 2025-03-13 Boehringer Ingelheim Animal Health Usa Inc Composiciones parasiticidas que comprenden derivados de indol, metodos y usos de los mismos.
AU2015339096B2 (en) 2014-10-31 2018-08-02 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal composition comprising fipronil
EP3023092A1 (en) 2014-11-20 2016-05-25 Ceva Sante Animale Eprinomectin parenteral compositions
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
KR102593069B1 (ko) 2015-04-08 2023-10-23 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 이속사졸린 활성제를 포함하는 서방형 주사 제형, 이의 방법 및 용도
CA2986478C (en) 2015-05-20 2023-08-08 Merial, Inc. Anthelmintic depsipeptide compounds
US20160347829A1 (en) 2015-05-27 2016-12-01 Merial Inc. Compositions containing antimicrobial IgY antibodies, for treatment and prevention of disorders and diseases caused by oral health compromising (OHC) microorganisms
KR101687973B1 (ko) 2015-12-08 2016-12-21 주식회사 씨티씨바이오 마이크로필름 코팅을 이용한 동물 사료용 프리믹스 제조방법
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
RU2630316C1 (ru) * 2016-06-24 2017-09-07 Карина Микаилевна Мирзаева Препарат для борьбы с насекомыми-кератофагами
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
WO2018055022A1 (en) 2016-09-22 2018-03-29 Syngenta Participations Ag Pesticidal mixtures
WO2018071535A1 (en) 2016-10-14 2018-04-19 Merial, Inc. Pesticidal and parasiticidal vinyl isoxazoline compounds
CA3044038A1 (en) 2016-11-16 2018-05-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
AU2018292285B2 (en) 2017-06-26 2023-05-25 Boehringer Ingelheim Animal Health USA Inc. Dual active parasiticidal granule compositions, methods and uses thereof
BR112020003217A2 (pt) 2017-08-14 2020-10-06 Boehringer Ingelheim Animal Health USA Inc. compostos pesticidas e parasiticidas de pirazolisoxazolina
WO2019152808A1 (en) 2018-02-01 2019-08-08 Yale University Compositions and methods for inhibition of nuclear-penetrating antibodies
EP3749096A1 (en) 2018-02-08 2020-12-16 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
BR112021000257A2 (pt) 2018-07-09 2021-04-06 Boehringer Ingelheim Animal Health USA Inc. Compostos heterocíclicos anti-helmínticos
US11773066B2 (en) 2018-11-20 2023-10-03 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
AU2020208145B2 (en) 2019-01-16 2023-02-02 Boehringer Ingelheim Vetmedica Gmbh Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof
AR118215A1 (es) 2019-03-01 2021-09-22 Boehringer Ingelheim Animal Health Usa Inc Composiciones inyectables de clorsulón, sus métodos y usos
PE20220281A1 (es) 2019-03-19 2022-02-25 Boehringer Ingelheim Animal Health Usa Inc Compuestos de aza-benzotiofeno y aza-benzofurano como antihelminticos
MX2022000843A (es) 2019-07-22 2022-02-10 Intervet Int Bv Forma de dosificacion blanda masticable de uso veterinario.
WO2021242581A1 (en) 2020-05-29 2021-12-02 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
WO2022034226A1 (en) 2020-08-14 2022-02-17 Universidad De Navarra Avermectin and milbemycin compositions for inhalation
CA3205997A1 (en) 2020-12-21 2022-06-30 University Of Georgia Research Foundation Inc. Parasiticidal collar comprising isoxazoline compounds
US20250017210A1 (en) 2021-11-25 2025-01-16 Syngenta Crop Protection Ag Pesticidal compositions
WO2025257633A1 (en) 2024-06-12 2025-12-18 Boehringer Ingelheim Vetmedica Gmbh Long-acting castor oil-containing injectable formulations and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4914624A (enExample) * 1972-06-08 1974-02-08
US3950360A (en) * 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US4134973A (en) * 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4160083A (en) * 1977-10-03 1979-07-03 Merck & Co., Inc. Process for the separation of antibiotic macrolides
US4160861A (en) * 1977-10-03 1979-07-10 Merck & Co., Inc. Method for the separation of antibiotic macrolides
US4161583A (en) * 1977-10-03 1979-07-17 Merck & Co., Inc. Method for the separation and purification of antibiotic macrolides
US4160084A (en) * 1977-10-11 1979-07-03 Merck & Co., Inc. Method for the separation of antibiotic macrolides

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HK38481A (en) 1981-08-07
NL971001I1 (nl) 1997-06-02
BG35900A3 (bg) 1984-07-16
NL188859C (nl) 1992-10-16
AU2422077A (en) 1978-10-19
BE853702A (fr) 1977-10-18
FR2348970A1 (fr) 1977-11-18
CA1098063A (en) 1981-03-24
NL971001I2 (nl) 1997-08-01
DK149077A (da) 1977-10-20
IE44822L (en) 1977-10-19
FI771124A7 (enExample) 1977-10-20
HU179041B (en) 1982-08-28
IL51854A0 (en) 1977-06-30

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