CS207397B2 - Method of preparation of the new anthelmintic compounds - Google Patents
Method of preparation of the new anthelmintic compounds Download PDFInfo
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- CS207397B2 CS207397B2 CS772465A CS246577A CS207397B2 CS 207397 B2 CS207397 B2 CS 207397B2 CS 772465 A CS772465 A CS 772465A CS 246577 A CS246577 A CS 246577A CS 207397 B2 CS207397 B2 CS 207397B2
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67832876A | 1976-04-19 | 1976-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS207397B2 true CS207397B2 (en) | 1981-07-31 |
Family
ID=24722350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS772465A CS207397B2 (en) | 1976-04-19 | 1977-04-14 | Method of preparation of the new anthelmintic compounds |
Country Status (40)
Families Citing this family (271)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ186851A (en) * | 1977-04-11 | 1984-12-14 | Merck & Co Inc | Glycosyloxy derivatives of milbemycin and parasiticidal compositions |
| US4093629A (en) * | 1977-04-11 | 1978-06-06 | Merck & Co., Inc. | Derivatives of antibiotic substance milbemycin and processes therefor |
| PH15982A (en) | 1977-10-03 | 1983-05-18 | Merck & Co Inc | Selective hydrogenation producta of c-076 compounds and derivatives thereof |
| NZ188459A (en) * | 1977-10-03 | 1982-09-07 | Merck & Co Inc | Derivatives of c-076 compounds and pesticidal compositions |
| US4206205A (en) * | 1977-10-03 | 1980-06-03 | Merck & Co., Inc. | Monosaccharide and aglycone derivatives of C-076 |
| IL56149A (en) * | 1977-12-19 | 1989-09-28 | Merck & Co Inc | 13-halo and 13-deoxy derivatives of c-076 compounds,their preparation and method for the treatment of parasitic infections in animals therewith |
| US4203976A (en) * | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| US4200581A (en) * | 1978-08-04 | 1980-04-29 | Merck & Co., Inc. | Alkyl derivatives of C-076 compounds |
| US4263168A (en) * | 1979-01-10 | 1981-04-21 | Imperial Chemical Industries Limited | Olefine polymerization catalyst |
| US4550160A (en) * | 1979-08-13 | 1985-10-29 | Merck & Co., Inc. | Processes for the interconversion of C-076 compounds |
| JPS5632481A (en) * | 1979-08-23 | 1981-04-01 | Sankyo Co Ltd | Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent |
| US4289760A (en) * | 1980-05-02 | 1981-09-15 | Merck & Co., Inc. | 23-Keto derivatives of C-076 compounds |
| US4285963A (en) * | 1980-08-07 | 1981-08-25 | Merck & Co., Inc. | Novel derivatives of C-076 compounds |
| US4385065A (en) | 1980-10-23 | 1983-05-24 | Merck & Co., Inc. | Novel substances and process for their production |
| US4378353A (en) | 1981-02-17 | 1983-03-29 | Merck & Co., Inc. | Novel C-076 compounds |
| US4333925A (en) | 1981-05-11 | 1982-06-08 | Merck & Co., Inc. | Derivatives of C-076 compounds |
| US4399274A (en) | 1981-07-02 | 1983-08-16 | Merck & Co., Inc. | Isolation of non-ionic lipophilic materials on macroreticular polymeric absorbents |
| US4412991A (en) * | 1981-08-28 | 1983-11-01 | Merck & Co., Inc. | 22-Hydroxy derivatives of C-076 compounds, pharmaceutical compositions and method of use |
| US4457920A (en) * | 1981-09-03 | 1984-07-03 | Merck & Co., Inc. | 4a-Substituted avermectin compounds |
| NZ201681A (en) * | 1981-09-03 | 1985-11-08 | Merck & Co Inc | Avermectin derivatives and parasiticidal compositions |
| US4423211A (en) * | 1981-12-21 | 1983-12-27 | Merck & Co., Inc. | Process for the whole broth extraction of avermectin |
| US4423209A (en) * | 1982-02-26 | 1983-12-27 | Merck & Co., Inc. | Processes for the interconversion of avermectin compounds |
| US4427663A (en) | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| NZ204074A (en) * | 1982-05-10 | 1986-05-09 | Merck & Co Inc | Synergistic compositions containing avermectins |
| US4430329A (en) | 1982-05-17 | 1984-02-07 | Merck & Co., Inc. | Synergistic treatment of adult canine heartworm with thiacetarsamide and ivermectin |
| EP0102702B1 (en) * | 1982-07-22 | 1987-07-29 | Imperial Chemical Industries Plc | Methods and compositions of combating pests |
| US4469682A (en) * | 1983-01-28 | 1984-09-04 | Merck & Co., Inc. | Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use |
| NZ207655A (en) * | 1983-04-07 | 1986-09-10 | Merck & Co Inc | Synergistic veterinary compositions containing an avermectin compound and clorsulon |
| EP0125155A1 (en) * | 1983-04-07 | 1984-11-14 | Merck & Co. Inc. | Novel synergistic agricultural insecticidal, pesticidal and acaricidal combinations |
| US4530921A (en) * | 1983-10-03 | 1985-07-23 | Merck & Co., Inc. | Avermectin epoxide derivatives and method of use |
| US4560677A (en) * | 1984-01-31 | 1985-12-24 | Merck & Co., Inc. | Synergistic avermectin combination for treating plant pests |
| US5169956A (en) * | 1984-06-05 | 1992-12-08 | American Cyanamid Company | Macrolide antibiotic compounds |
| US4579864A (en) * | 1984-06-11 | 1986-04-01 | Merck & Co., Inc. | Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives |
| CA1313155C (en) * | 1984-09-14 | 1993-01-26 | Richard Alan Fletton | Antibiotic compounds and their preparation |
| US5182207A (en) * | 1984-09-14 | 1993-01-26 | American Cyanamid Company | Strains of streptomyces thermoarchaensis |
| US4587247A (en) * | 1985-02-25 | 1986-05-06 | Merck & Co., Inc. | Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use |
| US4666937A (en) * | 1985-03-04 | 1987-05-19 | Merck & Co., Inc. | Avermectin bioconversion products |
| NZ215917A (en) | 1985-05-02 | 1989-10-27 | Merck & Co Inc | 22-oh milbemycin derivatives and parasiticidal compositions |
| US4789684A (en) * | 1985-05-02 | 1988-12-06 | Merck & Co., Inc. | Anthelmintic fermentation products of microorganisms |
| US4678774A (en) * | 1985-06-06 | 1987-07-07 | Merck & Co., Inc. | Novel synergistic compositions |
| ES8800986A1 (es) * | 1985-07-27 | 1987-12-01 | Pfizer | Un procedimiento para la produccion de un nuevo derivado de avermectina |
| US4766112A (en) * | 1985-07-29 | 1988-08-23 | Merck & Co. Inc. | Anthelmintic fermentation products of a microorganism |
| US4668696A (en) * | 1985-07-29 | 1987-05-26 | Merck & Co., Inc. | Novel averonectin fermentation product of a microorganism with anthelmintic activity |
| NZ216908A (en) | 1985-07-29 | 1989-06-28 | Merck & Co Inc | Avermectin derivatives |
| US4622313A (en) * | 1985-08-01 | 1986-11-11 | Merck & Co., Inc. | O-sulfate derivatives of avermectins and milbemycins having improved water solubility |
| ES8605582A1 (es) * | 1985-12-11 | 1986-03-16 | Antibioticos Sa | Un procedimiento para la preparacion de avermectinas |
| GB8606116D0 (en) * | 1986-03-12 | 1986-04-16 | Glaxo Group Ltd | Process |
| GB8606120D0 (en) * | 1986-03-12 | 1986-04-16 | Glaxo Group Ltd | Process |
| EP0240274A3 (en) * | 1986-04-03 | 1990-03-14 | Merck & Co. Inc. | Avermectins as growth promotant agents |
| US5840704A (en) * | 1986-07-16 | 1998-11-24 | Pfizer Inc. | Antiparasitic agents and process for their preparation |
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| US4833168A (en) * | 1986-10-03 | 1989-05-23 | Merck & Co., Inc. | Avermectin reformatsky adducts |
| US5077398A (en) * | 1986-11-18 | 1991-12-31 | Merck & Co., Inc. | Process for isolation of avermectin B1 components with improved purity and subsequent isolaton of B2 components |
| US5238848A (en) * | 1987-01-23 | 1993-08-24 | Pfizer Inc | Cultures for production of avermectins |
| US5525506A (en) * | 1987-01-23 | 1996-06-11 | Pfizer Inc. | Process for production of avermectins and cultures therefor |
| IN167980B (enExample) * | 1987-01-23 | 1991-01-19 | Pfizer | |
| DE3883408T2 (de) * | 1987-01-23 | 1993-12-09 | Pfizer | Verfahren zur Herstellung von Avermectinen und die verwendeten Kulturen. |
| US5234831A (en) * | 1987-01-23 | 1993-08-10 | Pfizer Inc | Cultures for production of B avermectins |
| US5077278A (en) * | 1987-01-23 | 1991-12-31 | Pfizer Inc. | Non-natural demethylavermectins compositions and method of use |
| US4806527A (en) * | 1987-03-16 | 1989-02-21 | Merck & Co., Inc. | Avermectin derivatives |
| US4831017A (en) * | 1987-06-29 | 1989-05-16 | Merck & Co., Inc. | Increased litter size in monogastric domestic animals after treatment in mid-gestation of gravid female with avermectin or milbemycin compound |
| US4847243A (en) * | 1987-10-08 | 1989-07-11 | Merck & Co., Inc. | Treatment for fescue toxicosis in grazing animals |
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| US5240850A (en) * | 1987-10-23 | 1993-08-31 | Pfizer Inc. | Cultures for production of avermectin aglycones |
| EP0316124B1 (en) * | 1987-11-09 | 1993-04-07 | Pfizer Inc. | Ethylated avermectins |
| US4963667A (en) * | 1987-11-10 | 1990-10-16 | Merck & Co., Inc. | Ivermectin derivative compounds and process for preparing the same |
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| US4895837A (en) * | 1988-01-29 | 1990-01-23 | Merck & Co., Inc. | Avermectin derivatives |
| GB8804440D0 (en) * | 1988-02-25 | 1988-03-23 | Pfizer Ltd | Antiparasitic agents |
| US4918097A (en) * | 1988-03-11 | 1990-04-17 | Ciba-Geigy Corporation | Insecticides and parasiticides |
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| US5120646A (en) * | 1988-10-18 | 1992-06-09 | Chen Shieh Shung T | Process for the preparation of anthelmintive bioconversion products |
| US5015662A (en) * | 1988-10-18 | 1991-05-14 | Merck & Co., Inc. | Anthelmintic bioconversion products |
| US5015630A (en) * | 1989-01-19 | 1991-05-14 | Merck & Co., Inc. | 5-oxime avermectin derivatives |
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| JPS4914624A (enExample) * | 1972-06-08 | 1974-02-08 | ||
| US3950360A (en) * | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| US4134973A (en) * | 1977-04-11 | 1979-01-16 | Merck & Co., Inc. | Carbohydrate derivatives of milbemycin and processes therefor |
| US4161583A (en) * | 1977-10-03 | 1979-07-17 | Merck & Co., Inc. | Method for the separation and purification of antibiotic macrolides |
| US4160083A (en) * | 1977-10-03 | 1979-07-03 | Merck & Co., Inc. | Process for the separation of antibiotic macrolides |
| US4160861A (en) * | 1977-10-03 | 1979-07-10 | Merck & Co., Inc. | Method for the separation of antibiotic macrolides |
| US4160084A (en) * | 1977-10-11 | 1979-07-03 | Merck & Co., Inc. | Method for the separation of antibiotic macrolides |
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- 1977-04-13 AU AU24220/77A patent/AU513641B2/en not_active Expired
- 1977-04-14 RO RO7790023A patent/RO71785A/ro unknown
- 1977-04-14 CS CS772465A patent/CS207397B2/cs unknown
- 1977-04-15 IT IT48991/77A patent/IT1106424B/it active
- 1977-04-15 FR FR7711432A patent/FR2348970A1/fr active Granted
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- 1977-04-15 AT AT266277A patent/AT357503B/de not_active IP Right Cessation
- 1977-04-15 AR AR267229A patent/AR215000A1/es active
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- 1977-04-15 IE IE785/77A patent/IE44822B1/en not_active IP Right Cessation
- 1977-04-15 DD DD77198421A patent/DD137727A5/xx unknown
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- 1977-04-18 CH CH477177A patent/CH639422A5/de not_active IP Right Cessation
- 1977-04-18 SU SU772474802A patent/SU716524A3/ru active
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- 1977-04-18 DE DE2717040A patent/DE2717040C2/de not_active Expired
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