CA3022097C - Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement - Google Patents

Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement Download PDF

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Publication number
CA3022097C
CA3022097C CA3022097A CA3022097A CA3022097C CA 3022097 C CA3022097 C CA 3022097C CA 3022097 A CA3022097 A CA 3022097A CA 3022097 A CA3022097 A CA 3022097A CA 3022097 C CA3022097 C CA 3022097C
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Prior art keywords
antibody
eculizumab
complement
antibodies
patients
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CA3022097A
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English (en)
French (fr)
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CA3022097A1 (en
Inventor
Leonard Bell
Russell P. Rother
Mark J. Evans
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Alexion Pharmaceuticals Inc
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Alexion Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
CA3022097A 2006-03-15 2007-03-15 Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement Active CA3022097C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78307006P 2006-03-15 2006-03-15
US60/783,070 2006-03-15
CA2645810A CA2645810C (en) 2006-03-15 2007-03-15 Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2645810A Division CA2645810C (en) 2006-03-15 2007-03-15 Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement

Publications (2)

Publication Number Publication Date
CA3022097A1 CA3022097A1 (en) 2007-09-20
CA3022097C true CA3022097C (en) 2020-10-27

Family

ID=38222520

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Application Number Title Priority Date Filing Date
CA3022097A Active CA3022097C (en) 2006-03-15 2007-03-15 Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement
CA2645810A Active CA2645810C (en) 2006-03-15 2007-03-15 Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2645810A Active CA2645810C (en) 2006-03-15 2007-03-15 Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement

Country Status (16)

Country Link
US (8) US20090220508A1 (https=)
EP (5) EP2001490A1 (https=)
JP (9) JP2009530299A (https=)
KR (2) KR20140057635A (https=)
AU (1) AU2007225044C1 (https=)
BR (2) BRPI0708909B8 (https=)
CA (2) CA3022097C (https=)
DK (1) DK2359834T5 (https=)
ES (2) ES2612118T3 (https=)
HU (2) HUE030105T2 (https=)
IL (4) IL302157A (https=)
MX (2) MX340784B (https=)
PL (2) PL3167888T3 (https=)
PT (1) PT2359834T (https=)
SI (1) SI2359834T1 (https=)
WO (1) WO2007106585A1 (https=)

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