CA2968382A1 - Antibodies comprising modified heavy constant regions - Google Patents
Antibodies comprising modified heavy constant regions Download PDFInfo
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- CA2968382A1 CA2968382A1 CA2968382A CA2968382A CA2968382A1 CA 2968382 A1 CA2968382 A1 CA 2968382A1 CA 2968382 A CA2968382 A CA 2968382A CA 2968382 A CA2968382 A CA 2968382A CA 2968382 A1 CA2968382 A1 CA 2968382A1
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| AU2015305754B2 (en) | 2014-08-19 | 2018-10-25 | Merck Sharp & Dohme Llc | Anti-tigit antibodies |
| SG11201703192SA (en) | 2014-11-21 | 2017-05-30 | Bristol Myers Squibb Co | Antibodies against cd73 and uses thereof |
| CN107250157B (zh) * | 2014-11-21 | 2021-06-29 | 百时美施贵宝公司 | 包含修饰的重链恒定区的抗体 |
| RU2732042C2 (ru) | 2015-02-19 | 2020-09-10 | Компьюджен Лтд. | Анти-pvrig антитела и способы применения |
| EP3259597B1 (en) | 2015-02-19 | 2022-04-06 | Compugen Ltd. | Pvrig polypeptides and methods of treatment |
| CA2994555A1 (en) | 2015-08-14 | 2017-02-23 | Merck Sharp & Dohme Corp. | Anti-tigit antibodies |
| WO2017064043A1 (en) * | 2015-10-12 | 2017-04-20 | Innate Pharma | Cd73 blocking agents |
| JP6983776B2 (ja) * | 2015-11-19 | 2021-12-17 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | グルココルチコイド誘発腫瘍壊死因子受容体（ｇｉｔｒ）に対する抗体およびその使用 |
| US11447557B2 (en) | 2015-12-02 | 2022-09-20 | Agenus Inc. | Antibodies and methods of use thereof |
| SG10201913033UA (en) * | 2016-03-04 | 2020-03-30 | Bristol Myers Squibb Co | Combination therapy with anti-cd73 antibodies |
| NZ749355A (en) | 2016-05-27 | 2023-04-28 | Agenus Inc | Anti-tim-3 antibodies and methods of use thereof |
| WO2017211321A1 (zh) * | 2016-06-08 | 2017-12-14 | 上海交通大学医学院 | 增强激动型抗体活性的抗体重链恒定区序列 |
| CA3030765A1 (en) * | 2016-07-14 | 2018-01-18 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| EP3487534A4 (en) * | 2016-07-22 | 2020-03-25 | Gliknik Inc. | FUSION PROTEINS FROM HUMAN PROTEIN FRAGMENTS FOR THE PRODUCTION OF MULTIMERIZED IMMUNOGLOBULIN FC COMPOSITIONS WITH INCREASED FC RECEPTOR BINDING |
| KR102585976B1 (ko) | 2016-08-17 | 2023-10-05 | 컴퓨젠 엘티디. | 항-tigit 항체, 항-pvrig 항체 및 이들의 조합 |
| KR20230130174A (ko) * | 2016-08-30 | 2023-09-11 | 젠코어 인코포레이티드 | 공자극 및 체크포인트 수용체에 결합하는 이중특이적 면역조절 항체 |
| CA3037380A1 (en) | 2016-10-11 | 2018-04-19 | Agenus Inc. | Anti-lag-3 antibodies and methods of use thereof |
| AR109770A1 (es) * | 2016-10-18 | 2019-01-23 | Lilly Co Eli | ANTICUERPOS DEL RECEPTOR II DE TGF-b |
| MA46770A (fr) | 2016-11-09 | 2019-09-18 | Agenus Inc | Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation |
| EP3538552B1 (en) | 2016-11-14 | 2023-09-13 | MorphoSys AG | Fab molecules with a rodent hinge region and a non-rodent ch1 region |
| GB201619652D0 (en) * | 2016-11-21 | 2017-01-04 | Alligator Bioscience Ab | Novel polypeptides |
| ES2908662T3 (es) | 2017-01-24 | 2022-05-03 | I Mab Biopharma Us Ltd | Anticuerpos anti-CD73 y usos de los mismos |
| CN114989305A (zh) * | 2017-03-31 | 2022-09-02 | 北京智仁美博生物科技有限公司 | 新型双特异性抗体及其用途 |
| EP3625260A1 (en) | 2017-05-16 | 2020-03-25 | Bristol-Myers Squibb Company | Treatment of cancer with anti-gitr agonist antibodies |
| KR20200013241A (ko) * | 2017-05-25 | 2020-02-06 | 브리스톨-마이어스 스큅 컴퍼니 | 변형된 중쇄 불변 영역을 포함하는 항체 |
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| TW202400654A (zh) | 2017-12-30 | 2024-01-01 | 英屬開曼群島商百濟神州有限公司 | 抗tigit抗體及其作為治療和診斷的用途 |
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| AU2019231172B2 (en) | 2018-03-09 | 2023-08-24 | Phanes Therapeutics, Inc. | Anti-CD73 antibodies and uses thereof |
| EP3768716A1 (en) | 2018-03-21 | 2021-01-27 | Five Prime Therapeutics, Inc. | Antibodies binding to vista at acidic ph |
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| CN107250157B (zh) | 2021-06-29 |
| LT3221346T (lt) | 2020-11-10 |
| BR112017010094A2 (pt) | 2018-02-06 |
| JP2018501208A (ja) | 2018-01-18 |
| PL3221346T3 (pl) | 2021-03-08 |
| WO2016081746A2 (en) | 2016-05-26 |
| MX2017006323A (es) | 2017-08-21 |
| US20180333502A1 (en) | 2018-11-22 |
| CY1123534T1 (el) | 2022-03-24 |
| RS60998B1 (sr) | 2020-11-30 |
| WO2016081746A8 (en) | 2017-06-29 |
| HRP20201756T1 (hr) | 2020-12-25 |
| PT3221346T (pt) | 2020-10-23 |
| EA201791127A1 (ru) | 2017-11-30 |
| CN107250157A (zh) | 2017-10-13 |
| EP3221346B1 (en) | 2020-09-02 |
| EP3789399A1 (en) | 2021-03-10 |
| US20200268901A1 (en) | 2020-08-27 |
| EP3221346A2 (en) | 2017-09-27 |
| HUE052526T2 (hu) | 2021-05-28 |
| JP7091379B2 (ja) | 2022-06-27 |
| JP2020100645A (ja) | 2020-07-02 |
| US10653791B2 (en) | 2020-05-19 |
| DK3221346T3 (da) | 2020-10-12 |
| CN113929770A (zh) | 2022-01-14 |
| WO2016081746A3 (en) | 2016-08-18 |
| HRP20201756T8 (hr) | 2021-08-20 |
| EA038349B1 (ru) | 2021-08-12 |
| SI3221346T1 (sl) | 2020-11-30 |
| ES2826566T3 (es) | 2021-05-18 |
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