CA2931134C - Heteroaryl derivatives as cftr modulators - Google Patents

Heteroaryl derivatives as cftr modulators Download PDF

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Publication number
CA2931134C
CA2931134C CA2931134A CA2931134A CA2931134C CA 2931134 C CA2931134 C CA 2931134C CA 2931134 A CA2931134 A CA 2931134A CA 2931134 A CA2931134 A CA 2931134A CA 2931134 C CA2931134 C CA 2931134C
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Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
disease
heteroaryl
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CA2931134A
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English (en)
French (fr)
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CA2931134A1 (en
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Sara Hadida-Ruah
Mark Miller
Jinglan Zhou
Brian Bear
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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