HUP0400316A2 - CRF1 modulátor hatású 5-szubsztituált-2-arilpiridin származékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

CRF1 modulátor hatású 5-szubsztituált-2-arilpiridin származékok és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0400316A2
HUP0400316A2 HU0400316A HUP0400316A HUP0400316A2 HU P0400316 A2 HUP0400316 A2 HU P0400316A2 HU 0400316 A HU0400316 A HU 0400316A HU P0400316 A HUP0400316 A HU P0400316A HU P0400316 A2 HUP0400316 A2 HU P0400316A2
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Hungary
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optionally substituted
mono
alkyl
compounds
cycloalkyl
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HU0400316A
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Ping Ge
Taeyoung Yoon
Lu Yan Zhang
Raymond F. Horvath
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Neurogen Corporation
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Publication of HUP0400316A2 publication Critical patent/HUP0400316A2/hu

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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

A találmány tárgya (I) általános képletű 5-szubsztituált-2-arilpiridin-származékokra, a vegyületeket tartalmazógyógyszerkészítményekre, valamint e vegyületek alkalmazására isvonatkozik, pszichiátriai betegségek, valamint neurológiai betegségek,így súlyos depresszió, szorongás, poszttraumatikus stressz,szupranukleáris bénulás és táplálkozási rendellenességek kezelésénél,valamint immunológiai, szív és érrendszeri betegségek, érzékenyvastagbél szindróma és pszichopatológiai zavarok és stressz miattbekövetkező vastagbél-túlérzékenység kezelésénél. Az (I) általánosképletű vegyületek vagy gyógyászatilag elfogadható sója, ahol Arjelentése fenil-, 1-naftil-, 2-naftil-csoport, amelyek bármelyikeegy-, két- vagy három helyen lehet szubsztituálva, továbbá Arjelentése 1-3 gyűrűt tartalmazó, mono-, di- vagy triszubsztituáltheteroarilcsoport, ahol mindegyik gyűrű 5-7 tagú és legalább egy gyűrű1-3 heteroatomot tartalmaz. R jelentése oxigénatom vagy hiányzik. R2jelentése adott esetben szubsztituált alkil-, adott esetbenszubsztituált alkenil-, adott esetben szubsztituált alkinil-, adottesetben szubsztituált alkoxi-, adott esetben szubsztituált mono- vagydialkil-amino-, adott esetben szubsztituált alkil-tio-, adott esetbenszubsztituált alkilszulfinil-, adott esetben szubsztituált alkil-szulfonil-, adott esetben szubsztituált mono- vagy dialkil-karboxamid-, adott esetben szubsztituált aril- vagy adott esetbenszubsztituált heteroarilcsoport, ahol a heteroarilcsoport 1-3 gyűrűttartalmaz, mindegyik gyűrű 5-7 tagú és legalább egy gyűrű 1-3heteroatomot tartalmaz. R1, R3 és R4 jelentése egymástól függetlenülhidrogénatom, halogénatom, nitro-, adott esetben szubsztituált alkil-,adott esetben szubsztituált alkenil-, adott esetben szubsztituáltalkinil-, adott esetben szubsztituált alkoxi-, adott esetbenszubsztituált mono- vagy dialkil-amino-, adott esetben szubsztituáltcikloalkil-, adott esetben szubsztituált cikloalkil-alkil-, adottesetben szubsztituált cikloaklil-oxi-, adott esetben szubsztituáltcikloalkil-alkoxi-, adott esetben szubsztituált alkil-tio-, adottesetben szubsztituált alkilszulfinil-, adott esetben szubsztituáltalkil-szulfonil- vagy adott esetben szubsztituált mono- vagy dialkil-karboxamid-csoport. Ó
HU0400316A 2001-05-22 2002-05-22 CRF1 modulátor hatású 5-szubsztituált-2-arilpiridin származékok és ezeket tartalmazó gyógyszerkészítmények HUP0400316A2 (hu)

Applications Claiming Priority (2)

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US29270301P 2001-05-22 2001-05-22
PCT/US2002/016529 WO2002096421A1 (en) 2001-05-22 2002-05-22 5-substituted-2-arylpyridines as crf1 modulators

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HUP0400316A2 true HUP0400316A2 (hu) 2005-02-28

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US (2) US7223778B2 (hu)
EP (1) EP1392302A1 (hu)
JP (1) JP2004531570A (hu)
KR (1) KR20040015716A (hu)
AP (1) AP2003002920A0 (hu)
BG (1) BG108490A (hu)
BR (1) BR0209920A (hu)
CA (1) CA2448198A1 (hu)
EC (1) ECSP034860A (hu)
HR (1) HRP20031056A2 (hu)
HU (1) HUP0400316A2 (hu)
IL (1) IL158958A0 (hu)
IS (1) IS7046A (hu)
MX (1) MXPA03010692A (hu)
NO (1) NO20035183D0 (hu)
PL (1) PL367153A1 (hu)
RU (1) RU2003134010A (hu)
SK (1) SK15432003A3 (hu)
TN (1) TNSN03119A1 (hu)
WO (1) WO2002096421A1 (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003249369A1 (en) 2002-06-21 2004-01-06 Cellular Genomics, Inc. Certain amino-substituted monocycles as kinase modulators
WO2004043925A2 (en) * 2002-11-08 2004-05-27 Neurogen Corporation 3-substituted-6-aryl pyridined as ligands of c5a receptors
WO2005007627A1 (ja) * 2003-07-18 2005-01-27 Nihon Nohyaku Co., Ltd. フェニルピリジン誘導体、その中間体及びこれを有効成分とする除草剤
US20070099938A1 (en) * 2003-10-24 2007-05-03 Ono Pharmaceutical Co., Ltd. Antistress drug and medical use thereof
EP3696174A1 (en) 2005-11-08 2020-08-19 Vertex Pharmaceuticals Incorporated Heterocyclic modulators of atp-binding cassette transporters
CN101687842B (zh) 2007-05-09 2013-03-06 沃泰克斯药物股份有限公司 Cftr调节剂
CN101790517B (zh) * 2007-08-01 2013-08-21 大正制药株式会社 抑制s1p1结合的物质
LT2639223T (lt) * 2007-12-07 2017-06-26 Vertex Pharmaceuticals Incorporated Cikloalkilkarboksiamido-piridino benzenkarboksirūgščių gamybos būdas
AU2013205160B2 (en) * 2007-12-07 2016-05-19 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
CN103626744B (zh) 2007-12-07 2016-05-11 沃泰克斯药物股份有限公司 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的固体形式
ES2647531T3 (es) 2008-02-28 2017-12-22 Vertex Pharmaceuticals Incorporated Derivados de heteroarilo como moduladores de CFTR
WO2011127241A2 (en) 2010-04-07 2011-10-13 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof
JP6219922B2 (ja) * 2012-03-30 2017-10-25 ダウ アグロサイエンシィズ エルエルシー 3−置換−6−トリフルオロメチルピリジンを調製する方法およびハロゲン化6−トリクロロメチルピリジンを使用する方法
KR102280372B1 (ko) 2013-11-12 2021-07-22 버텍스 파마슈티칼스 인코포레이티드 Cftr 매개된 질환 치료용 약제학적 조성물의 제조 방법
CN107110831B (zh) 2014-11-18 2020-02-21 弗特克斯药品有限公司 进行高通量试验高效液相色谱的方法
KR101750453B1 (ko) 2015-09-11 2017-06-23 동아대학교 산학협력단 손잡이 세정이 가능한 샤워헤드용 방향제어밸브
US10336701B2 (en) 2017-08-10 2019-07-02 Janssen Pharmaceutica Nv Pyridin-2-one derivatives of formula (II) useful as EP3 receptor antagonists
US10590083B2 (en) 2017-08-10 2020-03-17 Janssen Pharmaceutica Nv Pyridin-2-one derivatives of formula (I) useful as EP3 receptor antagonists
US10399944B2 (en) 2017-08-10 2019-09-03 Janssen Pharmaceutica Nv Pyridin-2-one derivatives of formula (III) useful as EP3 receptor antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1147068A (en) * 1966-12-02 1969-04-02 Ici Ltd Phenyl-pyridine derivatives
GB9012017D0 (en) * 1990-05-30 1990-07-18 Ici Plc Fungicidal compounds
DE4315867A1 (de) * 1993-05-12 1994-11-17 Hoechst Ag 3-Chlorpyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Flüssigkristallmischungen
DE4323916A1 (de) * 1993-07-16 1995-01-19 Basf Ag Substituierte 2-Phenylpyridine
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US5849758A (en) * 1995-05-30 1998-12-15 American Cyanamid Company Herbicidal 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines
DE19748439A1 (de) * 1997-11-03 1999-05-06 Hoechst Ag 1,6-Disubstituierte Naphthalinderivate und ihre Verwendung in flüssigkristallinen Mischungen
EA006938B1 (ru) * 2000-02-16 2006-06-30 Ньюроджин Корпорейшн Замещенные арилпиразины
WO2001068614A2 (en) 2000-03-16 2001-09-20 Neurogen Corporation 5-substituted arylpyrimidines

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KR20040015716A (ko) 2004-02-19
IS7046A (is) 2003-11-20
BG108490A (bg) 2005-01-31
CA2448198A1 (en) 2002-12-05
US20030152520A1 (en) 2003-08-14
IL158958A0 (en) 2004-05-12
RU2003134010A (ru) 2005-05-20
HRP20031056A2 (en) 2005-08-31
NO20035183D0 (no) 2003-11-21
ECSP034860A (es) 2004-01-28
WO2002096421A1 (en) 2002-12-05
TNSN03119A1 (en) 2005-12-23
PL367153A1 (en) 2005-02-21
EP1392302A1 (en) 2004-03-03
US7223778B2 (en) 2007-05-29
US20080107608A1 (en) 2008-05-08
SK15432003A3 (sk) 2004-05-04
MXPA03010692A (es) 2004-07-01
AP2003002920A0 (en) 2003-12-31
BR0209920A (pt) 2004-03-30
JP2004531570A (ja) 2004-10-14

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