CA2906008C - Pyridazinone compounds and methods for the treatment of cystic fibrosis - Google Patents

Pyridazinone compounds and methods for the treatment of cystic fibrosis Download PDF

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Publication number
CA2906008C
CA2906008C CA2906008A CA2906008A CA2906008C CA 2906008 C CA2906008 C CA 2906008C CA 2906008 A CA2906008 A CA 2906008A CA 2906008 A CA2906008 A CA 2906008A CA 2906008 C CA2906008 C CA 2906008C
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Prior art keywords
substituted
oxo
compound
alkyl
mmol
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Expired - Fee Related
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CA2906008A
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English (en)
French (fr)
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CA2906008A1 (en
Inventor
Bridget M. Cole
Richard A. Nugent
Andrew Kolodziej
Karen HANDLEY
Yevgen Barsukov
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Flatley Discovery Lab LLC
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Flatley Discovery Lab LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
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CA2906008A 2013-03-13 2014-03-13 Pyridazinone compounds and methods for the treatment of cystic fibrosis Expired - Fee Related CA2906008C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3044766A CA3044766A1 (en) 2013-03-13 2014-03-13 Pyridazinone compounds and methods for the treatment of cystic fibrosis

Applications Claiming Priority (3)

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US201361778870P 2013-03-13 2013-03-13
US61/778,870 2013-03-13
PCT/US2014/026623 WO2014160440A1 (en) 2013-03-13 2014-03-13 Pyridazinone compounds and methods for the treatment of cystic fibrosis

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CA3044766A Division CA3044766A1 (en) 2013-03-13 2014-03-13 Pyridazinone compounds and methods for the treatment of cystic fibrosis

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CA2906008A1 CA2906008A1 (en) 2014-10-02
CA2906008C true CA2906008C (en) 2019-07-09

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CA3044766A Abandoned CA3044766A1 (en) 2013-03-13 2014-03-13 Pyridazinone compounds and methods for the treatment of cystic fibrosis

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US20190256505A1 (en) 2019-08-22
US9682969B2 (en) 2017-06-20
KR101943490B1 (ko) 2019-04-17
BR112015023328A2 (pt) 2017-07-18
US10370366B2 (en) 2019-08-06
US20200017486A1 (en) 2020-01-16
JP6545148B2 (ja) 2019-07-17
WO2014160440A1 (en) 2014-10-02
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US10280160B2 (en) 2019-05-07

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