MX2007003336A - Acidos aceticos de indol que muestran antagonismo de receptor crth2 y usos de los mismos. - Google Patents
Acidos aceticos de indol que muestran antagonismo de receptor crth2 y usos de los mismos.Info
- Publication number
- MX2007003336A MX2007003336A MX2007003336A MX2007003336A MX2007003336A MX 2007003336 A MX2007003336 A MX 2007003336A MX 2007003336 A MX2007003336 A MX 2007003336A MX 2007003336 A MX2007003336 A MX 2007003336A MX 2007003336 A MX2007003336 A MX 2007003336A
- Authority
- MX
- Mexico
- Prior art keywords
- crth2 receptor
- indole acetic
- acetic acids
- receptor antagonism
- acids exhibiting
- Prior art date
Links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
La invencion se refiere a compuestos de acido acetico de indol los cuales funcionan como antagonistas del receptor CRTH2. La invencion tambien se refiere al uso de estos compuestos para inhibir la union de prostaglandina D2 y sus metabolitos o ciertos metabolitos de tromboxano al receptor CRTH2 y para tratar los desordenes responsivos a tal inhibicion.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61131604P | 2004-09-21 | 2004-09-21 | |
PCT/US2005/034029 WO2006034419A2 (en) | 2004-09-21 | 2005-09-21 | Indole acetic acids exhibiting crth2 receptor antagonism and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007003336A true MX2007003336A (es) | 2007-06-05 |
Family
ID=36090683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007003336A MX2007003336A (es) | 2004-09-21 | 2005-09-21 | Acidos aceticos de indol que muestran antagonismo de receptor crth2 y usos de los mismos. |
Country Status (12)
Country | Link |
---|---|
US (4) | US7405215B2 (es) |
EP (1) | EP1805171A4 (es) |
JP (1) | JP2008513512A (es) |
KR (1) | KR20070089908A (es) |
CN (1) | CN101087784A (es) |
AU (1) | AU2005286718A1 (es) |
BR (1) | BRPI0515532A (es) |
CA (1) | CA2581338A1 (es) |
EA (1) | EA200700712A1 (es) |
IL (1) | IL182102A0 (es) |
MX (1) | MX2007003336A (es) |
WO (1) | WO2006034419A2 (es) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2007003336A (es) * | 2004-09-21 | 2007-06-05 | Athersys Inc | Acidos aceticos de indol que muestran antagonismo de receptor crth2 y usos de los mismos. |
HUE030850T2 (en) | 2006-06-16 | 2017-06-28 | Univ Pennsylvania | Prostaglandin D2 receptor antagonists for the treatment of hair loss |
TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
NZ574375A (en) | 2006-07-22 | 2011-06-30 | Oxagen Ltd | 2-(5-fluoro-2-methyI-3-(2-(phenylsulfonyl)benzyl)-1H-indol-1-yl) acetic acid derivatives having CRTH2 antagonist activity |
CN101500996B (zh) | 2006-08-07 | 2012-07-04 | 埃科特莱茵药品有限公司 | (3-胺基-1,2,3,4-四氢-9h-咔唑-9-基)-乙酸衍生物 |
WO2009005471A1 (en) * | 2007-07-05 | 2009-01-08 | Astrazeneca Ab | Aryl and heteroaryl substituted isoindole derivatives as bace inhibitors |
WO2009005470A1 (en) * | 2007-07-05 | 2009-01-08 | Astrazeneca Ab | Aryl and heteroaryl substituted isoindole derivatives as bace inhibitors |
US20100280049A1 (en) * | 2007-11-06 | 2010-11-04 | Amira Pharmaceuticals, Inc. | Antagonists of pgd2 receptors |
WO2009061681A2 (en) * | 2007-11-06 | 2009-05-14 | Amira Pharmaceuticals, Inc | Antagonists of pgd2 receptors |
EA017573B1 (ru) | 2007-12-14 | 2013-01-30 | Пульмаджен Терапьютикс (Эсме) Лимитед | Производные индол-1-илуксусной кислоты и их терапевтическое применение |
SI2250161T1 (sl) | 2008-01-18 | 2014-04-30 | Atopix Therapeutics Limited | Spojine, ki imajo aktivnost crth2 antagonista |
US7750027B2 (en) * | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
EP2265581A1 (en) | 2008-01-22 | 2010-12-29 | Oxagen Limited | Compounds having crth2 antagonist activity |
JP2011509991A (ja) | 2008-01-22 | 2011-03-31 | オキサジェン リミテッド | Crth2アンタゴニスト活性を有する化合物 |
GB2460597B8 (en) * | 2008-02-01 | 2014-03-12 | Amira Pharmaceuticals Inc | N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors |
US8067445B2 (en) * | 2008-02-01 | 2011-11-29 | Panmira Pharmaceuticals, Llc | N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors |
EP2257536A4 (en) * | 2008-02-14 | 2011-03-23 | Amira Pharmaceuticals Inc | CYCLIC DIARYL ETHERS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS |
US8497381B2 (en) * | 2008-02-25 | 2013-07-30 | Panmira Pharmaceuticals, Llc | Antagonists of prostaglandin D2 receptors |
EP2268611A2 (en) * | 2008-04-02 | 2011-01-05 | Amira Pharmaceuticals, Inc. | Aminoalkylphenyl antagonists of prostaglandin d2 receptors |
US20110144160A1 (en) | 2008-07-03 | 2011-06-16 | Amira Pharmaceuticals, Inc. | Antagonists of Prostaglandin D2 Receptors |
GB2463788B (en) * | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
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WO2010042652A2 (en) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors |
TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
WO2010057118A2 (en) | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
US20100173313A1 (en) * | 2009-01-08 | 2010-07-08 | Amira Pharmaceuticals, Inc. | Biomarkers of inflammation |
JP2013500978A (ja) | 2009-07-31 | 2013-01-10 | パンミラ ファーマシューティカルズ,エルエルシー. | Dp2受容体アンタゴニストの眼の医薬組成物 |
US8815917B2 (en) * | 2009-08-05 | 2014-08-26 | Panmira Pharmaceuticals, Llc | DP2 antagonist and uses thereof |
WO2011055270A1 (en) * | 2009-11-04 | 2011-05-12 | Wyeth Llc | Indole based receptor crth2 antagonists |
MX2012007927A (es) | 2010-01-06 | 2012-08-15 | Panmira Pharmaceuticals Llc | Antagonistas de dp2 y usos del mismo. |
RU2562255C2 (ru) | 2010-03-22 | 2015-09-10 | Актелион Фармасьютиклз Лтд | Производные 3-(гетероариламино)-1,2,3,4-тетрагидро-9н-карбазола и их применение в качестве модуляторов рецепторов простагландина d2 |
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WO2015140684A1 (en) | 2014-03-17 | 2015-09-24 | Actelion Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
CN106103437A (zh) | 2014-03-18 | 2016-11-09 | 埃科特莱茵药品有限公司 | 氮杂吲哚乙酸衍生物及其作为前列腺素d2受体调节剂的用途 |
GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
TWI695831B (zh) * | 2014-09-13 | 2020-06-11 | 香港商南北兄弟藥業投資有限公司 | Crth2拮抗劑化合物及其用途 |
JP6775516B2 (ja) * | 2015-03-17 | 2020-10-28 | ファイザー・インク | 新奇な3−インドール置換誘導体、医薬組成物、および使用方法 |
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US3590047A (en) | 1968-10-18 | 1971-06-29 | Merck & Co Inc | 2-benzoylbenzimidazol-1-ylacetic acids |
JPS6224244A (ja) | 1985-07-24 | 1987-02-02 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀写真感光材料 |
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SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
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2005
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- 2005-09-21 EP EP05800723A patent/EP1805171A4/en not_active Withdrawn
- 2005-09-21 JP JP2007532674A patent/JP2008513512A/ja not_active Withdrawn
- 2005-09-21 KR KR1020077009232A patent/KR20070089908A/ko not_active Application Discontinuation
- 2005-09-21 CA CA002581338A patent/CA2581338A1/en not_active Abandoned
- 2005-09-21 EA EA200700712A patent/EA200700712A1/ru unknown
- 2005-09-21 AU AU2005286718A patent/AU2005286718A1/en not_active Abandoned
- 2005-09-21 US US11/230,917 patent/US7405215B2/en not_active Expired - Fee Related
- 2005-09-21 BR BRPI0515532-0A patent/BRPI0515532A/pt not_active IP Right Cessation
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- 2008-12-16 US US12/336,274 patent/US7601749B2/en not_active Expired - Fee Related
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2009
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WO2006034419A3 (en) | 2007-06-14 |
EA200700712A1 (ru) | 2008-02-28 |
US7405215B2 (en) | 2008-07-29 |
CN101087784A (zh) | 2007-12-12 |
BRPI0515532A (pt) | 2008-07-29 |
US20080255100A1 (en) | 2008-10-16 |
AU2005286718A1 (en) | 2006-03-30 |
EP1805171A4 (en) | 2009-05-13 |
US7601749B2 (en) | 2009-10-13 |
EP1805171A2 (en) | 2007-07-11 |
IL182102A0 (en) | 2007-07-24 |
US7981912B2 (en) | 2011-07-19 |
US7476667B2 (en) | 2009-01-13 |
US20100016389A1 (en) | 2010-01-21 |
KR20070089908A (ko) | 2007-09-04 |
WO2006034419A2 (en) | 2006-03-30 |
CA2581338A1 (en) | 2006-03-30 |
US20090111867A1 (en) | 2009-04-30 |
JP2008513512A (ja) | 2008-05-01 |
US20060100425A1 (en) | 2006-05-11 |
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