PL2049529T3 - Podstawione związki diazepanowe - antagoniści receptora oreksyny - Google Patents

Podstawione związki diazepanowe - antagoniści receptora oreksyny

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Publication number
PL2049529T3
PL2049529T3 PL07796852T PL07796852T PL2049529T3 PL 2049529 T3 PL2049529 T3 PL 2049529T3 PL 07796852 T PL07796852 T PL 07796852T PL 07796852 T PL07796852 T PL 07796852T PL 2049529 T3 PL2049529 T3 PL 2049529T3
Authority
PL
Poland
Prior art keywords
receptor antagonists
orexin receptor
substituted diazepan
substituted
compounds
Prior art date
Application number
PL07796852T
Other languages
English (en)
Inventor
Christopher D Cox
Michael J Breslin
Paul J Coleman
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of PL2049529T3 publication Critical patent/PL2049529T3/pl

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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Molecular Biology (AREA)
PL07796852T 2006-07-14 2007-07-13 Podstawione związki diazepanowe - antagoniści receptora oreksyny PL2049529T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83098306P 2006-07-14 2006-07-14
EP07796852A EP2049529B1 (en) 2006-07-14 2007-07-13 Substituted diazepan orexin receptor antagonists
PCT/US2007/016038 WO2008008518A1 (en) 2006-07-14 2007-07-13 Substituted diazepan orexin receptor antagonists

Publications (1)

Publication Number Publication Date
PL2049529T3 true PL2049529T3 (pl) 2011-01-31

Family

ID=38654759

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07796852T PL2049529T3 (pl) 2006-07-14 2007-07-13 Podstawione związki diazepanowe - antagoniści receptora oreksyny

Country Status (14)

Country Link
US (1) US20090192143A1 (pl)
EP (1) EP2049529B1 (pl)
JP (1) JP5479893B2 (pl)
AT (1) ATE477252T1 (pl)
AU (1) AU2007272855B2 (pl)
CA (1) CA2657552A1 (pl)
CY (1) CY1110882T1 (pl)
DE (1) DE602007008434D1 (pl)
DK (1) DK2049529T3 (pl)
ES (1) ES2348685T3 (pl)
PL (1) PL2049529T3 (pl)
PT (1) PT2049529E (pl)
SI (1) SI2049529T1 (pl)
WO (1) WO2008008518A1 (pl)

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EP2049110B1 (en) 2006-07-14 2014-08-20 Merck Sharp & Dohme Corp. Bridged diazepan orexin receptor antagonists
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
EP2150114A4 (en) 2007-05-18 2012-01-18 Merck Sharp & Dohme OXO-BRIDGED DIAZEPANOREXINE RECEPTOR ANTAGONISTS
NZ580887A (en) 2007-05-23 2012-03-30 Merck Sharp & Dohme Pyridyl piperidine orexin receptor antagonists
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JP2011502146A (ja) * 2007-10-29 2011-01-20 メルク・シャープ・エンド・ドーム・コーポレイション 置換ジアゼパンオレキシン受容体アンタゴニスト
US8623863B2 (en) * 2008-10-21 2014-01-07 Merck Sharp & Dohme Corp. Disubstituted azepan orexin receptor antagonists
US8178666B2 (en) 2008-10-23 2012-05-15 Albany Molecular Research, Inc. 2-aminobenzoxazole process
US8853202B2 (en) 2008-11-04 2014-10-07 Chemocentryx, Inc. Modulators of CXCR7
CN102271681B (zh) * 2008-11-04 2014-11-12 凯莫森特里克斯股份有限公司 Cxcr7调节剂
WO2011050200A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
WO2011050202A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
MX2012004753A (es) 2009-10-23 2012-09-07 Janssen Pharmaceutica Nv Octahidropirrolo[3,4-c]pirrolos disustituidos como moduladores del receptor de orexina.
TW201204732A (en) 2010-07-09 2012-02-01 Leo Pharma As Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
RU2014136339A (ru) 2012-02-07 2016-03-27 Иолас Терапьютикс, Инк. Замещенные пролины/пиперидины как антагонисты орексиновых рецепторов
KR102196374B1 (ko) 2012-11-29 2020-12-31 케모센트릭스, 인크. Cxcr7 길항제
WO2015095111A1 (en) 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. Diazepane orexin receptor antagonists
WO2016020404A1 (en) * 2014-08-04 2016-02-11 Sandoz Ag Process for the resolution of (r,s)-diazepane and diazepanone derivatives
EP3180332B1 (en) 2014-08-13 2021-10-27 Eolas Therapeutics Inc. Difluoropyrrolidines as orexin receptor modulators
CN105461699B (zh) * 2014-09-25 2019-07-09 广东东阳光药业有限公司 取代的杂环化合物及其使用方法和用途
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