ATE477252T1 - Substituierte diazepane als antagonisten an orexinrezeptoren - Google Patents

Substituierte diazepane als antagonisten an orexinrezeptoren

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Publication number
ATE477252T1
ATE477252T1 AT07796852T AT07796852T ATE477252T1 AT E477252 T1 ATE477252 T1 AT E477252T1 AT 07796852 T AT07796852 T AT 07796852T AT 07796852 T AT07796852 T AT 07796852T AT E477252 T1 ATE477252 T1 AT E477252T1
Authority
AT
Austria
Prior art keywords
orexin receptors
antagonists
substituted
diazepanes
compounds
Prior art date
Application number
AT07796852T
Other languages
English (en)
Inventor
Christopher D Cox
Michael J Breslin
Paul J Coleman
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE477252T1 publication Critical patent/ATE477252T1/de

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
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AT07796852T 2006-07-14 2007-07-13 Substituierte diazepane als antagonisten an orexinrezeptoren ATE477252T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83098306P 2006-07-14 2006-07-14
PCT/US2007/016038 WO2008008518A1 (en) 2006-07-14 2007-07-13 Substituted diazepan orexin receptor antagonists

Publications (1)

Publication Number Publication Date
ATE477252T1 true ATE477252T1 (de) 2010-08-15

Family

ID=38654759

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07796852T ATE477252T1 (de) 2006-07-14 2007-07-13 Substituierte diazepane als antagonisten an orexinrezeptoren

Country Status (14)

Country Link
US (1) US20090192143A1 (de)
EP (1) EP2049529B1 (de)
JP (1) JP5479893B2 (de)
AT (1) ATE477252T1 (de)
AU (1) AU2007272855B2 (de)
CA (1) CA2657552A1 (de)
CY (1) CY1110882T1 (de)
DE (1) DE602007008434D1 (de)
DK (1) DK2049529T3 (de)
ES (1) ES2348685T3 (de)
PL (1) PL2049529T3 (de)
PT (1) PT2049529E (de)
SI (1) SI2049529T1 (de)
WO (1) WO2008008518A1 (de)

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CA2657623A1 (en) 2006-07-14 2008-01-17 Merck & Co., Inc. Bridged diazepan orexin receptor antagonists
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
JP2010527924A (ja) 2007-05-18 2010-08-19 メルク・シャープ・エンド・ドーム・コーポレイション オキソ架橋ジアゼパンオレキシン受容体アンタゴニスト
CN101679366B (zh) 2007-05-23 2013-08-07 默沙东公司 吡啶基哌啶食欲素受体拮抗剂
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JP2011502146A (ja) * 2007-10-29 2011-01-20 メルク・シャープ・エンド・ドーム・コーポレイション 置換ジアゼパンオレキシン受容体アンタゴニスト
EP2348846B1 (de) * 2008-10-21 2013-08-28 Merck Sharp & Dohme Corp. Disubstituierte azepanorexin-rezeptorantagonisten
US8178666B2 (en) 2008-10-23 2012-05-15 Albany Molecular Research, Inc. 2-aminobenzoxazole process
MX2011004490A (es) 2008-11-04 2011-07-20 Chemocentryx Inc Moduladores de cxcr7.
US8853202B2 (en) 2008-11-04 2014-10-07 Chemocentryx, Inc. Modulators of CXCR7
ME02437B (de) 2009-10-23 2016-09-20 Janssen Pharmaceutica Nv Disubstituierte octahy-dropyrrolo [3,4-c]pyrrole als orexinrezeptormodulatoren
US8680275B2 (en) 2009-10-23 2014-03-25 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
EP2491031B1 (de) * 2009-10-23 2013-08-07 Janssen Pharmaceutica N.V. Kondensierte heterocyclische verbindungen als orexinrezeptormodulatoren
TW201204732A (en) 2010-07-09 2012-02-01 Leo Pharma As Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
BR112014019426A8 (pt) 2012-02-07 2017-07-11 Eolas Therapeutics Inc Prolinas/ piperidinas substituídas como antagonistas do receptor de orexina
CA2892042C (en) 2012-11-29 2022-06-14 Chemocentryx, Inc. Cxcr7 antagonists
US9732077B2 (en) 2013-12-18 2017-08-15 Merck Sharp & Dohme Corp. Diazepane orexin receptor antagonists
WO2016020404A1 (en) * 2014-08-04 2016-02-11 Sandoz Ag Process for the resolution of (r,s)-diazepane and diazepanone derivatives
AR101558A1 (es) 2014-08-13 2016-12-28 Eolas Therapeutics Inc Difluoropirrolidinas como moduladores del receptor de orexina
CN105461699B (zh) * 2014-09-25 2019-07-09 广东东阳光药业有限公司 取代的杂环化合物及其使用方法和用途
WO2016085784A1 (en) * 2014-11-26 2016-06-02 Merck Sharp & Dohme Corp. Methyl diazepane orexin receptor antagonists
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AU2007272855B2 (en) 2013-08-01
DK2049529T3 (da) 2010-11-29
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EP2049529A1 (de) 2009-04-22
WO2008008518A1 (en) 2008-01-17
PL2049529T3 (pl) 2011-01-31
EP2049529B1 (de) 2010-08-11
PT2049529E (pt) 2010-10-13
AU2007272855A1 (en) 2008-01-17
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