SI2049529T1 - Substituiran diazepan oreksin receptor antagonist - Google Patents
Substituiran diazepan oreksin receptor antagonistInfo
- Publication number
- SI2049529T1 SI2049529T1 SI200730378T SI200730378T SI2049529T1 SI 2049529 T1 SI2049529 T1 SI 2049529T1 SI 200730378 T SI200730378 T SI 200730378T SI 200730378 T SI200730378 T SI 200730378T SI 2049529 T1 SI2049529 T1 SI 2049529T1
- Authority
- SI
- Slovenia
- Prior art keywords
- receptor antagonists
- orexin receptor
- substituted diazepan
- substituted
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83098306P | 2006-07-14 | 2006-07-14 | |
PCT/US2007/016038 WO2008008518A1 (en) | 2006-07-14 | 2007-07-13 | Substituted diazepan orexin receptor antagonists |
EP07796852A EP2049529B1 (en) | 2006-07-14 | 2007-07-13 | Substituted diazepan orexin receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2049529T1 true SI2049529T1 (sl) | 2010-11-30 |
Family
ID=38654759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200730378T SI2049529T1 (sl) | 2006-07-14 | 2007-07-13 | Substituiran diazepan oreksin receptor antagonist |
Country Status (14)
Country | Link |
---|---|
US (1) | US20090192143A1 (sl) |
EP (1) | EP2049529B1 (sl) |
JP (1) | JP5479893B2 (sl) |
AT (1) | ATE477252T1 (sl) |
AU (1) | AU2007272855B2 (sl) |
CA (1) | CA2657552A1 (sl) |
CY (1) | CY1110882T1 (sl) |
DE (1) | DE602007008434D1 (sl) |
DK (1) | DK2049529T3 (sl) |
ES (1) | ES2348685T3 (sl) |
PL (1) | PL2049529T3 (sl) |
PT (1) | PT2049529E (sl) |
SI (1) | SI2049529T1 (sl) |
WO (1) | WO2008008518A1 (sl) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8618102B2 (en) | 2006-07-14 | 2013-12-31 | Merck Sharp & Dohme Corp. | Bridged diazepan orexin receptor antagonists |
PE20081229A1 (es) * | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
WO2008143856A1 (en) | 2007-05-18 | 2008-11-27 | Merck & Co., Inc. | Oxo bridged diazepan orexin receptor antagonists |
BRPI0811842A2 (pt) | 2007-05-23 | 2014-11-18 | Merck & Co Inc | Composto, composição farmacêutica, uso de um composto, e, métodos para aumentar a qualidade do sono em um paciente mamífero, para tratar a insônia em um paciente mamífero, e para tratar ou controlar a obesidade em um paciente mamífero |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP2214676B1 (en) * | 2007-10-29 | 2012-11-21 | Merck Sharp & Dohme Corp. | Substituted diazepan orexin receptor antagonists |
JP2012506379A (ja) * | 2008-10-21 | 2012-03-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 二置換アゼパンオレキシン受容体アンタゴニスト |
WO2010048514A1 (en) | 2008-10-23 | 2010-04-29 | Albany Molecular Research, Inc. | Synthesis of 2-aminobenzoxazole compounds |
KR101701367B1 (ko) | 2008-11-04 | 2017-02-02 | 케모센트릭스, 인크. | Cxcr7의 모듈레이터 |
US8853202B2 (en) | 2008-11-04 | 2014-10-07 | Chemocentryx, Inc. | Modulators of CXCR7 |
JP5847087B2 (ja) | 2009-10-23 | 2016-01-20 | ヤンセン ファーマシューティカ エヌ.ベー. | オレキシン受容体調節因子としての縮合複素環式化合物 |
WO2011050202A1 (en) * | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Fused heterocyclic compounds as orexin receptor modulators |
KR101859409B1 (ko) | 2009-10-23 | 2018-05-18 | 얀센 파마슈티카 엔.브이. | 오렉신 수용체 조절제로서의 이치환된 옥타하이드로피롤로[3,4-c]피롤 |
EP2590981B1 (en) | 2010-07-09 | 2014-09-03 | Leo Pharma A/S | Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
WO2012145581A1 (en) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
NZ628491A (en) | 2012-02-07 | 2016-06-24 | Eolas Therapeutics Inc | Substituted prolines / piperidines as orexin receptor antagonists |
US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
ES2681593T3 (es) | 2012-11-29 | 2018-09-14 | Chemocentryx, Inc. | Antagonistas de CXCR7 |
WO2015095111A1 (en) | 2013-12-18 | 2015-06-25 | Merck Sharp & Dohme Corp. | Diazepane orexin receptor antagonists |
WO2016020404A1 (en) * | 2014-08-04 | 2016-02-11 | Sandoz Ag | Process for the resolution of (r,s)-diazepane and diazepanone derivatives |
EP3180332B1 (en) | 2014-08-13 | 2021-10-27 | Eolas Therapeutics Inc. | Difluoropyrrolidines as orexin receptor modulators |
CN105461699B (zh) * | 2014-09-25 | 2019-07-09 | 广东东阳光药业有限公司 | 取代的杂环化合物及其使用方法和用途 |
US10000499B2 (en) | 2014-11-26 | 2018-06-19 | Merck Sharp & Dohme Corp. | Methyl diazepane orexin receptor antagonists |
US10131653B2 (en) | 2015-04-24 | 2018-11-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
US10196383B2 (en) | 2015-07-17 | 2019-02-05 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
WO2017088759A1 (en) | 2015-11-23 | 2017-06-01 | Sunshine Lake Pharma Co., Ltd. | OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF |
CN107021964A (zh) * | 2016-02-01 | 2017-08-08 | 广东东阳光药业有限公司 | 萘啶衍生物及其用途 |
AU2017217931B2 (en) | 2016-02-12 | 2020-10-22 | Astrazeneca Ab | Halo-substituted piperidines as orexin receptor modulators |
MY197558A (en) | 2016-03-10 | 2023-06-23 | Janssen Pharmaceutica Nv | Methods of treating depression using orexin-2 receptor antagonists |
EP3454857A1 (en) | 2016-05-10 | 2019-03-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
GB201702174D0 (en) | 2017-02-09 | 2017-03-29 | Benevolentai Bio Ltd | Orexin receptor antagonists |
GB201707499D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
GB201707504D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
KR20210102338A (ko) | 2018-12-12 | 2021-08-19 | 케모센트릭스, 인크. | 암의 치료를 위한 cxcr7 억제제 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE107922T1 (de) * | 1989-03-03 | 1994-07-15 | Dainippon Pharmaceutical Co | 2-(1-piperazinyl)-4-phenylcycloalkanpyridin- derivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die sie enthalten. |
JPH0747574B2 (ja) * | 1989-03-03 | 1995-05-24 | 大日本製薬株式会社 | ピリジン誘導体及びそれを有効成分とする向精神剤 |
GB0127145D0 (en) * | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Compounds |
PE20081229A1 (es) * | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
EP2214676B1 (en) * | 2007-10-29 | 2012-11-21 | Merck Sharp & Dohme Corp. | Substituted diazepan orexin receptor antagonists |
-
2007
- 2007-07-13 DE DE602007008434T patent/DE602007008434D1/de active Active
- 2007-07-13 AT AT07796852T patent/ATE477252T1/de active
- 2007-07-13 ES ES07796852T patent/ES2348685T3/es active Active
- 2007-07-13 DK DK07796852.7T patent/DK2049529T3/da active
- 2007-07-13 PT PT07796852T patent/PT2049529E/pt unknown
- 2007-07-13 SI SI200730378T patent/SI2049529T1/sl unknown
- 2007-07-13 PL PL07796852T patent/PL2049529T3/pl unknown
- 2007-07-13 WO PCT/US2007/016038 patent/WO2008008518A1/en active Application Filing
- 2007-07-13 AU AU2007272855A patent/AU2007272855B2/en not_active Ceased
- 2007-07-13 JP JP2009519552A patent/JP5479893B2/ja not_active Expired - Fee Related
- 2007-07-13 CA CA002657552A patent/CA2657552A1/en not_active Abandoned
- 2007-07-13 US US12/309,239 patent/US20090192143A1/en not_active Abandoned
- 2007-07-13 EP EP07796852A patent/EP2049529B1/en active Active
-
2010
- 2010-11-10 CY CY20101101013T patent/CY1110882T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2009543786A (ja) | 2009-12-10 |
ES2348685T3 (es) | 2010-12-10 |
WO2008008518A1 (en) | 2008-01-17 |
JP5479893B2 (ja) | 2014-04-23 |
AU2007272855B2 (en) | 2013-08-01 |
PT2049529E (pt) | 2010-10-13 |
US20090192143A1 (en) | 2009-07-30 |
CA2657552A1 (en) | 2008-01-17 |
EP2049529A1 (en) | 2009-04-22 |
PL2049529T3 (pl) | 2011-01-31 |
AU2007272855A1 (en) | 2008-01-17 |
ATE477252T1 (de) | 2010-08-15 |
CY1110882T1 (el) | 2015-06-10 |
DE602007008434D1 (de) | 2010-09-23 |
EP2049529B1 (en) | 2010-08-11 |
DK2049529T3 (da) | 2010-11-29 |
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