BRPI0515532A - composto, composição farmacêutica, métodos de inibir a ligação de ligandos endógenos ao receptor de crth-2 em uma célula, de tratar, melhorar ou prevenir um distúrbio responsivo à inibição da ligação de ligandos endógenos ao receptor de crt-2 e de preparar um composto, e, kit - Google Patents

composto, composição farmacêutica, métodos de inibir a ligação de ligandos endógenos ao receptor de crth-2 em uma célula, de tratar, melhorar ou prevenir um distúrbio responsivo à inibição da ligação de ligandos endógenos ao receptor de crt-2 e de preparar um composto, e, kit

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Publication number
BRPI0515532A
BRPI0515532A BRPI0515532-0A BRPI0515532A BRPI0515532A BR PI0515532 A BRPI0515532 A BR PI0515532A BR PI0515532 A BRPI0515532 A BR PI0515532A BR PI0515532 A BRPI0515532 A BR PI0515532A
Authority
BR
Brazil
Prior art keywords
compound
inhibiting
binding
receptor
endogenous ligands
Prior art date
Application number
BRPI0515532-0A
Other languages
English (en)
Inventor
Youssef L Bennani
Lawrence N Tumey
Elizabeth Ann Gleason
Michael Joseph Robarge
Original Assignee
Athersys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Athersys Inc filed Critical Athersys Inc
Publication of BRPI0515532A publication Critical patent/BRPI0515532A/pt

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  • Orthopedic Medicine & Surgery (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
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Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODOS DE INIBIR A LIGAçãO DE LIGANDOS ENDóGENOS AO RECEPTOR DE CRTh-2 EM UMA CéLULA, DE TRATAR, MELHORAR OU PREVENIR UM DISTúRBIO RESPONSIVO à INIBIçãO DA LIGAçãO DE LIGANDOS ENDóGENOS AO RECEPTOR DE CRT-2 E DE PREPARAR UM COMPOSTO, E, KIT". A invenção diz respeito a compostos de ácido indol acético que funcionam como antagonistas do receptor de CRTH2. A invenção também diz respeito ao uso destes compostos para inibir a ligação de prostaglandina D2 e seus metabólitos ou de certos metabólitos de tromboxano ao receptor de CRTH2 e para tratar distúrbios responsivos a tal inibição.
BRPI0515532-0A 2004-09-21 2005-09-21 composto, composição farmacêutica, métodos de inibir a ligação de ligandos endógenos ao receptor de crth-2 em uma célula, de tratar, melhorar ou prevenir um distúrbio responsivo à inibição da ligação de ligandos endógenos ao receptor de crt-2 e de preparar um composto, e, kit BRPI0515532A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61131604P 2004-09-21 2004-09-21
PCT/US2005/034029 WO2006034419A2 (en) 2004-09-21 2005-09-21 Indole acetic acids exhibiting crth2 receptor antagonism and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0515532A true BRPI0515532A (pt) 2008-07-29

Family

ID=36090683

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515532-0A BRPI0515532A (pt) 2004-09-21 2005-09-21 composto, composição farmacêutica, métodos de inibir a ligação de ligandos endógenos ao receptor de crth-2 em uma célula, de tratar, melhorar ou prevenir um distúrbio responsivo à inibição da ligação de ligandos endógenos ao receptor de crt-2 e de preparar um composto, e, kit

Country Status (12)

Country Link
US (4) US7405215B2 (pt)
EP (1) EP1805171A4 (pt)
JP (1) JP2008513512A (pt)
KR (1) KR20070089908A (pt)
CN (1) CN101087784A (pt)
AU (1) AU2005286718A1 (pt)
BR (1) BRPI0515532A (pt)
CA (1) CA2581338A1 (pt)
EA (1) EA200700712A1 (pt)
IL (1) IL182102A0 (pt)
MX (1) MX2007003336A (pt)
WO (1) WO2006034419A2 (pt)

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MX2007003336A (es) * 2004-09-21 2007-06-05 Athersys Inc Acidos aceticos de indol que muestran antagonismo de receptor crth2 y usos de los mismos.
ES2618352T3 (es) 2006-06-16 2017-06-21 The Trustees Of The University Of Pennsylvania Antagonistas del receptor de prostaglandina D2 para el tratamiento de la alopecia androgenética
TW200815349A (en) 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
KR20090042808A (ko) 2006-07-22 2009-04-30 옥사겐 리미티드 씨알티에이치2 길항제 활성을 갖는 화합물
RU2448092C2 (ru) 2006-08-07 2012-04-20 Актелион Фармасьютиклз Лтд Производные (3-амино-1,2,3,4-тетрагидро-9н-карбазол-9-ил)уксусной кислоты
WO2009005470A1 (en) * 2007-07-05 2009-01-08 Astrazeneca Ab Aryl and heteroaryl substituted isoindole derivatives as bace inhibitors
WO2009005471A1 (en) * 2007-07-05 2009-01-08 Astrazeneca Ab Aryl and heteroaryl substituted isoindole derivatives as bace inhibitors
WO2009061676A2 (en) * 2007-11-06 2009-05-14 Amira Pharmaceuticals, Inc. Antagonists of pgd2 receptors
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AU2008337342B2 (en) 2007-12-14 2012-05-24 Pulmagen Therapeutics (Asthma) Limited Indoles and their therapeutic use
EP2250161B1 (en) 2008-01-18 2013-10-16 Atopix Therapeutics Limited Compounds having crth2 antagonist activity
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
WO2009093026A1 (en) 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
EP2240444A1 (en) 2008-01-22 2010-10-20 Oxagen Limited Compounds having crth2 antagonist activity
US8168678B2 (en) 2008-02-01 2012-05-01 Panmira Pharmaceuticals, Inc. N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors
EP2245002A4 (en) * 2008-02-01 2011-08-17 Amira Pharmaceuticals Inc AMINOALKYLBIPHENYL ANTAGONISTS N, N 'DISUBSTITUTED FROM D2 RECEPTORS OF PROSTAGLANDIN
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US8497381B2 (en) * 2008-02-25 2013-07-30 Panmira Pharmaceuticals, Llc Antagonists of prostaglandin D2 receptors
WO2009145989A2 (en) * 2008-04-02 2009-12-03 Amira Pharmaceuticals, Inc. Aminoalkylphenyl antagonists of prostaglandin d2 receptors
BRPI0913930A2 (pt) * 2008-07-03 2015-10-20 Amira Pharmaceuticals Inc antagonistas de receptores de prostaglandinas d2
GB2463788B (en) * 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
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JP2013501052A (ja) * 2009-08-05 2013-01-10 パンミラ ファーマシューティカルズ，エルエルシー． Ｄｐ２アンタゴニストおよびその用途
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