CA2737044C - High affinity human antibodies to human il-4 receptor - Google Patents
High affinity human antibodies to human il-4 receptor Download PDFInfo
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- CA2737044C CA2737044C CA2737044A CA2737044A CA2737044C CA 2737044 C CA2737044 C CA 2737044C CA 2737044 A CA2737044 A CA 2737044A CA 2737044 A CA2737044 A CA 2737044A CA 2737044 C CA2737044 C CA 2737044C
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/260,307 US7608693B2 (en) | 2006-10-02 | 2008-10-29 | High affinity human antibodies to human IL-4 receptor |
| US12/260,307 | 2008-10-29 | ||
| PCT/US2009/062168 WO2010053751A1 (en) | 2008-10-29 | 2009-10-27 | High affinity human antibodies to human il-4 receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2737044A1 CA2737044A1 (en) | 2010-05-14 |
| CA2737044C true CA2737044C (en) | 2017-02-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2737044A Active CA2737044C (en) | 2008-10-29 | 2009-10-27 | High affinity human antibodies to human il-4 receptor |
Country Status (47)
Families Citing this family (166)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1741783A4 (en) * | 2004-04-27 | 2009-05-27 | Chemo Sero Therapeut Res Inst | HUMAN ANTIAMYLOID BETA PEPTIDE ANTIBODY AND ANTIBODY FRAGMENT THEREOF |
| RS53340B (sr) * | 2006-10-02 | 2014-10-31 | Regeneron Pharmaceuticals, Inc. | Humana antitela visokog afiniteta za humani il-4 receptor |
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| NZ631363A (en) | 2010-02-08 | 2016-05-27 | Regeneron Pharma | Common light chain mouse |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| UA111731C2 (uk) * | 2010-10-06 | 2016-06-10 | Рідженерон Фармасьютікалз, Інк. | Стабілізована композиція, яка містить антитіло до рецептора інтерлейкіну-4 (іl-4r), варіанти |
| EP3354280B1 (en) | 2010-10-06 | 2020-07-29 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies |
| BR112013018877A2 (pt) | 2011-01-28 | 2016-10-04 | Sanofi Sa | composições farmacêuticas que compreendem anticorpos humanos para pcsk9 |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| LT3572517T (lt) | 2011-08-05 | 2021-04-26 | Regeneron Pharmaceuticals, Inc. | Humanizuotos universalios lengvosios grandinės pelės |
| EP2756004B1 (en) | 2011-09-16 | 2019-12-25 | Regeneron Pharmaceuticals, Inc. | INHIBITOR OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN-9 (PCSK9) FOR USE IN REDUCING LIPOPROTEIN(a) LEVELS |
| PT2796550T (pt) * | 2011-12-22 | 2018-04-18 | Astellas Pharma Inc | Novo anticorpo ctgf anti-humano |
| DK2825037T3 (da) | 2012-03-16 | 2019-07-29 | Regeneron Pharma | Gnavere, der udtrykker pH-sensitive immunoglobulinsekvenser |
| SMT201800229T1 (it) | 2012-03-16 | 2018-07-17 | Regeneron Pharma | Anticorpi a catena leggera ingegnerizzati con istidina e roditori modificati geneticamente per la generazione degli stessi |
| KR102307248B1 (ko) * | 2012-08-21 | 2021-10-01 | 사노피 바이오테크놀로지 | Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법 |
| TWI721272B (zh) * | 2012-08-21 | 2021-03-11 | 法商賽諾菲生物技術公司 | 投與il-4r拮抗劑以治療或預防氣喘之方法 |
| NZ630178A (en) | 2012-09-07 | 2017-06-30 | Regeneron Pharma | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| PT2892927T (pt) * | 2012-09-07 | 2018-08-02 | Regeneron Pharma | Métodos para tratamento da dermatite atópica por administração de um antagonista de il-4r |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| US10111953B2 (en) | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| TWI697334B (zh) | 2013-06-04 | 2020-07-01 | 美商再生元醫藥公司 | 藉由投與ｉｌ-４ｒ抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| CN105517570B (zh) * | 2013-06-21 | 2020-04-07 | 赛诺菲生物技术公司 | 通过施用il-4r拮抗剂治疗鼻息肉症的方法 |
| DK3010539T3 (da) * | 2013-06-21 | 2019-10-21 | Sanofi Biotechnology | Fremgangsmåder til behandling af nasal polyposis ved administration af en il-4r-antagonist |
| TWI682781B (zh) | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| CN106062003A (zh) | 2013-11-12 | 2016-10-26 | 赛诺菲生物技术公司 | 用于与pcsk9抑制剂一起使用的给药方案 |
| DE112014005747T5 (de) * | 2013-12-17 | 2016-10-06 | Kymab Limited | Antikörper zur Verwendung bei der Behandlung von Zuständen, die mit spezifischen PCSK9 Varianten in spezifischen Patientenpopulationen in Beziehung stehen |
| US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| US10167333B2 (en) * | 2014-01-16 | 2019-01-01 | Mario Umberto Francesco Mondelli | Neutralizing human monoclonal antibodies against hepatitis B virus surface antigen |
| IL247290B (en) * | 2014-02-21 | 2021-06-30 | Sanofi Biotechnology | Methods of treating or preventing asthma by adding an il-4r antagonist |
| IL315136A (en) | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| ES2973858T3 (es) | 2014-02-28 | 2024-06-24 | Regeneron Pharma | Métodos para tratar infecciones cutáneas mediante la administración de un antagonista de IL-4R |
| EP3895528A1 (en) | 2014-03-21 | 2021-10-20 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| NO2785538T3 (Direct) | 2014-05-07 | 2018-08-04 | ||
| KR20230074283A (ko) | 2014-07-16 | 2023-05-26 | 사노피 바이오테크놀로지 | 이형접합성 가족성 고콜레스테롤혈증(heFH) 환자의 치료방법 |
| AU2015346150B2 (en) | 2014-11-14 | 2021-08-19 | Regeneron Pharmaceuticals, Inc. | Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist |
| EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| JP6938383B2 (ja) * | 2015-04-02 | 2021-09-22 | インターベット インターナショナル ベー． フェー． | イヌインターロイキン４受容体アルファに対する抗体 |
| TWI899515B (zh) | 2015-08-04 | 2025-10-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| ES3052976T3 (en) | 2015-08-18 | 2026-01-16 | Regeneron Pharma | Anti-pcsk9 inhibitory antibodies for treating patients with hyperlipidemia undergoing lipoprotein apheresis |
| MX2018009990A (es) | 2016-02-19 | 2018-12-17 | Regeneron Pharma | Metodos para mejorar la eficacia de una vacuna mediante la administracion de un antagonista il-4r. |
| CN107474134B (zh) * | 2016-06-08 | 2021-07-27 | 苏州康乃德生物医药有限公司 | 用于结合白细胞介素4受体的抗体 |
| EP3504328A1 (en) | 2016-08-24 | 2019-07-03 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| CA3035202A1 (en) | 2016-09-01 | 2018-03-08 | Regeneron Pharmaceuticals, Inc. | Methods for preventing or treating allergy by administering an il-4r antagonist |
| WO2018057776A1 (en) | 2016-09-22 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an il-4r inhibitor |
| KR20190053250A (ko) | 2016-09-22 | 2019-05-17 | 리제너론 파아마슈티컬스, 인크. | Il-4r 저해제 투여에 의한 중증 아토피 피부염의 치료 방법 |
| EP3548514A1 (en) | 2016-11-29 | 2019-10-09 | Regeneron Pharmaceuticals, Inc. | Methods of treating prlr positive breast cancer |
| TWI784988B (zh) * | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| IL314591A (en) | 2017-04-13 | 2024-09-01 | Regeneron Pharma | Treatment and prevention of inflammatory lung diseases in patients with risk alleles in the genes encoding IL33 and IL1RL1 |
| CN110914293B (zh) | 2017-07-06 | 2024-08-13 | 里珍纳龙药品有限公司 | 用于制备糖蛋白的细胞培养工艺 |
| US11053309B2 (en) | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
| HUE064655T2 (hu) | 2017-10-30 | 2024-04-28 | Sanofi Biotechnology | IL-4R antagonista asztma kezelésére vagy megelõzésére szolgáló eljárásban |
| CA3084059A1 (en) | 2017-12-22 | 2019-06-27 | Regeneron Pharmaceuticals, Inc. | System and method for characterizing drug product impurities |
| BR112020013336A2 (pt) | 2018-01-31 | 2020-12-01 | Regeneron Pharmaceuticals, Inc. | produto farmacêutico proteico, métodos para caracterizar as impurezas do produto farmacêutico proteico de alto peso molecular intermediário, para produção de um anticorpo, e para caracterizar as impurezas de fármaco com variação de carga, anticorpo, e, sistema para caracterizar impurezas de fármaco de alto peso molecular intermediário. |
| CN110105451B (zh) * | 2018-02-01 | 2020-12-18 | 北京凯因科技股份有限公司 | IL-4Rα抗体及其用途 |
| KR102652133B1 (ko) * | 2018-02-01 | 2024-03-29 | 베이징 카윈 테크놀로지 쉐어-홀딩 컴퍼니 리미티드 | IL-4Rα 항체 및 그 용도 |
| TWI786265B (zh) | 2018-02-02 | 2022-12-11 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
| KR20260004591A (ko) | 2018-02-28 | 2026-01-08 | 리제너론 파마슈티칼스 인코포레이티드 | 바이러스 오염물질을 확인하기 위한 시스템 및 방법 |
| US12253490B2 (en) | 2018-03-19 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| IL277264B2 (en) | 2018-03-19 | 2024-03-01 | Regeneron Pharma | Microchip capillary electrophoresis assays and reagents |
| US12259355B2 (en) | 2018-03-19 | 2025-03-25 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| EP3768317A4 (en) | 2018-03-22 | 2021-12-22 | Surface Oncology, Inc. | ANTI-IL-27 ANTIBODIES AND USES THEREOF |
| CN108373505B (zh) * | 2018-04-20 | 2019-08-20 | 北京智仁美博生物科技有限公司 | 抗il-4r抗体及其用途 |
| TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
| AU2019270940A1 (en) | 2018-05-13 | 2020-11-26 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an IL-4R inhibitor |
| CN113101364B (zh) * | 2018-05-29 | 2023-12-01 | 康诺亚生物医药科技（成都）有限公司 | 一种自免疫抑制剂的开发和应用 |
| CA3104873A1 (en) | 2018-07-10 | 2020-01-16 | Regeneron Pharmaceuticals, Inc. | Modifying binding molecules to minimize pre-existing interactions |
| JP7405831B2 (ja) * | 2018-08-24 | 2023-12-26 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | ヒトｉｌ－４ｒ結合抗体、その抗原結合フラグメント、およびそれらの医学的使用 |
| AU2019329686A1 (en) | 2018-08-27 | 2020-12-03 | Regeneron Pharmaceuticals, Inc. | Use of raman spectroscopy in downstream purification |
| AU2019333047A1 (en) | 2018-08-30 | 2020-12-03 | Regeneron Pharmaceuticals, Inc. | Methods for characterizing protein complexes |
| CN110872349A (zh) | 2018-09-04 | 2020-03-10 | 三生国健药业（上海）股份有限公司 | 结合人il-4r的抗体、其制备方法和用途 |
| KR102330596B1 (ko) * | 2018-11-09 | 2021-11-26 | 아주대학교산학협력단 | 인간 il-4 수용체 알파에 대한 고친화도 인간 항체 및 이의 용도 |
| US11312778B2 (en) | 2018-11-21 | 2022-04-26 | Brian C. Machler | Method for treating allergic contact dermatitis |
| CN111494625B (zh) * | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物 |
| US11579150B2 (en) | 2019-01-16 | 2023-02-14 | Regeneron Pharmaceuticals, Inc. | Methods for characterizing disulfide bonds |
| JP7548924B2 (ja) | 2019-03-06 | 2024-09-10 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | がんの処置における増強された有効性のためのｉｌ－４／ｉｌ－１３経路阻害剤 |
| CN121102493A (zh) | 2019-03-21 | 2025-12-12 | 瑞泽恩制药公司 | 用于治疗过敏症的il-4/il-13途径抑制剂和浆细胞消融的组合 |
| KR20220007586A (ko) | 2019-05-13 | 2022-01-18 | 리제너론 파마슈티칼스 인코포레이티드 | 개선된 경쟁적 리간드 결합 검정 |
| CN112010977B (zh) | 2019-05-29 | 2022-04-26 | 山东博安生物技术股份有限公司 | 抗白介素4受体(il-4r)的抗体及其应用 |
| CN110343666B (zh) * | 2019-07-10 | 2023-05-30 | 通化东宝药业股份有限公司 | 一种cho细胞培养的补料培养基及其制备方法和应用 |
| BR112022000740A2 (pt) | 2019-07-16 | 2022-07-05 | Sanofi Biotechnology | Métodos para tratamento ou prevenção de asma por administração de um antagonista de il-4r |
| EP4010373A1 (en) | 2019-08-05 | 2022-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| JP2022543815A (ja) | 2019-08-05 | 2022-10-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｉｌ－４ｒアンタゴニストを投与することによりアレルギーを治療しアレルゲン特異的免疫療法を増強するための方法 |
| CN114667450B (zh) | 2019-09-24 | 2025-05-02 | 里珍纳龙药品有限公司 | 用于色谱介质的使用和再生的系统及方法 |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| CN111825766B (zh) | 2019-10-31 | 2021-05-11 | 上海洛启生物医药技术有限公司 | 抗il-4r单域抗体及其应用 |
| BR112022009974A2 (pt) | 2019-11-25 | 2022-08-16 | Regeneron Pharma | Métodos de produção de um polímero ou micropartículas revestidas com polímero, para produzir microesferas poliméricas ou revestidas com polímero e para produzir micropartículas, composição de liberação sustentada, micropartículas, e, composição farmacêutica |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| CN115461818A (zh) | 2019-12-09 | 2022-12-09 | 赛诺菲生物技术公司 | 治疗数字鉴定的il-4/il-13相关障碍的方法 |
| AU2020407853A1 (en) | 2019-12-20 | 2022-06-09 | Intervet International B.V. | Antibodies to canine interleukin-4 receptor alpha |
| CA3165060C (en) | 2020-01-21 | 2023-06-20 | Yiming Zhao | Deglycosylation methods for electrophoresis of glycosylated proteins |
| KR20220143882A (ko) | 2020-02-21 | 2022-10-25 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 항-il-4r 항체를 함유하는 약학적 조성물 및 이의 용도 |
| CN119708230A (zh) * | 2020-02-27 | 2025-03-28 | 正大天晴药业集团股份有限公司 | 结合il4r的抗体及其用途 |
| KR20220158821A (ko) | 2020-03-27 | 2022-12-01 | 리제너론 파아마슈티컬스, 인크. | Il-4r 길항제를 투여함에 의해 아토피 피부염을 치료하기 위한 방법 |
| CN113549151A (zh) * | 2020-04-24 | 2021-10-26 | 苏州康乃德生物医药有限公司 | 与人IL-4Rα中特定表位结合的抗体及其应用 |
| CN115768516A (zh) | 2020-05-22 | 2023-03-07 | 瑞泽恩制药公司 | 通过施用il-4r抑制剂治疗嗜酸细胞性食管炎的方法 |
| TW202432837A (zh) | 2020-08-31 | 2024-08-16 | 美商再生元醫藥公司 | 用以改良細胞培養效能及減少天冬醯胺序列變異之天冬醯胺饋料策略 |
| US20220169739A1 (en) | 2020-10-05 | 2022-06-02 | Sanofi Biotechnology | Methods for treating asthma in pediatric subjects by administering an il-4r antagonist |
| WO2022115588A1 (en) | 2020-11-25 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous membrane emulsification |
| CN116710124A (zh) | 2020-12-17 | 2023-09-05 | 瑞泽恩制药公司 | 包封蛋白质的微凝胶的制造 |
| TW202231663A (zh) * | 2020-12-22 | 2022-08-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗ｉｌ－４ｒ抗體或其抗原結合片段的複合物及醫藥用途 |
| EP4274609A1 (en) | 2021-01-08 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating peanut allergy and enhancing peanut allergen-specific immunotherapy by administering an il-4r antagonist |
| AU2022209730A1 (en) | 2021-01-20 | 2023-07-13 | Regeneron Pharmaceuticals, Inc. | Methods of improving protein titer in cell culture |
| BR112023017442A2 (pt) | 2021-03-03 | 2023-09-26 | Regeneron Pharma | Métodos para identificar regiões em uma proteína e para modificar a viscosidade de uma droga proteica, e, droga proteica |
| BR112023018665A2 (pt) | 2021-03-26 | 2023-10-03 | Regeneron Pharma | Métodos e sistemas para desenvolvimento de protocolos de mistura |
| KR20240015646A (ko) | 2021-06-01 | 2024-02-05 | 리제너론 파마슈티칼스 인코포레이티드 | 마이크로칩 모세관 전기영동 분석 및 시약 |
| AU2022316939A1 (en) | 2021-07-26 | 2024-03-07 | Regeneron Pharmaceuticals, Inc. | Methods for treating chronic spontaneous urticaria by administering an il-4r antagonist |
| TWI876192B (zh) * | 2021-08-05 | 2025-03-11 | 美商美國禮來大藥廠 | 人類介白素-4受體α抗體 |
| AU2022326849A1 (en) | 2021-08-10 | 2024-03-21 | Kymab Limited | Treatment of atopic dermatitis |
| US20230167171A1 (en) | 2021-08-23 | 2023-06-01 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| IL310427A (en) * | 2021-08-26 | 2024-03-01 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Pharmaceutical composition of anti-il4r antibody and use thereof |
| US20230077710A1 (en) | 2021-09-08 | 2023-03-16 | Regeneron Pharmaceuticals, Inc. | HIGH-THROUGHPUT AND MASS-SPECTROMETRY-BASED METHOD FOR QUANTITATING ANTIBODIES AND OTHER Fc-CONTAINING PROTEINS |
| CA3232463A1 (en) * | 2021-09-20 | 2023-03-23 | Philip Mellors | Methods of controlling antibody heterogeneity |
| EP4409037A1 (en) | 2021-09-30 | 2024-08-07 | Regeneron Pharmaceuticals, Inc. | Reticulocalbin-3 (rcn3) variants and treatment of asthma with interleukin-4 receptor alpha (il4r) antagonists |
| US20230110811A1 (en) | 2021-10-07 | 2023-04-13 | Regeneron Pharmaceuticals, Inc. | pH METER CALIBRATION AND CORRECTION |
| IL311245A (en) | 2021-10-07 | 2024-05-01 | Regeneron Pharma | Systems and methods for pH modeling and control |
| MX2024004762A (es) | 2021-10-20 | 2024-05-08 | Sanofi Biotechnology | Metodos para el tratamiento del prurigo nodular mediante la administracion de un antagonista de il-4r. |
| EP4423018A1 (en) | 2021-10-26 | 2024-09-04 | Regeneron Pharmaceuticals, Inc. | Systems and methods for generating laboratory water and distributing laboratory water at different temperatures |
| WO2023086887A1 (en) | 2021-11-11 | 2023-05-19 | Regeneron Pharmaceuticals, Inc. | Treatment of lung disease based upon stratification of polygenic risk score for interleukin 33 (il-33) |
| WO2023085978A1 (en) * | 2021-11-11 | 2023-05-19 | Joint Stock Company «Biocad» | Monoclonal antibody or antigen-binding fragment thereof that specifically binds to il-4ra, and use thereof |
| JP2024542194A (ja) | 2021-11-18 | 2024-11-13 | ツイスト バイオサイエンス コーポレーション | Ｄｉｃｋｋｏｐｆ－１バリアント抗体及び使用方法 |
| US20230272062A1 (en) | 2021-11-30 | 2023-08-31 | Regeneron Pharmaceuticals, Inc. | Treatment Of Lung Disease Based Upon Stratification Of Polygenic Score Relating To Response To A Therapeutic Agent |
| AU2022425608A1 (en) | 2021-12-30 | 2024-08-15 | Regeneron Pharmaceuticals, Inc. | Methods for attenuating atopic march by administering an il-4/il-13 antagonist |
| MX2024009080A (es) | 2022-01-29 | 2024-07-30 | Shanghai Shengdi Pharmaceutical Co Ltd | Conjugado farmacologico de glucocorticoide. |
| US20230348532A1 (en) | 2022-03-02 | 2023-11-02 | Regeneron Pharmaceuticals, Inc. | Manufacturing process for high titer antibody |
| AU2023233590A1 (en) | 2022-03-18 | 2024-10-17 | Regeneron Pharmaceuticals, Inc. | Methods and systems for analyzing polypeptide variants |
| WO2023191665A1 (en) * | 2022-03-31 | 2023-10-05 | Milaboratory, Limited Liability Company | ANTIBODIES TO HUMAN IL-4Rα HAVING REDUCED IMMUNOGENICITY AND APPLICATION THEREOF |
| JP2025522904A (ja) | 2022-07-08 | 2025-07-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｉｌ－４ｒアンタゴニストを投与することによる小児好酸球性食道炎の処置方法 |
| EP4580659A1 (en) | 2022-08-29 | 2025-07-09 | Sanofi Biotechnology | Methods for treating chronic inducible cold urticaria by administering an il-4r antagonist |
| KR20240038841A (ko) | 2022-09-16 | 2024-03-26 | 연세대학교 산학협력단 | 신규한 인간 인터류킨-4 수용체 결합 나노바디 및 이의 용도 |
| US20240141051A1 (en) | 2022-11-01 | 2024-05-02 | Regeneron Pharmaceuticals, Inc. | Methods for treating hand and foot dermatitis by administering an il-4r antagonist |
| WO2024112935A1 (en) | 2022-11-23 | 2024-05-30 | Regeneron Pharmaceuticals, Inc. | Methods for improving bone growth by administering an il-4r antagonist |
| WO2024130048A1 (en) | 2022-12-16 | 2024-06-20 | Regeneron Pharmaceuticals, Inc. | Methods and systems for assessing chromatographic column integrity |
| US20240245779A1 (en) | 2023-01-25 | 2024-07-25 | Regeneron Pharmaceuticals, Inc. | Methods of modeling liquid protein composition stability |
| EP4655595A1 (en) | 2023-01-25 | 2025-12-03 | Regeneron Pharmaceuticals, Inc. | Mass spectrometry-based characterization of antibodies co-expressed in vivo |
| US20240255519A1 (en) | 2023-02-01 | 2024-08-01 | Regeneron Pharmaceuticals, Inc. | Asymmetrical flow field-flow fractionation with mass spectrometry for biomacromolecule analysis |
| CN120530132A (zh) * | 2023-02-17 | 2025-08-22 | 顶峰疗法股份有限公司 | 结合白介素4受体α的抗体和使用方法 |
| WO2024178213A2 (en) | 2023-02-22 | 2024-08-29 | Regeneron Pharmaceuticals, Inc. | System suitability parameters and column aging |
| WO2024197119A1 (en) | 2023-03-22 | 2024-09-26 | Sanofi Biotechnology | Methods for treating chronic obstructive pulmonary disease (copd) by administering an il-4r antagonist |
| TW202502820A (zh) | 2023-03-27 | 2025-01-16 | 美商再生元醫藥公司 | 藉由投予ｉｌ—４ｒ拮抗劑治療嗜酸性球性胃腸炎之方法 |
| WO2024199665A1 (en) | 2023-03-30 | 2024-10-03 | Sandoz Ag | Stable composition comprising a high protein concentration |
| US20240366471A1 (en) | 2023-05-01 | 2024-11-07 | Regeneron Pharmaceuticals, Inc. | Multidose antibody drug products using phenol or benzyl alcohol |
| KR20240170605A (ko) * | 2023-05-23 | 2024-12-04 | 연세대학교 산학협력단 | 신규한 인간 인터류킨-4 수용체 결합 나노바디 및 이를 포함하는 비강 분무 제형 |
| WO2025054406A1 (en) | 2023-09-08 | 2025-03-13 | Regeneron Pharmaceuticals, Inc. | Methods and systems for assessing chromatographic column integrity |
| US20250095773A1 (en) | 2023-09-18 | 2025-03-20 | Regeneron Pharmaceuticals, Inc. | Methods and systems for developing chromatography protocols |
| WO2025072597A2 (en) | 2023-09-29 | 2025-04-03 | Regeneron Pharmaceuticals, Inc. | Lyophilization using controlled nucleation |
| WO2025075970A1 (en) | 2023-10-02 | 2025-04-10 | Regeneron Pharmaceuticals, Inc. | Drug delivery device safety system |
| US20250129117A1 (en) | 2023-10-18 | 2025-04-24 | Regeneron Pharmaceuticals, Inc. | Rapid purification of monoclonal antibody from in-process upstream cell culture material |
| TW202535934A (zh) | 2023-11-02 | 2025-09-16 | 美商再生元醫藥公司 | 利用應力來降低脂酶活性的方法 |
| WO2025117516A1 (en) | 2023-11-30 | 2025-06-05 | Genzyme Corporation | Methods for treating cd20-related disorders |
| TW202535949A (zh) | 2023-12-20 | 2025-09-16 | 美商必治妥美雅史谷比公司 | 靶向IL-18受體β(IL-18RB)之抗體及相關方法 |
| CN117924490B (zh) * | 2023-12-22 | 2024-10-22 | 华润生物医药有限公司 | 抗il-4r抗体及其用途 |
| WO2025166234A1 (en) * | 2024-01-31 | 2025-08-07 | Apogee Therapeutics, Inc. | Methods of administering antibodies that bind interleukin 4 receptor alpha |
| WO2025166281A1 (en) | 2024-02-01 | 2025-08-07 | Regeneron Pharmaceuticals, Inc. | Platform for charge-detection mass spectrometry analysis of aavs |
| WO2025175164A1 (en) | 2024-02-16 | 2025-08-21 | Regeneron Pharmaceuticals, Inc. | Methods of producing concentrated formulated drug substances comprising proteins, and concentrated formulated drug substance made by the methods |
| WO2025194043A1 (en) | 2024-03-15 | 2025-09-18 | Regeneron Pharmaceuticals, Inc. | Polysorbate and polyoxyethylene sorbitan as excipients for stable protein formulations |
| EP4623903A1 (en) | 2024-03-28 | 2025-10-01 | Fresenius Kabi Deutschland GmbH | Pharmaceutical composition comprising dupilumab |
| US20250388685A1 (en) | 2024-04-15 | 2025-12-25 | Sanofi Biotechnology | Methods for treating chronic rhinosinusitis without nasal polyps by administering an il-4r antagonist |
| US20260008857A1 (en) * | 2024-06-13 | 2026-01-08 | Flagship Pioneering Innovations Vi, Llc | Antigen Binding Molecules Targeting Interleukine-4 Receptor Subunit Alpha (IL-4Ra) |
| WO2025259840A1 (en) | 2024-06-13 | 2025-12-18 | Regeneron Pharmaceuticals, Inc. | Methods and systems for scaled chromatography |
| WO2025264860A2 (en) | 2024-06-18 | 2025-12-26 | Yale University | Methods of treating post-covid airway disease |
| WO2026025028A1 (en) | 2024-07-26 | 2026-01-29 | Regeneron Pharmaceuticals, Inc. | Methods of making ultra-high concentrated protein formulations using lyophilization |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5041381A (en) * | 1986-07-03 | 1991-08-20 | Schering Corporation | Monoclonal antibodies against human interleukin-4 and hybridomas producing the same |
| GB8808015D0 (en) * | 1988-04-06 | 1988-05-05 | Ritter M A | Chemical compounds |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| EP0668774A1 (en) * | 1991-05-03 | 1995-08-30 | Seragen, Inc. | Interleukin receptor targeted molecules for treatment of inflammatory arthritis |
| US5863537A (en) * | 1992-02-19 | 1999-01-26 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| JP3315427B2 (ja) | 1992-03-05 | 2002-08-19 | 大日本除蟲菊株式会社 | 皮膚炎治療剤 |
| EP0652950B1 (en) | 1992-07-24 | 2007-12-19 | Amgen Fremont Inc. | Generation of xenogeneic antibodies |
| US5714146A (en) | 1992-08-26 | 1998-02-03 | Board Of Regents Of The University Of Washington | IL-4 bone therapy |
| EP0604693A1 (en) | 1992-12-29 | 1994-07-06 | Schering-Plough | Monoclonal antibodies against the human interleukin-4 receptor and hybridomas producing the same |
| ZA946875B (en) * | 1993-09-07 | 1995-07-06 | Smithkline Beecham Corp | Recombinant il4 antibodies useful in treatment of il4 mediated disorders |
| US6387632B2 (en) * | 1998-06-11 | 2002-05-14 | Hitachi, Ltd. | Polynucleotide separation method and apparatus therefor |
| JP2003524602A (ja) | 1998-09-18 | 2003-08-19 | ダイナバックス テクノロジーズ コーポレイション | ＩｇＥ関連疾患の治療方法と、その治療において使用する組成物 |
| US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| EP3190126A1 (en) | 2000-05-26 | 2017-07-12 | Immunex Corporation | Use of interleukin-4 receptor (il-4r) antibodies and compositions thereof |
| US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| ATE372764T1 (de) | 2000-07-26 | 2007-09-15 | Hououdou Co Ltd | Antipruritische zusammensetzungen und die wundheilung fördernde zusammensetzungen |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| KR20030065539A (ko) | 2000-12-22 | 2003-08-06 | 소시에떼 데 프로듀이 네슬레 소시에떼아노님 | 내성 유도 |
| US20030103938A1 (en) | 2001-05-09 | 2003-06-05 | Alk-Abello A/S | Pharmaceutical compositions for preventing or treating Th1 and Th2 cell related diseases by modulating the Th1/Th2 ratio |
| WO2002092125A1 (en) | 2001-05-11 | 2002-11-21 | Novartis Ag | Compositions for use in treating ige-associated disorders |
| US20050074462A1 (en) | 2001-05-23 | 2005-04-07 | Duotol Ab | Supression of allergic reactions by transdermal administration of allergens conjugated to cholera toxin or fragments thereof |
| EP2298717B1 (en) | 2001-11-30 | 2015-10-28 | Biogen MA Inc. | Antibodies against monocyte chemotactic proteins |
| DE60328195D1 (de) | 2002-03-29 | 2009-08-13 | Schering Corp | Menschliche monoklonale antikörper gegen interleukin-5 sowie diese umfassende verfahren und zusammensetzungen |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| CA2514840C (en) | 2003-02-01 | 2017-11-07 | Tanox, Inc. | High affinity, anti-human ige antibodies |
| US7923209B2 (en) | 2003-03-14 | 2011-04-12 | Anergis, S.A. | Allergen peptide fragments and use thereof |
| US20050112694A1 (en) | 2003-11-07 | 2005-05-26 | Carter Paul J. | Antibodies that bind interleukin-4 receptor |
| CA2550933A1 (en) | 2003-12-22 | 2005-07-14 | Amgen Inc. | Methods for identifying functional antibodies |
| CA2554596A1 (en) | 2004-02-27 | 2005-09-15 | Regeneron Pharmaceuticals, Inc. | Il-4/il-13 specific polypetides and therapeutic uses thereof |
| AR049390A1 (es) * | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
| US20090098142A1 (en) | 2004-06-09 | 2009-04-16 | Kasaian Marion T | Methods and compositions for treating and monitoring treatment of IL-13-associated disorders |
| TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
| PE20060560A1 (es) * | 2004-08-03 | 2006-06-27 | Novartis Ag | Anticuerpos de interleucina-4 humana |
| JP5234445B2 (ja) | 2004-10-05 | 2013-07-10 | 源一郎 杣 | 薬剤 |
| US8030003B2 (en) | 2004-12-07 | 2011-10-04 | Children's Hospital Medical Center | Diagnosis of eosinophilic esophagitis based on presence of an elevated level of eotaxin-3 |
| TW200902555A (en) | 2005-01-03 | 2009-01-16 | Hoffmann La Roche | Antibodies against IL-13 receptor alpha 1 and uses thereof |
| US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| JP2009523460A (ja) | 2006-01-24 | 2009-06-25 | ドマンティス リミテッド | Ｉｌ−４および／またはｉｌ−１３に結合するリガンド |
| SI2041177T1 (sl) | 2006-06-02 | 2012-03-30 | Regeneron Pharma | Visoko afinitetna protitelesa za humani IL receptor |
| JP4221018B2 (ja) | 2006-08-31 | 2009-02-12 | トヨタ自動車株式会社 | 頭部保護エアバッグ装置 |
| RS53340B (sr) | 2006-10-02 | 2014-10-31 | Regeneron Pharmaceuticals, Inc. | Humana antitela visokog afiniteta za humani il-4 receptor |
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| SI2132230T1 (sl) | 2007-03-22 | 2014-07-31 | Genentech, Inc. | Apoptotska protitelesa, ki veĹľejo membransko-vezan IgE |
| EP2022507A1 (en) | 2007-08-07 | 2009-02-11 | Universität Hamburg | Antibody compositions specific for lgE, lgG4 and lgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy |
| WO2009061819A1 (en) | 2007-11-05 | 2009-05-14 | The Regents Of The University Of Colorado | Minimally-invasive measurement of esophageal inflammation |
| AU2008339576B2 (en) | 2007-12-21 | 2014-05-22 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Ralpha) |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| DE202008006598U1 (de) | 2008-04-11 | 2008-10-02 | Alk-Abelló A/S | Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung |
| US20090264392A1 (en) | 2008-04-21 | 2009-10-22 | Meritage Pharma, Inc. | Treating eosinophilic esophagitis |
| US20120004205A1 (en) | 2008-12-01 | 2012-01-05 | Cincinnati Children's Hospital Medical Center | Il-13 induced gene signature for eosinophilic esophagitis |
| WO2010120524A2 (en) | 2009-03-31 | 2010-10-21 | Altair Therapeutics, Inc. | Methods of modulating an immune response to a viral infection |
| US8497528B2 (en) | 2010-05-06 | 2013-07-30 | Taiwan Semiconductor Manufacturing Company, Ltd. | Method for fabricating a strained structure |
| EP2475382B1 (en) | 2009-09-07 | 2015-01-14 | DBV Technologies | Method of treating eosinophilic esophagitis |
| US8993347B2 (en) | 2009-12-17 | 2015-03-31 | Cornell University | Methods for detecting antibodies in mucosal samples and device for sampling mucosal material |
| EP2585075B8 (en) | 2010-06-24 | 2021-09-22 | ViroPharma Biologics LLC | Methods of treatment for esophageal inflammation |
| EP3354280B1 (en) * | 2010-10-06 | 2020-07-29 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies |
| RU2453303C1 (ru) | 2010-12-23 | 2012-06-20 | Общество с ограниченной ответственностью "ЦитоНИР" (ООО "ЦитоНИР") | Фармацевтическая композиция для лечения атопического дерматита |
| EP2661631A4 (en) | 2011-01-06 | 2014-05-21 | Childrens Hosp Medical Center | EXPRESSION PROFILES FOR OSSOPHAGEAL CYTOKINE IN EOSINOPHILIAN ESOPHAGITIS |
| US20130052190A1 (en) | 2011-02-22 | 2013-02-28 | Oxagen Limited | CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions |
| US9928344B2 (en) | 2011-06-21 | 2018-03-27 | Children's Hospital Medical Center | Diagnostic methods of eosinophilic esophagitis |
| WO2013051928A1 (en) | 2011-10-06 | 2013-04-11 | N.V. Nutricia | Treatment of eosinophilic esophagitis |
| CN104114169A (zh) | 2011-12-16 | 2014-10-22 | 阿托佩斯治疗有限公司 | 用于治疗嗜酸细胞性食管炎的crth2拮抗剂和质子泵抑制剂的组合物 |
| TW201334789A (zh) | 2012-01-31 | 2013-09-01 | Genentech Inc | 抗ｉｇｅ抗體及其使用方法 |
| WO2013155010A1 (en) | 2012-04-09 | 2013-10-17 | Children's Hospital Medical Center | Non-invasive biomarkers for eosinophilic esophagitis |
| KR102307248B1 (ko) * | 2012-08-21 | 2021-10-01 | 사노피 바이오테크놀로지 | Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법 |
| NZ630178A (en) | 2012-09-07 | 2017-06-30 | Regeneron Pharma | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| US10132809B2 (en) | 2012-10-10 | 2018-11-20 | Rhote Island Hospital | Differential expression of protein markers for the diagnosis and treatment of eosinophilic esophagitis |
| ES2667420T3 (es) | 2013-02-05 | 2018-05-10 | Engmab Sàrl | Anticuerpos biespecíficos contra cd3epsilon y bcma |
| TWI697334B (zh) | 2013-06-04 | 2020-07-01 | 美商再生元醫藥公司 | 藉由投與ｉｌ-４ｒ抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| CN105517570B (zh) | 2013-06-21 | 2020-04-07 | 赛诺菲生物技术公司 | 通过施用il-4r拮抗剂治疗鼻息肉症的方法 |
| TWI682781B (zh) | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| RU2552929C1 (ru) | 2013-11-14 | 2015-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний |
| IL315136A (en) * | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| ES2973858T3 (es) | 2014-02-28 | 2024-06-24 | Regeneron Pharma | Métodos para tratar infecciones cutáneas mediante la administración de un antagonista de IL-4R |
| AU2015346150B2 (en) * | 2014-11-14 | 2021-08-19 | Regeneron Pharmaceuticals, Inc. | Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist |
| MX2018009990A (es) | 2016-02-19 | 2018-12-17 | Regeneron Pharma | Metodos para mejorar la eficacia de una vacuna mediante la administracion de un antagonista il-4r. |
| TWI728172B (zh) | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
| CA3035202A1 (en) | 2016-09-01 | 2018-03-08 | Regeneron Pharmaceuticals, Inc. | Methods for preventing or treating allergy by administering an il-4r antagonist |
| WO2018057776A1 (en) | 2016-09-22 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an il-4r inhibitor |
| KR20190053250A (ko) | 2016-09-22 | 2019-05-17 | 리제너론 파아마슈티컬스, 인크. | Il-4r 저해제 투여에 의한 중증 아토피 피부염의 치료 방법 |
| IL268349B2 (en) | 2017-02-17 | 2024-08-01 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| EP3615068A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| US11053309B2 (en) | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
| HUE064655T2 (hu) | 2017-10-30 | 2024-04-28 | Sanofi Biotechnology | IL-4R antagonista asztma kezelésére vagy megelõzésére szolgáló eljárásban |
| AU2019270940A1 (en) | 2018-05-13 | 2020-11-26 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an IL-4R inhibitor |
| CN121102493A (zh) | 2019-03-21 | 2025-12-12 | 瑞泽恩制药公司 | 用于治疗过敏症的il-4/il-13途径抑制剂和浆细胞消融的组合 |
| JP2022543815A (ja) | 2019-08-05 | 2022-10-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｉｌ－４ｒアンタゴニストを投与することによりアレルギーを治療しアレルゲン特異的免疫療法を増強するための方法 |
| EP4010373A1 (en) | 2019-08-05 | 2022-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| CN115461818A (zh) | 2019-12-09 | 2022-12-09 | 赛诺菲生物技术公司 | 治疗数字鉴定的il-4/il-13相关障碍的方法 |
| KR20220158821A (ko) | 2020-03-27 | 2022-12-01 | 리제너론 파아마슈티컬스, 인크. | Il-4r 길항제를 투여함에 의해 아토피 피부염을 치료하기 위한 방법 |
| CN115768516A (zh) | 2020-05-22 | 2023-03-07 | 瑞泽恩制药公司 | 通过施用il-4r抑制剂治疗嗜酸细胞性食管炎的方法 |
| EP4274609A1 (en) | 2021-01-08 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating peanut allergy and enhancing peanut allergen-specific immunotherapy by administering an il-4r antagonist |
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