BR112022009974A2 - Métodos de produção de um polímero ou micropartículas revestidas com polímero, para produzir microesferas poliméricas ou revestidas com polímero e para produzir micropartículas, composição de liberação sustentada, micropartículas, e, composição farmacêutica - Google Patents
Métodos de produção de um polímero ou micropartículas revestidas com polímero, para produzir microesferas poliméricas ou revestidas com polímero e para produzir micropartículas, composição de liberação sustentada, micropartículas, e, composição farmacêuticaInfo
- Publication number
- BR112022009974A2 BR112022009974A2 BR112022009974A BR112022009974A BR112022009974A2 BR 112022009974 A2 BR112022009974 A2 BR 112022009974A2 BR 112022009974 A BR112022009974 A BR 112022009974A BR 112022009974 A BR112022009974 A BR 112022009974A BR 112022009974 A2 BR112022009974 A2 BR 112022009974A2
- Authority
- BR
- Brazil
- Prior art keywords
- polymer
- microparticles
- coated
- produce
- solution
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Métodos de emulsão não aquosa para a produção de micropartículas poliméricas ou revestidas com polímero são providos. Um método produz uma composição de micropartículas de liberação sustentada combinando proteína em pó e um polímero em um solvente de hidrocarboneto para formar uma primeira solução não aquosa e adicionar a primeira solução a uma segunda solução, em que a segunda solução compreende um líquido de fluorocarboneto e um fluorotensoativo para formar uma emulsão não aquosa compreendendo múltiplas gotículas de hidrocarboneto de emulsão no líquido de fluorocarboneto. O processo de endurecimento de micropartículas subsequente inclui as etapas de remoção do solvente de hidrocarboneto das gotículas de emulsão formadas, que podem ser alcançadas através da evaporação do hidrocarboneto na condição ambiente sob agitação, ou endurecimento acelerado por meio do vácuo, ou por meio da adição de hidrofluoroéster no fluorocarboneto como um cossolvente. Remover o líquido de fluorocarboneto e lavar com líquido de fluorocarboneto extra para isolar as micropartículas de liberação sustentada, em que as micropartículas de liberação sustentada compreendem um ou mais núcleos de proteína e um córtex de polímero.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962940009P | 2019-11-25 | 2019-11-25 | |
PCT/US2020/062228 WO2021108548A1 (en) | 2019-11-25 | 2020-11-25 | Sustained release formulations using non-aqueous emulsions |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022009974A2 true BR112022009974A2 (pt) | 2022-08-16 |
Family
ID=73943344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022009974A BR112022009974A2 (pt) | 2019-11-25 | 2020-11-25 | Métodos de produção de um polímero ou micropartículas revestidas com polímero, para produzir microesferas poliméricas ou revestidas com polímero e para produzir micropartículas, composição de liberação sustentada, micropartículas, e, composição farmacêutica |
Country Status (13)
Country | Link |
---|---|
US (2) | US11730793B2 (pt) |
EP (1) | EP4065086A1 (pt) |
JP (1) | JP2023502500A (pt) |
KR (1) | KR20220104797A (pt) |
CN (1) | CN114760986A (pt) |
AU (1) | AU2020394428A1 (pt) |
BR (1) | BR112022009974A2 (pt) |
CA (1) | CA3158119A1 (pt) |
CO (1) | CO2022008679A2 (pt) |
IL (1) | IL293112A (pt) |
MX (1) | MX2022006236A (pt) |
WO (1) | WO2021108548A1 (pt) |
ZA (1) | ZA202206381B (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116940347A (zh) * | 2020-11-25 | 2023-10-24 | 里珍纳龙药品有限公司 | 使用非水性膜乳化的持续释放调配物 |
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-
2020
- 2020-11-25 AU AU2020394428A patent/AU2020394428A1/en active Pending
- 2020-11-25 BR BR112022009974A patent/BR112022009974A2/pt unknown
- 2020-11-25 EP EP20828892.8A patent/EP4065086A1/en active Pending
- 2020-11-25 KR KR1020227021408A patent/KR20220104797A/ko active Search and Examination
- 2020-11-25 JP JP2022529778A patent/JP2023502500A/ja active Pending
- 2020-11-25 US US17/104,566 patent/US11730793B2/en active Active
- 2020-11-25 CA CA3158119A patent/CA3158119A1/en active Pending
- 2020-11-25 MX MX2022006236A patent/MX2022006236A/es unknown
- 2020-11-25 CN CN202080082188.2A patent/CN114760986A/zh active Pending
- 2020-11-25 IL IL293112A patent/IL293112A/en unknown
- 2020-11-25 WO PCT/US2020/062228 patent/WO2021108548A1/en unknown
-
2022
- 2022-06-08 ZA ZA2022/06381A patent/ZA202206381B/en unknown
- 2022-06-22 CO CONC2022/0008679A patent/CO2022008679A2/es unknown
-
2023
- 2023-06-28 US US18/215,698 patent/US20230414716A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US11730793B2 (en) | 2023-08-22 |
MX2022006236A (es) | 2022-06-22 |
IL293112A (en) | 2022-07-01 |
KR20220104797A (ko) | 2022-07-26 |
ZA202206381B (en) | 2023-11-29 |
CN114760986A (zh) | 2022-07-15 |
JP2023502500A (ja) | 2023-01-24 |
EP4065086A1 (en) | 2022-10-05 |
WO2021108548A1 (en) | 2021-06-03 |
CA3158119A1 (en) | 2021-06-03 |
CO2022008679A2 (es) | 2022-07-19 |
US20230414716A1 (en) | 2023-12-28 |
US20220008505A1 (en) | 2022-01-13 |
AU2020394428A1 (en) | 2022-07-14 |
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