BR112015031094A2 - células progenitoras renais - Google Patents
células progenitoras renaisInfo
- Publication number
- BR112015031094A2 BR112015031094A2 BR112015031094A BR112015031094A BR112015031094A2 BR 112015031094 A2 BR112015031094 A2 BR 112015031094A2 BR 112015031094 A BR112015031094 A BR 112015031094A BR 112015031094 A BR112015031094 A BR 112015031094A BR 112015031094 A2 BR112015031094 A2 BR 112015031094A2
- Authority
- BR
- Brazil
- Prior art keywords
- progenitor cells
- cells
- antagonist
- nephron
- growth factor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0687—Renal stem cells; Renal progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Developmental Biology & Embryology (AREA)
Abstract
a presente-se invenção refere-se a um método fornecido para produzir simultaneamente tanto células progenitoras de néfron quanto células progenitoras epiteliais uretéricas, que inclui a etapa de colocar células mesodérmicas intermediárias em contato com: fator de crescimento de fibroblasto (9) e/ou fator de crescimento de fibroblasto (20) e, opcionalmente, um ou mais dos selecionados a partir do grupo que consiste em: proteína morfogênica de osso 7; heparina; um ago-nista de wnt; ácido retinoico; e um antagonista de ra. as concentra-ções de agonista de wnt, ácido retinoico e/ou antagonista de ra podem ser manipuladas para favorecer a produção relativa de células progenitoras de néfron e células progenitoras epiteliais uretéricas. as células mesodérmicas intermediárias são, por fim, derivadas de células-tronco pluripotentes humanas por meio de um estágio de linhagem primitiva posterior. as células progenitoras de néfron e células progeni-toras epiteliais uretéricas podem ter finalidades como para reparação e regeneração de rim, bioimpressão de rins e compostos de triagem para nefrotoxicidade.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2013902215A AU2013902215A0 (en) | 2013-06-14 | Renal progenitor cells | |
AU2013904580A AU2013904580A0 (en) | 2013-11-27 | Renal progenitor cells | |
PCT/AU2014/000608 WO2014197934A1 (en) | 2013-06-14 | 2014-06-13 | Renal progenitor cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015031094A2 true BR112015031094A2 (pt) | 2017-07-25 |
Family
ID=52021491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015031094A BR112015031094A2 (pt) | 2013-06-14 | 2014-06-13 | células progenitoras renais |
Country Status (13)
Country | Link |
---|---|
US (2) | US10900022B2 (pt) |
EP (1) | EP3011014A4 (pt) |
JP (2) | JP2016527878A (pt) |
KR (1) | KR102375753B1 (pt) |
CN (1) | CN105473706B (pt) |
AU (1) | AU2014280843B2 (pt) |
BR (1) | BR112015031094A2 (pt) |
CA (1) | CA2915097C (pt) |
HK (1) | HK1223976A1 (pt) |
NZ (1) | NZ715302A (pt) |
RU (1) | RU2016100232A (pt) |
SG (1) | SG11201510238TA (pt) |
WO (1) | WO2014197934A1 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
AU2014280843B2 (en) | 2013-06-14 | 2017-04-20 | The University Of Queensland | Renal progenitor cells |
MX2015017330A (es) * | 2013-07-29 | 2016-04-06 | Hoffmann La Roche | Metodo para la diferenciacion de celulas madre pluripotenciales en precursores renales multi-competentes. |
AU2015267148B2 (en) | 2014-05-28 | 2021-07-29 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
AU2014277667B2 (en) * | 2014-12-15 | 2022-07-14 | The University Of Queensland | Differentiation of pluripotent stem cells to form renal organoids |
JP6914920B2 (ja) * | 2015-09-03 | 2021-08-04 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | ステージ特異的な上皮の生理機能、形態形成、および疾患をモデル化する、胚盤葉上層スフェロイドの腎臓オルガノイドへの三次元分化 |
WO2017049243A1 (en) * | 2015-09-17 | 2017-03-23 | Bonventre Joseph V | Methods of generating nephrons from human pluripotent stem cells |
ES2929758T3 (es) | 2016-05-05 | 2022-12-01 | Childrens Hospital Med Ct | Métodos para la fabricación in vitro de tejido del fondo gástrico y composiciones relacionadas con el mismo |
AU2017335841A1 (en) | 2016-09-28 | 2019-04-04 | Organovo, Inc. | Use of engineered renal tissues in assays |
CA3045145A1 (en) | 2016-12-05 | 2018-06-14 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
US11492644B2 (en) | 2017-05-24 | 2022-11-08 | Murdoch Childrens Research Institute | Genetically induced nephron progenitors |
CN117802033A (zh) * | 2017-05-25 | 2024-04-02 | 国立大学法人京都大学 | 由多能干细胞制造中胚层谱系原条细胞的方法 |
WO2019006127A1 (en) * | 2017-06-28 | 2019-01-03 | Rutgers, The State University Of New Jersey | ORGANOIDS DERIVED FROM A SINGLE RENAL CELL |
AU2018360620A1 (en) * | 2017-10-31 | 2020-04-23 | Murdoch Childrens Research Institute | Composition and method |
CN110468095A (zh) * | 2019-09-05 | 2019-11-19 | 安徽中盛溯源生物科技有限公司 | 一种肾上皮细胞及其制备方法和应用 |
BR112022006286A2 (pt) * | 2019-10-01 | 2022-06-21 | Univ Kyoto | Métodos para isolar uma célula da ponta do broto uretérico, para produzir uma colônia celular da ponta do broto uretérico, para produzir um organoide, para produzir uma célula progenitora do duto de coleta, para produzir uma população celular de ponta do broto uretérico e para monitorar uma célula da ponta do broto uretérico, e, composição para isolar ou monitorar uma célula da ponta do broto uretérico |
CN111961640B (zh) * | 2020-04-27 | 2023-05-12 | 同济大学 | 一种尿源性肾干细胞三维分化模型的构建方法及培养体系 |
CN111638342A (zh) * | 2020-07-08 | 2020-09-08 | 上海市浦东新区公利医院(第二军医大学附属公利医院) | Sox17蛋白在制备肾透明细胞癌诊断或预后评估试剂盒中的应用 |
WO2023028550A1 (en) * | 2021-08-26 | 2023-03-02 | Vanderbilt University | Accelerated protocol for the differentiation of podocytes from human pluripotent stem cells |
TW202313964A (zh) | 2021-09-03 | 2023-04-01 | 日商大塚製藥股份有限公司 | 腎臟類器官及其製造方法 |
WO2023060190A1 (en) | 2021-10-08 | 2023-04-13 | Vanderbilt University | Nephron progenitor exosomes |
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US6517872B1 (en) | 1995-06-12 | 2003-02-11 | Yeda Research And Development Co., Ltd. | FGFR3 as a marker for mesenchymal skeletal progenitor cells |
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US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
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CA2536909A1 (en) | 2003-08-29 | 2005-03-10 | Regents Of The University Of Minnesota | Kidney derived stem cells and methods for their isolation, differentiation and use |
WO2005075636A1 (en) * | 2004-02-09 | 2005-08-18 | The University Of Queensland | Molecular markers associated with metanephric development and renal progenitors |
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GB0615327D0 (en) | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
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US8278105B2 (en) | 2008-09-09 | 2012-10-02 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
EP3312269A1 (en) | 2008-12-17 | 2018-04-25 | The Scripps Research Institute | Generation and maintenance of stem cells |
US20120207744A1 (en) | 2009-03-19 | 2012-08-16 | Mendlein John D | Reprogramming compositions and methods of using the same |
US10894944B2 (en) | 2009-04-10 | 2021-01-19 | Monash University | Cell culture media |
CN102597220A (zh) * | 2009-08-17 | 2012-07-18 | 株式会社器官再生工学 | 生物人工内脏器官的制造方法 |
CN102242146B (zh) | 2010-05-10 | 2015-11-25 | 高丽大学校产学协力团 | 组合物和用其产生诱导全能干细胞的方法 |
WO2011141914A1 (en) | 2010-05-13 | 2011-11-17 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Isolated populations of adult renal cells and methods of isolating and using same |
JP5896360B2 (ja) | 2010-07-21 | 2016-04-13 | 国立大学法人京都大学 | ヒト多能性幹細胞から中間中胚葉細胞への分化誘導方法 |
WO2013056072A1 (en) | 2011-10-13 | 2013-04-18 | Wisconsin Alumni Research Foundation | Generation of cardiomyocytes from human pluripotent stem cells |
EP2794860B1 (en) | 2011-12-19 | 2017-05-03 | Kyoto University | Method for inducing differentiation of human pluripotent stem cells into intermediate mesoderm cells |
KR20130119683A (ko) | 2012-04-24 | 2013-11-01 | 사회복지법인 삼성생명공익재단 | 줄기세포 배양 배지 및 이를 이용한 줄기세포의 배양방법 |
KR101523040B1 (ko) | 2012-06-26 | 2015-05-26 | 라정찬 | 고농도의 줄기세포 제조방법 |
US8962322B2 (en) | 2012-12-03 | 2015-02-24 | City Of Hope | Enhancers of induced pluripotent stem cell reprogramming |
US20150037883A1 (en) | 2013-03-03 | 2015-02-05 | Royan Institute | Method for derivation and long-term establishment of ground state pluripotent embryonic stem cells |
AU2014279065B2 (en) * | 2013-06-11 | 2020-04-09 | Astellas Pharma Inc. | Method for producing renal precursor cells, and drug containing renal precursor cells |
AU2014280843B2 (en) | 2013-06-14 | 2017-04-20 | The University Of Queensland | Renal progenitor cells |
CN103555660B (zh) | 2013-09-09 | 2016-03-30 | 依科赛生物科技(太仓)有限公司 | 一种胚胎干细胞无血清培养基及其应用 |
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2014
- 2014-06-13 AU AU2014280843A patent/AU2014280843B2/en active Active
- 2014-06-13 NZ NZ715302A patent/NZ715302A/en unknown
- 2014-06-13 JP JP2016518798A patent/JP2016527878A/ja active Pending
- 2014-06-13 CA CA2915097A patent/CA2915097C/en active Active
- 2014-06-13 SG SG11201510238TA patent/SG11201510238TA/en unknown
- 2014-06-13 US US14/898,213 patent/US10900022B2/en active Active
- 2014-06-13 KR KR1020167000925A patent/KR102375753B1/ko active IP Right Grant
- 2014-06-13 EP EP14810526.5A patent/EP3011014A4/en active Pending
- 2014-06-13 BR BR112015031094A patent/BR112015031094A2/pt not_active Application Discontinuation
- 2014-06-13 CN CN201480045180.3A patent/CN105473706B/zh active Active
- 2014-06-13 RU RU2016100232A patent/RU2016100232A/ru not_active Application Discontinuation
- 2014-06-13 WO PCT/AU2014/000608 patent/WO2014197934A1/en active Application Filing
-
2016
- 2016-10-26 HK HK16112330.6A patent/HK1223976A1/zh unknown
-
2019
- 2019-10-23 JP JP2019192404A patent/JP6937810B2/ja active Active
-
2021
- 2021-01-22 US US17/155,631 patent/US20210371826A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
NZ715302A (en) | 2021-12-24 |
KR102375753B1 (ko) | 2022-03-18 |
SG11201510238TA (en) | 2016-01-28 |
WO2014197934A1 (en) | 2014-12-18 |
AU2014280843B2 (en) | 2017-04-20 |
EP3011014A1 (en) | 2016-04-27 |
US10900022B2 (en) | 2021-01-26 |
CA2915097A1 (en) | 2014-12-18 |
US20210371826A1 (en) | 2021-12-02 |
HK1223976A1 (zh) | 2017-08-11 |
AU2014280843A1 (en) | 2016-01-21 |
EP3011014A4 (en) | 2017-02-08 |
CN105473706A (zh) | 2016-04-06 |
CN105473706B (zh) | 2021-10-26 |
JP2016527878A (ja) | 2016-09-15 |
JP2020031648A (ja) | 2020-03-05 |
US20160237409A1 (en) | 2016-08-18 |
RU2016100232A (ru) | 2017-07-17 |
CA2915097C (en) | 2021-12-07 |
JP6937810B2 (ja) | 2021-09-22 |
KR20160030178A (ko) | 2016-03-16 |
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