BR112013026501A2 - “métodos para preparar um oócito, de fertilização in vitro, e para aumentar a capacidade de geração de atp de um oócito, oócito, e, composição” - Google Patents

“métodos para preparar um oócito, de fertilização in vitro, e para aumentar a capacidade de geração de atp de um oócito, oócito, e, composição”

Info

Publication number
BR112013026501A2
BR112013026501A2 BR112013026501A BR112013026501A BR112013026501A2 BR 112013026501 A2 BR112013026501 A2 BR 112013026501A2 BR 112013026501 A BR112013026501 A BR 112013026501A BR 112013026501 A BR112013026501 A BR 112013026501A BR 112013026501 A2 BR112013026501 A2 BR 112013026501A2
Authority
BR
Brazil
Prior art keywords
oocyte
preparing
composition
methods
vitro fertilization
Prior art date
Application number
BR112013026501A
Other languages
English (en)
Inventor
Dori C Woods
Jonathan Lee Tilly
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47010014&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013026501(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of BR112013026501A2 publication Critical patent/BR112013026501A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0609—Oocytes, oogonia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0611—Primordial germ cells, e.g. embryonic germ cells [EG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/235—Leukemia inhibitory factor [LIF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer

Abstract

métodos para preparar um oócito, de fertilização in vitro, para isolar e para identificar uma população de mitocôndrias funcionais, e para aumentar a capacidade de geração de atp, oócito, composição, e, kit são descritas composições derivadas de células-tronco oogoniais (osc), tal como citoplasma nuclear livre ou mitocôndrias isoladas, e usos de composições derivadas de osc em procedimentos de aumento da fertilidade autólogos.
BR112013026501A 2011-04-14 2012-04-13 “métodos para preparar um oócito, de fertilização in vitro, e para aumentar a capacidade de geração de atp de um oócito, oócito, e, composição” BR112013026501A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161475561P 2011-04-14 2011-04-14
US201261600505P 2012-02-17 2012-02-17
PCT/US2012/033643 WO2012142500A2 (en) 2011-04-14 2012-04-13 Compositions and methods for autologous germline mitochondrial energy transfer

Publications (1)

Publication Number Publication Date
BR112013026501A2 true BR112013026501A2 (pt) 2016-11-29

Family

ID=47010014

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013026501A BR112013026501A2 (pt) 2011-04-14 2012-04-13 “métodos para preparar um oócito, de fertilização in vitro, e para aumentar a capacidade de geração de atp de um oócito, oócito, e, composição”

Country Status (24)

Country Link
US (5) US8647869B2 (pt)
EP (3) EP2787073B1 (pt)
JP (3) JP5793237B2 (pt)
CN (2) CN103562378B (pt)
AP (1) AP2013007229A0 (pt)
AU (1) AU2012242591B2 (pt)
BR (1) BR112013026501A2 (pt)
CA (2) CA2868239C (pt)
CL (1) CL2013002989A1 (pt)
CO (1) CO6862102A2 (pt)
CR (1) CR20130592A (pt)
DO (1) DOP2013000240A (pt)
EA (1) EA201391523A1 (pt)
GT (1) GT201300248A (pt)
HK (1) HK1202890A1 (pt)
IL (3) IL228829A (pt)
MA (1) MA35105B1 (pt)
MX (1) MX2013011990A (pt)
NI (1) NI201300108A (pt)
NZ (1) NZ706806A (pt)
PE (1) PE20141517A1 (pt)
SG (2) SG194448A1 (pt)
WO (1) WO2012142500A2 (pt)
ZA (2) ZA201308494B (pt)

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EP2787073B1 (en) 2011-04-14 2019-03-20 The General Hospital Corporation Compositions and methods for autologous germline mitochondrial energy transfer
CN103827293A (zh) 2011-06-29 2014-05-28 通用医疗公司 用于增强雌性生殖细胞中生物能状态的组合物和方法
CN103146644B (zh) * 2013-02-27 2014-09-24 青岛农业大学 一种小鼠毛囊干细胞体外向原始生殖细胞分化的技术方法
CN103969232A (zh) * 2014-04-03 2014-08-06 浙江大学 一种三色荧光标记筛选抗阿霉素肾毒性活性物质的方法
EP3194448A4 (en) 2014-09-16 2018-03-14 Ovascience, Inc. Anti-vasa antibodies, and methods of production and use thereof
BR112017012033A2 (pt) * 2014-12-08 2017-12-26 Ovascience Inc coleta e concentração mitocondrial e usos das mesmas
JP2018530353A (ja) * 2015-10-16 2018-10-18 クーパーサージカル・インコーポレイテッドＣｏｏｐｅｒＳｕｒｇｉｃａｌ， Ｉｎｃ． ミトコンドリアｄｎａの定量化および胚の品質を決定するための方法
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RU2771328C2 (ru) * 2016-06-23 2022-04-29 Титон Биотек, Инк. Клетки, экспрессирующие рецептор паратиреоидного гормона 1, и их применение
CN106190963A (zh) * 2016-07-13 2016-12-07 浙江大学 一种采用线粒体移植促进损伤神经元存活的方法
WO2019060297A1 (en) * 2017-09-19 2019-03-28 Unity Biotechnology, Inc. MITOCHONDRIAL REJUVENATION AS A TREATMENT FOR AGE-RELATED AND NEURODEGENERATIVE CONDITIONS
CN108004200A (zh) * 2017-12-01 2018-05-08 佳学基因医学技术（北京）有限公司 一种线粒体转移液及其制备方法
CN111621555A (zh) * 2019-06-13 2020-09-04 中国科学院广州生物医药与健康研究院 生物标志物及其应用
CN114134106B (zh) * 2021-11-26 2024-01-26 北京大学人民医院 一种尿源间充质干细胞线粒体及其移植方法与应用

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Also Published As

Publication number Publication date
PE20141517A1 (es) 2014-10-25
EP2697365A4 (en) 2014-07-23
CL2013002989A1 (es) 2014-05-02
AP2013007229A0 (en) 2013-11-30
JP5793237B2 (ja) 2015-10-14
SG194448A1 (en) 2013-12-30
JP6170103B2 (ja) 2017-07-26
CN106350479A (zh) 2017-01-25
CA2832336C (en) 2016-08-09
NI201300108A (es) 2014-08-26
CO6862102A2 (es) 2014-02-10
IL247447B (en) 2018-10-31
US8642329B2 (en) 2014-02-04
CN103562378B (zh) 2016-09-07
ZA201502630B (en) 2016-01-27
NZ617582A (en) 2015-06-26
US20150353887A1 (en) 2015-12-10
CA2868239A1 (en) 2012-10-18
EP2787073B1 (en) 2019-03-20
CR20130592A (es) 2014-03-05
MX2013011990A (es) 2013-11-20
IL228829A0 (en) 2013-12-31
EP2697365A2 (en) 2014-02-19
US20190300850A1 (en) 2019-10-03
CA2832336A1 (en) 2012-10-18
JP2018007659A (ja) 2018-01-18
SG10201406171QA (en) 2014-10-30
ZA201308494B (en) 2016-02-24
AU2012242591B2 (en) 2014-10-23
US20130052727A1 (en) 2013-02-28
NZ706806A (en) 2016-12-23
EP3498826A1 (en) 2019-06-19
CN103562378A (zh) 2014-02-05
IL228829A (en) 2015-02-26
JP2016019532A (ja) 2016-02-04
GT201300248A (es) 2015-09-01
WO2012142500A3 (en) 2012-12-13
AU2012242591A1 (en) 2013-10-17
MA35105B1 (fr) 2014-05-02
US20120315651A1 (en) 2012-12-13
US20130060079A1 (en) 2013-03-07
JP2014514928A (ja) 2014-06-26
US9150830B2 (en) 2015-10-06
WO2012142500A2 (en) 2012-10-18
IL237089A (en) 2017-05-29
EP2787073A1 (en) 2014-10-08
CA2868239C (en) 2018-07-31
US8647869B2 (en) 2014-02-11
DOP2013000240A (es) 2014-06-30
EA201391523A1 (ru) 2014-03-31
HK1202890A1 (en) 2015-10-09

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