MA35105B1 - Compositions et méthodes de transfert d'énergie autologue des mitochondries dans les cellules germinales - Google Patents

Compositions et méthodes de transfert d'énergie autologue des mitochondries dans les cellules germinales

Info

Publication number
MA35105B1
MA35105B1 MA36400A MA36400A MA35105B1 MA 35105 B1 MA35105 B1 MA 35105B1 MA 36400 A MA36400 A MA 36400A MA 36400 A MA36400 A MA 36400A MA 35105 B1 MA35105 B1 MA 35105B1
Authority
MA
Morocco
Prior art keywords
autologous
compositions
germ cells
mitochondria
methods
Prior art date
Application number
MA36400A
Other languages
English (en)
Inventor
Jonathan Lee Tilly
Dori C Woods
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47010014&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35105(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of MA35105B1 publication Critical patent/MA35105B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0609—Oocytes, oogonia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0611—Primordial germ cells, e.g. embryonic germ cells [EG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/235—Leukemia inhibitory factor [LIF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Veterinary Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Cette invention concerne des compositions dérivées de cellules souches germinales (osc), par exemple les éléments anucléés du cytoplasme ou les mitochondries isolées, et les utilisations de ces compositions dans les procédures autologues de stimulation de la fertilité.
MA36400A 2011-04-14 2013-11-07 Compositions et méthodes de transfert d'énergie autologue des mitochondries dans les cellules germinales MA35105B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161475561P 2011-04-14 2011-04-14
US201261600505P 2012-02-17 2012-02-17
PCT/US2012/033643 WO2012142500A2 (fr) 2011-04-14 2012-04-13 Compositions et méthodes de transfert d'énergie autologue des mitochondries dans les cellules germinales

Publications (1)

Publication Number Publication Date
MA35105B1 true MA35105B1 (fr) 2014-05-02

Family

ID=47010014

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36400A MA35105B1 (fr) 2011-04-14 2013-11-07 Compositions et méthodes de transfert d'énergie autologue des mitochondries dans les cellules germinales

Country Status (24)

Country Link
US (5) US8647869B2 (fr)
EP (3) EP3498826A1 (fr)
JP (3) JP5793237B2 (fr)
CN (2) CN106350479A (fr)
AP (1) AP2013007229A0 (fr)
AU (1) AU2012242591B2 (fr)
BR (1) BR112013026501A2 (fr)
CA (2) CA2832336C (fr)
CL (1) CL2013002989A1 (fr)
CO (1) CO6862102A2 (fr)
CR (1) CR20130592A (fr)
DO (1) DOP2013000240A (fr)
EA (1) EA201391523A1 (fr)
GT (1) GT201300248A (fr)
HK (1) HK1202890A1 (fr)
IL (3) IL228829A (fr)
MA (1) MA35105B1 (fr)
MX (1) MX2013011990A (fr)
NI (1) NI201300108A (fr)
NZ (1) NZ706806A (fr)
PE (1) PE20141517A1 (fr)
SG (2) SG194448A1 (fr)
WO (1) WO2012142500A2 (fr)
ZA (2) ZA201308494B (fr)

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AU2005252636A1 (en) 2004-05-17 2005-12-22 The General Hospital Corporation Compositions comprising female germline stem cells and methods of use thereof
US7955846B2 (en) 2004-05-17 2011-06-07 The General Hospital Corporation Compositions comprising female germline stem cells and methods of use thereof
CA2832336C (fr) * 2011-04-14 2016-08-09 The General Hospital Corporation Compositions et methodes de transfert d'energie autologue des mitochondries dans les cellules germinales
CA2847292A1 (fr) 2011-06-29 2013-01-03 The General Hospital Corporation Compositions et procedes pour ameliorer l'etat bioenergetique de cellules germinales femelles
CN103146644B (zh) * 2013-02-27 2014-09-24 青岛农业大学 一种小鼠毛囊干细胞体外向原始生殖细胞分化的技术方法
CN103969232A (zh) * 2014-04-03 2014-08-06 浙江大学 一种三色荧光标记筛选抗阿霉素肾毒性活性物质的方法
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KR20170125801A (ko) * 2014-12-08 2017-11-15 오바사이언스, 인크. 미토콘드리아 수집 및 농축, 및 이의 용도
WO2017065839A1 (fr) * 2015-10-16 2017-04-20 Coopersurgical, Inc. Quantification d'adn mitochondrial et procédés permettant de déterminer la qualité d'un embryon
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CN106190963A (zh) * 2016-07-13 2016-12-07 浙江大学 一种采用线粒体移植促进损伤神经元存活的方法
WO2019060297A1 (fr) * 2017-09-19 2019-03-28 Unity Biotechnology, Inc. Rajeunissement mitochondrial comme traitement pour des états pathologiques liés à l'âge et à une neurodégénérescence
CN108004200A (zh) * 2017-12-01 2018-05-08 佳学基因医学技术（北京）有限公司 一种线粒体转移液及其制备方法
CN111621555A (zh) * 2019-06-13 2020-09-04 中国科学院广州生物医药与健康研究院 生物标志物及其应用
WO2021168419A1 (fr) * 2020-02-20 2021-08-26 Northeastern University Méthodes et compositions destinées à être utilisées dans des thérapies mitochondriales pour améliorer le potentiel reproductif chez la femme
CN114134106B (zh) * 2021-11-26 2024-01-26 北京大学人民医院 一种尿源间充质干细胞线粒体及其移植方法与应用
CN116024296A (zh) * 2022-11-25 2023-04-28 中国科学院深圳先进技术研究院 一种基于有机荧光探针评估活生殖细胞及其早期胚胎线粒体状态的应用方法

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Also Published As

Publication number Publication date
CA2868239C (fr) 2018-07-31
JP2014514928A (ja) 2014-06-26
SG10201406171QA (en) 2014-10-30
NZ706806A (en) 2016-12-23
US20150353887A1 (en) 2015-12-10
SG194448A1 (en) 2013-12-30
WO2012142500A2 (fr) 2012-10-18
CR20130592A (es) 2014-03-05
US20130052727A1 (en) 2013-02-28
IL247447B (en) 2018-10-31
CA2832336C (fr) 2016-08-09
CN103562378B (zh) 2016-09-07
CN106350479A (zh) 2017-01-25
EP2787073A1 (fr) 2014-10-08
US20120315651A1 (en) 2012-12-13
ZA201308494B (en) 2016-02-24
CN103562378A (zh) 2014-02-05
AU2012242591A1 (en) 2013-10-17
US8647869B2 (en) 2014-02-11
GT201300248A (es) 2015-09-01
JP2018007659A (ja) 2018-01-18
EP2787073B1 (fr) 2019-03-20
CO6862102A2 (es) 2014-02-10
ZA201502630B (en) 2016-01-27
IL228829A (en) 2015-02-26
PE20141517A1 (es) 2014-10-25
EP3498826A1 (fr) 2019-06-19
IL228829A0 (en) 2013-12-31
US8642329B2 (en) 2014-02-04
BR112013026501A2 (pt) 2016-11-29
JP5793237B2 (ja) 2015-10-14
US20190300850A1 (en) 2019-10-03
AU2012242591B2 (en) 2014-10-23
NZ617582A (en) 2015-06-26
JP2016019532A (ja) 2016-02-04
CL2013002989A1 (es) 2014-05-02
EA201391523A1 (ru) 2014-03-31
IL237089A (en) 2017-05-29
DOP2013000240A (es) 2014-06-30
CA2832336A1 (fr) 2012-10-18
CA2868239A1 (fr) 2012-10-18
WO2012142500A3 (fr) 2012-12-13
AP2013007229A0 (en) 2013-11-30
HK1202890A1 (en) 2015-10-09
NI201300108A (es) 2014-08-26
MX2013011990A (es) 2013-11-20
US9150830B2 (en) 2015-10-06
JP6170103B2 (ja) 2017-07-26
US20130060079A1 (en) 2013-03-07
EP2697365A4 (fr) 2014-07-23
EP2697365A2 (fr) 2014-02-19

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