CL2013002989A1 - Composicion para ser transferida a un ovocito que es preparado para fertilizacion in vitro o inseminacion artificial. - Google Patents
Composicion para ser transferida a un ovocito que es preparado para fertilizacion in vitro o inseminacion artificial.Info
- Publication number
- CL2013002989A1 CL2013002989A1 CL2013002989A CL2013002989A CL2013002989A1 CL 2013002989 A1 CL2013002989 A1 CL 2013002989A1 CL 2013002989 A CL2013002989 A CL 2013002989A CL 2013002989 A CL2013002989 A CL 2013002989A CL 2013002989 A1 CL2013002989 A1 CL 2013002989A1
- Authority
- CL
- Chile
- Prior art keywords
- composition
- oocyte
- osc
- mitochondria
- transferred
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/0609—Oocytes, oogonia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/0611—Primordial germ cells, e.g. embryonic germ cells [EG]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Veterinary Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
El invento se relaciona con una composición para ser transferida en un ovocito que es preparado para fertilización in vitro (IVF) o inseminación artificial porque comprende i) mitocondrias de células madres oogoniales (OSC) o ii) mitocondrias aisladas de una progenie de una OSC, donde la OSC es autóloga para el ovocito, no es una célula madre embrionaria, es mitóticamente competente, expresa Vasa, Oct-4, Dazl, Stella y opcionalmente, un antígeno embrionario etapa especifico. También se relaciona con un ovocito que comprende la composición de mitocondrias de células madres oogoniales. Y por último, el invento describe un método para preparar un ovocito que incluye la etapa de transferir la composición de mitocondrias de OSC en el ovocito
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161475561P | 2011-04-14 | 2011-04-14 | |
US201261600505P | 2012-02-17 | 2012-02-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2013002989A1 true CL2013002989A1 (es) | 2014-05-02 |
Family
ID=47010014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013002989A CL2013002989A1 (es) | 2011-04-14 | 2013-10-14 | Composicion para ser transferida a un ovocito que es preparado para fertilizacion in vitro o inseminacion artificial. |
Country Status (24)
Country | Link |
---|---|
US (5) | US8647869B2 (es) |
EP (3) | EP3498826A1 (es) |
JP (3) | JP5793237B2 (es) |
CN (2) | CN103562378B (es) |
AP (1) | AP2013007229A0 (es) |
AU (1) | AU2012242591B2 (es) |
BR (1) | BR112013026501A2 (es) |
CA (2) | CA2832336C (es) |
CL (1) | CL2013002989A1 (es) |
CO (1) | CO6862102A2 (es) |
CR (1) | CR20130592A (es) |
DO (1) | DOP2013000240A (es) |
EA (1) | EA201391523A1 (es) |
GT (1) | GT201300248A (es) |
HK (1) | HK1202890A1 (es) |
IL (3) | IL228829A (es) |
MA (1) | MA35105B1 (es) |
MX (1) | MX2013011990A (es) |
NI (1) | NI201300108A (es) |
NZ (1) | NZ706806A (es) |
PE (1) | PE20141517A1 (es) |
SG (2) | SG10201406171QA (es) |
WO (1) | WO2012142500A2 (es) |
ZA (2) | ZA201308494B (es) |
Families Citing this family (19)
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EP1765983A4 (en) | 2004-05-17 | 2008-10-22 | Gen Hospital Corp | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF STEM CELLS FROM GERMINAL STEM CELLS DERIVED FROM SPINAL CORD |
US7955846B2 (en) | 2004-05-17 | 2011-06-07 | The General Hospital Corporation | Compositions comprising female germline stem cells and methods of use thereof |
CN103562378B (zh) | 2011-04-14 | 2016-09-07 | 通用医疗公司 | 用于自体种系线粒体能量转移的组合物和方法 |
EP3495470A1 (en) | 2011-06-29 | 2019-06-12 | The General Hospital Corporation | In vivo methods for enhancing bioenergetic status in female germ cells |
CN103146644B (zh) * | 2013-02-27 | 2014-09-24 | 青岛农业大学 | 一种小鼠毛囊干细胞体外向原始生殖细胞分化的技术方法 |
CN103969232A (zh) * | 2014-04-03 | 2014-08-06 | 浙江大学 | 一种三色荧光标记筛选抗阿霉素肾毒性活性物质的方法 |
KR20170056521A (ko) | 2014-09-16 | 2017-05-23 | 오바사이언스, 인크. | 항-vasa 항체, 및 이것의 제조 및 사용 방법 |
MX2017007463A (es) * | 2014-12-08 | 2018-03-23 | Ovascience Inc | Recolección y concentración de mitocondrias y usos de las mismas. |
WO2017065839A1 (en) * | 2015-10-16 | 2017-04-20 | Coopersurgical, Inc. | Quantification of mitochondrial dna and methods for determining the quality of an embryo |
WO2017197425A1 (en) * | 2016-05-18 | 2017-11-23 | Hudson Institute of Medical Research | A method of treatment |
US11103537B2 (en) | 2016-06-23 | 2021-08-31 | Tithon Biotech Inc. | Cells expressing parathyroid hormone 1 receptor and uses thereof |
AU2017281631B2 (en) * | 2016-06-23 | 2023-06-15 | Tithon Biotech, Inc. | Cells expressing parathyroid hormone 1 receptor and uses thereof |
CN106190963A (zh) * | 2016-07-13 | 2016-12-07 | 浙江大学 | 一种采用线粒体移植促进损伤神经元存活的方法 |
WO2019060297A1 (en) * | 2017-09-19 | 2019-03-28 | Unity Biotechnology, Inc. | MITOCHONDRIAL REJUVENATION AS A TREATMENT FOR AGE-RELATED AND NEURODEGENERATIVE CONDITIONS |
CN108004200A (zh) * | 2017-12-01 | 2018-05-08 | 佳学基因医学技术(北京)有限公司 | 一种线粒体转移液及其制备方法 |
CN111621555A (zh) * | 2019-06-13 | 2020-09-04 | 中国科学院广州生物医药与健康研究院 | 生物标志物及其应用 |
EP4106649A4 (en) * | 2020-02-20 | 2024-04-24 | Northeastern University | METHODS AND COMPOSITIONS FOR USING MITOCHONDRIAL THERAPIES TO IMPROVE FEMALE REPRODUCTIVE POTENTIAL |
CN114134106B (zh) * | 2021-11-26 | 2024-01-26 | 北京大学人民医院 | 一种尿源间充质干细胞线粒体及其移植方法与应用 |
CN116024296A (zh) * | 2022-11-25 | 2023-04-28 | 中国科学院深圳先进技术研究院 | 一种基于有机荧光探针评估活生殖细胞及其早期胚胎线粒体状态的应用方法 |
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2012
- 2012-04-13 CN CN201280018195.1A patent/CN103562378B/zh not_active Expired - Fee Related
- 2012-04-13 EA EA201391523A patent/EA201391523A1/ru unknown
- 2012-04-13 AP AP2013007229A patent/AP2013007229A0/xx unknown
- 2012-04-13 US US13/447,075 patent/US8647869B2/en not_active Expired - Fee Related
- 2012-04-13 WO PCT/US2012/033643 patent/WO2012142500A2/en active Application Filing
- 2012-04-13 EP EP18205564.0A patent/EP3498826A1/en not_active Withdrawn
- 2012-04-13 AU AU2012242591A patent/AU2012242591B2/en not_active Ceased
- 2012-04-13 CA CA2832336A patent/CA2832336C/en not_active Expired - Fee Related
- 2012-04-13 PE PE2013002292A patent/PE20141517A1/es not_active Application Discontinuation
- 2012-04-13 CA CA2868239A patent/CA2868239C/en not_active Expired - Fee Related
- 2012-04-13 EP EP14164380.9A patent/EP2787073B1/en active Active
- 2012-04-13 EP EP12770662.0A patent/EP2697365A4/en not_active Withdrawn
- 2012-04-13 MX MX2013011990A patent/MX2013011990A/es active IP Right Grant
- 2012-04-13 JP JP2014505369A patent/JP5793237B2/ja not_active Expired - Fee Related
- 2012-04-13 BR BR112013026501A patent/BR112013026501A2/pt not_active Application Discontinuation
- 2012-04-13 SG SG10201406171QA patent/SG10201406171QA/en unknown
- 2012-04-13 SG SG2013075510A patent/SG194448A1/en unknown
- 2012-04-13 CN CN201610796859.7A patent/CN106350479A/zh active Pending
- 2012-04-13 NZ NZ706806A patent/NZ706806A/en not_active IP Right Cessation
- 2012-08-21 US US13/590,812 patent/US8642329B2/en not_active Expired - Fee Related
- 2012-09-07 US US13/606,914 patent/US9150830B2/en not_active Expired - Fee Related
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2013
- 2013-10-10 IL IL228829A patent/IL228829A/en active IP Right Grant
- 2013-10-14 DO DO2013000240A patent/DOP2013000240A/es unknown
- 2013-10-14 GT GT201300248A patent/GT201300248A/es unknown
- 2013-10-14 NI NI201300108A patent/NI201300108A/es unknown
- 2013-10-14 CL CL2013002989A patent/CL2013002989A1/es unknown
- 2013-11-07 MA MA36400A patent/MA35105B1/fr unknown
- 2013-11-12 ZA ZA2013/08494A patent/ZA201308494B/en unknown
- 2013-11-13 CR CR20130592A patent/CR20130592A/es unknown
- 2013-11-14 CO CO13268347A patent/CO6862102A2/es unknown
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2014
- 2014-07-25 HK HK15103372.5A patent/HK1202890A1/xx not_active IP Right Cessation
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2015
- 2015-02-04 IL IL237089A patent/IL237089A/en active IP Right Grant
- 2015-04-20 ZA ZA2015/02630A patent/ZA201502630B/en unknown
- 2015-08-07 JP JP2015156663A patent/JP6170103B2/ja not_active Expired - Fee Related
- 2015-08-11 US US14/823,481 patent/US20150353887A1/en not_active Abandoned
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2016
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2017
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2018
- 2018-12-21 US US16/230,839 patent/US20190300850A1/en not_active Abandoned
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