ES2541486T3 - Injertos quirúrgicos para reparar defectos condrales - Google Patents
Injertos quirúrgicos para reparar defectos condrales Download PDFInfo
- Publication number
- ES2541486T3 ES2541486T3 ES11152942.6T ES11152942T ES2541486T3 ES 2541486 T3 ES2541486 T3 ES 2541486T3 ES 11152942 T ES11152942 T ES 11152942T ES 2541486 T3 ES2541486 T3 ES 2541486T3
- Authority
- ES
- Spain
- Prior art keywords
- collagen
- cells
- mscs
- implant
- chondrocyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Procedimiento de preparación de un implante destinado a reparar un defecto condral, que comprende: proporcionar unas células madre mesenquimatosas (MSC); cultivar las MSC en un medio de colágeno que contiene colágeno a una concentración del 1% al 10% p/v y complementado con un factor de crecimiento transformante beta uno (TGF-b1) durante de 7 a 21 días en condiciones que permiten la formación de una matriz de colágeno y la diferenciación de las MSC para dar células de tipo condrocitos, que se incorporan a la matriz de colágeno; que está caracterizado por que las células de tipo condrocitos secretan glicosaminoglicano y el implante está libre de lagunas.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/700,469 US8574614B2 (en) | 2010-02-04 | 2010-02-04 | Surgical grafts for repairing chondral defects |
US700469 | 2010-02-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2541486T3 true ES2541486T3 (es) | 2015-07-21 |
Family
ID=44341891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11152942.6T Active ES2541486T3 (es) | 2010-02-04 | 2011-02-01 | Injertos quirúrgicos para reparar defectos condrales |
Country Status (8)
Country | Link |
---|---|
US (1) | US8574614B2 (es) |
EP (1) | EP2392358B1 (es) |
JP (2) | JP5764807B2 (es) |
CN (1) | CN102145195B (es) |
ES (1) | ES2541486T3 (es) |
PT (1) | PT2392358E (es) |
SG (3) | SG10201402811YA (es) |
TW (1) | TWI469993B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
PT2775928T (pt) | 2011-11-08 | 2019-05-30 | Auxocell Laboratories Inc | Sistemas e métodos para processar células |
RU2494469C1 (ru) * | 2012-04-02 | 2013-09-27 | Федеральное государственное бюджетное учреждение "Новосибирский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "ННИИТО" Минздравсоцразвития России) | Способ коррекции дефекта межпозвонкового диска в эксперименте |
CN103387959A (zh) * | 2012-10-19 | 2013-11-13 | 夏佑红 | 一种乳牙干细胞及其制备方法和应用 |
CN102899287B (zh) * | 2012-10-24 | 2013-08-21 | 天津和泽干细胞科技有限公司 | 一种诱导间充质干细胞向软骨细胞分化的方法及其在骨关节炎中的应用 |
US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
USD748462S1 (en) | 2014-08-11 | 2016-02-02 | Auxocell Laboratories, Inc. | Centrifuge clip |
US9993748B2 (en) | 2014-08-11 | 2018-06-12 | Auxocell Laboratories, Inc. | Centrifuge clip and method |
WO2016187413A1 (en) | 2015-05-21 | 2016-11-24 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
CN111821518B (zh) * | 2019-04-15 | 2023-01-10 | 弗元(上海)生物科技有限公司 | 一种具有再生能力的组织工程骨的制备方法 |
CN111821519A (zh) * | 2019-04-15 | 2020-10-27 | 弗元(上海)生物科技有限公司 | 一种组织工程软骨的制备方法及其应用 |
CN115845142A (zh) * | 2022-12-23 | 2023-03-28 | 武汉大学 | 快速修复颌骨缺损的软骨样微组织的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
ES2251746T3 (es) * | 1996-12-06 | 2006-05-01 | Osiris Therapeutics, Inc. | Diferenciacion condrogenica mejorada de celulas precursoras mesenquimatosas humanas. |
ATE220564T1 (de) | 1997-08-14 | 2002-08-15 | Sulzer Innotec Ag | Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren |
US6197586B1 (en) * | 1997-12-12 | 2001-03-06 | The Regents Of The University Of California | Chondrocyte-like cells useful for tissue engineering and methods |
DE20019809U1 (de) | 2000-05-31 | 2001-07-12 | Fraunhofer Ges Forschung | Knorpelersatz und Biomatrix zur Kultivierung von Zellen |
US20030050709A1 (en) * | 2001-02-23 | 2003-03-13 | Ulrich Noth | Trabecular bone-derived human mesenchymal stem cells |
KR100494265B1 (ko) | 2001-08-14 | 2005-06-13 | 메디포스트(주) | 관절연골손상 치료용 조성물 |
US20040258731A1 (en) * | 2001-11-21 | 2004-12-23 | Tsuyoshi Shimoboji | Preparation approriate for cartilage tissue formation |
ES2245879B1 (es) | 2004-05-21 | 2006-12-16 | Universidad De Malaga | Composicion para la reparacion osea o cartilaginosa. |
CN100477971C (zh) * | 2005-05-27 | 2009-04-15 | 中国人民解放军总医院 | 一种关节软骨原性微载体 |
-
2010
- 2010-02-04 US US12/700,469 patent/US8574614B2/en active Active
- 2010-06-11 TW TW99119088A patent/TWI469993B/zh active
-
2011
- 2011-01-24 SG SG10201402811YA patent/SG10201402811YA/en unknown
- 2011-01-24 SG SG2011004793A patent/SG173284A1/en unknown
- 2011-01-24 SG SG2013037825A patent/SG190660A1/en unknown
- 2011-01-27 JP JP2011015143A patent/JP5764807B2/ja active Active
- 2011-01-30 CN CN201110034680.5A patent/CN102145195B/zh active Active
- 2011-02-01 EP EP11152942.6A patent/EP2392358B1/en active Active
- 2011-02-01 PT PT111529426T patent/PT2392358E/pt unknown
- 2011-02-01 ES ES11152942.6T patent/ES2541486T3/es active Active
-
2015
- 2015-01-15 JP JP2015006164A patent/JP2015091401A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2011161225A (ja) | 2011-08-25 |
PT2392358E (pt) | 2015-08-26 |
TW201127851A (en) | 2011-08-16 |
EP2392358A3 (en) | 2012-04-04 |
CN102145195A (zh) | 2011-08-10 |
SG10201402811YA (en) | 2014-07-30 |
JP5764807B2 (ja) | 2015-08-19 |
SG190660A1 (en) | 2013-06-28 |
US20110189254A1 (en) | 2011-08-04 |
SG173284A1 (en) | 2011-08-29 |
EP2392358B1 (en) | 2015-04-08 |
CN102145195B (zh) | 2015-08-26 |
JP2015091401A (ja) | 2015-05-14 |
US8574614B2 (en) | 2013-11-05 |
TWI469993B (zh) | 2015-01-21 |
EP2392358A2 (en) | 2011-12-07 |
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