MA45747A - Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines - Google Patents
Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humainesInfo
- Publication number
- MA45747A MA45747A MA045747A MA45747A MA45747A MA 45747 A MA45747 A MA 45747A MA 045747 A MA045747 A MA 045747A MA 45747 A MA45747 A MA 45747A MA 45747 A MA45747 A MA 45747A
- Authority
- MA
- Morocco
- Prior art keywords
- cells
- generation
- souh
- human pluripotent
- functional beta
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/80—Neurotransmitters; Neurohormones
- C12N2501/845—Gamma amino butyric acid [GABA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne la génération de cellules bêta fonctionnelles à partir de progéniteurs endocriniens dérivés de cellules souches pluripotentes humaines. La présente invention concerne également des cellules bêta fonctionnelles produites par lesdits procédés et utilisations de ces cellules bêta.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16157181 | 2016-02-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA45747A true MA45747A (fr) | 2019-01-02 |
Family
ID=55588039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA045747A MA45747A (fr) | 2016-02-24 | 2017-02-24 | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines |
Country Status (7)
Country | Link |
---|---|
US (1) | US11274280B2 (fr) |
EP (1) | EP3420073B1 (fr) |
JP (1) | JP7123802B2 (fr) |
CN (1) | CN108699515A (fr) |
ES (1) | ES2967942T3 (fr) |
MA (1) | MA45747A (fr) |
WO (1) | WO2017144695A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112014015417A8 (pt) | 2011-12-22 | 2017-07-04 | Janssen Biotech Inc | diferenciação de células-tronco embrionárias humanas em células positivas de insulina hormonal únicas |
RU2694311C2 (ru) | 2014-05-16 | 2019-07-11 | Янссен Байотек, Инк. | Применение малых молекул для увеличения экспрессии mafa в панкреатических эндокринных клетках |
CN108699515A (zh) | 2016-02-24 | 2018-10-23 | 诺和诺德股份有限公司 | 由人多能干细胞衍生的内分泌祖细胞生成功能性β细胞 |
MA45502A (fr) | 2016-06-21 | 2019-04-24 | Janssen Biotech Inc | Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines ayant une respiration mitochondriale glucose-dépendante et une réponse en sécrétion d'insuline en deux phases |
MA50279A (fr) * | 2017-09-11 | 2020-07-22 | Novo Nordisk As | Enrichissement de cellules coexprimant nkx6.1 et le peptide c, dérivées in vitro à partir de cellules souches |
CA3081762A1 (fr) | 2017-11-15 | 2019-05-23 | Semma Therapeutics, Inc. | Compositions pour la fabrication de cellules d'ilots et procedes d'utilisation |
EP3758719A4 (fr) * | 2018-03-02 | 2021-12-08 | Vertex Pharmaceuticals Inc. | Procédés d'amélioration de la différenciation de cellules souches en cellules bêta |
CA3108275A1 (fr) | 2018-08-10 | 2020-02-13 | Vertex Pharmaceuticals Incorporated | Differenciation d'ilot derive de cellules souches |
US20210230554A1 (en) * | 2018-08-30 | 2021-07-29 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
CN113728090B (zh) | 2019-04-08 | 2024-04-05 | 诺和诺德股份有限公司 | 从干细胞衍生的定形内胚层生成胰腺内胚层 |
TW202115245A (zh) | 2019-06-27 | 2021-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 安全免疫隱形細胞 |
CN114729323A (zh) | 2019-11-22 | 2022-07-08 | 诺和诺德股份有限公司 | 旋转聚集的神经微球及其应用 |
WO2021174201A1 (fr) * | 2020-02-28 | 2021-09-02 | The Trustees Of The University Of Pennsylvania | Milieu de culture tissulaire pour la survie et la prise de greffe d'îlots pancréatiques humains |
US20230340595A1 (en) | 2020-03-02 | 2023-10-26 | Novo Nordisk A/S | Use of pluripotent markers to detect contaminating residual undifferentiated pluripotent stem cells |
EP4204542A1 (fr) | 2020-08-28 | 2023-07-05 | Novo Nordisk A/S | Procédé de criblage d'une population in vitro de cellules de type bêta dérivées de cellules souches et nouveaux marqueurs associés |
AR124419A1 (es) | 2020-12-18 | 2023-03-29 | Novo Nordisk As | Células seguras invisibles para el sistema inmunitario |
WO2022136215A1 (fr) | 2020-12-21 | 2022-06-30 | Novo Nordisk A/S | Cellules immuno-furtives sûres |
CN113069440A (zh) * | 2021-04-08 | 2021-07-06 | 澳门大学 | 甲状腺素的新的应用、培养多能干细胞的方法和培养基 |
WO2023076554A1 (fr) * | 2021-10-28 | 2023-05-04 | Memorial Sloan-Kettering Cancer Center | COMPOSITIONS ET PROCÉDÉS POUR FAVORISER LA MATURATION DE CELLULES IN VITRO<i /> |
WO2023118050A1 (fr) | 2021-12-21 | 2023-06-29 | Novo Nordisk A/S | Utilisation de nouveaux marqueurs pour détecter des cellules souches pluripotentes |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9150833B2 (en) | 2009-12-23 | 2015-10-06 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
CN102884176B (zh) | 2010-05-12 | 2017-09-05 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
ES2902650T3 (es) | 2011-06-21 | 2022-03-29 | Novo Nordisk As | Inducción eficiente de endodermo definitivo a partir de células madre pluripotentes |
CN108004199B (zh) * | 2012-04-30 | 2022-03-18 | 大学健康网络 | 用于从hPSC生成胰腺祖细胞和功能性β细胞的方法和组合物 |
US20150247123A1 (en) * | 2012-09-03 | 2015-09-03 | Novo Nordisk A/S | Generation of pancreatic endoderm from Pluripotent Stem cells using small molecules |
ES2666465T3 (es) | 2012-09-27 | 2018-05-04 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Métodos para producir una población de células beta pancreáticas |
MX2015008578A (es) | 2012-12-31 | 2015-09-07 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9. |
US20150368616A1 (en) | 2013-02-14 | 2015-12-24 | The Cleveland Clinic Foundation | Methods for induction of cell fates from pluripotent cells |
US10920192B2 (en) | 2013-04-23 | 2021-02-16 | Yeda Research And Development Co. Ltd. | Isolated naive pluripotent stem cells and methods of generating same |
WO2014179198A1 (fr) | 2013-04-29 | 2014-11-06 | Wisconsin Alumni Research Foundation | Procédés pour produire des cellules bêta insulino-sécrétrices à partir de cellules souches pluripotentes humaines |
CN106414718A (zh) * | 2013-06-11 | 2017-02-15 | 哈佛学院校长同事会 | SC-β细胞以及用于产生其的组合物和方法 |
EP3039122B1 (fr) * | 2013-08-30 | 2019-07-17 | Novo Nordisk A/S | Génération de cellules progénitrices endocrines à partir de cellules souches pluripotentes humaines à l'aide de petites molécules |
US20150250824A1 (en) * | 2014-03-07 | 2015-09-10 | The Research Foundation For The State University Of New York | Methods and compositions for expansion of stem cells and other cells |
RU2694311C2 (ru) | 2014-05-16 | 2019-07-11 | Янссен Байотек, Инк. | Применение малых молекул для увеличения экспрессии mafa в панкреатических эндокринных клетках |
CN108699515A (zh) | 2016-02-24 | 2018-10-23 | 诺和诺德股份有限公司 | 由人多能干细胞衍生的内分泌祖细胞生成功能性β细胞 |
US20210230554A1 (en) | 2018-08-30 | 2021-07-29 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
-
2017
- 2017-02-24 CN CN201780013255.3A patent/CN108699515A/zh active Pending
- 2017-02-24 ES ES17709385T patent/ES2967942T3/es active Active
- 2017-02-24 MA MA045747A patent/MA45747A/fr unknown
- 2017-02-24 US US16/078,763 patent/US11274280B2/en active Active
- 2017-02-24 JP JP2018544785A patent/JP7123802B2/ja active Active
- 2017-02-24 EP EP17709385.3A patent/EP3420073B1/fr active Active
- 2017-02-24 WO PCT/EP2017/054390 patent/WO2017144695A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CN108699515A (zh) | 2018-10-23 |
EP3420073A1 (fr) | 2019-01-02 |
US11274280B2 (en) | 2022-03-15 |
EP3420073B1 (fr) | 2023-11-08 |
JP2019510482A (ja) | 2019-04-18 |
WO2017144695A1 (fr) | 2017-08-31 |
US20190085295A1 (en) | 2019-03-21 |
WO2017144695A9 (fr) | 2017-10-19 |
JP7123802B2 (ja) | 2022-08-23 |
ES2967942T3 (es) | 2024-05-06 |
EP3420073C0 (fr) | 2023-11-08 |
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