CA2550361C - Compounds and methods for development of ret modulators - Google Patents

Compounds and methods for development of ret modulators Download PDF

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Publication number
CA2550361C
CA2550361C CA2550361A CA2550361A CA2550361C CA 2550361 C CA2550361 C CA 2550361C CA 2550361 A CA2550361 A CA 2550361A CA 2550361 A CA2550361 A CA 2550361A CA 2550361 C CA2550361 C CA 2550361C
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compound
aryl
heteroaryl
substituted
following structure
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French (fr)
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CA2550361A1 (en
Inventor
Prabha Ibrahim
Dean Richard Artis
Ryan Bremer
Clarence R. Hurt
Shumeye Mamo
Marika Nespi
Chao Zhang
Jiazhong Zhang
Yong Zhu
Rebecca Zuckerman
Heike Krupka
Brian West
Gaston Habets
Abhinav Kumar
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Plexxikon Inc
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Plexxikon Inc
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
CA2550361A 2003-12-19 2004-12-17 Compounds and methods for development of ret modulators Active CA2550361C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US53128103P 2003-12-19 2003-12-19
US60/531,281 2003-12-19
US55858104P 2004-03-31 2004-03-31
US60/558,581 2004-03-31
PCT/US2004/042470 WO2005062795A2 (en) 2003-12-19 2004-12-17 Compounds and methods for development of ret modulators

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CA2550361A1 CA2550361A1 (en) 2005-07-14
CA2550361C true CA2550361C (en) 2014-04-29

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EP (1) EP1696920B8 (US07504509-20090317-C00279.png)
JP (1) JP5138938B2 (US07504509-20090317-C00279.png)
CN (1) CN1925855B (US07504509-20090317-C00279.png)
AU (1) AU2004308299B2 (US07504509-20090317-C00279.png)
CA (1) CA2550361C (US07504509-20090317-C00279.png)
CY (1) CY1118328T1 (US07504509-20090317-C00279.png)
DK (1) DK1696920T3 (US07504509-20090317-C00279.png)
ES (1) ES2527118T3 (US07504509-20090317-C00279.png)
HK (1) HK1094878A1 (US07504509-20090317-C00279.png)
HR (1) HRP20141228T1 (US07504509-20090317-C00279.png)
PL (1) PL1696920T3 (US07504509-20090317-C00279.png)
PT (1) PT1696920E (US07504509-20090317-C00279.png)
SI (1) SI1696920T1 (US07504509-20090317-C00279.png)
WO (1) WO2005062795A2 (US07504509-20090317-C00279.png)

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US9096593B2 (en) 2009-11-06 2015-08-04 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US9447089B2 (en) 2009-04-03 2016-09-20 Plexxikon Inc. Compositions and uses thereof
US9469640B2 (en) 2007-07-17 2016-10-18 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor

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AU2004308299A1 (en) 2005-07-14
US7504509B2 (en) 2009-03-17
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US20100324065A1 (en) 2010-12-23
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US20070049615A1 (en) 2007-03-01
US8067434B2 (en) 2011-11-29
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EP1696920B1 (en) 2014-10-29
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