CA2501870C - Single chain recombinant t cell receptors - Google Patents
Single chain recombinant t cell receptors Download PDFInfo
- Publication number
- CA2501870C CA2501870C CA2501870A CA2501870A CA2501870C CA 2501870 C CA2501870 C CA 2501870C CA 2501870 A CA2501870 A CA 2501870A CA 2501870 A CA2501870 A CA 2501870A CA 2501870 C CA2501870 C CA 2501870C
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- Prior art keywords
- tcr
- ser
- beta
- alpha
- sctcr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Landscapes
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| US20060122784A1 (en) * | 2004-12-03 | 2006-06-08 | Ishikawa Muriel Y | System and method for augmenting a humoral immune response |
| US20060182742A1 (en) * | 2004-08-24 | 2006-08-17 | Ishikawa Muriel Y | System and method for magnifying a humoral immune response |
| US20060095211A1 (en) * | 2003-12-05 | 2006-05-04 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System and method for modulating a cell mediated immune response |
| US20060047436A1 (en) * | 2004-08-25 | 2006-03-02 | Ishikawa Muriel Y | System and method for magnifying an immune response |
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| US20060116824A1 (en) * | 2004-12-01 | 2006-06-01 | Ishikawa Muriel Y | System and method for modulating a humoral immune response |
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| GB0328363D0 (en) | 2003-12-06 | 2004-01-14 | Imp College Innovations Ltd | Therapeutically useful molecules |
| EP1791865B1 (en) | 2004-06-29 | 2010-07-28 | Immunocore Ltd. | Cells expressing a modified t cell receptor |
| US20070207492A1 (en) * | 2004-08-24 | 2007-09-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems to adjust a humoral immune response |
| US20070198196A1 (en) * | 2004-08-24 | 2007-08-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems and methods relating to ameliorating an immune system |
| US20070265819A1 (en) * | 2004-08-24 | 2007-11-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems for improving cell-mediated immune response |
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| US20070196362A1 (en) * | 2004-08-24 | 2007-08-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems to bolster an immune response |
| EP1809669A2 (en) * | 2004-10-01 | 2007-07-25 | Avidex Ltd | T-cell receptors containing a non-native disulfide interchain bond linked to therapeutic agents |
| WO2006054096A2 (en) * | 2004-11-18 | 2006-05-26 | Avidex Ltd | Soluble bifunctional proteins |
| ATE423140T1 (de) | 2005-01-05 | 2009-03-15 | F Star Biotech Forsch & Entw | Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften |
| CN105461802A (zh) | 2005-04-01 | 2016-04-06 | 英美偌科有限公司 | 高亲和力hiv t细胞受体 |
| ATE525401T1 (de) | 2005-05-13 | 2011-10-15 | Oxford Biomedica Ltd | Vom tumorantigen 5t4 abgeleitete mhc-klasse-i- und ii-peptidantigene |
| GB0511124D0 (en) | 2005-06-01 | 2005-07-06 | Avidex Ltd | High affinity melan-a t cell receptors |
| US8883507B2 (en) | 2005-10-18 | 2014-11-11 | The Regents Of The University Of Colorado | Conditionally immortalized long-term hematopoietic stem cells and methods of making and using such cells |
| WO2007085266A1 (en) * | 2006-01-30 | 2007-08-02 | Dako Denmark A/S | High-speed quantification of antigen specific t-cells in whole blood by flow cytometry |
| AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| AT503861B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von t-zell-rezeptoren |
| EP2155782A2 (en) | 2007-03-26 | 2010-02-24 | Dako Denmark A/S | Mhc peptide complexes and uses thereof in infectious diseases |
| PL3241842T3 (pl) | 2007-06-26 | 2024-06-10 | F-Star Therapeutics Limited | Prezentacja środków wiążących |
| WO2009003493A2 (en) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Mhc multimers, methods for their generation, labeling and use |
| WO2009039854A2 (en) | 2007-09-27 | 2009-04-02 | Dako Denmark A/S | Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics |
| DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
| EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
| SG10201803982TA (en) | 2008-05-16 | 2018-07-30 | Taiga Biotechnologies Inc | Antibodies and processes for preparing the same |
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| US8784825B2 (en) | 2008-08-28 | 2014-07-22 | Taiga Biotechnologies, Inc. | Modulators of MYC, methods of using the same, and methods of identifying agents that modulate MYC |
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| GB0817244D0 (en) * | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
| US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
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| GB0908613D0 (en) | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
| WO2011044186A1 (en) | 2009-10-06 | 2011-04-14 | The Board Of Trustees Of The University Of Illinois | Human single-chain t cell receptors |
| EP2502934B1 (en) | 2011-03-24 | 2018-01-17 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Single chain antigen recognizing constructs (scARCs) stabilized by the introduction of novel disulfide bonds |
| RS61455B1 (sr) | 2011-10-28 | 2021-03-31 | Regeneron Pharma | Genetski modifikovani miševi t ćelijskog receptora |
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| GB201313377D0 (en) | 2013-07-26 | 2013-09-11 | Adaptimmune Ltd | T cell receptors |
| TWI714869B (zh) | 2013-08-05 | 2021-01-01 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物 |
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| JP6476182B2 (ja) | 2013-11-22 | 2019-02-27 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 改変された高親和性ヒトｔ細胞受容体 |
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| EP3137100B1 (en) | 2014-04-15 | 2023-12-20 | University Of Virginia Patent Foundation | Isolated t cell receptors and methods of use therefor |
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| WO2026047601A1 (en) | 2024-08-28 | 2026-03-05 | BioNTech SE | T-cell receptors (tcrs) |
| WO2026058153A2 (en) | 2024-09-10 | 2026-03-19 | BioNTech SE | Hpv-16 t cell receptor uses and compositions thereof |
| WO2026078231A1 (en) | 2024-10-11 | 2026-04-16 | T-Therapeutics Limited | Soluble non-aggregating immune ligand |
| GB202418460D0 (en) | 2024-12-16 | 2025-01-29 | Univ Oxford Innovation Ltd | Multivalent binding proteins |
| GB202418912D0 (en) | 2024-12-20 | 2025-02-05 | Immunocore Ltd | Specific binding molecules |
| WO2026163079A1 (en) | 2025-01-28 | 2026-08-06 | BioNTech SE | T cell receptor constructs and uses thereof |
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| US6080840A (en) * | 1992-01-17 | 2000-06-27 | Slanetz; Alfred E. | Soluble T cell receptors |
| WO1996018105A1 (en) | 1994-12-06 | 1996-06-13 | The President And Fellows Of Harvard College | Single chain t-cell receptor |
| CA2305630C (en) * | 1997-10-02 | 2012-11-06 | Sunol Molecular Corporation | Soluble single-chain t-cell receptor proteins |
| NZ507886A (en) * | 1998-05-19 | 2003-05-30 | Avidex Ltd | Multivalent T cell receptor complexes |
| IL127142A0 (en) | 1998-11-19 | 1999-09-22 | Yeda Res & Dev | Immune cells having predefined biological specificity |
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- 2003-10-03 JP JP2005500992A patent/JP4436319B2/ja not_active Expired - Fee Related
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2005
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- 2005-05-04 NO NO20052198A patent/NO335365B1/no not_active IP Right Cessation
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| US7569664B2 (en) | 2009-08-04 |
| EP1549748B1 (en) | 2014-10-01 |
| US20060166875A1 (en) | 2006-07-27 |
| JP4436319B2 (ja) | 2010-03-24 |
| JP2006502741A (ja) | 2006-01-26 |
| IL167652A (en) | 2011-07-31 |
| CA2501870A1 (en) | 2004-04-22 |
| NO20052198D0 (no) | 2005-05-04 |
| AU2003271904A1 (en) | 2004-05-04 |
| NZ539225A (en) | 2006-09-29 |
| WO2004033685A1 (en) | 2004-04-22 |
| AU2003271904B2 (en) | 2009-03-05 |
| EP1549748A1 (en) | 2005-07-06 |
| NO20052198L (no) | 2005-05-04 |
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