CA2466779C - Procedes de preparation de o-desmethyle venlafaxine - Google Patents

Procedes de preparation de o-desmethyle venlafaxine Download PDF

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Publication number
CA2466779C
CA2466779C CA2466779A CA2466779A CA2466779C CA 2466779 C CA2466779 C CA 2466779C CA 2466779 A CA2466779 A CA 2466779A CA 2466779 A CA2466779 A CA 2466779A CA 2466779 C CA2466779 C CA 2466779C
Authority
CA
Canada
Prior art keywords
thiolate
carbon atoms
venlafaxine
desmethylvenlafaxine
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2466779A
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English (en)
Other versions
CA2466779A1 (fr
Inventor
Beat Theodor Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23309595&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2466779(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of CA2466779A1 publication Critical patent/CA2466779A1/fr
Application granted granted Critical
Publication of CA2466779C publication Critical patent/CA2466779C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'invention concerne un procédé efficace permettant de préparer de l'O-desméthyle venlafaxine par déméthylation de venlafaxine avec un anion thiolate.
CA2466779A 2001-12-04 2002-12-03 Procedes de preparation de o-desmethyle venlafaxine Expired - Lifetime CA2466779C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33495301P 2001-12-04 2001-12-04
US60/334,953 2001-12-04
PCT/US2002/038403 WO2003048104A1 (fr) 2001-12-04 2002-12-03 Procedes de preparation de o-desmethyle venlafaxine

Publications (2)

Publication Number Publication Date
CA2466779A1 CA2466779A1 (fr) 2003-06-12
CA2466779C true CA2466779C (fr) 2013-11-19

Family

ID=23309595

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2466779A Expired - Lifetime CA2466779C (fr) 2001-12-04 2002-12-03 Procedes de preparation de o-desmethyle venlafaxine

Country Status (29)

Country Link
US (4) US6689912B2 (fr)
EP (1) EP1451143B9 (fr)
JP (1) JP4342312B2 (fr)
KR (1) KR100939650B1 (fr)
CN (1) CN1319934C (fr)
AR (1) AR037622A1 (fr)
AT (1) ATE403641T1 (fr)
AU (1) AU2002357049B2 (fr)
BR (1) BR0214701A (fr)
CA (1) CA2466779C (fr)
CO (1) CO5580816A2 (fr)
DE (1) DE60228118D1 (fr)
DK (1) DK1451143T3 (fr)
EC (1) ECSP045135A (fr)
ES (1) ES2311647T4 (fr)
HK (1) HK1065778A1 (fr)
HU (1) HUP0402269A3 (fr)
IL (3) IL162253A0 (fr)
MX (1) MXPA04005309A (fr)
NO (1) NO20042680L (fr)
NZ (1) NZ533316A (fr)
PL (1) PL369299A1 (fr)
PT (1) PT1451143E (fr)
RU (1) RU2317286C2 (fr)
SI (1) SI1451143T1 (fr)
TW (1) TWI260982B (fr)
UA (1) UA80543C2 (fr)
WO (1) WO2003048104A1 (fr)
ZA (1) ZA200405250B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
DE60039132D1 (de) * 1999-04-06 2008-07-17 Sepracor Inc O-Desmethylvenlafaxin-Succinat
CN101671260A (zh) * 2001-02-12 2010-03-17 惠氏公司 制备o-去甲基-文拉法辛的方法
UA80543C2 (en) * 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine
MX2008000249A (es) * 2005-07-06 2008-03-18 Sepracor Inc Combinaciones de eszopiclona y o-desmetilvenlafaxina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y cognitivos.
US7612210B2 (en) * 2005-12-05 2009-11-03 Wyeth Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols
WO2007071404A1 (fr) * 2005-12-20 2007-06-28 Synthon B.V. Procédé de fabrication de la desvenlafaxine
EP2007708A1 (fr) 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd O-desméthylvenlafaxine essentiellement pure et ses procédés de préparation
MX2007016179A (es) 2006-04-17 2008-03-11 Teva Pharma Formas cristalinas de o-desmetilvenlafaxina.
WO2008035369A2 (fr) * 2006-06-30 2008-03-27 Alembic Limited Nouvelle forme de o-desméthyl venlafaxine
US20090069601A1 (en) * 2006-07-26 2009-03-12 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
CA2656166A1 (fr) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Procedes pour synthetiser le compose o-desmethylvenlafaxine
CA2656285A1 (fr) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Procedes pour la synthese d'o-desmethylvenlafaxine
US20080177110A1 (en) * 2006-07-26 2008-07-24 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
US20090137846A1 (en) * 2006-07-26 2009-05-28 Valerie Niddam-Hildesheim Processes for the synthesis of O-Desmethylvenlafaxine
US20080221356A1 (en) * 2006-07-26 2008-09-11 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
WO2008013994A2 (fr) 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Procédé pour synthétiser le composé o-desméthylvenlafaxine
US20100121108A1 (en) * 2006-08-04 2010-05-13 Medichem, S.A. Process for synthesizing desvenlafaxine free base and salts or solvates thereof
AU2008211711A1 (en) * 2007-01-31 2008-08-07 Generics [Uk] Limited Process for the preparation of O-desmethyl venlafaxine
US20080234516A1 (en) * 2007-03-14 2008-09-25 Valerie Niddam-Hildesheim Processes for preparing solid states of O-desmethylvenlafaxine succinate
BRPI0812501A2 (pt) * 2007-07-12 2015-06-16 Reddys Lab Ltd Dr O-desmetil venlafaxina
IN2007CH01519A (fr) * 2007-07-16 2009-09-11 Matrix Lab Ltd
WO2009034434A2 (fr) * 2007-09-10 2009-03-19 Cadila Pharmaceuticals Limited Procédé amélioré pour la préparation de o-desméthylvenlafaxine
US20110118357A1 (en) * 2007-10-26 2011-05-19 Generics Limited Process for preparing o-desmethylvenlafaxine
US8063250B2 (en) * 2007-11-26 2011-11-22 Teva Pharmaceutical Industries, Ltd. Crystal forms of O-desmethylvenlafaxine fumarate
WO2009084038A2 (fr) * 2007-12-28 2009-07-09 Ind-Swift Laboratories Limited Procédé amélioré d'élaboration d'o-desméthyl venlafaxine
CA2717580A1 (fr) * 2008-03-06 2009-12-17 Teva Pharmaceutical Industries Ltd. Procedes de preparation de la o-desmethylvenlafaxine, exempte de ses impuretes dimeres
EP2119696A1 (fr) 2008-05-16 2009-11-18 Krka Préparation de sels de O-desméthylvenlafaxine
EP2119695A1 (fr) 2008-05-16 2009-11-18 Krka Préparation de sels de O-desméthylvenlafaxine
KR20100132069A (ko) * 2008-06-16 2010-12-16 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신염의 고체 상태
US20100016638A1 (en) * 2008-07-21 2010-01-21 Zdenko Hamersak Method for preparation of o-desmethylvenlafaxine using polythiolates
CA2731165A1 (fr) * 2008-07-30 2010-02-04 Generics (Uk) Limited Procede pour l'elaboration d'o-desmethylvenlafaxine
CZ2008756A3 (cs) 2008-11-27 2010-03-24 Zentiva, A. S. Zpusob prípravy desvenlafaxinu a jeho solí
CZ200969A3 (cs) 2009-02-06 2010-06-30 Zentiva, K.S. Nové soli desvenlafaxinu a zpusob jejich prípravy
CZ2009454A3 (cs) 2009-07-15 2010-11-10 Zentiva, K. S. Zpusob prípravy desvenlafaxinu a jeho solí
WO2011007136A2 (fr) 2009-07-16 2011-01-20 Cipla Limited Procédé pour la préparation d'o-déméthyl-venlafaxine et intermédiaire destiné à être utilisé dans celui-ci
US20110098506A1 (en) * 2009-10-26 2011-04-28 Intas Pharmaceuticals Limited Method of preparing o-desmethylvenlafaxine
US20110184067A1 (en) * 2010-01-25 2011-07-28 Intas Pharmaceuticals Ltd. O-desmethylvenlafaxine succinate polymorph & process for preparing thereof
CA2795023A1 (fr) * 2010-03-29 2011-10-06 Pliva Hrvatska D.O.O. Formes cristallines du fumarate de o-desmethylvenlafaxine
CZ303249B6 (cs) 2010-04-06 2012-06-20 Zentiva, K.S. Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu
EP2394976A1 (fr) 2010-06-11 2011-12-14 LEK Pharmaceuticals d.d. Procédé pour déméthyler des éthers méthyliques aromatiques à l'aide d'acide mercaptopropionique
EP3580198B1 (fr) 2017-02-09 2023-08-09 R L Finechem Private Limited Procédé de préparation de 1-[2-(diméthylamino)-1-(4-hydroxyphényl) éthyl]-cyclohexanol et de ses sels
CN109232189B (zh) * 2018-09-25 2021-10-08 杭州盛弗泰新材料科技有限公司 一种高纯度1-羟基芘的制备方法
CN109665966A (zh) * 2018-11-01 2019-04-23 山东蒲济医药科技有限公司 一种琥珀酸去甲文拉法辛化合物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2741009A1 (de) * 1976-09-22 1978-03-23 Sandoz Ag 4-styryl-4-indolinol-derivate, ihre verwendung und herstellung
US4535186A (en) 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
CA1227304A (fr) * 1984-08-01 1987-09-29 Raymond C. Francis Defibrage de la pate a papier
GB8902209D0 (en) 1989-02-01 1989-03-22 Wyeth John And Brother Limited Preparation of cyclohexanol derivatives and novel thioamide intermediates
US6197828B1 (en) * 1998-12-01 2001-03-06 Sepracor, Inc. Derivatives of (+)-venlafaxine and methods of preparing and using the same
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
DE60039132D1 (de) 1999-04-06 2008-07-17 Sepracor Inc O-Desmethylvenlafaxin-Succinat
AU5738700A (en) 1999-06-15 2001-01-02 American Home Products Corporation Enantiomers of o-desmethyl venlafaxine
US20030171324A1 (en) 2000-07-18 2003-09-11 Shyam Ramakrishnan Regulation of human desc1-like serine protease
CN101671260A (zh) * 2001-02-12 2010-03-17 惠氏公司 制备o-去甲基-文拉法辛的方法
UA80543C2 (en) * 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine

Also Published As

Publication number Publication date
SI1451143T1 (sl) 2008-12-31
US20030105358A1 (en) 2003-06-05
TW200301102A (en) 2003-07-01
CA2466779A1 (fr) 2003-06-12
BR0214701A (pt) 2004-08-31
ECSP045135A (es) 2004-07-23
CN1319934C (zh) 2007-06-06
US7435854B2 (en) 2008-10-14
HK1065778A1 (en) 2005-03-04
RU2317286C2 (ru) 2008-02-20
JP2005511681A (ja) 2005-04-28
US20070225525A1 (en) 2007-09-27
WO2003048104A1 (fr) 2003-06-12
DK1451143T3 (da) 2008-11-10
UA80543C2 (en) 2007-10-10
DE60228118D1 (de) 2008-09-18
NO20042680L (no) 2004-06-25
ES2311647T3 (es) 2009-02-16
TWI260982B (en) 2006-09-01
JP4342312B2 (ja) 2009-10-14
US20090018365A1 (en) 2009-01-15
RU2004120284A (ru) 2005-04-10
CN1625546A (zh) 2005-06-08
NZ533316A (en) 2005-12-23
CO5580816A2 (es) 2005-11-30
HUP0402269A2 (hu) 2005-02-28
ATE403641T1 (de) 2008-08-15
AU2002357049A1 (en) 2003-06-17
US6689912B2 (en) 2004-02-10
HUP0402269A3 (en) 2010-06-28
AU2002357049B2 (en) 2009-07-16
KR20050044671A (ko) 2005-05-12
IL162253A (en) 2009-02-11
ES2311647T4 (es) 2009-11-10
EP1451143A1 (fr) 2004-09-01
IL194034A (en) 2010-12-30
PL369299A1 (en) 2005-04-18
ZA200405250B (en) 2005-12-28
MXPA04005309A (es) 2004-09-13
EP1451143B9 (fr) 2009-08-12
AR037622A1 (es) 2004-11-17
EP1451143B1 (fr) 2008-08-06
KR100939650B1 (ko) 2010-02-05
IL162253A0 (en) 2005-11-20
US20040158101A1 (en) 2004-08-12
PT1451143E (pt) 2008-10-21

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Effective date: 20221205