CA2457891C - Method of preservation of circulating tumor cells - Google Patents

Method of preservation of circulating tumor cells Download PDF

Info

Publication number
CA2457891C
CA2457891C CA2457891A CA2457891A CA2457891C CA 2457891 C CA2457891 C CA 2457891C CA 2457891 A CA2457891 A CA 2457891A CA 2457891 A CA2457891 A CA 2457891A CA 2457891 C CA2457891 C CA 2457891C
Authority
CA
Canada
Prior art keywords
ctc
blood
cells
polyethylene glycol
tumor cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2457891A
Other languages
English (en)
French (fr)
Other versions
CA2457891A1 (en
Inventor
Galla Chandra Rao
Melissa Hermann
Herman Rutner
Leon Terstappen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Diagnostics LLC
Original Assignee
Veridex LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26979228&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2457891(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Veridex LLC filed Critical Veridex LLC
Publication of CA2457891A1 publication Critical patent/CA2457891A1/en
Application granted granted Critical
Publication of CA2457891C publication Critical patent/CA2457891C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA2457891A 2001-08-23 2002-08-23 Method of preservation of circulating tumor cells Expired - Fee Related CA2457891C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31415101P 2001-08-23 2001-08-23
US60/314,151 2001-08-23
US36962802P 2002-04-03 2002-04-03
US60/369,628 2002-04-03
PCT/US2002/026867 WO2003018757A2 (en) 2001-08-23 2002-08-23 Stabilization of cells and biological specimens for analysis

Publications (2)

Publication Number Publication Date
CA2457891A1 CA2457891A1 (en) 2003-03-06
CA2457891C true CA2457891C (en) 2019-10-01

Family

ID=26979228

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2457891A Expired - Fee Related CA2457891C (en) 2001-08-23 2002-08-23 Method of preservation of circulating tumor cells
CA2457894A Expired - Fee Related CA2457894C (en) 2001-08-23 2002-08-23 Analysis of circulating tumor cells, fragments, and debris

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2457894A Expired - Fee Related CA2457894C (en) 2001-08-23 2002-08-23 Analysis of circulating tumor cells, fragments, and debris

Country Status (11)

Country Link
EP (2) EP1425294B2 (https=)
JP (3) JP2005501236A (https=)
KR (2) KR20040030984A (https=)
CN (2) CN1596265A (https=)
AT (1) ATE401574T1 (https=)
AU (2) AU2008288601B2 (https=)
BR (2) BR0212124A (https=)
CA (2) CA2457891C (https=)
DE (1) DE60227678D1 (https=)
IL (2) IL160209A0 (https=)
WO (2) WO2003019141A2 (https=)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1425294B2 (en) * 2001-08-23 2012-12-12 Veridex, LLC Analysis of circulating tumor cells, fragments, and debris
US7863012B2 (en) 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
AU2003234382B2 (en) 2002-05-13 2010-07-08 Becton, Dickinson And Company Protease inhibitor sample collection system
CA2500392C (en) 2002-09-27 2012-11-27 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
EP1413874A1 (en) 2002-10-16 2004-04-28 Streck Laboratories, Inc. Method and device for collecting and preserving cells for analysis
EP1597353B1 (en) 2003-02-27 2010-11-24 Veridex, LLC CIRCULATING TUMOR CELLS (CTC's): EARLY ASSESSMENT OF TIME TO PROGRESSION SURVIVAL AND RESPONSE TO THERAPY IN METASTATIC CANCER PATIENTS
CA2539108A1 (en) * 2003-09-18 2005-03-31 Immunivest Corporation Operator independent programmable sample preparation and analysis system
CA2600225C (en) * 2005-03-14 2016-06-28 Immunivest Corporation A method for predicting progression free and overall survival at each follow-up time point during therapy of metastatic breast cancer patients using circulating tumor cells
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
ES2511218T5 (es) 2005-06-20 2017-12-07 Advanced Cell Diagnostics, Inc. Kits y productos para detección de ácidos nucleicos en células individuales y para identificación de células raras en grandes poblaciones de células heterogéneas
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US8337755B2 (en) 2006-03-13 2012-12-25 Veridex, Llc Operator independent programmable sample preparation and analysis system
MX2008015425A (es) * 2006-06-02 2008-12-12 Pfizer Prod Inc Ensayo de celulas tumorales circulantes.
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
WO2007147074A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
CN101583722A (zh) 2006-07-14 2009-11-18 阿维瓦生物科学股份有限公司 从生物学样品检测稀有细胞的方法和组合物
CN101669031A (zh) * 2007-02-27 2010-03-10 森托科隆股份公司 使用与细胞外标记物结合的试剂组多重检测肿瘤细胞
GB2461476B (en) 2007-04-16 2012-02-22 Immunivest Corp A rapid, semi-automated method to detect respiratory virus infected cells in direct specimens
US8003314B2 (en) 2007-04-16 2011-08-23 Diagnostic Hybrids, Inc. Methods for direct fluorescent antibody virus detection in liquids
US8110101B2 (en) 2007-08-30 2012-02-07 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
US7828968B2 (en) 2007-08-30 2010-11-09 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
US8071395B2 (en) 2007-12-12 2011-12-06 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for magnetic separation of cells
HUE031848T2 (en) 2008-09-20 2017-08-28 Univ Leland Stanford Junior Non-invasive diagnosis of fetal aneuploidy by sequencing
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
DE202010018569U1 (de) 2009-02-18 2017-09-26 Streck Inc. Konservierung zellfreier Nukleinsäuren
US20130023433A1 (en) 2009-09-28 2013-01-24 Yuling Luo Methods of detecting nucleic acid sequences with high specificity
EP3045918B1 (en) * 2009-10-21 2017-12-06 The Scripps Research Institute Method of using non-rare cells to detect rare cells
US20130171621A1 (en) 2010-01-29 2013-07-04 Advanced Cell Diagnostics Inc. Methods of in situ detection of nucleic acids
WO2011099565A1 (ja) * 2010-02-10 2011-08-18 シスメックス株式会社 血液中癌細胞の検出方法及びそれに用いるプログラム
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12545960B2 (en) 2010-05-18 2026-02-10 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
EP2572003A4 (en) 2010-05-18 2016-01-13 Natera Inc METHOD FOR NONINVASIVE PRANATAL PLOIDIE ASSIGNMENT
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
DE102010020785A1 (de) * 2010-05-18 2011-11-24 Siemens Aktiengesellschaft Vorrichtung und Verfahren zum Erkennen von magnetisch markierten Mikroobjekten
WO2012088456A2 (en) 2010-12-22 2012-06-28 Natera, Inc. Methods for non-invasive prenatal paternity testing
AU2011358564B9 (en) 2011-02-09 2017-07-13 Natera, Inc Methods for non-invasive prenatal ploidy calling
US20120252038A1 (en) * 2011-04-01 2012-10-04 Chianese David A Steroid receptor assays
US9956281B2 (en) 2011-05-04 2018-05-01 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
US20140295426A1 (en) * 2011-07-28 2014-10-02 Veridex Llc Methods for Diagnosing Cancer by Characterization of Tumor Cells Associated with Pleural or Serous Fluids
JP6329072B2 (ja) 2011-09-26 2018-05-23 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング 細胞外核酸の安定化および単離
US11021733B2 (en) 2011-09-26 2021-06-01 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
CN103827303B (zh) 2011-09-26 2021-10-22 普瑞阿那利提克斯有限公司 细胞外核酸的稳定化和分离
KR102037891B1 (ko) * 2012-03-09 2019-10-30 한국전자통신연구원 다중 분리 장치 및 혈중 암세포 분리 방법
EP2848935A4 (en) 2012-05-10 2015-12-09 Konica Minolta Inc PROCESS FOR REMOVING RED BLOOD BODIES AND CENTRIFUGAL TUBES FOR BLOOD TREATMENT
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
CN104755628B (zh) 2012-09-25 2019-03-01 凯杰有限公司 生物样品的稳定化
US12590955B2 (en) 2013-03-15 2026-03-31 Zeon Corporation Methods and systems for processing particles
EP3569313A1 (en) 2013-03-15 2019-11-20 GPB Scientific, LLC On-chip microfluidic processing of particles
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
EP3608022A1 (en) 2013-03-15 2020-02-12 The Trustees of Princeton University Methods and devices for high throughput purification
US11525155B2 (en) 2013-03-18 2022-12-13 Qiagen Gmbh Stabilisation of biological samples
JP6407248B2 (ja) * 2013-03-18 2018-10-17 キアゲン ゲーエムベーハー 細胞外核酸の安定化および単離
ES2938048T3 (es) 2013-07-24 2023-04-04 Streck Llc Composiciones y procedimientos para estabilizar las células tumorales circulantes
EP3502270B1 (en) 2013-10-21 2020-03-18 The General Hospital Corporation Methods relating to circulating tumor cell clusters and the treatment of cancer
EA201691496A1 (ru) 2014-01-27 2016-12-30 Эпик Сайенсиз, Инк. Диагностика биомаркеров рака предстательной железы с помощью циркулирующих опухолевых клеток
EA201691682A1 (ru) 2014-02-21 2017-02-28 Эпик Сайенсиз, Инк. Способы анализирования редких циркулирующих в крови клеток
JP6664332B2 (ja) * 2014-03-18 2020-03-13 キアゲン ゲーエムベーハー 細胞外核酸の安定化および単離
CN103940997B (zh) * 2014-03-21 2017-01-04 上海柏慧康生物科技有限公司 一种乳腺癌循环肿瘤细胞检测系统及试剂盒
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
EP3957749A1 (en) 2014-04-21 2022-02-23 Natera, Inc. Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples
CN103980365A (zh) * 2014-06-03 2014-08-13 国家纳米科学中心 一种表面固载炭疽致死因子的磁性纳米粒子、其制备方法及用途
US20180173845A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
EP3164204B1 (en) * 2014-07-02 2021-03-10 Siemens Healthcare Diagnostics Inc. Selective nucleic acid separation
EP3262195A1 (en) * 2015-02-24 2018-01-03 Siemens Healthcare Diagnostics Inc. Prefixation for increased rare cell recovery
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
WO2016183106A1 (en) 2015-05-11 2016-11-17 Natera, Inc. Methods and compositions for determining ploidy
US20170097361A1 (en) * 2015-07-15 2017-04-06 Streck, Inc. Method and device for stabilizing of proteins
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
JP6617495B2 (ja) * 2015-09-18 2019-12-11 東ソー株式会社 腫瘍細胞の検出方法
WO2017079212A1 (en) * 2015-11-04 2017-05-11 Axon Dx, Llc Cell detection, capture, analysis, aggregation, and output methods and apparatus
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
EP3377645B1 (en) 2015-11-20 2023-10-04 Qiagen GmbH Method of preparing sterilized compositions for stabilization of extracellular nucleic acids
CN105372109A (zh) * 2015-12-15 2016-03-02 苏州药明康德新药开发股份有限公司 添加稳定剂的生物基质的制备方法
WO2017152028A1 (en) * 2016-03-04 2017-09-08 Janssen Diagnostics, Llc Preservation of cellular components from cells with a preservative
JP7064665B2 (ja) * 2016-03-07 2022-05-11 ファーザー フラナガンズ ボーイズ ホーム ドゥーイング ビジネス アズ ボーイズ タウン ナショナル リサーチ ホスピタル 非侵襲的分子対照
WO2017181202A2 (en) 2016-04-15 2017-10-19 Natera, Inc. Methods for lung cancer detection
JP2017219479A (ja) 2016-06-09 2017-12-14 住友電気工業株式会社 微小粒子計測装置及び分析方法
EP4656715A3 (en) 2016-07-29 2026-02-25 Streck LLC Suspension composition for hematology analysis control
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
KR102313431B1 (ko) 2016-11-21 2021-10-18 나노스트링 테크놀로지스, 인크. 화학적 조성물 및 이것을 사용하는 방법
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
PL3662080T3 (pl) * 2017-08-02 2022-04-19 Sarstedt Ag & Co. Kg Sposób i formulacja do stabilizacji bezkomórkowych kwasów nukleinowych i komórek
EP3675876A4 (en) 2017-09-01 2021-06-02 GPB Scientific, Inc. METHOD FOR PRODUCING THERAPEUTICALLY ACTIVE CELLS USING MICROFLUIDICS
CN115119829B (zh) * 2017-10-19 2024-07-12 斯特雷克股份有限公司 用于胞外囊泡的溶血和凝血调节以及稳定化的组合物
JP2021506342A (ja) 2017-12-14 2021-02-22 ティーエーアイ ダイアグノスティックス インコーポレイテッドＴａｉ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． 移植のための移植片適合性の評価
CA3090426A1 (en) 2018-04-14 2019-10-17 Natera, Inc. Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna
AU2019271028B2 (en) 2018-05-14 2025-09-18 Bruker Spatial Biology, Inc. Chemical compositions and methods of using same
JP7334468B2 (ja) * 2018-05-29 2023-08-29 東ソー株式会社 血液試料保存剤
JP7036670B2 (ja) 2018-05-31 2022-03-15 アークレイ株式会社 血液中の稀少細胞検査、該検査ための血液処理方法及び採血管
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN108865976B (zh) * 2018-07-19 2022-06-28 复旦大学附属中山医院 一种离散汲取收集外泌体(exosome)的方法及试剂
CN110250159A (zh) * 2019-05-28 2019-09-20 天津中科生物科技有限公司 一种细胞保护液及其制备方法和应用
EP3980559A1 (en) 2019-06-06 2022-04-13 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
KR20240168912A (ko) * 2022-03-25 2024-12-02 세키스이 메디칼 가부시키가이샤 순환 종양 세포 분리 키트, 순환 종양 세포 분리 용기 및 순환 종양 세포의 분리 방법
WO2024238350A1 (en) * 2023-05-12 2024-11-21 The Children's Medical Center Corporation Single-cell regulatory multi-omics with deep mitochondrial mutation profiling (redeem)

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4040785A (en) * 1976-10-18 1977-08-09 Technicon Instruments Corporation Lysable blood preservative composition
US4320111A (en) * 1977-06-14 1982-03-16 American Home Products Corporation Immunologic compositions methods of preparation and use
FR2475737A1 (fr) * 1980-02-07 1981-08-14 Pasteur Institut Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede
US4404181A (en) * 1981-10-15 1983-09-13 Cambridge Chemical Products, Inc. Extended-life tissue fixative composition and method of using the same
FR2523810B1 (fr) * 1982-03-23 1988-11-25 Carpentier Alain Tissu biologique greffable et procede pour sa preparation
FR2528848A1 (fr) * 1982-06-16 1983-12-23 Sanofi Sa Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique
EP0156537A3 (en) * 1984-03-02 1987-05-13 Board Of Regents University Of Texas System Biological magnetic fluids
US4654312A (en) * 1984-05-14 1987-03-31 Becton, Dickinson And Company Lysing agent for analysis of peripheral blood cells
US4788139A (en) * 1987-08-06 1988-11-29 Streck Laboratories, Inc. Platelet aggregation reagent, reagent container and method of determining platelet aggregation in EDTA-anticoagulated blood
US5385707A (en) * 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
US5698271A (en) * 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
US5849517A (en) * 1991-05-08 1998-12-15 Streck Laboratories, Inc. Method and composition for preserving antigens and nucleic acids and process for utilizing cytological material produced by same
JPH07507266A (ja) * 1991-09-20 1995-08-10 カミナー，ジェラルド・ダブリュー アルデヒド安定化溶液を用いる方法および組成物
EP0685994B1 (en) * 1993-02-25 2007-03-21 Abbott Laboratories Multipurpose reagent system for rapid lysis of whole blood samples
US6190870B1 (en) * 1995-08-28 2001-02-20 Amcell Corporation Efficient enrichment and detection of disseminated tumor cells
GB2313288B (en) * 1996-05-24 2000-07-12 North Gen Hospital Nhs Trust Specimen collection fluid
US6197523B1 (en) * 1997-11-24 2001-03-06 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood
US6670197B2 (en) * 1997-11-24 2003-12-30 David L. Rimm Method for assaying whole blood for the presence or absence of circulating cancer or other target cell fragments
WO1999041613A1 (en) * 1998-02-12 1999-08-19 Immunivest Methods and reagents for the rapid and efficient isolation of circulating cancer cells
AU2876900A (en) * 1999-02-10 2000-08-29 Cell Works Inc. Class characterization of circulating cancer cells isolated from body fluids andmethods of use
WO2001019956A2 (en) * 1999-09-13 2001-03-22 Bander Neil H A method for isolation of prostatic epithelial cells from semen
EP1425294B2 (en) * 2001-08-23 2012-12-12 Veridex, LLC Analysis of circulating tumor cells, fragments, and debris

Also Published As

Publication number Publication date
BR0212125A (pt) 2005-06-28
AU2008288601B2 (en) 2012-05-31
AU2009200013A1 (en) 2009-02-05
AU2009200013B2 (en) 2012-03-08
WO2003019141A2 (en) 2003-03-06
EP1425383A2 (en) 2004-06-09
AU2008288601A1 (en) 2009-04-02
EP1425383A4 (en) 2005-11-09
IL160209A0 (en) 2004-07-25
JP2009109514A (ja) 2009-05-21
KR20040053115A (ko) 2004-06-23
ATE401574T1 (de) 2008-08-15
JP2005501236A (ja) 2005-01-13
JP2005502863A (ja) 2005-01-27
EP1425294B2 (en) 2012-12-12
KR20040030984A (ko) 2004-04-09
WO2003018757A3 (en) 2003-09-12
WO2003019141A3 (en) 2004-04-01
BR0212124A (pt) 2004-07-20
CN1571634A (zh) 2005-01-26
CA2457894A1 (en) 2003-03-06
EP1425294A4 (en) 2005-11-16
EP1425294A2 (en) 2004-06-09
IL160210A0 (en) 2004-07-25
WO2003018757A2 (en) 2003-03-06
CA2457894C (en) 2014-07-08
EP1425294B1 (en) 2008-07-16
CN1596265A (zh) 2005-03-16
DE60227678D1 (de) 2008-08-28
CA2457891A1 (en) 2003-03-06

Similar Documents

Publication Publication Date Title
CA2457891C (en) Method of preservation of circulating tumor cells
US20050181353A1 (en) Stabilization of cells and biological specimens for analysis
US8329422B2 (en) Analysis of circulating tumor cells, fragments, and debris
US10966421B2 (en) Method and device for collecting and preserving cells for analysis
US20130137094A1 (en) One-Step Cell and Tissue Preservative for Morphologic and Molecular Analysis
ES2357101T3 (es) Celulas marcadas para su uso como control funcional interno en ensayos de detección de celulas raras.
US4668618A (en) Nuclear isolation medium and procedure for separating cell nuclei
WO2006054991A1 (en) Magnetic enrichment of circulating cells, fragments and debris for enabling hts proteomics and genomics in disease detection
JP6617495B2 (ja) 腫瘍細胞の検出方法
JP6617516B2 (ja) 血液試料中に含まれる目的細胞の検出方法
Terstappen et al. Flowcytometry‐Principles and Feasibility in Transfusion Medicine. Enumeration of Epithelial Derived Tumor Cells in Peripheral Blood
JP7143678B2 (ja) 標的細胞を検出する方法
CN112504793B (zh) 用于渗透和固定血细胞的试剂及分析方法
AU2002331696A1 (en) Stabilization of cells and biological specimens for analysis
US20070122909A1 (en) Method of treating cells
JP7279542B2 (ja) 試料中に含まれる目的細胞の定量方法
Rao et al. Analysis of circulating tumor cells, fragments, and debris
WO2024251933A1 (en) An improved method for the enrichment of circulating tumor cells from diagnostic leukapheresis products
CA2787920A1 (en) Improved one-step cell and tissue preservative for morphologic and molecular analysis
AU2002326741A1 (en) Analysis of circulating tumor cells, fragments, and debris
Hong et al. Use of Anti-Phosphohistone H3 (PHH3) as a Mitosis Marker for Classifying Pulmonary Carcinoid Tumors

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20220301

MKLA Lapsed

Effective date: 20200831