BR0212124A - Composições, métodos e aparelhos para conservar espécimes biológicos e amostras de sangue suspeitas de conter células tumorais circulantes, e, composição celular estabilizada - Google Patents
Composições, métodos e aparelhos para conservar espécimes biológicos e amostras de sangue suspeitas de conter células tumorais circulantes, e, composição celular estabilizadaInfo
- Publication number
- BR0212124A BR0212124A BR0212124-7A BR0212124A BR0212124A BR 0212124 A BR0212124 A BR 0212124A BR 0212124 A BR0212124 A BR 0212124A BR 0212124 A BR0212124 A BR 0212124A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- damage
- tumor cells
- circulating tumor
- biological specimens
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
"COMPOSIçõES, MéTODOS E APARELHOS PARA CONSERVAR ESPéCIMES BIOLóGICOS E AMOSTRAS DE SANGUE SUSPEITAS DE CONTER CéLULAS TUMORAIS CIRCULANTES E, COMPOSIçãO CELULAR ESTABILIZADA". São descritos composições e métodos que minimizam perdas de células alvo (por exemplo, células tumorais circulantes) e formação de detritos e agregados de células alvo, células não-alvo e componentes plasmáticos, para estabilizar células raras em espécimes sang³íneos, conservar a qualidade dos espécimes sang³íneos e também servir como fixadores celulares, desse modo permitindo análise e classificação mais precisa das células tumorais circulantes (CTC) e, finalmente, de cargas tumorais em pacientes cancerosos. Para estabilização dos espécimes são particularmente desejáveis n protocolos requerendo enriquecimento de células raras de espécies sang³íneas extraçãos de pacientes cancerosos. Exposição de tais espécimes a condições potencialmente estressantes, encontradas, por exemplo, em processamento normal, mistura, agitação e retardos devido a transporte de sangue, tem sido observada não somente diminuir o número de CTC mas também gerar detritos e agregados nos espécimes sang³íneos que foram constatados interferir com a enumeração precisa de células alvo, se presentes. Estabilizadores são necessários para discriminar entre desintegração CTC in vivo e degradação de amostra in vivo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31415101P | 2001-08-23 | 2001-08-23 | |
US36962802P | 2002-04-03 | 2002-04-03 | |
PCT/US2002/026867 WO2003018757A2 (en) | 2001-08-23 | 2002-08-23 | Stabilization of cells and biological specimens for analysis |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0212124A true BR0212124A (pt) | 2004-07-20 |
Family
ID=26979228
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0212124-7A BR0212124A (pt) | 2001-08-23 | 2002-08-23 | Composições, métodos e aparelhos para conservar espécimes biológicos e amostras de sangue suspeitas de conter células tumorais circulantes, e, composição celular estabilizada |
BR0212125-5A BR0212125A (pt) | 2001-08-23 | 2002-08-23 | Métodos para diagnosticar doença, diagnosticar malignidade, triar malignidade e monitorar malignidade, em um indivìduo sob teste, e, kit para examinar um espécime biológico quanto à presença de células malignas, fragmentos celulares derivados de células malignas ou detritos celulares derivados de células malignas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0212125-5A BR0212125A (pt) | 2001-08-23 | 2002-08-23 | Métodos para diagnosticar doença, diagnosticar malignidade, triar malignidade e monitorar malignidade, em um indivìduo sob teste, e, kit para examinar um espécime biológico quanto à presença de células malignas, fragmentos celulares derivados de células malignas ou detritos celulares derivados de células malignas |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP1425294B2 (pt) |
JP (3) | JP2005501236A (pt) |
KR (2) | KR20040053115A (pt) |
CN (2) | CN1596265A (pt) |
AT (1) | ATE401574T1 (pt) |
AU (2) | AU2008288601B2 (pt) |
BR (2) | BR0212124A (pt) |
CA (2) | CA2457891C (pt) |
DE (1) | DE60227678D1 (pt) |
IL (2) | IL160210A0 (pt) |
WO (2) | WO2003019141A2 (pt) |
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AU2008288601A1 (en) | 2009-04-02 |
IL160210A0 (en) | 2004-07-25 |
AU2009200013B2 (en) | 2012-03-08 |
EP1425383A2 (en) | 2004-06-09 |
EP1425294A2 (en) | 2004-06-09 |
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AU2008288601B2 (en) | 2012-05-31 |
WO2003019141A2 (en) | 2003-03-06 |
CA2457894A1 (en) | 2003-03-06 |
JP2005502863A (ja) | 2005-01-27 |
JP2009109514A (ja) | 2009-05-21 |
ATE401574T1 (de) | 2008-08-15 |
CN1571634A (zh) | 2005-01-26 |
BR0212125A (pt) | 2005-06-28 |
WO2003018757A3 (en) | 2003-09-12 |
WO2003018757A2 (en) | 2003-03-06 |
WO2003019141A3 (en) | 2004-04-01 |
CA2457891A1 (en) | 2003-03-06 |
EP1425294B1 (en) | 2008-07-16 |
EP1425383A4 (en) | 2005-11-09 |
KR20040053115A (ko) | 2004-06-23 |
DE60227678D1 (de) | 2008-08-28 |
AU2009200013A1 (en) | 2009-02-05 |
EP1425294A4 (en) | 2005-11-16 |
EP1425294B2 (en) | 2012-12-12 |
IL160209A0 (en) | 2004-07-25 |
CN1596265A (zh) | 2005-03-16 |
CA2457894C (en) | 2014-07-08 |
JP2005501236A (ja) | 2005-01-13 |
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