BR0212124A - Composições, métodos e aparelhos para conservar espécimes biológicos e amostras de sangue suspeitas de conter células tumorais circulantes, e, composição celular estabilizada - Google Patents
Composições, métodos e aparelhos para conservar espécimes biológicos e amostras de sangue suspeitas de conter células tumorais circulantes, e, composição celular estabilizadaInfo
- Publication number
- BR0212124A BR0212124A BR0212124-7A BR0212124A BR0212124A BR 0212124 A BR0212124 A BR 0212124A BR 0212124 A BR0212124 A BR 0212124A BR 0212124 A BR0212124 A BR 0212124A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- damage
- tumor cells
- circulating tumor
- biological specimens
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
Abstract
"COMPOSIçõES, MéTODOS E APARELHOS PARA CONSERVAR ESPéCIMES BIOLóGICOS E AMOSTRAS DE SANGUE SUSPEITAS DE CONTER CéLULAS TUMORAIS CIRCULANTES E, COMPOSIçãO CELULAR ESTABILIZADA". São descritos composições e métodos que minimizam perdas de células alvo (por exemplo, células tumorais circulantes) e formação de detritos e agregados de células alvo, células não-alvo e componentes plasmáticos, para estabilizar células raras em espécimes sang³íneos, conservar a qualidade dos espécimes sang³íneos e também servir como fixadores celulares, desse modo permitindo análise e classificação mais precisa das células tumorais circulantes (CTC) e, finalmente, de cargas tumorais em pacientes cancerosos. Para estabilização dos espécimes são particularmente desejáveis n protocolos requerendo enriquecimento de células raras de espécies sang³íneas extraçãos de pacientes cancerosos. Exposição de tais espécimes a condições potencialmente estressantes, encontradas, por exemplo, em processamento normal, mistura, agitação e retardos devido a transporte de sangue, tem sido observada não somente diminuir o número de CTC mas também gerar detritos e agregados nos espécimes sang³íneos que foram constatados interferir com a enumeração precisa de células alvo, se presentes. Estabilizadores são necessários para discriminar entre desintegração CTC in vivo e degradação de amostra in vivo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31415101P | 2001-08-23 | 2001-08-23 | |
US36962802P | 2002-04-03 | 2002-04-03 | |
PCT/US2002/026867 WO2003018757A2 (en) | 2001-08-23 | 2002-08-23 | Stabilization of cells and biological specimens for analysis |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0212124A true BR0212124A (pt) | 2004-07-20 |
Family
ID=26979228
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0212125-5A BR0212125A (pt) | 2001-08-23 | 2002-08-23 | Métodos para diagnosticar doença, diagnosticar malignidade, triar malignidade e monitorar malignidade, em um indivìduo sob teste, e, kit para examinar um espécime biológico quanto à presença de células malignas, fragmentos celulares derivados de células malignas ou detritos celulares derivados de células malignas |
BR0212124-7A BR0212124A (pt) | 2001-08-23 | 2002-08-23 | Composições, métodos e aparelhos para conservar espécimes biológicos e amostras de sangue suspeitas de conter células tumorais circulantes, e, composição celular estabilizada |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0212125-5A BR0212125A (pt) | 2001-08-23 | 2002-08-23 | Métodos para diagnosticar doença, diagnosticar malignidade, triar malignidade e monitorar malignidade, em um indivìduo sob teste, e, kit para examinar um espécime biológico quanto à presença de células malignas, fragmentos celulares derivados de células malignas ou detritos celulares derivados de células malignas |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP1425294B2 (pt) |
JP (3) | JP2005502863A (pt) |
KR (2) | KR20040030984A (pt) |
CN (2) | CN1596265A (pt) |
AT (1) | ATE401574T1 (pt) |
AU (2) | AU2008288601B2 (pt) |
BR (2) | BR0212125A (pt) |
CA (2) | CA2457891C (pt) |
DE (1) | DE60227678D1 (pt) |
IL (2) | IL160209A0 (pt) |
WO (2) | WO2003018757A2 (pt) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7863012B2 (en) | 2004-02-17 | 2011-01-04 | Veridex, Llc | Analysis of circulating tumor cells, fragments, and debris |
WO2003018757A2 (en) * | 2001-08-23 | 2003-03-06 | Immunivest Corporation | Stabilization of cells and biological specimens for analysis |
US8980568B2 (en) | 2001-10-11 | 2015-03-17 | Aviva Biosciences Corporation | Methods and compositions for detecting non-hematopoietic cells from a blood sample |
US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
EP2260942A3 (en) | 2002-05-13 | 2011-03-09 | Becton, Dickinson and Company | Protease Inhibitor Sample Collection System |
ATE531257T1 (de) | 2002-09-27 | 2011-11-15 | Gen Hospital Corp | Mikrofluidische vorrichtung zur zelltrennung und verwendungen davon |
ES2784011T3 (es) | 2002-10-16 | 2020-09-21 | Streck Inc | Procedimiento y dispositivo para recoger y preservar las células para su análisis |
ATE489452T1 (de) | 2003-02-27 | 2010-12-15 | Veridex Llc | Zirkulierende tumorzellen (ctc's): frühe beurteilung von time-to-progression, überleben und ansprechen auf therapie bei patienten mit metastasiertem krebs |
WO2005028663A2 (en) * | 2003-09-18 | 2005-03-31 | Immunivest Corporation | Operator independent programmable sample preparation and analysis system |
JP2008533487A (ja) * | 2005-03-14 | 2008-08-21 | イムニベスト・コーポレイション | 循環腫瘍細胞を用いる転移性乳癌患者の療法中の各追跡期間ポイントでの無増悪および全生存を予測する方法 |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
CN101495650B (zh) | 2005-06-20 | 2015-02-04 | 领先细胞医疗诊断有限公司 | 检测单个细胞中的核酸和鉴定异质大细胞群中罕见细胞的方法 |
US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US8337755B2 (en) | 2006-03-13 | 2012-12-25 | Veridex, Llc | Operator independent programmable sample preparation and analysis system |
US8940493B2 (en) * | 2006-06-02 | 2015-01-27 | Veridex Llc | Circulating tumor cell assay |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
EP2041299A4 (en) | 2006-07-14 | 2010-01-13 | Aviva Biosciences Corp | METHOD AND COMPOSITIONS FOR DETECTION OF RARE CELLS FROM A BIOLOGICAL SAMPLE |
US20110312511A1 (en) * | 2007-02-27 | 2011-12-22 | Ola Winquist | Multiplex Detection of Tumour Cells Using a Panel of Agents Binding to Extracellular Markers |
US8003314B2 (en) | 2007-04-16 | 2011-08-23 | Diagnostic Hybrids, Inc. | Methods for direct fluorescent antibody virus detection in liquids |
WO2008128243A1 (en) | 2007-04-16 | 2008-10-23 | Immunivest Corporation | A rapid, semi-automated method to detect respiratory virus infected cells in direct specimens |
US7828968B2 (en) | 2007-08-30 | 2010-11-09 | Veridex, Llc | Method and apparatus for imaging target components in a biological sample using permanent magnets |
US8110101B2 (en) | 2007-08-30 | 2012-02-07 | Veridex, Llc | Method and apparatus for imaging target components in a biological sample using permanent magnets |
EP2229441B1 (en) | 2007-12-12 | 2014-10-01 | The Board of Trustees of The Leland Stanford Junior University | Method and apparatus for magnetic separation of cells |
SI2562268T1 (sl) | 2008-09-20 | 2017-05-31 | The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 | Neinvazivna diagnoza fetalne anevploidije s sekvenciranjem |
US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
US8304187B2 (en) | 2009-02-18 | 2012-11-06 | Streck, Inc. | Preservation of cell-free RNA in blood samples |
US20130023433A1 (en) | 2009-09-28 | 2013-01-24 | Yuling Luo | Methods of detecting nucleic acid sequences with high specificity |
EP3045918B1 (en) | 2009-10-21 | 2017-12-06 | The Scripps Research Institute | Method of using non-rare cells to detect rare cells |
EP2529030B1 (en) | 2010-01-29 | 2019-03-13 | Advanced Cell Diagnostics, Inc. | Methods of in situ detection of nucleic acids |
WO2011099565A1 (ja) * | 2010-02-10 | 2011-08-18 | シスメックス株式会社 | 血液中癌細胞の検出方法及びそれに用いるプログラム |
US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
DE102010020785A1 (de) * | 2010-05-18 | 2011-11-24 | Siemens Aktiengesellschaft | Vorrichtung und Verfahren zum Erkennen von magnetisch markierten Mikroobjekten |
US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
EP2572003A4 (en) | 2010-05-18 | 2016-01-13 | Natera Inc | METHOD FOR NONINVASIVE PRANATAL PLOIDIE ASSIGNMENT |
US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US20120252038A1 (en) * | 2011-04-01 | 2012-10-04 | Chianese David A | Steroid receptor assays |
WO2012151391A2 (en) | 2011-05-04 | 2012-11-08 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
TW201312117A (zh) * | 2011-07-28 | 2013-03-16 | Univ Pennsylvania | 用以診斷與漿液相關之腫瘤細胞的症狀及特性的方法及試劑 |
US11021733B2 (en) | 2011-09-26 | 2021-06-01 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
AU2012314515B2 (en) | 2011-09-26 | 2018-03-15 | Preanalytix Gmbh | Stabilisation and isolation of extracellular nucleic acids |
KR102037891B1 (ko) * | 2012-03-09 | 2019-10-30 | 한국전자통신연구원 | 다중 분리 장치 및 혈중 암세포 분리 방법 |
JP6179508B2 (ja) * | 2012-05-10 | 2017-08-16 | コニカミノルタ株式会社 | 希少細胞の検出方法 |
JP6608280B2 (ja) | 2012-09-25 | 2019-11-20 | キアゲン ゲーエムベーハー | 生物学的試料の安定化 |
WO2014145075A2 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Princeton University | Methods and devices for high throughpout purification |
WO2014145152A2 (en) | 2013-03-15 | 2014-09-18 | Gpb Scientific, Llc | On-chip microfluidic processing of particles |
US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
US10144952B2 (en) * | 2013-03-18 | 2018-12-04 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
WO2014146781A1 (en) | 2013-03-18 | 2014-09-25 | Qiagen Gmbh | Stabilisation of biological samples |
US10091984B2 (en) | 2013-07-24 | 2018-10-09 | Streck, Inc. | Compositions and methods for stabilizing circulating tumor cells |
CA2928779A1 (en) | 2013-10-21 | 2015-04-30 | The General Hospital Corporation | Methods relating to circulating tumor cell clusters and the treatment of cancer |
EP3100047B1 (en) | 2014-01-27 | 2021-08-11 | Epic Sciences, Inc. | Circulating tumor cell diagnostics for prostate cancer biomarkers |
EP3108246B1 (en) | 2014-02-21 | 2019-10-09 | Epic Sciences, Inc. | Methods for analyzing rare circulating cells |
CA2940692A1 (en) * | 2014-03-18 | 2015-09-24 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
CN103940997B (zh) * | 2014-03-21 | 2017-01-04 | 上海柏慧康生物科技有限公司 | 一种乳腺癌循环肿瘤细胞检测系统及试剂盒 |
CN106460070B (zh) | 2014-04-21 | 2021-10-08 | 纳特拉公司 | 检测染色体片段中的突变和倍性 |
CN103980365A (zh) * | 2014-06-03 | 2014-08-13 | 国家纳米科学中心 | 一种表面固载炭疽致死因子的磁性纳米粒子、其制备方法及用途 |
EP3164204B1 (en) * | 2014-07-02 | 2021-03-10 | Siemens Healthcare Diagnostics Inc. | Selective nucleic acid separation |
US10564075B2 (en) | 2015-02-24 | 2020-02-18 | Siemens Healthcare Diagnostics Inc. | Prefixation for increased rare cell recovery |
US11168351B2 (en) | 2015-03-05 | 2021-11-09 | Streck, Inc. | Stabilization of nucleic acids in urine |
US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
CA2936167A1 (en) * | 2015-07-15 | 2017-01-15 | Streck, Inc. | Method and device for stabilizing of proteins |
JP6617495B2 (ja) * | 2015-09-18 | 2019-12-11 | 東ソー株式会社 | 腫瘍細胞の検出方法 |
US20180328848A1 (en) * | 2015-11-04 | 2018-11-15 | Axon Dx, Llc | Cell detection, capture, analysis, aggregation, and output methods and apparatus |
US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
CN108291250B (zh) | 2015-11-20 | 2022-05-27 | 凯杰有限公司 | 用于稳定细胞外核酸的已灭菌组合物的制备方法 |
CN105372109A (zh) * | 2015-12-15 | 2016-03-02 | 苏州药明康德新药开发股份有限公司 | 添加稳定剂的生物基质的制备方法 |
WO2017152028A1 (en) * | 2016-03-04 | 2017-09-08 | Janssen Diagnostics, Llc | Preservation of cellular components from cells with a preservative |
CA3014773A1 (en) * | 2016-03-07 | 2017-09-14 | Cfgenome, Llc | Noninvasive molecular controls |
JP2017219479A (ja) | 2016-06-09 | 2017-12-14 | 住友電気工業株式会社 | 微小粒子計測装置及び分析方法 |
EP3491381A1 (en) | 2016-07-29 | 2019-06-05 | Streck, Inc. | Suspension composition for hematology analysis control |
US11485996B2 (en) | 2016-10-04 | 2022-11-01 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
WO2018094385A1 (en) | 2016-11-21 | 2018-05-24 | Nanostring Technologies, Inc. | Chemical compositions and methods of using same |
US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
RU2764245C2 (ru) * | 2017-08-02 | 2022-01-14 | Зарштедт Аг Унд Ко. Кг | Способ и состав для стабилизации нуклеиновых кислот, свободных от клеток, и клеток |
CN111065399B (zh) | 2017-09-01 | 2023-11-28 | Gpb科学有限公司 | 使用微流体制备治疗活性细胞的方法 |
CA3079415A1 (en) * | 2017-10-19 | 2019-04-25 | Streck, Inc. | Compositions for hemolysis and coagulation regulation and stabilization of extracellular vesicles |
EP3794146A1 (en) | 2018-05-14 | 2021-03-24 | Nanostring Technologies, Inc. | Chemical compositions and methods of using same |
JP7334468B2 (ja) * | 2018-05-29 | 2023-08-29 | 東ソー株式会社 | 血液試料保存剤 |
JP7036670B2 (ja) | 2018-05-31 | 2022-03-15 | アークレイ株式会社 | 血液中の稀少細胞検査、該検査ための血液処理方法及び採血管 |
US11525159B2 (en) | 2018-07-03 | 2022-12-13 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
CN108865976B (zh) * | 2018-07-19 | 2022-06-28 | 复旦大学附属中山医院 | 一种离散汲取收集外泌体(exosome)的方法及试剂 |
CN110250159A (zh) * | 2019-05-28 | 2019-09-20 | 天津中科生物科技有限公司 | 一种细胞保护液及其制备方法和应用 |
JP7355473B1 (ja) | 2022-03-25 | 2023-10-03 | 積水メディカル株式会社 | 循環腫瘍細胞分離キット、循環腫瘍細胞分離容器及び循環腫瘍細胞の分離方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4040785A (en) * | 1976-10-18 | 1977-08-09 | Technicon Instruments Corporation | Lysable blood preservative composition |
US4320111A (en) * | 1977-06-14 | 1982-03-16 | American Home Products Corporation | Immunologic compositions methods of preparation and use |
FR2475737A1 (fr) * | 1980-02-07 | 1981-08-14 | Pasteur Institut | Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede |
US4404181A (en) * | 1981-10-15 | 1983-09-13 | Cambridge Chemical Products, Inc. | Extended-life tissue fixative composition and method of using the same |
FR2523810B1 (fr) * | 1982-03-23 | 1988-11-25 | Carpentier Alain | Tissu biologique greffable et procede pour sa preparation |
FR2528848A1 (fr) * | 1982-06-16 | 1983-12-23 | Sanofi Sa | Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique |
EP0156537A3 (en) * | 1984-03-02 | 1987-05-13 | Board Of Regents University Of Texas System | Biological magnetic fluids |
US4654312A (en) * | 1984-05-14 | 1987-03-31 | Becton, Dickinson And Company | Lysing agent for analysis of peripheral blood cells |
US4788139A (en) * | 1987-08-06 | 1988-11-29 | Streck Laboratories, Inc. | Platelet aggregation reagent, reagent container and method of determining platelet aggregation in EDTA-anticoagulated blood |
US5385707A (en) * | 1988-12-28 | 1995-01-31 | Stefan Miltenyi | Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same |
US5698271A (en) * | 1989-08-22 | 1997-12-16 | Immunivest Corporation | Methods for the manufacture of magnetically responsive particles |
US5849517A (en) * | 1991-05-08 | 1998-12-15 | Streck Laboratories, Inc. | Method and composition for preserving antigens and nucleic acids and process for utilizing cytological material produced by same |
EP0627879A1 (en) * | 1991-09-20 | 1994-12-14 | CAMIENER, Gerald, W. | Methods and compositions with aldehyde stabilizing solution |
DE69434942T2 (de) * | 1993-02-25 | 2007-11-29 | Abbott Laboratories, Abbott Park | Mehrzweckreagenzsystem zur schnellen lysierung von vollblutproben |
US6190870B1 (en) * | 1995-08-28 | 2001-02-20 | Amcell Corporation | Efficient enrichment and detection of disseminated tumor cells |
GB2313288B (en) * | 1996-05-24 | 2000-07-12 | North Gen Hospital Nhs Trust | Specimen collection fluid |
US6197523B1 (en) * | 1997-11-24 | 2001-03-06 | Robert A. Levine | Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood |
US6670197B2 (en) * | 1997-11-24 | 2003-12-30 | David L. Rimm | Method for assaying whole blood for the presence or absence of circulating cancer or other target cell fragments |
WO1999041613A1 (en) * | 1998-02-12 | 1999-08-19 | Immunivest | Methods and reagents for the rapid and efficient isolation of circulating cancer cells |
AU2876900A (en) * | 1999-02-10 | 2000-08-29 | Cell Works Inc. | Class characterization of circulating cancer cells isolated from body fluids andmethods of use |
AU7351800A (en) * | 1999-09-13 | 2001-04-17 | Neil H. Bander | A method for isolation of prostatic epithelial cells from semen |
WO2003018757A2 (en) * | 2001-08-23 | 2003-03-06 | Immunivest Corporation | Stabilization of cells and biological specimens for analysis |
-
2002
- 2002-08-23 WO PCT/US2002/026867 patent/WO2003018757A2/en active Application Filing
- 2002-08-23 DE DE60227678T patent/DE60227678D1/de not_active Expired - Lifetime
- 2002-08-23 CA CA2457891A patent/CA2457891C/en not_active Expired - Fee Related
- 2002-08-23 CN CNA028212002A patent/CN1596265A/zh active Pending
- 2002-08-23 EP EP02761478A patent/EP1425294B2/en not_active Expired - Lifetime
- 2002-08-23 IL IL16020902A patent/IL160209A0/xx unknown
- 2002-08-23 CN CNA02820820XA patent/CN1571634A/zh active Pending
- 2002-08-23 JP JP2003523961A patent/JP2005502863A/ja active Pending
- 2002-08-23 EP EP02768676A patent/EP1425383A4/en not_active Withdrawn
- 2002-08-23 KR KR10-2004-7002572A patent/KR20040030984A/ko not_active Application Discontinuation
- 2002-08-23 CA CA2457894A patent/CA2457894C/en not_active Expired - Fee Related
- 2002-08-23 WO PCT/US2002/026861 patent/WO2003019141A2/en active Application Filing
- 2002-08-23 KR KR10-2004-7002473A patent/KR20040053115A/ko not_active Application Discontinuation
- 2002-08-23 BR BR0212125-5A patent/BR0212125A/pt not_active IP Right Cessation
- 2002-08-23 BR BR0212124-7A patent/BR0212124A/pt not_active Application Discontinuation
- 2002-08-23 IL IL16021002A patent/IL160210A0/xx unknown
- 2002-08-23 AT AT02761478T patent/ATE401574T1/de not_active IP Right Cessation
- 2002-08-23 JP JP2003523608A patent/JP2005501236A/ja active Pending
-
2008
- 2008-12-24 AU AU2008288601A patent/AU2008288601B2/en not_active Ceased
-
2009
- 2009-01-02 AU AU2009200013A patent/AU2009200013B2/en not_active Ceased
- 2009-01-21 JP JP2009011194A patent/JP2009109514A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1425294B1 (en) | 2008-07-16 |
BR0212125A (pt) | 2005-06-28 |
WO2003019141A3 (en) | 2004-04-01 |
CA2457891A1 (en) | 2003-03-06 |
EP1425383A2 (en) | 2004-06-09 |
CA2457894C (en) | 2014-07-08 |
JP2009109514A (ja) | 2009-05-21 |
JP2005501236A (ja) | 2005-01-13 |
WO2003018757A2 (en) | 2003-03-06 |
AU2009200013A1 (en) | 2009-02-05 |
ATE401574T1 (de) | 2008-08-15 |
JP2005502863A (ja) | 2005-01-27 |
IL160210A0 (en) | 2004-07-25 |
CN1571634A (zh) | 2005-01-26 |
AU2008288601A1 (en) | 2009-04-02 |
IL160209A0 (en) | 2004-07-25 |
AU2009200013B2 (en) | 2012-03-08 |
DE60227678D1 (de) | 2008-08-28 |
CA2457891C (en) | 2019-10-01 |
WO2003019141A2 (en) | 2003-03-06 |
CA2457894A1 (en) | 2003-03-06 |
EP1425294A4 (en) | 2005-11-16 |
CN1596265A (zh) | 2005-03-16 |
KR20040030984A (ko) | 2004-04-09 |
EP1425294A2 (en) | 2004-06-09 |
EP1425294B2 (en) | 2012-12-12 |
KR20040053115A (ko) | 2004-06-23 |
WO2003018757A3 (en) | 2003-09-12 |
AU2008288601B2 (en) | 2012-05-31 |
EP1425383A4 (en) | 2005-11-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0212124A (pt) | Composições, métodos e aparelhos para conservar espécimes biológicos e amostras de sangue suspeitas de conter células tumorais circulantes, e, composição celular estabilizada | |
KR101764597B1 (ko) | 생물학적 샘플에서 희귀 사건 분석을 위한 고감도 다중매개변수 방법 | |
Marrinucci et al. | Case study of the morphologic variation of circulating tumor cells | |
Lazar et al. | Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line | |
Kervarrec et al. | Merkel cell carcinomas infiltrated with CD33+ myeloid cells and CD8+ T cells are associated with improved outcome | |
WO2008109414A3 (en) | Use of endogenous fluorescence to identify invading metastatic breast tumor cells | |
Subramanian et al. | Significance of bone marrow fibrosis in multiple myeloma | |
Steu et al. | A procedure for tissue freezing and processing applicable to both intra-operative frozen section diagnosis and tissue banking in surgical pathology | |
Cattan et al. | Circulating gastrin, endocrine cells, histamine content, and histidine decarboxylase activity in atrophic gastritis | |
Simons et al. | Effects of histological staining on the analysis of human DNA from archived slides | |
Umlas et al. | The effects of glyoxal fixation on the histological evaluation of breast specimens | |
Jones | Papanicolaou staining of air‐dried smears: value in rapid diagnosis | |
US20210252518A1 (en) | Biological sample holder and handler | |
WO2003099222A3 (en) | Pseudo-tissues and uses thereof | |
Zhang et al. | A high-quality biobank supports breast cancer research in Harbin, China | |
Sarioglu et al. | Quantitative digital histochemistry with methenamine silver staining in renal allograft biopsies excluding pure chronic allograft nephropathy cases | |
CN105779559A (zh) | 一种液基细胞处理液 | |
Farcas et al. | High throughput processing and analysis of prostate core biopsies for research applications 1 | |
Zickuhr et al. | Spatial Metabolomics co-registered with Multiplex Phenotyping for the Evaluation of Human Kidney Tissue | |
Stevens et al. | Frozen sections of bone biopsies in metabolic and other bone diseases | |
Bravaccini et al. | Is Ki67 still a powerful ally in predicting the clinical benefit of anthracyclines for the adjuvant treatment of early breast cancer? | |
Balasubramanian et al. | Isolation and characterization of circulating tumor cells (CTCs) from peripheral blood specimens of patients with advanced solid tumor malignancies (using ApoStream (TM) instrumentation) | |
Sri-in et al. | Quantitative evaluation of cellular intensity in cytologic staining over difference time period of post air-dried smear in canine mammary gland tumor. | |
Ramanathan et al. | Validation of Tissue Microarray for Immunohistochemical Analysis of Oral Squamous Cell Carcinoma by Using Virtual Cores | |
Wara et al. | The Efficiency of Corn Solution as a Cytological Fixative in Buccal Smear: Corn Solution as Cytological Fixative |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |