CA2359705C - Chromatographic process for purification of albumin - Google Patents

Chromatographic process for purification of albumin Download PDF

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Publication number
CA2359705C
CA2359705C CA2359705A CA2359705A CA2359705C CA 2359705 C CA2359705 C CA 2359705C CA 2359705 A CA2359705 A CA 2359705A CA 2359705 A CA2359705 A CA 2359705A CA 2359705 C CA2359705 C CA 2359705C
Authority
CA
Canada
Prior art keywords
albumin
anion exchange
concentration
process according
cation exchange
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2359705A
Other languages
English (en)
French (fr)
Other versions
CA2359705A1 (en
Inventor
Hendrik Van Urk
David John Mead
Philip Harvey Morton
Andrew John Cartwright
Jason Cameron
David James Ballance
Michel Gaston Joseph Grandgeorge
Stephen Berezenko
John Rodney Woodrow
Darrell Sleep
Jean-Luc Bernard Veron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albumedix Ltd
Original Assignee
Novozymes Biopharma DK AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes Biopharma DK AS filed Critical Novozymes Biopharma DK AS
Publication of CA2359705A1 publication Critical patent/CA2359705A1/en
Application granted granted Critical
Publication of CA2359705C publication Critical patent/CA2359705C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CA2359705A 1999-01-30 2000-01-31 Chromatographic process for purification of albumin Expired - Lifetime CA2359705C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9902000A GB9902000D0 (en) 1999-01-30 1999-01-30 Process
GB9902000.0 1999-01-30
PCT/GB2000/000257 WO2000044772A2 (en) 1999-01-30 2000-01-31 Human serum albumin

Publications (2)

Publication Number Publication Date
CA2359705A1 CA2359705A1 (en) 2000-08-03
CA2359705C true CA2359705C (en) 2011-06-14

Family

ID=10846743

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2359705A Expired - Lifetime CA2359705C (en) 1999-01-30 2000-01-31 Chromatographic process for purification of albumin

Country Status (16)

Country Link
US (3) US7993877B2 (US07993877-20110809-P00003.png)
EP (3) EP2272961A1 (US07993877-20110809-P00003.png)
JP (3) JP4586150B2 (US07993877-20110809-P00003.png)
KR (2) KR100577493B1 (US07993877-20110809-P00003.png)
CN (4) CN1810834B (US07993877-20110809-P00003.png)
AT (1) ATE416254T1 (US07993877-20110809-P00003.png)
AU (2) AU763899B2 (US07993877-20110809-P00003.png)
CA (1) CA2359705C (US07993877-20110809-P00003.png)
DE (1) DE60040967D1 (US07993877-20110809-P00003.png)
DK (1) DK2048234T3 (US07993877-20110809-P00003.png)
ES (1) ES2317827T3 (US07993877-20110809-P00003.png)
GB (1) GB9902000D0 (US07993877-20110809-P00003.png)
HK (2) HK1096691A1 (US07993877-20110809-P00003.png)
MX (1) MXPA01007719A (US07993877-20110809-P00003.png)
SG (2) SG174629A1 (US07993877-20110809-P00003.png)
WO (1) WO2000044772A2 (US07993877-20110809-P00003.png)

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