CA2262454C - Purine inhibitors of cyclin dependent kinase 2 and ikb-.alpha. - Google Patents

Purine inhibitors of cyclin dependent kinase 2 and ikb-.alpha. Download PDF

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Publication number
CA2262454C
CA2262454C CA002262454A CA2262454A CA2262454C CA 2262454 C CA2262454 C CA 2262454C CA 002262454 A CA002262454 A CA 002262454A CA 2262454 A CA2262454 A CA 2262454A CA 2262454 C CA2262454 C CA 2262454C
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CA
Canada
Prior art keywords
substituted
alkyl
compound according
lower alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002262454A
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English (en)
French (fr)
Other versions
CA2262454A1 (en
Inventor
Robert T. Lum
Cheri Lynn Blum
Richard Mackman
Michael M. Wick
Steven R. Schow
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Gilead Palo Alto Inc
Original Assignee
CV Therapeutics Inc
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Application filed by CV Therapeutics Inc filed Critical CV Therapeutics Inc
Publication of CA2262454A1 publication Critical patent/CA2262454A1/en
Application granted granted Critical
Publication of CA2262454C publication Critical patent/CA2262454C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002262454A 1996-08-02 1997-08-01 Purine inhibitors of cyclin dependent kinase 2 and ikb-.alpha. Expired - Fee Related CA2262454C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/692,012 US5866702A (en) 1996-08-02 1996-08-02 Purine inhibitors of cyclin dependent kinase 2
US08/692,012 1996-08-02
PCT/US1997/013386 WO1998005335A1 (en) 1996-08-02 1997-08-01 PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IλB-$g(a)

Publications (2)

Publication Number Publication Date
CA2262454A1 CA2262454A1 (en) 1998-02-12
CA2262454C true CA2262454C (en) 2006-02-07

Family

ID=24778922

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002262454A Expired - Fee Related CA2262454C (en) 1996-08-02 1997-08-01 Purine inhibitors of cyclin dependent kinase 2 and ikb-.alpha.

Country Status (25)

Country Link
US (1) US5866702A (cg-RX-API-DMAC10.html)
EP (1) EP1021186B1 (cg-RX-API-DMAC10.html)
JP (1) JP2000515550A (cg-RX-API-DMAC10.html)
KR (1) KR100403336B1 (cg-RX-API-DMAC10.html)
CN (1) CN1161356C (cg-RX-API-DMAC10.html)
AT (1) ATE298572T1 (cg-RX-API-DMAC10.html)
AU (1) AU731778B2 (cg-RX-API-DMAC10.html)
BR (1) BR9710801A (cg-RX-API-DMAC10.html)
CA (1) CA2262454C (cg-RX-API-DMAC10.html)
CZ (1) CZ299381B6 (cg-RX-API-DMAC10.html)
DE (1) DE69733674T2 (cg-RX-API-DMAC10.html)
DK (1) DK1021186T3 (cg-RX-API-DMAC10.html)
ES (1) ES2242981T3 (cg-RX-API-DMAC10.html)
GE (1) GEP20022786B (cg-RX-API-DMAC10.html)
HU (1) HUP9902414A3 (cg-RX-API-DMAC10.html)
IL (1) IL128323A (cg-RX-API-DMAC10.html)
NO (1) NO323775B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ334061A (cg-RX-API-DMAC10.html)
PL (1) PL189775B1 (cg-RX-API-DMAC10.html)
PT (1) PT1021186E (cg-RX-API-DMAC10.html)
RU (1) RU2220968C2 (cg-RX-API-DMAC10.html)
SI (1) SI1021186T1 (cg-RX-API-DMAC10.html)
TR (1) TR199900683T2 (cg-RX-API-DMAC10.html)
UA (1) UA71890C2 (cg-RX-API-DMAC10.html)
WO (1) WO1998005335A1 (cg-RX-API-DMAC10.html)

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