CA1327799C - Piperazinecarboxylic acid, its preparation and pharmaceutical compositions containing it - Google Patents

Piperazinecarboxylic acid, its preparation and pharmaceutical compositions containing it

Info

Publication number
CA1327799C
CA1327799C CA000559170A CA559170A CA1327799C CA 1327799 C CA1327799 C CA 1327799C CA 000559170 A CA000559170 A CA 000559170A CA 559170 A CA559170 A CA 559170A CA 1327799 C CA1327799 C CA 1327799C
Authority
CA
Canada
Prior art keywords
compound
formula
treatment
pharmaceutically acceptable
monohydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000559170A
Other languages
English (en)
French (fr)
Inventor
Bernhard Aebischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of CA1327799C publication Critical patent/CA1327799C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000559170A 1987-02-18 1988-02-16 Piperazinecarboxylic acid, its preparation and pharmaceutical compositions containing it Expired - Fee Related CA1327799C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8703749 1987-02-18
GB878703749A GB8703749D0 (en) 1987-02-18 1987-02-18 Piperazinecarboxylic acid

Publications (1)

Publication Number Publication Date
CA1327799C true CA1327799C (en) 1994-03-15

Family

ID=10612501

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000559170A Expired - Fee Related CA1327799C (en) 1987-02-18 1988-02-16 Piperazinecarboxylic acid, its preparation and pharmaceutical compositions containing it

Country Status (28)

Country Link
JP (1) JPH0723387B2 (enrdf_load_stackoverflow)
KR (1) KR960015190B1 (enrdf_load_stackoverflow)
AT (1) AT391320B (enrdf_load_stackoverflow)
AU (1) AU613009B2 (enrdf_load_stackoverflow)
BE (1) BE1002427A3 (enrdf_load_stackoverflow)
CA (1) CA1327799C (enrdf_load_stackoverflow)
CH (1) CH675125A5 (enrdf_load_stackoverflow)
CY (1) CY1739A (enrdf_load_stackoverflow)
DE (1) DE3804936C2 (enrdf_load_stackoverflow)
DK (1) DK168441B1 (enrdf_load_stackoverflow)
ES (2) ES2011319A6 (enrdf_load_stackoverflow)
FI (1) FI86733C (enrdf_load_stackoverflow)
FR (1) FR2610932B1 (enrdf_load_stackoverflow)
GB (2) GB8703749D0 (enrdf_load_stackoverflow)
GR (1) GR1002471B (enrdf_load_stackoverflow)
HK (1) HK142093A (enrdf_load_stackoverflow)
HU (2) HU199858B (enrdf_load_stackoverflow)
IE (1) IE59098B1 (enrdf_load_stackoverflow)
IL (1) IL85436A0 (enrdf_load_stackoverflow)
IT (1) IT1219447B (enrdf_load_stackoverflow)
LU (1) LU87129A1 (enrdf_load_stackoverflow)
MY (1) MY103206A (enrdf_load_stackoverflow)
NL (1) NL8800412A (enrdf_load_stackoverflow)
NZ (1) NZ223529A (enrdf_load_stackoverflow)
PH (1) PH25512A (enrdf_load_stackoverflow)
PT (1) PT86776B (enrdf_load_stackoverflow)
SE (1) SE467256B (enrdf_load_stackoverflow)
ZA (1) ZA881146B (enrdf_load_stackoverflow)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU202111B (en) * 1988-03-11 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing (r)-(e)-4--(3-phosphono-2-propenyl)-2-piperazine-carboxylic acid as active component
US5086072A (en) * 1990-06-18 1992-02-04 The United States Of America As Represented By The Department Of Health And Human Services Treatment of mood disorders with functional antagonists of the glycine/nmda receptor complex
EP0488959A3 (en) * 1990-11-28 1992-08-05 Sandoz Ltd. New uses of competitive nmda receptor antagonists
US5260286A (en) * 1992-10-16 1993-11-09 Japan Tobacco, Inc. 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists
EP0826032A1 (de) * 1995-05-08 1998-03-04 Lonza Ag Biotechnologisches verfahren zur herstellung von r-alpha-piperazincarbonsäure und s-alpha-piperazincarbonsäureamid
IL132836A0 (en) 1997-05-12 2001-03-19 Ortho Mcneil Pharm Inc Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
GB9821179D0 (en) * 1998-09-30 1998-11-25 Merck Sharp & Dohme Therapeutic use
JP2008124531A (ja) 2006-11-08 2008-05-29 Nec Electronics Corp 半導体装置およびオーディオプロセッサチップ
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids

Also Published As

Publication number Publication date
GR880100084A (el) 1988-12-16
PT86776B (pt) 1992-05-29
GR1002471B (el) 1996-11-15
HU199858B (en) 1990-03-28
SE8800541D0 (sv) 1988-02-17
FI880744A0 (fi) 1988-02-17
CY1739A (en) 1995-10-20
ES2021904A6 (es) 1991-11-16
FI86733C (fi) 1992-10-12
IE59098B1 (en) 1994-01-12
FI880744L (fi) 1988-08-19
PT86776A (pt) 1988-03-01
MY103206A (en) 1993-05-29
IE880413L (en) 1988-08-18
IL85436A (enrdf_load_stackoverflow) 1992-12-01
JPH0723387B2 (ja) 1995-03-15
AT391320B (de) 1990-09-25
GB8803438D0 (en) 1988-03-16
GB2201676B (en) 1991-01-02
FR2610932B1 (fr) 1990-11-16
HU211269A9 (en) 1995-11-28
DE3804936C2 (de) 1997-02-13
ZA881146B (en) 1989-10-25
AU613009B2 (en) 1991-07-25
PH25512A (en) 1991-07-24
KR880009944A (ko) 1988-10-06
NZ223529A (en) 1991-02-26
IT1219447B (it) 1990-05-18
FI86733B (fi) 1992-06-30
JPS63203691A (ja) 1988-08-23
DK168441B1 (da) 1994-03-28
BE1002427A3 (fr) 1991-02-05
SE467256B (sv) 1992-06-22
IL85436A0 (en) 1988-07-31
KR960015190B1 (ko) 1996-11-01
LU87129A1 (fr) 1988-09-20
CH675125A5 (enrdf_load_stackoverflow) 1990-08-31
AU1175888A (en) 1988-08-25
DK79688D0 (da) 1988-02-16
ATA36788A (de) 1990-03-15
DE3804936A1 (de) 1988-09-01
NL8800412A (nl) 1988-09-16
GB8703749D0 (en) 1987-03-25
IT8847631A0 (it) 1988-02-12
ES2011319A6 (es) 1990-01-01
FR2610932A1 (fr) 1988-08-19
HUT49361A (en) 1989-09-28
GB2201676A (en) 1988-09-07
DK79688A (da) 1988-08-19
HK142093A (en) 1994-01-07

Similar Documents

Publication Publication Date Title
JPH07223953A (ja) 中枢神経系疾患治療用薬剤組成物
SK283313B6 (sk) (S)-Oxybutynín a (S)-deetyloxybutynín, farmaceutické prostriedky s ich obsahom, spôsob prípravy (S)-deetyloxybutynínu a ich použitie na liečenie urinárnej inkontinencie
HK52391A (en) (s)-alpha-ethyl-2-oxo-1-pyrrolidinacetamide
JPH05320162A (ja) ペプチド性キヌクリジン
GB2086393A (en) Bicyclic compounds
CA1327799C (en) Piperazinecarboxylic acid, its preparation and pharmaceutical compositions containing it
EP1044186B1 (en) Substituted 2-benzylamino-2-phenyl-acetamide compounds
EP0726265B1 (de) Antineurodegenerativ wirksame 10-Aminoaliphatyl-dibenz- b,f oxepine
RU2157802C2 (ru) Бициклические производные изотиомочевины, способ их получения и фармацевтическая композиция на их основе
HU211517A9 (en) 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them
RO104347B1 (en) Production method of amids acids cyclomethylen - 1,2 - dicarboxylic
EP0146159B1 (en) Ether of n-propanolamine derivative
US6943195B2 (en) Cycloalkenone derivative
US4218479A (en) Novel benzylalcohols and pharmaceutical compositions and use thereof
CA1278572C (en) Ameliorant of cerebral circulation and metabolism
EP0171912B1 (en) Pyrrolizidine compounds, methods for their production, and their uses
JPH07119224B2 (ja) 癲癇およびコカイン嗜癖治療用の５―アミノカルボニル―５Ｈ―ジベンゾ〔ａ，ｄ〕シクロヘプテン―５，１０―イミン
DE2843328A1 (de) Phenylacetamidverbindungen und sie enthaltende zusammensetzung
SK162295A3 (en) N-substituted azaheterocyclic carboxylic acids and esters thereof
PL153236B1 (pl) Sposób wytwarzania kwasu piperazynokarboksylowego
JPH03163079A (ja) キサンチン誘導体、それらを有効成分とする気管支拡張剤及び脳機能改善剤
HK1028021B (en) Substituted 2-benzylamino-2-phenyl-acetamide compounds
JPH0543579A (ja) フイソスチグミン誘導体

Legal Events

Date Code Title Description
MKLA Lapsed