CA1128512A - 2-amino-3-benzoyl-phenylacetamides and cyclic homologues - Google Patents

2-amino-3-benzoyl-phenylacetamides and cyclic homologues

Info

Publication number
CA1128512A
CA1128512A CA361,068A CA361068A CA1128512A CA 1128512 A CA1128512 A CA 1128512A CA 361068 A CA361068 A CA 361068A CA 1128512 A CA1128512 A CA 1128512A
Authority
CA
Canada
Prior art keywords
amino
compound
benzoyl
process according
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA361,068A
Other languages
English (en)
French (fr)
Inventor
James R. Shanklin, Jr.
Dwight A. Shamblee
David A. Walsh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Application granted granted Critical
Publication of CA1128512A publication Critical patent/CA1128512A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA361,068A 1979-09-26 1980-09-25 2-amino-3-benzoyl-phenylacetamides and cyclic homologues Expired CA1128512A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7886079A 1979-09-26 1979-09-26
US078,860 1979-09-26

Publications (1)

Publication Number Publication Date
CA1128512A true CA1128512A (en) 1982-07-27

Family

ID=22146633

Family Applications (1)

Application Number Title Priority Date Filing Date
CA361,068A Expired CA1128512A (en) 1979-09-26 1980-09-25 2-amino-3-benzoyl-phenylacetamides and cyclic homologues

Country Status (36)

Country Link
JP (1) JPS5657751A (xx)
KR (1) KR840000763B1 (xx)
AT (1) AT374170B (xx)
AU (1) AU532359B2 (xx)
BE (1) BE885393A (xx)
BR (1) BR8006042A (xx)
CA (1) CA1128512A (xx)
CH (1) CH646138A5 (xx)
CS (1) CS227012B2 (xx)
DE (1) DE3035688A1 (xx)
DK (1) DK154136C (xx)
EG (1) EG15020A (xx)
ES (2) ES8200329A1 (xx)
FI (1) FI72967C (xx)
FR (1) FR2465710A1 (xx)
GB (1) GB2059963B (xx)
GR (1) GR70049B (xx)
HK (1) HK59383A (xx)
HU (1) HU183215B (xx)
IE (1) IE50268B1 (xx)
IL (1) IL60999A (xx)
IN (3) IN151313B (xx)
IT (1) IT1133823B (xx)
KE (1) KE3307A (xx)
LU (1) LU82797A1 (xx)
MX (1) MX7159E (xx)
NL (1) NL8005346A (xx)
NO (1) NO152128C (xx)
NZ (1) NZ195061A (xx)
PH (1) PH22628A (xx)
PL (1) PL128998B1 (xx)
PT (1) PT71839B (xx)
SE (1) SE448626B (xx)
SG (1) SG42983G (xx)
YU (3) YU41734B (xx)
ZA (1) ZA805476B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them
US6646001B2 (en) 1997-12-19 2003-11-11 Alcon Manufacturing, Ltd. Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
US6066671A (en) * 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
AR030345A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes relacionados con angiogenesis
JP4350508B2 (ja) 2001-09-03 2009-10-21 ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー ガバペンチンまたはその類似体とα−アミノアミドとを含む薬剤組成物およびその鎮痛用途
EP1438956A1 (en) 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
CZ2009367A3 (cs) * 2009-06-08 2010-06-16 Farmak, A.S. Postup prípravy 2-amino-3-benzoylfenylacetamidu (nepafenacu) s minimem vedlejších produktu
CN112794809B (zh) * 2019-11-14 2023-12-29 南京济群医药科技股份有限公司 一种高纯度奈帕芬胺中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (xx) * 1967-07-31 1971-03-24
CH577461A5 (xx) * 1975-08-13 1976-07-15 Robins Co Inc A H
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2465710B1 (xx) 1984-10-12
CH646138A5 (fr) 1984-11-15
JPH0141616B2 (xx) 1989-09-06
NO152128C (no) 1985-08-07
FI72967B (fi) 1987-04-30
IN156255B (xx) 1985-06-08
EG15020A (en) 1985-03-31
FI803002A (fi) 1981-03-27
PH22628A (en) 1988-10-28
ATA474580A (de) 1983-08-15
IT8024948A0 (it) 1980-09-26
FI72967C (fi) 1987-08-10
AU6211680A (en) 1981-04-02
LU82797A1 (fr) 1982-05-10
YU43306B (en) 1989-06-30
YU43305B (en) 1989-06-30
NO152128B (no) 1985-04-29
IN156254B (xx) 1985-06-08
PL226919A1 (xx) 1982-02-01
ZA805476B (en) 1981-11-25
FR2465710A1 (fr) 1981-03-27
GB2059963B (en) 1983-04-20
GR70049B (xx) 1982-07-26
NL8005346A (nl) 1981-03-30
ES8204715A1 (es) 1982-05-01
DK154136B (da) 1988-10-17
KR830004210A (ko) 1983-07-06
YU73083A (en) 1983-12-31
JPS5657751A (en) 1981-05-20
HU183215B (en) 1984-04-28
PL128998B1 (en) 1984-03-31
GB2059963A (en) 1981-04-29
IT1133823B (it) 1986-07-24
CS227012B2 (en) 1984-04-16
BR8006042A (pt) 1981-04-07
ES495329A0 (es) 1981-10-16
BE885393A (fr) 1981-01-16
KR840000763B1 (ko) 1984-06-08
DE3035688A1 (de) 1981-04-16
KE3307A (en) 1983-08-19
IE801946L (en) 1981-03-26
YU73183A (en) 1983-12-31
PT71839B (en) 1981-06-25
ES8200329A1 (es) 1981-10-16
NO802834L (no) 1981-03-27
PT71839A (en) 1980-10-01
IL60999A0 (en) 1980-11-30
AU532359B2 (en) 1983-09-29
SG42983G (en) 1985-01-11
MX7159E (es) 1987-12-02
SE8006668L (sv) 1981-03-27
DK154136C (da) 1989-03-06
AT374170B (de) 1984-03-26
IN151313B (xx) 1983-03-26
IL60999A (en) 1984-05-31
ES503019A0 (es) 1982-05-01
HK59383A (en) 1983-12-02
DK405780A (da) 1981-03-27
NZ195061A (en) 1984-04-27
IE50268B1 (en) 1986-03-19
SE448626B (sv) 1987-03-09
DE3035688C2 (xx) 1990-05-17
YU245080A (en) 1983-09-30
YU41734B (en) 1987-12-31

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Legal Events

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