BRPI0416852A - inibidores da quinase akt - Google Patents

inibidores da quinase akt

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Publication number
BRPI0416852A
BRPI0416852A BRPI0416852-6A BRPI0416852A BRPI0416852A BR PI0416852 A BRPI0416852 A BR PI0416852A BR PI0416852 A BRPI0416852 A BR PI0416852A BR PI0416852 A BRPI0416852 A BR PI0416852A
Authority
BR
Brazil
Prior art keywords
kinase inhibitors
akt kinase
present
akt
compounds
Prior art date
Application number
BRPI0416852-6A
Other languages
English (en)
Inventor
Ian S Mitchell
Keith L Spencer
Peter Stengel
Yongxin Han
Nicholas C Kallan
Mark Munson
Guy P A Vigers
James Blake
Anthony Piscopio
John Josey
Scott Miller
Dengming Xiao
Riu Xu
Rao Chang
Bin Wang
April L Bernacki
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of BRPI0416852A publication Critical patent/BRPI0416852A/pt

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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • Geometry (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"INIBIDORES DA QUINASE AKT". A presente invenção proporciona compostos, incluindo enantiómeros, diastereómeros, solvatos e sais farmaceuticamente aceitáveis decompostos dos mesmos, compreendendo a Fórmula: A-L-CR, em que CR é um grupo com núcleo cíclico, L é um grupo de ligação e A é conforme definido aqui. Também proporcionados são métodos de uso dos compostos da presente invenção como inibidores da quinase de proteína AKT e para o tratamento de doenças hiperproliferativas, tal como câncer.
BRPI0416852-6A 2003-11-21 2004-11-19 inibidores da quinase akt BRPI0416852A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52400303P 2003-11-21 2003-11-21
PCT/US2004/039094 WO2005051304A2 (en) 2003-11-21 2004-11-19 Akt protein kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0416852A true BRPI0416852A (pt) 2007-02-27

Family

ID=34632854

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416852-6A BRPI0416852A (pt) 2003-11-21 2004-11-19 inibidores da quinase akt

Country Status (14)

Country Link
US (3) US20050130954A1 (pt)
EP (1) EP1684694A2 (pt)
JP (1) JP2007512364A (pt)
KR (2) KR20110137838A (pt)
CN (2) CN102786482A (pt)
AU (1) AU2004293026B2 (pt)
BR (1) BRPI0416852A (pt)
CA (1) CA2546754A1 (pt)
IL (2) IL175221A (pt)
NO (1) NO20062884L (pt)
NZ (2) NZ547327A (pt)
RU (1) RU2006121990A (pt)
WO (1) WO2005051304A2 (pt)
ZA (1) ZA200604069B (pt)

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MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
EP2463268B1 (en) 2004-12-02 2013-08-28 Daiichi Sankyo Company, Limited 4-(Aminomethyl)benzoic acids as intermediates for the preparation of chymase inhibiting 1,4-diazepan-2,5-dione compounds
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EP1702916A1 (en) * 2005-03-18 2006-09-20 Santhera Pharmaceuticals (Schweiz) GmbH DPP-IV inhibitors
EP2354140A1 (en) * 2005-05-20 2011-08-10 Vertex Pharmaceuticals Incorporated Pyrrolopyridines useful as inhibitors of protein kinase
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