BR122019021689B8 - composto, composição farmacêutica, método para a preparação do composto e uso do composto - Google Patents

composto, composição farmacêutica, método para a preparação do composto e uso do composto

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Publication number
BR122019021689B8
BR122019021689B8 BR122019021689A BR122019021689A BR122019021689B8 BR 122019021689 B8 BR122019021689 B8 BR 122019021689B8 BR 122019021689 A BR122019021689 A BR 122019021689A BR 122019021689 A BR122019021689 A BR 122019021689A BR 122019021689 B8 BR122019021689 B8 BR 122019021689B8
Authority
BR
Brazil
Prior art keywords
compound
preparing
pharmaceutical composition
crystallized
pseudopolymorphic
Prior art date
Application number
BR122019021689A
Other languages
English (en)
Other versions
BR122019021689B1 (pt
Inventor
Bonnet Alain
Priour Alain
Giuliani Alexandre
G Dedhiya Mahendra
Spargo Peter
Bhattacharya Sisir
Ravaux Valérie
Ducandas Veronique
Original Assignee
Astra Zeneca Holding France S A S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42154208&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR122019021689(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astra Zeneca Holding France S A S filed Critical Astra Zeneca Holding France S A S
Publication of BR122019021689B1 publication Critical patent/BR122019021689B1/pt
Publication of BR122019021689B8 publication Critical patent/BR122019021689B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

a invenção diz respeito ao sal de sódio de (1r,2s,5r)-7-oxo-6-sulfoóxi-l,6-diazabiciclo[3,2,1]octano-2-carboxamida na forma enantiomérica cristalizada hidratada ou anidra e em particular formas cristalizadas novas polimórficas e pseudopolimórficas "a", "b", "d" e "e" definidos no pedido, assim como o método de preparação. o composto da invenção pode ser usado como um medicamento, em particular um inibidor da beta-lactamase.
BR122019021689A 2009-10-09 2010-10-08 composto, composição farmacêutica, método para a preparação do composto e uso do composto BR122019021689B8 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR0904864 2009-10-09
FR0904864A FR2951171A1 (fr) 2009-10-09 2009-10-09 Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
US26366309P 2009-11-23 2009-11-23
US61/263,663 2009-11-23
PCT/EP2010/065147 WO2011042560A1 (en) 2009-10-09 2010-10-08 Polymorphic and pseudopolymorphic forms of a pharmaceutical compound
BR112012007976-0A BR112012007976B1 (pt) 2009-10-09 2010-10-08 Composto, composição farmacêutica, método para a preparação do composto e uso do composto

Publications (2)

Publication Number Publication Date
BR122019021689B1 BR122019021689B1 (pt) 2020-10-27
BR122019021689B8 true BR122019021689B8 (pt) 2021-05-25

Family

ID=42154208

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122019021689A BR122019021689B8 (pt) 2009-10-09 2010-10-08 composto, composição farmacêutica, método para a preparação do composto e uso do composto
BR112012007976-0A BR112012007976B1 (pt) 2009-10-09 2010-10-08 Composto, composição farmacêutica, método para a preparação do composto e uso do composto

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112012007976-0A BR112012007976B1 (pt) 2009-10-09 2010-10-08 Composto, composição farmacêutica, método para a preparação do composto e uso do composto

Country Status (22)

Country Link
US (5) US8471025B2 (pt)
EP (3) EP3269717B9 (pt)
JP (4) JP6072540B2 (pt)
KR (4) KR20170134791A (pt)
CN (3) CN102834395B (pt)
AU (1) AU2010304974B2 (pt)
BR (2) BR122019021689B8 (pt)
CA (1) CA2716914C (pt)
CY (1) CY1121583T1 (pt)
DK (1) DK3269717T5 (pt)
ES (2) ES2721228T5 (pt)
FI (1) FI3269717T4 (pt)
FR (1) FR2951171A1 (pt)
HU (1) HUE043086T2 (pt)
IL (3) IL218565A0 (pt)
MX (1) MX2012003730A (pt)
MY (1) MY174776A (pt)
PL (1) PL3269717T5 (pt)
PT (1) PT3269717T (pt)
RU (1) RU2727509C2 (pt)
SI (1) SI3269717T2 (pt)
WO (1) WO2011042560A1 (pt)

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Also Published As

Publication number Publication date
AU2010304974B2 (en) 2014-10-23
IL218565A0 (en) 2012-05-31
US9580424B2 (en) 2017-02-28
CN102834395B (zh) 2016-06-29
DK3269717T4 (da) 2023-06-26
US9062053B2 (en) 2015-06-23
PT3269717T (pt) 2019-05-16
KR20170134791A (ko) 2017-12-06
US20140349967A1 (en) 2014-11-27
PL3269717T3 (pl) 2019-07-31
HUE043086T2 (hu) 2019-08-28
JP6321853B2 (ja) 2018-05-09
CN102834395A (zh) 2012-12-19
KR20120106720A (ko) 2012-09-26
EP2486038A1 (en) 2012-08-15
EP3269717B2 (en) 2023-06-14
DK3269717T5 (da) 2023-11-27
RU2012118247A (ru) 2013-11-20
IL239663A0 (en) 2015-08-31
WO2011042560A1 (en) 2011-04-14
EP3269717B9 (en) 2023-08-09
JP2017149754A (ja) 2017-08-31
US20110152311A1 (en) 2011-06-23
AU2010304974A1 (en) 2012-04-05
CN104592229A (zh) 2015-05-06
DK3269717T3 (en) 2019-04-23
US20170210742A1 (en) 2017-07-27
US8471025B2 (en) 2013-06-25
FR2951171A1 (fr) 2011-04-15
KR101817811B1 (ko) 2018-01-11
JP2013507346A (ja) 2013-03-04
US20130267480A1 (en) 2013-10-10
EP2486038B1 (en) 2017-08-30
KR20200010586A (ko) 2020-01-30
JP2016029082A (ja) 2016-03-03
EP3269717B1 (en) 2019-02-27
PL3269717T5 (pl) 2023-09-18
JP6197170B2 (ja) 2017-09-20
KR20180067717A (ko) 2018-06-20
JP6630391B2 (ja) 2020-01-15
RU2015137928A (ru) 2018-12-25
ES2645110T3 (es) 2017-12-04
SI3269717T2 (sl) 2023-09-29
US20150246920A1 (en) 2015-09-03
IL259296B (en) 2021-10-31
IL259296A (en) 2018-07-31
EP3269717A1 (en) 2018-01-17
ES2721228T5 (es) 2023-10-30
EP3505518A1 (en) 2019-07-03
MY174776A (en) 2020-05-14
JP6072540B2 (ja) 2017-02-01
FI3269717T4 (fi) 2023-08-31
CA2716914A1 (en) 2011-04-09
CA2716914C (en) 2020-10-27
ES2721228T3 (es) 2019-07-29
RU2727509C2 (ru) 2020-07-22
BR122019021689B1 (pt) 2020-10-27
CY1121583T1 (el) 2020-05-29
RU2015137928A3 (pt) 2019-04-04
JP2018123151A (ja) 2018-08-09
US8835455B2 (en) 2014-09-16
MX2012003730A (es) 2012-10-03
SI3269717T1 (sl) 2019-05-31
BR112012007976B1 (pt) 2020-03-03
CN109824668A (zh) 2019-05-31

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