BR112015025847B1 - Tampa de recipiente de droga para montagem em recipiente de drogaaberto no topo para formar montagem de reconstituição de droga para uso comseringa sem agulha e montagem de reconstituição de droga pronta para uso - Google Patents
Tampa de recipiente de droga para montagem em recipiente de drogaaberto no topo para formar montagem de reconstituição de droga para uso comseringa sem agulha e montagem de reconstituição de droga pronta para uso Download PDFInfo
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Abstract
Patente de Invenção: "TAMPA DE RECIPIENTE DE DROGA PARA MONTAGEM EM RECIPIENTE DE DROGA ABERTO NO TOPO PARA FORMAR MONTAGEM DE RECONSTITUIÇÃO DE DROGA PARA USO COM SERINGA SEM AGULHA". A presente invenção refere-se a uma tampa de recipiente de droga para montagem em um recipiente de droga aberto no topo para formar uma montagem de reconstituição de droga pronta para uso com uma seringa sem agulha. A tampa de recipiente de droga inclui um batente do recipiente de droga para vedação do recipiente de droga e um membro de transferência de fluido com um conector de seringa sem agulha integral e uma cânula de puncionamento. O membro de transferência de fluido é manualmente disposto ao longo de um par de trilhos em forma de L invertidos diamétricos de uma posição inicial de não punção a uma posição de puncionamento. O par de trilhos em forma de L invertido inclui membros de pressão de uma via para impedir um usuário a retornar o membro de transferência de fluido a uma posição mais anterior, e indicando progresso da ativação do usuário.
Description
[0001] A presente invenção se relaciona a tampas de recipiente de droga para montagem nos recipientes de droga abertos no topo para formar denominadas montagens de reconstituição de droga prontas para uso para uso com seringas sem agulha. As tampas de recipiente de droga incluem um batente do recipiente de droga para vedação de um recipiente de droga aberto no topo e um membro de transferência de fluido com um conector de seringa sem agulha integral e cânula de puncionamento.
[0002] As montagens de reconstituição de droga prontas para uso, incluindo um recipiente de droga aberto no topo e uma tampa de recipiente de droga tendo um membro de transferência de fluido com um conector de seringa sem agulha integral e cânula de puncionamento, são conhecidas na técnica anterior. A técnica anterior exemplar inclui, entre outros:
[0003] Patente dos Estados Unidos No. 4.576.211 para Valentini et al. intitulada SAFETY DEVICE FOR CONNECTION OF A SYRINGE WITH THE MOUTH OR OPENING OF A BOTTLE CONTAINING A DRUG OR A SMALL TUBE FOR DRUG DELIVERY FROM THE SYRINGE
[0004] Patente dos Estados Unidos No. 5.429.614 para Fowles et al. intitulado DRUG DELIVERY SYSTEM;
[0005] Patente dos Estados Unidos No. 5.776.116 para Lopez et al. intitulada MEDICAL CONNECTOR;
[0006] Patente dos Estados Unidos No. 5.902.280 para Powles et al. intitulada ASPIRATION NEEDLE APPARATUS INCORPORATING ITS OWN VACUUM AND METHOD AND ADAPTER FOR USE THEREWITH;
[0007] Patente dos Estados Unidos No. 6.070.623 para Aneas in titulada CONNECTING DEVICE IN PARTICULAR BETWEEN A RECEPTACLE WITH A STOPPER CAPABLE OF BEING PERFORATED AND A SYRINGE;
[0008] Patente dos Estados Unidos No. 6.382.442 para Thibault et al. intitulada PLASTIC CLOSURE FOR VIALS AND OTHER MEDICAL CONTAINERS;
[0009] Patente dos Estados Unidos No. 6.478.788 para Aneas inti tulada DEVICE FOR CONNECTION BETWEEN A RECIPIENT AND A CONTAINER AND READY-TO-USE ASSEMBLY COMPRISING SUCH A DEVICE;
[00010] Patente dos Estados Unidos No. 6.706.031 para Manera intitulada NEEDLELESS ACCESS APPARATUS AND SYSTEM;
[00011] Patente dos Estados Unidos No. 7.074.216 para Fowles et al. intitulada SLIDING RECONSTITUTION DEVICE FOR A DILUENT CONTAINER;
[00012] Patente dos Estados Unidos No. 7.195.623 para Burroughs et al. intitulada KIT INCLUDING SIDE FIRING SYRINGE NEEDLE FOR PREPARING A DRUG IN NA INJECTION PEN CARTRIDGE;
[00013] Patente dos Estados Unidos No. 7.615.041 para Sullivan et al. intitulada VIAL ADAPTER;
[00014] Patente dos Estados Unidos No. 8.225.949 para Aneas intitulada PLUG DEVICE FOR A CONTAINER AND CONTAINER PROVIDED WITH ONE SUCH DEVICE;
[00015] Patente dos Estados Unidos No. 8.480.646 para Nord et al. intitulada MEDICAL DEVICE CONNECTOR;
[00016] Patente dos Estados Unidos No. 8.562.582 para Tuckwell et al. intitulada RECONSTITUTION DEVICE;
[00017] Publicação de Pedido de Patente dos Estados Unidos No. 2012/0310203 intitulada APPARATUS AND METHOD;
[00018] Publicação de Pedido de Patente dos Estados Unidos No. 2013/0053814 intitulada DEVICE.
[00019] Existe uma necessidade de montagens de reconstituição de droga aperfeiçoadas prontas para uso incluindo um recipiente de droga aberto no topo e uma tampa de recipiente de droga montada no mesmo.
[00020] A presente invenção é direcionada a tampas de recipiente de droga para montagem em um recipiente de droga aberto no topo para formar uma assim denominada montagem de reconstituição de droga pronta para uso para uso com uma seringa sem agulha.
[00021] As tampas de recipiente de droga incluem três componentes maiores conforme segue: um alojamento de tampa para montagem seguramente em um recipiente de droga aberto no topo, um batente do recipiente de droga seguramente montado no alojamento de tampa para vedação do recipiente de droga, e um membro de transferência de fluido deslizantemente montado no alojamento de tampa. O membro de transferência de fluido inclui um conector de seringa sem agulha integralmente formado com uma cânula de puncionamento para puncionamento do batente do recipiente de droga, e em comunicação de fluxo com o conector de seringa sem agulha.
[00022] O alojamento de tampa, de preferência, inclui um par de trilhos em forma de L invertidos diamétricos para guiar o deslocamento descendente do membro de transferência de fluido de uma posição inicial de não punção para uma posição de punção final. Alternativa- mente, os alojamentos de tampa podem ser projetados com um trilho em forma de L invertido único, ou três ou mais trilhos em forma de L invertidos.
[00023] Os trilhos em forma de L invertidos são configurados para requererem que um usuário realize duas ações para guiar um membro de transferência de fluido de sua posição inicial de não punção para sua posição de punção final, conforme segue: Uma rotação horária menor inicial para iniciar a montagem de reconstituição de droga pronta para ativação e um subsequente deslocamento de ativação maior para puncionamento de um batente do recipiente de droga. Os trilhos em forma de L invertidos asseguram uma trajetória segura, evitando pré-puncionamento inadvertente, e incluem membros de pressão de uma via para impedir que um usuário retorne o membro de transferência de fluido para uma posição mais anterior proporcionando, desse modo, evidência de integridade. Os membros de pressão de uma via também proporcionam indicações audíveis ao usuário para indicar para proceder para a próxima ação do usuário.
[00024] As tampas de recipiente de droga podem ter alojamentos de tampa com trilhos em forma de L invertidos, ou abertos, ou fechados. O primeiro requer uma blindagem adicional para vedar hermeticamente uma cânula de puncionamento dependente para baixo. O último requer uma luva adicional exterior montada no alojamento de tampa para vedação dos trilhos abertos, evitando, desse modo, a ne-cessidade da blindagem adicional.
[00025] Os membros de transferência de fluido podem ser providos em uma versão ventilada, ou em uma versão não ventilada. Os conectores de seringa sem agulha podem ser formados como um conector Luer fêmea. Os conectores de seringa sem agulha podem ser formados como um orifício de autovedação que pode ser limpo para aspirações múltiplas de conteúdos de droga líquidos.
[00026] De modo a compreender a invenção, e ver como ela pode ser efetuada na prática, modalidades preferidas serão agora descritas, por meio de exemplos não limitativos somente, com referência aos desenhos acompanhantes em que partes similares são, do mesmo modo, numeradas, e em que:
[00027] A Fig. 1 é uma representação pictórica de uma primeira modalidade de uma montagem de reconstituição de droga de acordo com a presente invenção em uma posição inicial de não punção para uso com uma seringa sem agulha;
[00028] A Fig. 2 é uma vista em elevação frontal desmontada da montagem de reconstituição de droga da Figura 1;
[00029] A Fig. 3 é uma vista em elevação superior da montagem de reconstituição de droga da Figura 1;
[00030] A Fig. 4 é um corte transversal longitudinal da montagem de reconstituição de droga da Figura 1 ao longo da linha A-A na Figura 3;
[00031] A Fig. 5 é um corte transversal longitudinal da montagem de reconstituição de droga da Figura 1 ao longo da linha B-B na Figura 3;
[00032] A Fig. 6 é uma vista em elevação frontal explodida da montagem de reconstituição de droga da Figura 1;
[00033] A Fig. 7 é um corte transversal longitudinal da montagem de reconstituição de droga da Figura 1 ao longo da linha C-C na Figura 6;
[00034] A Fig. 8 é uma vista em elevação frontal do membro de transferência de fluido da Figura 6 com conector de seringa sem agulha integral e cânula de puncionamento;
[00035] A Fig. 9 é um corte transversal longitudinal do membro de transferência de fluido da Figura 8 ao longo da linha D-D desta;
[00036] A Fig. 10 é um corte transversal longitudinal do alojamento de tampa da tampa de recipiente de droga da Figura 1 e o batente do recipiente de droga;
[00037] A Fig. 11 é um corte transversal longitudinal da tampa de recipiente de droga da Figura 1 em uma posição inicial de não punção;
[00038] A Fig. 12 é um corte transversal longitudinal da tampa de recipiente de droga da Figura 1 sendo impelida a uma posição preparada pronta para ativação;
[00039] A Fig. 13 é um corte transversal longitudinal da tampa de recipiente de droga da Figura in em uma posição de punção final;
[00040] As Figs. 14A a 14C mostram o uso da montagem de reconstituição de droga da Figura 1;
[00041] A Fig. 15 é uma vista em elevação frontal de uma segunda modalidade de uma montagem de reconstituição de droga de acordo com a presente invenção em uma posição inicial de não punção; e
[00042] A Fig. 16 é um corte transversal longitudinal da montagem de reconstituição de droga da Figura 15 ao longo da linha E-E desta.
[00043] A Figura 1 mostra uma montagem de reconstituição de droga 100 pronta para uso para uso com uma seringa sem agulha 10 que constitui uma fonte de fluido fisiológico. A montagem de reconstituição de droga 100 inclui um recipiente de droga aberto no topo 20 constituído por um frasco de droga aberto no topo e uma tampa de recipiente de droga 30 seguramente montada no mesmo. O recipiente de droga aberto no topo 20 pode ser alternativamente constituído por outros recipientes médicos e receptáculos para armazenagem de drogas em pó ou líquida.
[00044] A seringa 10 inclui um tambor 11 com um êmbolo 12 e um conector Luer lock macho 13. A seringa 10 pode ser formada com outros tipos de conectores machos. A seringa 10 é preenchida com um componente líquido 14. O componente líquido 14 pode ser diluente somente. Alternativamente, o componente líquido 14 pode incluir um componente ativo.
[00045] A Figura 2 mostra que o frasco de droga aberto no topo 20 tem um eixo longitudinal 21 e inclui um ressalto do frasco de droga 22, um aro do frasco de droga 23 e um gargalo do frasco de droga estreito intermediário 24. O aro do frasco de droga 23 define uma abertura do frasco de droga 26. O frasco de droga 20 contém uma droga em pó ou uma droga líquida 27.
[00046] As Figuras 2 a 13 mostram que a tampa de recipiente de droga 30 inclui uma linha de centro longitudinal 31 e um alojamento de tampa 32 para encaixe seguro da montagem no frasco de droga 20 e um batente do recipiente de droga 33 para vedação da abertura do frasco de droga 26. O alojamento de tampa 32 acomoda um membro de transferência de fluido 34 que desliza deslocavelmente de uma posição inicial de não punção para uma posição de punção final para puncionamento do batente do recipiente de droga 33. O membro de transferência de fluido 34 inclui um conector de seringa sem agulha integral 36 e uma cânula de puncionamento 37 em comunicação de fluxo com o conector de seringa 36. O conector de seringa sem agulha 36 é formado como um conector Luer fêmea que pode ser limpo para montagem de rosca de um conector fêmea 13 no mesmo. A tampa de recipiente de droga 30 inclui uma tampa de fechamento 38 para vedação do conector de seringa sem agulha 36.
[00047] O alojamento de tampa 32 é produzido de material plástico adequado, e inclui um par de trilhos em forma de L invertidos diamétri- cos 39 para guiar o deslocamento de ativação do membro de transferência de fluido 34 de sua posição inicial de não punção para sua posição de punção final. A tampa de recipiente de droga 30 inclui uma luva 41 exterior ao alojamento de tampa 32 para vedação do par de trilhos em forma de L invertidos diamétricos 39 para assegurar a esterilidade da cânula de puncionamento 37. A luva 41 inclui membros de encaixe 42 para encaixe no aro do frasco de droga 23 na depressão descendente da tampa de recipiente de droga 30 no frasco de droga 20 durante montagem da montagem de reconstituição de droga 100 pronta para uso.
[00048] O membro de transferência de fluido 34 inclui um membro de base circular 43 formado com o conector de seringa sem agulha 36 e a cânula de puncionamento 37. O membro de base 43 inclui um par de pinos direcionados externos diamétricos 44 para deslocamento ao longo do par de trilhos em forma de L invertidos diamétricos 39 para deslocamento de ativação guiado do membro de transferência de fluido 34. O membro de transferência de fluido 34 opcionalmente inclui uma disposição de ventilação 46 conforme revelada na Publicação Internacional WIPO No. WO 2011/104712 comumente cedida intitulada LIQUID DRUG TRANSFER DEVICE WITH VENTED VIAL ADAPTER.
[00049] O alojamento de tampa 32 inclui um membro cruzado 47 tendo um lado superior do membro cruzado 47A e um lado inferior do membro cruzado 47B, e formado com uma abertura central 48 para passagem através do mesmo da cânula de puncionamento 37. O lado inferior do alojamento cruzado 47B é integralmente formado com o batente do recipiente de droga 33. O membro cruzado 47 e o batente do recipiente de droga 33 podem ser sobremoldados juntos. Alternativa-mente, o membro cruzado 47 pode ser mecanicamente fixado ao batente do recipiente de droga 33, rebitado a este, aderido a este, e similares.
[00050] Os trilhos em forma de L invertidos 39 cada inclui uma perna de acesso vertical de extremidade aberta 49 codirecional com a linha de centro longitudinal 31, uma perna de iniciação horizontal 51 transversal à linha de centro longitudinal 31, e uma perna de ativação vertical 52 codirecional com a linha de centro longitudinal 31. A perna de ativação vertical maior 52 tem uma extremidade de perna de ativa-ção proximal 52A e uma extremidade de perna de ativação distal 54B correspondentemente adjacente e distal à perna de iniciação 51.
[00051] Os trilhos em forma de L invertidos 39 também cada um inclui três membros de pressão de uma via, conforme segue:
[00052] Um membro de pressão de retenção de uma via 53 em uma junção 54 entre a perna de acesso vertical aberta 49 e a perna de iniciação horizontal 51. O membro de pressão de retenção de uma via 53 retém o membro de transferência de fluido 34 no alojamento de tampa 32 antes do uso.
[00053] Um membro de pressão iniciado de uma via 56 em uma junção 57 entre a perna de iniciação horizontal 51 e a extremidade de perna de ativação proximal 52A.
[00054] Um membro de pressão ativado de uma via 58 na extremidade de perna de ativação distal 52B.
[00055] A Figura 11 mostra o membro de transferência de fluido 34 em sua posição de instalação inicial antes do uso. O par de pinos direcionados para fora 44 está localizado ao longo do par de pernas de iniciação horizontal 51 que ultrapassa o par de membros de pressão de retenção de uma via 53 e antes do par de membros de pressão iniciado de uma via 56. A cânula de puncionamento 36 é desdobrada acima da abertura central 48 em posição para puncionar o batente do recipiente de droga 33.
[00056] A Figura 12 mostra o membro de transferência de fluido 34 sendo impelido ultrapassando o par de membros de pressão iniciado de uma via 56 para sua posição iniciada no par de extremidades de perna de ativação proximal 52A pronto para ativação. Esta posição é capacitada por um usuário rosquear uma seringa sem agulha 10 na montagem de reconstituição de droga 100, e procedendo a girar a seringa sem agulha 10 em uma direção de aperto horária até que o par de pinos direcionados para fora 44 pressione o par de membros de pressão iniciado de uma via 56. O usuário ouve um clique a medida que o par de pinos direcionados para fora 44 pressiona o par de membros de pressão iniciado de uma via 56 para indicar que ele pode proceder com a ativação. A cânula de puncionamento 36 permanece desdobrada acima da abertura central 48 em posição para puncionar o batente do recipiente de droga 33. O par de membros de pressão iniciado de uma via 56 impede o membro de transferência de fluido 34 de ser retornado ao par de pernas de iniciação horizontal 51.
[00057] A Figura 13 mostra o membro de transferência de fluido 34 em sua posição ativada no par de extremidades de perna de ativação distal 52B. Esta posição é capacitada por um usuário pressionando a seringa sem agulha 10 em direção ao frasco de droga 20 até que o par de pinos direcionados para fora 44 pressione o par de membros de pressão ativado de uma via 58. O usuário ouve um clique a medida que o par de pinos direcionados para fora 44 pressiona o par de membros de pressão ativado de uma via 58, indicando que ele pode proceder com a reconstituição e administração da droga. O par de membros de pressão ativado de uma via 58 impede o membro de transferência de fluido 34 de ser retornado a uma posição mais anterior.
[00058] O uso da montagem de reconstituição de droga 100 é agora descrito com referência às Figuras 14A a 14C conforme segue:
[00059] A Figura 14A mostra a montagem de reconstituição de droga 100 em sua posição de montagem antes do uso conforme mostrado na Figura 11. Um usuário remove a tampa de fechamento 38 da montagem de reconstituição de droga 100 para expor o conector de seringa sem agulha 36.
[00060] A Figura 14B mostra o usuário rosqueando a seringa sem agulha 10 no conector de seringa sem agulha 36 em uma direção horária denotada pela seta A para inicialmente vedar a seringa 10 no mesmo e, subsequentemente, impelir o membro de transferência de fluido 34 a parar no par de extremidades de perna de ativação proxi mal 52A, conforme mostrado na Figura 12. O usuário ouve um clique a medida que o membro de transferência de fluido 34 ultrapassa o par de membros de pressão iniciado de uma via 56 para indicar que a montagem de reconstituição de droga 100 é iniciada para ativação.
[00061] A Figura 14C mostra que o usuário empurra o membro de transferência de fluido 34 para baixo ao longo das pernas de ativação 52, conforme denotado pela seta B para parar na extremidade do par de pernas de ativação distal 52B, conforme mostrado na Figura 13. O deslocamento faz com que a cânula de puncionamento 37 puncione através do batente do recipiente de droga 33. O usuário ouve um clique a medida que o membro de transferência de fluido 34 ultrapassa o par de membros de pressão ativado de uma via 58 para indicar que ele proceda com a reconstituição e administração da droga.
[00062] As Figuras 15 e 16 mostram uma montagem de reconstituição de droga 200 pronta para uso similar em construção e operação conforme a montagem de reconstituição de droga 100 pronta para uso, e, portanto, partes similares são, do mesmo modo, numeradas. A última 200 difere da primeira 100, visto que a última 200 não tem a luva 41 e, portanto, seu alojamento de tampa 32 é formado com os membros de encaixe 42, e tem um par de trilhos em forma de L invertidos abertos diamétricos 39. A última 200 inclui uma blindagem 61 colocada na cânula de puncionamento 37 para assegurar esterilidade. A blindagem 61 se rompe, e é impelida para cima contra o lado inferior do membro cruzado 48B no deslocamento descendente do membro de transferência de fluido 34 para sua posição de punção final.
[00063] Enquanto que a invenção foi descrita com relação a um número limitado de modalidades, será apreciado que muitas variações, modificações, e outras aplicações da invenção podem ser feitas dentro do escopo das reivindicações em anexo.
Claims (4)
1. Tampa de recipiente de droga para montagem em um recipiente de droga aberto no topo para formar uma montagem de reconstituição de droga pronta para uso para uso com uma seringa sem agulha, o recipiente de droga aberto no topo tendo um aro de recipiente de droga que define uma abertura do recipiente de droga, a tampa de recipiente de droga tendo uma linha de centro longitudinal, e sendo caracterizada pelo fato de compreender: (a) um alojamento de tampa tubular para montagem segura no aro do recipiente de droga, o referido alojamento de tampa incluindo pelo menos um trilho em forma de L invertido (39) tendo uma perna de acesso vertical de extremidade aberta (49), uma perna de iniciação horizontal (51), e uma perna de ativação vertical (52), a referida perna de ativação tendo uma extremidade de perna de ativação proximal (52A) e uma extremidade de perna de ativação distal (54B) correspondentemente adjacentes e distais à referida perna de iniciação, cada referido trilho em forma de L invertido tendo: i) um membro de pressão de retenção de uma via (53) entre referida perna de acesso vertical de extremidade aberta e referida perna de iniciação horizontal (51), ii) um membro de pressão iniciado de uma via (56) entre referida perna de iniciação horizontal (51) e referida extremidade de perna de ativação proximal (52A), e iii) um membro de pressão ativado de uma via (58) em direção à referida extremidade de perna de ativação distal (54B); (b) um batente do recipiente de droga (33) montado fixamente no referido alojamento de tampa para vedação da abertura do recipiente de droga na montagem segura do referido alojamento de tampa no aro do recipiente de droga; e (c) um membro de transferência de fluido (34) tendo um conector de seringa sem agulha integral (36) e uma cânula de puncio- namento (37) em comunicação de fluxo com estes, referido conector de seringa sem agulha para fixação da seringa sem agulha ao mesmo, referida cânula de puncionamento (37) para puncionamento do referido batente do recipiente de droga (33), o referido membro de transferência de fluido (34) sendo inicialmente disposto ao longo de cada referida perna de iniciação horizontal (51) ao que, na rotação manual do referido membro de transferência de fluido (34) relativo à referida linha de centro longitudinal, o referido membro de transferência de fluido (34) é impelido a ultrapassar cada referido membro de pressão iniciado de uma via para cada referida extremidade de perna de ativação proximal (52A) antes de ser manualmente impelido a ultrapassar cada referido membro de pressão ativado de uma via para cada referida extremidade de perna de ativação distal (54B) para puncionamento do referido batente do recipiente de droga (33) para comunicação de fluxo com o recipiente de droga.
2. Tampa, de acordo com a reivindicação 1, caracterizada pelo fato de que compreende adicionalmente uma luva exterior ao referido alojamento de tampa para vedação de cada referido trilho em forma de L invertido para assegurar esterilidade da referida cânula de puncionamento (37).
3. Tampa, de acordo com a reivindicação 1, caracterizada pelo fato de que compreende adicionalmente uma blindagem na referida cânula de puncionamento (37).
4. Montagem de reconstituição de droga pronta para uso, caracterizada pelo fato de que inclui um recipiente de droga aberto no topo, e uma tampa de recipiente de droga, como definida em qualquer uma das reivindicações 1 a 3, montados na mesma.
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US9308020B2 (en) | 2013-03-14 | 2016-04-12 | Cook Medical Technologies Llc | Tri-fluted vascular access needle |
USD733293S1 (en) | 2013-03-15 | 2015-06-30 | Rocomp Global, Llc | Energy guide |
USD720850S1 (en) | 2013-03-15 | 2015-01-06 | Sanovas, Inc. | Catheter hub |
US9919826B2 (en) | 2013-09-23 | 2018-03-20 | Becton Dickinson and Company Ltd. | Piercing member for container access device |
AU353353S (en) | 2013-10-02 | 2014-01-21 | Terumo Corp | Medical syringe |
US20150305770A1 (en) | 2014-03-12 | 2015-10-29 | Epicardial Frontiers, LLC | System and method of image guided pericardial procedures including pericardioscopy, pericardial ablation, pericardial material delivery, pericardial tissue grasping and manipulation, pericardial lead placement, and pericardial surgical fastener placement |
USD750235S1 (en) | 2014-03-19 | 2016-02-23 | ERBE-USA, Inc. | Endoscope connector |
JP6368603B2 (ja) | 2014-09-25 | 2018-08-01 | テルモ株式会社 | 消毒キャップ |
-
2013
- 2013-04-14 IL IL225734A patent/IL225734A0/en unknown
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2014
- 2014-04-03 EP EP14723892.7A patent/EP2986267B1/en active Active
- 2014-04-03 US US14/784,300 patent/US9801786B2/en active Active
- 2014-04-03 BR BR112015025847-6A patent/BR112015025847B1/pt active IP Right Grant
- 2014-04-03 JP JP2016507113A patent/JP5993533B2/ja active Active
- 2014-04-03 CN CN201480021147.7A patent/CN105120826B/zh active Active
- 2014-04-03 DK DK14723892.7T patent/DK2986267T3/en active
- 2014-04-03 WO PCT/IL2014/050327 patent/WO2014170888A1/en active Application Filing
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2015
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US20160051446A1 (en) | 2016-02-25 |
WO2014170888A1 (en) | 2014-10-23 |
BR112015025847A2 (pt) | 2017-07-25 |
JP5993533B2 (ja) | 2016-09-14 |
IL225734A0 (en) | 2013-09-30 |
US9801786B2 (en) | 2017-10-31 |
IL241889B (en) | 2019-02-28 |
EP2986267B1 (en) | 2017-06-07 |
CN105120826B (zh) | 2016-09-21 |
CN105120826A (zh) | 2015-12-02 |
DK2986267T3 (en) | 2017-09-11 |
EP2986267A1 (en) | 2016-02-24 |
JP2016515439A (ja) | 2016-05-30 |
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