BR112015024423A2 - polipeptídeo glicosilado com cadeia de açúcar sialilada - Google Patents

polipeptídeo glicosilado com cadeia de açúcar sialilada

Info

Publication number
BR112015024423A2
BR112015024423A2 BR112015024423A BR112015024423A BR112015024423A2 BR 112015024423 A2 BR112015024423 A2 BR 112015024423A2 BR 112015024423 A BR112015024423 A BR 112015024423A BR 112015024423 A BR112015024423 A BR 112015024423A BR 112015024423 A2 BR112015024423 A2 BR 112015024423A2
Authority
BR
Brazil
Prior art keywords
polypeptide
sugar chain
glycosylated
sialylated
seq
Prior art date
Application number
BR112015024423A
Other languages
English (en)
Other versions
BR112015024423B1 (pt
Inventor
Sakamoto Izumi
Tezuka Katsunari
Ohuchi Masaki
Maeda Masatoshi
Nishihara Mika
Kajihara Yasuhiro
Original Assignee
Glytech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glytech Inc filed Critical Glytech Inc
Publication of BR112015024423A2 publication Critical patent/BR112015024423A2/pt
Publication of BR112015024423B1 publication Critical patent/BR112015024423B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

resumo “polipeptídeo glicosilado com cadeia de açúcar sialilada” o objeto da presente invenção consiste em proporcionar polipeptídeo glicosilado possuindo uma atividade de interferão ß com cadeias de açúcar sialiladas altamente uniformes. o presente invento é um polipeptídeo glicosilado, em que o polipeptídeo é qualquer polipeptídeo selecionado a partir do grupo consistindo dos seguintes (1) a (4): (1) um polipeptídeo que consiste na sequência de aminoácidos representada pela seq id no. 1; (2) um polipeptídeo possuindo um ou poucos aminoácidos eliminados, substituídos ou adicionados no polipeptídeo que consiste na sequência de aminoácidos representada pela seq id no. 1; (3) um polipeptídeo que é um análogo de interferão ß; e (4) um polipeptídeo possuindo 80% ou mais de homologia com o polipeptídeo consistindo na sequência de aminoácidos representada pela seq id no. 1; em que os aminoácidos nas posições 4 a 6 são substituídos com aminoácidos glicosilados; e em que todos os terminais não-redutores da referida cadeia de açúcar são sialilados.
BR112015024423-8A 2013-03-29 2014-03-24 Polipeptídeo glicosilado tendo atividade de interferon ?, composição farmacêutica e uso de um polipeptídeo glicosilado BR112015024423B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013-073703 2013-03-29
JP2013073703 2013-03-29
PCT/JP2014/058127 WO2014157107A1 (ja) 2013-03-29 2014-03-24 シアリル化糖鎖が付加されたポリペプチド

Publications (2)

Publication Number Publication Date
BR112015024423A2 true BR112015024423A2 (pt) 2017-07-18
BR112015024423B1 BR112015024423B1 (pt) 2023-04-25

Family

ID=51624080

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015024423-8A BR112015024423B1 (pt) 2013-03-29 2014-03-24 Polipeptídeo glicosilado tendo atividade de interferon ?, composição farmacêutica e uso de um polipeptídeo glicosilado

Country Status (16)

Country Link
US (1) US10053499B2 (pt)
EP (1) EP2982686B1 (pt)
JP (1) JP6368706B2 (pt)
KR (1) KR102186063B1 (pt)
CN (1) CN104334574B (pt)
AU (1) AU2014245917B2 (pt)
BR (1) BR112015024423B1 (pt)
CA (1) CA2908211C (pt)
DK (1) DK2982686T3 (pt)
ES (1) ES2687801T3 (pt)
MY (1) MY171183A (pt)
PH (1) PH12015502224B1 (pt)
RU (1) RU2668163C2 (pt)
SG (1) SG11201507769SA (pt)
TW (1) TWI638830B (pt)
WO (1) WO2014157107A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102493562B1 (ko) * 2016-07-01 2023-01-30 다이이찌 산쿄 가부시키가이샤 hANP-Fc 함유 분자 콘주게이트
JP6852397B2 (ja) * 2016-12-28 2021-03-31 株式会社島津製作所 分析用試料の調製方法および分析方法
WO2023145812A1 (ja) * 2022-01-31 2023-08-03 株式会社日本触媒 グルコセレブロシダーゼ活性を有する糖鎖付加タンパク質

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0237019A3 (en) 1986-03-14 1988-03-09 Toray Industries, Inc. Interferon conjugate and production thereof using recombinant gene
AU736993B2 (en) 1997-01-16 2001-08-09 Novo Nordisk A/S Practical in vitro sialylation of recombinant glycoproteins
DE19717864C2 (de) 1997-04-23 2001-05-17 Fraunhofer Ges Forschung Humanes rekombinantes Interferon-beta, Verfahren zu seiner Herstellung und seine Verwendung
EA003789B1 (ru) 1998-04-28 2003-10-30 Апплайд Резеч Системз Арс Холдинг Н.В. КОНЪЮГАТЫ ПОЛИОЛ-β-ИНТЕРФЕРОН
CN100480266C (zh) 1998-10-16 2009-04-22 拜奥根Idec马萨诸塞公司 干扰素-β融合蛋白及用途
LT2599503T (lt) 1998-10-16 2017-06-26 Biogen Ma Inc. Interferono beta-1a polimero konjugatai ir jų panaudojimas
US6514729B1 (en) 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
ATE385517T1 (de) 1999-12-08 2008-02-15 Amgen Inc Interferon ähnliche moleküle, und deren verwendungen
US7795002B2 (en) 2000-06-28 2010-09-14 Glycofi, Inc. Production of galactosylated glycoproteins in lower eukaryotes
KR20030046411A (ko) 2000-09-08 2003-06-12 그리폰 테라퓨틱스, 인코포레이티드 '위'-천연 화학적 라이게이션
PT1381397E (pt) 2000-10-24 2007-05-31 Cis Bio Int Estabilização de composições radiofarmacêuticas utilizando um tioeter hidrofilo ou um 6-hidroxi-cromano hidrofilo.
DE10104869A1 (de) 2001-02-03 2002-08-08 Cognis Deutschland Gmbh Additiv für ölbasierte Invert-Bohrspülungen
HUP0303251A2 (hu) * 2001-02-27 2003-12-29 Maxygen Aps Béta-interferon-szerű molekulák
EP1368377A2 (en) 2001-03-15 2003-12-10 MERCK PATENT GmbH Modified interferon beta with reduced immunogenicity
AUPR544401A0 (en) 2001-06-04 2001-06-28 Bischof, Robert Juergen Animal model for allergy
DK1405858T3 (da) 2001-06-19 2013-02-18 Glytech Inc Fremgangsmåde til at fremstille sukkerkædeasparaginderivat.
US7226903B2 (en) 2001-10-10 2007-06-05 Neose Technologies, Inc. Interferon beta: remodeling and glycoconjugation of interferon beta
AU2002358181A1 (en) 2001-12-11 2003-07-09 Aventis Pasteur Mutated hiv tat
JP2005519946A (ja) 2002-03-12 2005-07-07 マキシジェン エーピーエス 発作の処置のためのインターフェロンβ様分子
US7943763B2 (en) 2002-07-05 2011-05-17 Otsuka Chemical Holdings Co., Ltd. Process for preparing glycopeptides having asparagine-linked oligosaccharides, and the glycopeptides
AU2003254641A1 (en) 2002-08-28 2004-03-19 Maxygen Aps Interferon beta-like molecules for treatment of cancer
DE60332358D1 (de) * 2002-09-09 2010-06-10 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
CA2500626A1 (en) 2002-10-01 2004-04-15 Xencor, Inc. Interferon variants with improved properties
US20040070046A1 (en) 2002-10-15 2004-04-15 Hiroaki Niimi Reliable dual gate dielectrics for MOS transistors
TWI335920B (en) 2002-12-24 2011-01-11 Yasuhiro Kajihara Sugar chain asparagine derivatives, sugar chain asparagine and sugar chain and manufacture thereof
US7273934B2 (en) 2002-12-26 2007-09-25 Otsuka Chemical Co., Ltd. Three-branched sugar-chain asparagine derivatives, the sugar-chain asparagines, the sugar chains, and processes for producing these
KR20050095609A (ko) 2003-02-04 2005-09-29 오츠카 가가쿠 가부시키가이샤 당사슬 아스파라긴 유도체의 제조방법
US7378531B2 (en) 2003-04-21 2008-05-27 Teva Pharmaceutical Industries Ltd Process for the preparation of valsartan
JP4607017B2 (ja) 2003-07-28 2011-01-05 大塚化学株式会社 アミノ化複合型糖鎖誘導体及びその製造方法
EP1666496B1 (en) 2003-08-25 2014-03-12 Toray Industries, Inc. Interferon-beta composite
EP1734988A4 (en) 2004-03-01 2009-08-05 Enzon Pharmaceuticals Inc INTERFERON BETA-polymer
RU2392963C2 (ru) 2004-08-09 2010-06-27 Элиоз Байофарма, Инк. Синтетические варианты гипергликозилированного протеазо-резистентного полипептида, пероральные композиции и способы применения таких вариантов
EP1789074A4 (en) 2004-08-09 2009-08-12 Alios Biopharma Inc PROTEASE-RESISTANT HYPERGLYCOSYL SYNTHETIC POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME
KR100781666B1 (ko) 2004-11-02 2007-12-03 신영기 인간 인터페론-베타 변이체
US20070011055A1 (en) 2005-07-05 2007-01-11 Netfire 1 Pty Ltd E-commerce with direct access to real-time inventory
US20080003202A1 (en) * 2006-03-28 2008-01-03 Thierry Guyon Modified interferon-beta (IFN-beta) polypeptides
US20080096819A1 (en) 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
CA2696615A1 (en) * 2007-06-19 2008-12-24 Otsuka Chemical Co., Ltd. Oligosaccharide chain added glp-1 peptide
WO2009017154A1 (ja) 2007-07-31 2009-02-05 Otsuka Chemical Co., Ltd. ペプチドの製造方法
JP2009242372A (ja) 2008-03-11 2009-10-22 Yokohama City Univ 均一な糖鎖構造を有するエリスロポエチン誘導体
US8765669B2 (en) 2008-06-17 2014-07-01 Glytech, Inc. Glycosylated GLP-1 peptide
CA2733362C (en) 2008-08-08 2016-10-18 Universiteit Gent Cells producing glycoproteins having altered glycosylation patterns and methods and use thereof
AU2009283678B2 (en) 2008-08-19 2014-01-16 Glytech, Inc. Glycoprotein production method and screening method
WO2012051615A1 (en) 2010-10-15 2012-04-19 Transgenrx, Inc. Novel vectors for production of glycosylated interferon
RU2586524C2 (ru) 2011-03-10 2016-06-10 Глитек, Инк. Способ получения гликопептида, имеющего сиалированную сахарную цепь, и способ получения производного сиалилгликоаспарагина
WO2013002330A1 (ja) * 2011-06-29 2013-01-03 協和発酵キリン株式会社 たん白質の精製方法
MY168902A (en) 2011-10-01 2018-12-04 Glytech Inc Glycosylated polypeptide and pharmaceutical composition containing same

Also Published As

Publication number Publication date
RU2668163C2 (ru) 2018-09-26
PH12015502224A1 (en) 2016-02-01
SG11201507769SA (en) 2015-10-29
EP2982686A1 (en) 2016-02-10
CA2908211C (en) 2022-07-19
US20160052987A1 (en) 2016-02-25
JP6368706B2 (ja) 2018-08-01
EP2982686B1 (en) 2018-06-27
KR102186063B1 (ko) 2020-12-03
KR20150139411A (ko) 2015-12-11
US10053499B2 (en) 2018-08-21
CA2908211A1 (en) 2014-10-02
BR112015024423B1 (pt) 2023-04-25
MY171183A (en) 2019-09-30
DK2982686T3 (en) 2018-10-08
WO2014157107A1 (ja) 2014-10-02
TWI638830B (zh) 2018-10-21
RU2015146509A (ru) 2017-05-10
CN104334574A (zh) 2015-02-04
JPWO2014157107A1 (ja) 2017-02-16
EP2982686A4 (en) 2016-10-26
CN104334574B (zh) 2020-01-14
PH12015502224B1 (en) 2016-02-01
AU2014245917A1 (en) 2015-09-24
ES2687801T3 (es) 2018-10-29
TW201518318A (zh) 2015-05-16
AU2014245917B2 (en) 2017-09-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/03/2014, OBSERVADAS AS CONDICOES LEGAIS