BR112015021483A2 - arginina deiminase com reduzida reatividade cruzada para anticorpos adi-peg 20 para o tratamento do câncer - Google Patents
arginina deiminase com reduzida reatividade cruzada para anticorpos adi-peg 20 para o tratamento do câncerInfo
- Publication number
- BR112015021483A2 BR112015021483A2 BR112015021483A BR112015021483A BR112015021483A2 BR 112015021483 A2 BR112015021483 A2 BR 112015021483A2 BR 112015021483 A BR112015021483 A BR 112015021483A BR 112015021483 A BR112015021483 A BR 112015021483A BR 112015021483 A2 BR112015021483 A2 BR 112015021483A2
- Authority
- BR
- Brazil
- Prior art keywords
- adi
- peg
- antibodies
- arginine deiminase
- cancer treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
- C12Y305/03006—Arginine deiminase (3.5.3.6)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
resumo patente de invenção: "arginina deiminase com reduzida reatividade cruzada para anticorpos adi-peg 20 para o tratamento do câncer". a presente invenção refere-se genericamente a proteínas arginina deiminase (adi) isoladas que têm uma reatividade cruzada reduzida com anticorpos anti-adi-peg 20, em comparação com adi-peg 20, mas que podem ter características funcionais comparáveis ou melhores do que as de adi-peg 20, as composições que compreendem as proteínas da adi, e os métodos relacionados de tratamento de doenças dependentes de arginina ou de doenças afins, tais como o câncer. 1/1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361790833P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/026766 WO2014151982A2 (en) | 2013-03-15 | 2014-03-13 | Arginine deiminase with reduced cross-reactivity toward adi – peg 20 antibodies for cancer treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015021483A2 true BR112015021483A2 (pt) | 2017-10-10 |
Family
ID=51581665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015021483A BR112015021483A2 (pt) | 2013-03-15 | 2014-03-13 | arginina deiminase com reduzida reatividade cruzada para anticorpos adi-peg 20 para o tratamento do câncer |
Country Status (13)
Country | Link |
---|---|
US (2) | US11235037B2 (pt) |
EP (2) | EP2968482B1 (pt) |
JP (1) | JP6382934B2 (pt) |
KR (2) | KR102455753B1 (pt) |
CN (1) | CN105188739B (pt) |
AU (1) | AU2014236653B2 (pt) |
BR (1) | BR112015021483A2 (pt) |
CA (1) | CA2901795C (pt) |
ES (1) | ES2805360T3 (pt) |
HK (2) | HK1214139A1 (pt) |
RU (1) | RU2015141932A (pt) |
SG (1) | SG11201507354QA (pt) |
WO (1) | WO2014151982A2 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201611843A (en) | 2012-04-04 | 2016-04-01 | Polaris Group | Methods of treatment with arginine deiminase |
JP6382934B2 (ja) | 2013-03-15 | 2018-08-29 | ポラリス グループ | 癌治療のためのadi−peg20抗体に対して低減された交差反応性を有するアルギニンデイミナーゼ |
US10463721B2 (en) | 2014-03-18 | 2019-11-05 | Tdw Group | Engineered chimeric pegylated ADI and methods of use |
TWI708789B (zh) | 2014-07-08 | 2020-11-01 | 開曼群島商瑞華藥業集團 | 精胺琥珀酸合成酶之抗體及相關方法 |
WO2016044376A1 (en) * | 2014-09-16 | 2016-03-24 | Polaris Group | Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment |
TWI699210B (zh) * | 2015-03-18 | 2020-07-21 | 開曼群島商瑞華藥業集團 | 工程化之嵌合聚乙二醇化adi及使用方法 |
WO2018085551A2 (en) * | 2016-11-02 | 2018-05-11 | Polaris Group | Formulations of pegylated arginine deiminase |
WO2018167780A1 (en) * | 2017-03-12 | 2018-09-20 | Yeda Research And Development Co. Ltd. | Methods of prognosing and treating cancer |
CN108324951B (zh) * | 2018-04-16 | 2021-05-25 | 薛剑峰 | 一种精氨酸脱亚胺酶注射剂及其制备方法 |
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US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
JP2900279B2 (ja) | 1989-08-02 | 1999-06-02 | 株式会社ジャパンエナジー | 新規なアルギニンデイミナーゼ、その製造法及び該酵素を有効成分とする制癌剤 |
US5804183A (en) | 1997-01-31 | 1998-09-08 | Enzon, Inc. | Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same |
US6183738B1 (en) * | 1997-05-12 | 2001-02-06 | Phoenix Pharamacologics, Inc. | Modified arginine deiminase |
US6635462B1 (en) * | 1997-05-12 | 2003-10-21 | Phoenix Pharmacologies, Inc. | Mutated form of arginine deiminase |
US6180387B1 (en) | 1997-08-11 | 2001-01-30 | Smithkline Beecham Corporation | Arginine deiminase |
IT1298918B1 (it) | 1998-02-20 | 2000-02-07 | Mendes Srl | Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche |
AU2001275810A1 (en) * | 2000-07-27 | 2002-02-13 | Angiolab, Inc. | The pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis |
AU2001289132A1 (en) | 2000-11-28 | 2002-06-11 | Phoenix Pharmacologics, Inc. | Modified arginine deiminase |
US8129330B2 (en) | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
CA2506244C (en) * | 2002-11-18 | 2012-10-30 | Phoenix Pharmacologics, Inc. | Methods for inhibiting viral replication in vivo |
US20050202451A1 (en) | 2003-04-29 | 2005-09-15 | Burczynski Michael E. | Methods and apparatuses for diagnosing AML and MDS |
US20070212311A1 (en) | 2003-10-07 | 2007-09-13 | University Of Florida Research Foundation, Inc. | Recombinant Alkalinizing Bacteria |
CN101002945B (zh) | 2006-01-20 | 2012-09-05 | 清华大学 | 一种用于肿瘤治疗的新型复合物 |
WO2009006590A2 (en) | 2007-07-04 | 2009-01-08 | Dr. Reddy's Laboratories Ltd. | Docetaxel process and polymorphs |
US20090238813A1 (en) * | 2007-12-28 | 2009-09-24 | Board Of Regents, The University Of Texas System | Compositions And Methods For Engineered Human Arginine Deiminases |
US20120015049A1 (en) | 2009-01-14 | 2012-01-19 | Lin Zhang | Microrna biomarker in cancer |
US20110111403A1 (en) * | 2009-10-30 | 2011-05-12 | Life Technologies Corporation | Multi-primer assay for mycoplasma detection |
AU2011260016B2 (en) | 2010-06-02 | 2013-08-22 | Fresenius Kabi Oncology Ltd. | Stable pharmaceutical compositions of Rapamycin esters |
WO2012075173A2 (en) | 2010-12-01 | 2012-06-07 | Board Of Regents The University Of Texas System | Compositions and method for deimmunization of proteins |
PL394618A1 (pl) | 2011-04-19 | 2012-10-22 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Przeciwnowotworowe bialko fuzyjne |
FR2978416B1 (fr) | 2011-07-26 | 2013-11-29 | Decathlon Sa | Vehicule, par exemple du type trottinette, avec systeme de repliage |
US8663967B2 (en) * | 2011-08-22 | 2014-03-04 | Jiangsu T-Mab Biopharma Co., Ltd. | Arginine deiminase mutant and preparation and application thereof |
TW201611843A (en) | 2012-04-04 | 2016-04-01 | Polaris Group | Methods of treatment with arginine deiminase |
JP6382934B2 (ja) | 2013-03-15 | 2018-08-29 | ポラリス グループ | 癌治療のためのadi−peg20抗体に対して低減された交差反応性を有するアルギニンデイミナーゼ |
US10463721B2 (en) | 2014-03-18 | 2019-11-05 | Tdw Group | Engineered chimeric pegylated ADI and methods of use |
WO2016044376A1 (en) | 2014-09-16 | 2016-03-24 | Polaris Group | Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment |
-
2014
- 2014-03-13 JP JP2016502236A patent/JP6382934B2/ja active Active
- 2014-03-13 KR KR1020217016900A patent/KR102455753B1/ko active IP Right Grant
- 2014-03-13 WO PCT/US2014/026766 patent/WO2014151982A2/en active Application Filing
- 2014-03-13 EP EP14769340.2A patent/EP2968482B1/en active Active
- 2014-03-13 EP EP20172604.9A patent/EP3744341A1/en active Pending
- 2014-03-13 RU RU2015141932A patent/RU2015141932A/ru not_active Application Discontinuation
- 2014-03-13 SG SG11201507354QA patent/SG11201507354QA/en unknown
- 2014-03-13 CN CN201480026318.5A patent/CN105188739B/zh active Active
- 2014-03-13 KR KR1020157024832A patent/KR102263038B1/ko active Application Filing
- 2014-03-13 BR BR112015021483A patent/BR112015021483A2/pt not_active Application Discontinuation
- 2014-03-13 AU AU2014236653A patent/AU2014236653B2/en active Active
- 2014-03-13 CA CA2901795A patent/CA2901795C/en active Active
- 2014-03-13 ES ES14769340T patent/ES2805360T3/es active Active
- 2014-03-14 US US14/214,040 patent/US11235037B2/en active Active
-
2016
- 2016-02-24 HK HK16102073.8A patent/HK1214139A1/zh unknown
- 2016-06-23 HK HK16107312.8A patent/HK1219232A1/zh unknown
-
2021
- 2021-12-20 US US17/556,361 patent/US20220105160A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2805360T3 (es) | 2021-02-11 |
CA2901795A1 (en) | 2014-09-25 |
EP2968482A4 (en) | 2016-07-20 |
EP2968482B1 (en) | 2020-05-06 |
US20220105160A1 (en) | 2022-04-07 |
AU2014236653B2 (en) | 2019-04-18 |
US20140348814A1 (en) | 2014-11-27 |
KR20210069126A (ko) | 2021-06-10 |
EP3744341A1 (en) | 2020-12-02 |
SG11201507354QA (en) | 2015-10-29 |
CN105188739B (zh) | 2017-06-23 |
CN105188739A (zh) | 2015-12-23 |
HK1214139A1 (zh) | 2016-07-22 |
US11235037B2 (en) | 2022-02-01 |
KR102263038B1 (ko) | 2021-06-14 |
WO2014151982A2 (en) | 2014-09-25 |
WO2014151982A3 (en) | 2015-01-08 |
KR102455753B1 (ko) | 2022-10-17 |
JP2016519069A (ja) | 2016-06-30 |
AU2014236653A1 (en) | 2015-09-10 |
JP6382934B2 (ja) | 2018-08-29 |
KR20150129728A (ko) | 2015-11-20 |
EP2968482A2 (en) | 2016-01-20 |
RU2015141932A (ru) | 2017-04-26 |
CA2901795C (en) | 2022-08-02 |
HK1219232A1 (zh) | 2017-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: TDW GROUP (TW) |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B12B | Appeal against refusal [chapter 12.2 patent gazette] |