BR112016011489A2 - composição nutricional pediátrica com peptídeos do leite para crescimento e desenvolvimento saudável - Google Patents

composição nutricional pediátrica com peptídeos do leite para crescimento e desenvolvimento saudável

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Publication number
BR112016011489A2
BR112016011489A2 BR112016011489A BR112016011489A BR112016011489A2 BR 112016011489 A2 BR112016011489 A2 BR 112016011489A2 BR 112016011489 A BR112016011489 A BR 112016011489A BR 112016011489 A BR112016011489 A BR 112016011489A BR 112016011489 A2 BR112016011489 A2 BR 112016011489A2
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BR
Brazil
Prior art keywords
protein
pediatric nutritional
development
source
nutritional composition
Prior art date
Application number
BR112016011489A
Other languages
English (en)
Other versions
BR112016011489B1 (pt
Inventor
Banavara Dattatreya
P Batema Rosanne
Original Assignee
Mjn Us Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mjn Us Holdings Llc filed Critical Mjn Us Holdings Llc
Publication of BR112016011489A2 publication Critical patent/BR112016011489A2/pt
Publication of BR112016011489B1 publication Critical patent/BR112016011489B1/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20Milk; Whey; Colostrum
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12Fatty acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13Nucleic acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135Bacteria or derivatives thereof, e.g. probiotics
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/14Yeasts or derivatives thereof
    • A23L33/145Extracts
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/19Dairy proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21Addition of substantially indigestible substances, e.g. dietary fibres
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/01Hydrolysed proteins; Derivatives thereof
    • A61K38/012Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/018Hydrolysed proteins; Derivatives thereof from animals from milk
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00Food ingredients
    • A23V2250/54Proteins
    • A23V2250/542Animal Protein
    • A23V2250/5424Dairy protein
    • A23V2250/54242Alpha lactalbumin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pediatric Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

a presente revelação proporciona geralmente composições nutricionais pediátricas compreendendo uma fonte de proteína compreendendo uma proteína do leite intacta e uma proteína do leite parcialmente hidrolisada, no qual cerca de 5% a cerca de 25% de teor de nitrogênio total da composição são nitrogênio não proteico. as composições nutricionais pediátricas aqui descritas também compreendem uma fonte de gordura e uma fonte de hidrato de carbono. uma fonte de proteína parcialmente hidrolisada, em certas concretizações, proporciona peptídeos que têm estrutura e função similares aos peptídeos encontrados no leite humano.
BR112016011489-2A 2014-01-07 2014-12-11 Composição nutricional pediátrica com peptídeos do leite para crescimento e desenvolvimento saudável BR112016011489B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/149,424 2014-01-07
US14/149,424 US10639334B2 (en) 2014-01-07 2014-01-07 Pediatric nutritional composition with milk peptides for healthy growth and development
PCT/US2014/069738 WO2015105616A1 (en) 2014-01-07 2014-12-11 Pediatric nutritional composition with milk peptides for healthy growth and development

Publications (2)

Publication Number Publication Date
BR112016011489A2 true BR112016011489A2 (pt) 2017-09-26
BR112016011489B1 BR112016011489B1 (pt) 2021-10-26

Family

ID=52273570

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016011489-2A BR112016011489B1 (pt) 2014-01-07 2014-12-11 Composição nutricional pediátrica com peptídeos do leite para crescimento e desenvolvimento saudável

Country Status (12)

Country Link
US (1) US10639334B2 (pt)
EP (1) EP3102052A1 (pt)
CN (1) CN105873457A (pt)
AR (1) AR099030A1 (pt)
AU (1) AU2014376232B2 (pt)
BR (1) BR112016011489B1 (pt)
CA (1) CA2932839A1 (pt)
MX (1) MX2016008495A (pt)
MY (1) MY183250A (pt)
PH (1) PH12016500894B1 (pt)
TW (1) TW201538086A (pt)
WO (1) WO2015105616A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3397078A1 (en) 2015-12-28 2018-11-07 Abbott Laboratories Nutritional compositions comprising hydrolyzed protein and a modified fat system and uses thereof
KR20230037067A (ko) 2016-07-06 2023-03-15 빌딩 블록 뉴트리셔널즈, 엘엘씨 영양 조제식
US10980269B2 (en) 2016-12-12 2021-04-20 Mead Johnson Nutrition Company Protein hydrolysates and methods of making same
US11197917B2 (en) 2017-12-01 2021-12-14 ByHeart, Inc. Formulations for nutritional support in subjects in need thereof
US20190208807A1 (en) * 2018-01-05 2019-07-11 Mead Johnson Nutrition Company Nutritional compositions containing milk-derived peptides and uses thereof
EP3646739A1 (en) 2018-11-01 2020-05-06 N.V. Nutricia Nutritional composition comprising urea and non-digestible oligosaccharides
EP3984595A4 (en) * 2019-06-11 2023-08-16 Ajinomoto Co., Inc. PEPTIDE AND USE THEREOF
IL299098A (en) 2020-06-15 2023-02-01 Building Block Nutritionals Llc Nutritional formula

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE61701B1 (en) 1986-07-17 1994-11-30 Morinaga Milk Industry Co Ltd Process for producing bovine lactoferrin in high purity
US5407957A (en) 1990-02-13 1995-04-18 Martek Corporation Production of docosahexaenoic acid by dinoflagellates
EP1787532A3 (en) 1991-01-24 2010-03-31 Martek Biosciences Corporation Microbial oil mixtures and uses thereof
US5374567A (en) 1993-05-20 1994-12-20 The United States Of America As Represented By The Secretary Of The Navy Operational amplifier using bipolar junction transistors in silicon-on-sapphire
US5405637A (en) * 1993-06-30 1995-04-11 Bristol-Myers Squibb Company Milk protein partial hydrolysate and infant formula containing same
US5861491A (en) 1994-02-16 1999-01-19 Pharming B.V. Isolation of lactoferrin from milk
NZ506866A (en) * 2000-09-11 2003-05-30 New Zealand Dairy Board Bioactive whey protein hydrolysate free of bitter flavours wherein the enzyme used is a heat labile protease
WO2003073866A1 (en) 2002-03-07 2003-09-12 Upfront Chromatography A/S A process of isolating lactoferrin
JP5068174B2 (ja) * 2004-12-23 2012-11-07 カンピナ ネーデルランド ホールディング ビー.ブイ. Dpp−ivを阻害するペプチド中に濃縮されたタンパク質の加水分解物及びその使用
PT1841330E (pt) * 2004-12-27 2011-03-14 Nestec Sa Utilização de fórmula para lactentes com teor proteico reduzido
US7618669B2 (en) * 2005-06-01 2009-11-17 Mead Johnson Nutrition Company Low-lactose partially hydrolyzed infant formula
DE602006016444D1 (de) * 2005-07-01 2010-10-07 Nutricia Nv Babynahrung mit hydrolisierten proteinen
US8361534B2 (en) 2007-12-20 2013-01-29 Abbott Laboratories Stable nutritional powder
AU2008343689A1 (en) * 2007-12-20 2009-07-09 Abbott Laboratories Stable nutritional powder
JP2011530274A (ja) * 2008-06-20 2011-12-22 ソレイ リミテッド ライアビリティ カンパニー 酸性条件下で安定なタンパク質加水分解組成物
JP5946642B2 (ja) * 2009-11-30 2016-07-06 株式会社明治 小腸に良い栄養組成物
CN101978841B (zh) * 2010-08-31 2013-04-10 浙江贝因美科工贸股份有限公司 一种抗蛋白过敏及营养婴儿配方奶粉
US9474298B2 (en) 2011-10-11 2016-10-25 Mead Johnson Nutrition Company Partially hydrolyzed casein-whey nutritional compositions for reducing the onset of allergies

Also Published As

Publication number Publication date
AU2014376232A1 (en) 2016-06-09
WO2015105616A1 (en) 2015-07-16
TW201538086A (zh) 2015-10-16
PH12016500894A1 (en) 2016-06-20
AR099030A1 (es) 2016-06-22
EP3102052A1 (en) 2016-12-14
BR112016011489B1 (pt) 2021-10-26
CA2932839A1 (en) 2015-07-16
US20150189905A1 (en) 2015-07-09
CN105873457A (zh) 2016-08-17
PH12016500894B1 (en) 2016-06-20
US10639334B2 (en) 2020-05-05
MX2016008495A (es) 2016-10-21
AU2014376232B2 (en) 2018-01-18
MY183250A (en) 2021-02-18

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