BR112015009004A2 - forma amorfa de derivado de quinolina e método de produção da mesma - Google Patents

forma amorfa de derivado de quinolina e método de produção da mesma Download PDF

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Publication number
BR112015009004A2
BR112015009004A2 BR112015009004A BR112015009004A BR112015009004A2 BR 112015009004 A2 BR112015009004 A2 BR 112015009004A2 BR 112015009004 A BR112015009004 A BR 112015009004A BR 112015009004 A BR112015009004 A BR 112015009004A BR 112015009004 A2 BR112015009004 A2 BR 112015009004A2
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BR
Brazil
Prior art keywords
amorphous form
production
quinoline derivative
quinoline
derivative
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BR112015009004A
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English (en)
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BR112015009004A8 (pt
Inventor
Yoshida Kenshi
Gotoda Masaharu
Shibuguchi Nao
Original Assignee
Eisai R&D Man Co Ltd
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Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of BR112015009004A2 publication Critical patent/BR112015009004A2/pt
Publication of BR112015009004A8 publication Critical patent/BR112015009004A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)

Abstract

resumo patente de invenção para "forma amorfa de derivado de quinolina e método de produção da mesma" a presente invenção proporciona uma forma amorfa de 4-(3-cloro-4-(ciclopropilaminocarbonil)aminofenoxi)-7-metoxi-6-quinolinacarboxamida.
BR112015009004A 2012-12-21 2013-12-19 forma amorfa de derivado de quinolina e método de produção da mesma BR112015009004A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012279158 2012-12-21
PCT/JP2013/084052 WO2014098176A1 (ja) 2012-12-21 2013-12-19 キノリン誘導体のアモルファス及びその製造方法

Publications (2)

Publication Number Publication Date
BR112015009004A2 true BR112015009004A2 (pt) 2017-07-04
BR112015009004A8 BR112015009004A8 (pt) 2021-07-20

Family

ID=50978496

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015009004A BR112015009004A8 (pt) 2012-12-21 2013-12-19 forma amorfa de derivado de quinolina e método de produção da mesma

Country Status (12)

Country Link
US (1) US9334239B2 (pt)
EP (1) EP2937337A4 (pt)
JP (1) JPWO2014098176A1 (pt)
KR (1) KR20150098605A (pt)
CN (1) CN104755463A (pt)
AU (1) AU2013364953A1 (pt)
BR (1) BR112015009004A8 (pt)
CA (1) CA2889866A1 (pt)
IL (1) IL238463A0 (pt)
MX (1) MX2015004979A (pt)
RU (1) RU2015115397A (pt)
WO (1) WO2014098176A1 (pt)

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KR20240064733A (ko) * 2015-03-04 2024-05-13 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CN112028825A (zh) * 2015-04-07 2020-12-04 广东众生睿创生物科技有限公司 酪氨酸激酶抑制剂及包含该酪氨酸激酶抑制剂的药物组合物
CN104876864B (zh) * 2015-06-05 2017-03-08 北京康立生医药技术开发有限公司 一种乐伐替尼的制备方法
CZ2016240A3 (cs) 2016-04-27 2017-11-08 Zentiva, K.S. Soli lenvatinibu
WO2017218365A1 (en) * 2016-06-16 2017-12-21 Sunshine Lake Pharma Co., Ltd. Crystalline form of a substituted quinoline compound and pharmaceutical compositions thereof
WO2021226738A1 (zh) * 2020-05-09 2021-11-18 北京睿创康泰医药研究院有限公司 包含仑伐替尼的分子水平的药物组合物及其制备方法和应用
CN113831283B (zh) * 2021-11-04 2024-04-19 南京科默生物医药有限公司 一种仑伐替尼盐无定形物的制备方法

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US20150291532A1 (en) 2015-10-15
WO2014098176A1 (ja) 2014-06-26
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JPWO2014098176A1 (ja) 2017-01-12
AU2013364953A1 (en) 2015-04-30
KR20150098605A (ko) 2015-08-28
MX2015004979A (es) 2015-07-17
CA2889866A1 (en) 2014-06-26
RU2015115397A (ru) 2017-01-25
US9334239B2 (en) 2016-05-10
EP2937337A1 (en) 2015-10-28
CN104755463A (zh) 2015-07-01
BR112015009004A8 (pt) 2021-07-20

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