BR112014016808A2 - composições de biguanida e métodos de tratamento de distúrbios metabólicos - Google Patents

composições de biguanida e métodos de tratamento de distúrbios metabólicos

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Publication number
BR112014016808A2
BR112014016808A2 BR112014016808A BR112014016808A BR112014016808A2 BR 112014016808 A2 BR112014016808 A2 BR 112014016808A2 BR 112014016808 A BR112014016808 A BR 112014016808A BR 112014016808 A BR112014016808 A BR 112014016808A BR 112014016808 A2 BR112014016808 A2 BR 112014016808A2
Authority
BR
Brazil
Prior art keywords
methods
metabolic disorders
biguanide
compositions
treating metabolic
Prior art date
Application number
BR112014016808A
Other languages
English (en)
Other versions
BR112014016808B1 (pt
BR112014016808A8 (pt
Inventor
D Baron Alain
S Fineman Mark
R A Beeley Nigel
Original Assignee
Elcelyx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/020548 external-priority patent/WO2012094636A2/en
Application filed by Elcelyx Therapeutics Inc filed Critical Elcelyx Therapeutics Inc
Publication of BR112014016808A2 publication Critical patent/BR112014016808A2/pt
Publication of BR112014016808A8 publication Critical patent/BR112014016808A8/pt
Publication of BR112014016808B1 publication Critical patent/BR112014016808B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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Abstract

composições de biguanida e métodos de tratamento de distúrbios metabólicos resumo a presente invenção refere-se a métodos para o tratamento de certas distúrbios incluindo diabetes, obesidade e outras doenças metabólicas, doenças ou condições de administrar uma composição que inclua um uma biguanida ou composto heterocíclico relacionado, por exemplo, a metformina. também fornecidos neste documento são composições biguanida ou de compostos heterocíclicos relacionados e métodos para a sua preparação para utilização nos métodos da presente invenção. também são aqui fornecidas composições compreendendo metformina e seus sais e métodos de utilização.
BR112014016808-3A 2012-01-06 2012-07-11 Uso de um composto de biguanida para a fabricação de um medicamento para baixar os níveis de glicose no sangue e para o tratamento de um distúrbio do metabolismo de glicose BR112014016808B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
USPCT/US2012/020548 2012-01-06
PCT/US2012/020548 WO2012094636A2 (en) 2011-01-07 2012-01-06 Chemosensory receptor ligand-based therapies
US13/345,135 2012-01-06
US13/345,135 US20120177730A1 (en) 2011-01-07 2012-01-06 Chemosensory Receptor Ligand-Based Therapies
US201261649171P 2012-05-18 2012-05-18
US61/649,171 2012-05-18
PCT/US2012/046335 WO2013103384A1 (en) 2012-01-06 2012-07-11 Biguanide compositions and methods of treating metabolic disorders

Publications (3)

Publication Number Publication Date
BR112014016808A2 true BR112014016808A2 (pt) 2017-06-13
BR112014016808A8 BR112014016808A8 (pt) 2017-07-04
BR112014016808B1 BR112014016808B1 (pt) 2022-01-11

Family

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BR112014016808-3A BR112014016808B1 (pt) 2012-01-06 2012-07-11 Uso de um composto de biguanida para a fabricação de um medicamento para baixar os níveis de glicose no sangue e para o tratamento de um distúrbio do metabolismo de glicose

Country Status (16)

Country Link
US (2) US10154972B2 (pt)
EP (1) EP2800561B1 (pt)
JP (4) JP2015503582A (pt)
KR (4) KR20200137035A (pt)
CN (2) CN110693868A (pt)
AU (2) AU2012363873B2 (pt)
BR (1) BR112014016808B1 (pt)
CA (1) CA2862533C (pt)
EA (1) EA201491335A1 (pt)
ES (1) ES2832773T3 (pt)
HK (1) HK1203829A1 (pt)
IL (1) IL233506B (pt)
MX (2) MX2014008190A (pt)
SG (2) SG10201911743TA (pt)
WO (1) WO2013103384A1 (pt)
ZA (1) ZA201405046B (pt)

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US8796338B2 (en) 2011-01-07 2014-08-05 Elcelyx Therapeutics, Inc Biguanide compositions and methods of treating metabolic disorders
US9211263B2 (en) 2012-01-06 2015-12-15 Elcelyx Therapeutics, Inc. Compositions and methods of treating metabolic disorders
US9572784B2 (en) 2011-01-07 2017-02-21 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
US9480663B2 (en) 2011-01-07 2016-11-01 Elcelyx Therapeutics, Inc. Biguanide compositions and methods of treating metabolic disorders
US11759441B2 (en) 2011-01-07 2023-09-19 Anji Pharmaceuticals Inc. Biguanide compositions and methods of treating metabolic disorders
SG11201403873UA (en) * 2012-01-06 2014-08-28 Elcelyx Therapeutics Inc Compositions and methods for treating metabolic disorders
CN110693868A (zh) * 2012-01-06 2020-01-17 埃尔舍利克斯治疗公司 双胍组合物和治疗代谢性病症的方法
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KR101994145B1 (ko) * 2013-01-28 2019-07-01 한올바이오파마주식회사 Ν１-고리아민-ν５-치환된 바이구아나이드 유도체를 유효성분으로 함유하는 시차증후군의 예방 또는 치료용 약학 조성물
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