BR112012008858A2 - métodos para preparar éster do ácido aril-2-tetrazolil-etil carbânico, e um composto de álcool. - Google Patents

métodos para preparar éster do ácido aril-2-tetrazolil-etil carbânico, e um composto de álcool.

Info

Publication number
BR112012008858A2
BR112012008858A2 BR112012008858A BR112012008858A BR112012008858A2 BR 112012008858 A2 BR112012008858 A2 BR 112012008858A2 BR 112012008858 A BR112012008858 A BR 112012008858A BR 112012008858 A BR112012008858 A BR 112012008858A BR 112012008858 A2 BR112012008858 A2 BR 112012008858A2
Authority
BR
Brazil
Prior art keywords
acid ester
methods
alcohol compound
tetrazolyl
preparing aryl
Prior art date
Application number
BR112012008858A
Other languages
English (en)
Other versions
BR112012008858B1 (pt
Inventor
Dae Won Lee
Dong Ho Lee
Hui Ho Kim
Hyun Seok Lee
Moo Yong Uhm
Sang Chul Lim
Original Assignee
Sk Biopharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sk Biopharmaceuticals Co Ltd filed Critical Sk Biopharmaceuticals Co Ltd
Publication of BR112012008858A2 publication Critical patent/BR112012008858A2/pt
Publication of BR112012008858B1 publication Critical patent/BR112012008858B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

métodos para preparar éster do ácido aril-2-tetrazolil-etil carbânico, e um composto de álcool - é descrito um método para a preparação de éster do ácido (r)-1-aril-2-tetrazolil-etil carbâmico, que compreende a redução da enzima enantiosseletiva da arilcetona correspondente e a carbamação do álcool resultante.
BR112012008858-0A 2009-10-15 2010-10-15 Métodos para preparar um éster do ácido aril-2-tetrazolil-etil carbâmico e um composto de álcool BR112012008858B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25186709P 2009-10-15 2009-10-15
US61/251,867 2009-10-15
PCT/KR2010/007069 WO2011046380A2 (en) 2009-10-15 2010-10-15 Method for preparation of carbamic acid (r)-1-aryl-2-tetrazolyl-ethyl ester

Publications (2)

Publication Number Publication Date
BR112012008858A2 true BR112012008858A2 (pt) 2015-09-22
BR112012008858B1 BR112012008858B1 (pt) 2021-07-20

Family

ID=43876717

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012008858-0A BR112012008858B1 (pt) 2009-10-15 2010-10-15 Métodos para preparar um éster do ácido aril-2-tetrazolil-etil carbâmico e um composto de álcool

Country Status (19)

Country Link
US (3) US8404461B2 (pt)
EP (1) EP2488505B1 (pt)
JP (1) JP5797656B2 (pt)
KR (1) KR101708437B1 (pt)
CN (1) CN102574821B (pt)
AU (1) AU2010307466B2 (pt)
BR (1) BR112012008858B1 (pt)
CA (1) CA2776743C (pt)
CL (1) CL2012000959A1 (pt)
ES (1) ES2536488T3 (pt)
HK (1) HK1172625A1 (pt)
HU (1) HUE025816T2 (pt)
IL (1) IL218787A0 (pt)
MX (1) MX2012004055A (pt)
MY (1) MY162997A (pt)
PL (1) PL2488505T3 (pt)
RU (1) RU2539983C2 (pt)
WO (1) WO2011046380A2 (pt)
ZA (1) ZA201202629B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011009824A (es) 2009-03-23 2012-01-25 Glenmark Pharmaceuticals Sa Derivados de pirimidina-diona fusionados como moduladores del trpa1.
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
CN103694187A (zh) * 2014-01-06 2014-04-02 四川大学 5-氨基-1-苯甲酰氨基四唑及其金属配合物
KR102421006B1 (ko) * 2016-05-19 2022-07-14 에스케이바이오팜 주식회사 두통의 예방학적 치료를 위한 카바메이트 화합물의 용도
KR102489052B1 (ko) * 2016-05-19 2023-01-16 에스케이바이오팜 주식회사 섬유근육통 또는 섬유근육통의 연관된 기능적 증후군을 예방 또는 치료하기 위한 카바메이트 화합물의 용도
KR102421013B1 (ko) * 2016-05-19 2022-07-14 에스케이바이오팜 주식회사 삼차신경통을 예방 또는 치료하기 위한 카바메이트 화합물의 용도
IL267195B2 (en) 2016-12-14 2024-05-01 Sk Biopharmaceuticals Co Ltd Use of carbamate compounds to prevent, alleviate, or treat bipolar disorder
CA3046296A1 (en) * 2016-12-14 2018-06-21 Sk Biopharmaceuticals Co., Ltd. Orally disintegrated tablet comprising carbamate compound
MX2019006941A (es) 2016-12-14 2019-09-06 Sk Biopharmaceuticals Co Ltd Uso de compuesto de carbamato para prevenir, aliviar o tratar temblores o el sindrome de temblor.
KR102635931B1 (ko) 2016-12-14 2024-02-13 에스케이바이오팜 주식회사 가려움증의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도
WO2018111006A1 (ko) 2016-12-14 2018-06-21 에스케이바이오팜 주식회사 탈수초성 질환의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도
US12070447B2 (en) 2016-12-14 2024-08-27 Sk Biopharmaceuticals Co., Ltd. Parenteral liquid preparation comprising carbamate compound
PL3711758T3 (pl) * 2017-11-14 2024-07-01 Sk Biopharmaceuticals Co., Ltd. Zastosowanie związku karbaminianowego do zapobiegania, łagodzenia lub leczenia napadów nieświadomości lub padaczki wykazującej napady nieświadomości
US11389429B2 (en) 2017-11-14 2022-07-19 Sk Biopharmaceuticals Co., Ltd. Use of carbamate compound for preventing, alleviating or treating myotonia
WO2019098633A1 (ko) 2017-11-14 2019-05-23 에스케이바이오팜 주식회사 내장통 또는 내장 질환에서 기인한 통증을 예방, 경감 또는 치료하기 위한 카바메이트 화합물의 용도
ES2973111T3 (es) 2017-11-14 2024-06-18 Sk Biopharmaceuticals Co Ltd Uso de un compuesto de carbamato para prevenir o tratar enfermedades asociadas con el aumento de la corriente tardía de sodio
CA3081224A1 (en) 2017-11-14 2019-05-23 Sk Biopharmaceuticals Co., Ltd. Use of carbamate compound for reducing or treating developmental disorders including fragile x syndrome, angelman syndrome or rett syndrome
AU2018367733B2 (en) 2017-11-14 2024-06-20 Sk Biopharmaceuticals Co., Ltd. Blend containing carbamate compound for prevention, mitigation, or treatment of schizophrenia
CN113242735A (zh) 2018-09-21 2021-08-10 爱思开生物制药株式会社 使用氨基甲酸酯化合物预防、缓解或治疗并发的癫痫发作
CA3112166A1 (en) * 2018-09-21 2020-03-26 Sk Biopharmaceuticals Co., Ltd. Carbamate compound and use of formulation comprising same in preventing, alleviating, or treating acute stress disorder or post-traumatic stress disorder
KR20210062029A (ko) 2018-10-19 2021-05-28 에스케이바이오팜 주식회사 카바메이트 화합물의 당뇨병성 말초 신경병증 또는 화학요법 유발 말초 신경병증의 예방, 완화 또는 치료를 위한 용도
US10611737B1 (en) 2019-10-24 2020-04-07 Sk Biopharmaceuticals Co., Ltd. Method for preparing aryl 2-tetrazol-2-yl ketone with improved selectivity
MX2022004740A (es) * 2019-10-24 2022-05-16 Sk Biopharmaceuticals Co Ltd Metodo para preparar aril 2-tetrazol-2-il cetona con selectividad mejorada.
IL293096A (en) 2019-11-22 2022-07-01 Sk Biopharmaceuticals Co Ltd A pharmaceutical preparation for oral administration containing a carbamate compound and a method for its preparation
CN111705096A (zh) * 2020-06-29 2020-09-25 上海舒泽生物科技研究所 一种酶转化法生产β-烟酰胺单核苷酸的方法
WO2022031099A1 (ko) 2020-08-06 2022-02-10 에스케이바이오팜 주식회사 카바메이트 화합물을 포함하는 경구용 고형 제제 및 이의 제조방법
ES2931000B2 (es) * 2022-07-14 2023-07-07 Univ Madrid Complutense Proceso para la preparación de cenobamato

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61134339A (ja) 1984-12-05 1986-06-21 Seitetsu Kagaku Co Ltd α−ジケトンの立体特異的還元による光学活性アルコ−ルならびにその製造方法
JPH054943A (ja) 1990-08-30 1993-01-14 Sagami Chem Res Center 光学活性β，δ−ジケト酸エステル及びその還元体
EP0538693A3 (en) 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
JP3672307B2 (ja) 1992-03-13 2005-07-20 フォルシュングスツェントルム・ユーリッヒ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 新規ケトエステル‐還元酵素，その製造方法及びこれを酵素酸化還元反応に使用する方法
WO1994007888A1 (en) 1992-09-25 1994-04-14 Chiroscience Limited Chiral compounds and their use
CA2103932A1 (en) 1992-11-05 1994-05-06 Ramesh N. Patel Stereoselective reduction of ketones
JPH0759592A (ja) 1993-08-25 1995-03-07 Osaka City 光学活性ジオールの製造方法
JP3574682B2 (ja) 1993-09-24 2004-10-06 ダイセル化学工業株式会社 新規な酵素、該酵素を製造する方法、該酵素をコードするｄｎａ、該ｄｎａを含む形質転換体、該酵素による光学活性アルコール等の製造方法
PL177372B1 (pl) 1995-03-30 1999-11-30 Akad Rolnicza Sposób otrzymywaniaoptycznie czynnych alkoholi aromatycznych
DE19610984A1 (de) 1996-03-21 1997-09-25 Boehringer Mannheim Gmbh Alkohol-Dehydrogenase und deren Verwendung zur enzymatischen Herstellung chiraler Hydroxyverbindungen
JPH1094399A (ja) 1996-09-24 1998-04-14 Fukui Pref Gov Sangyo Shinko Zaidan 酵素を用いる光学活性アルコールの製造法
AU4032997A (en) 1997-02-07 1998-08-26 Kaneka Corporation Novel carbonyl reductase, gene that encodes the same, and method of utilizing these
DE19707008A1 (de) 1997-02-21 1998-08-27 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Alkoholen
JPH10248591A (ja) 1997-03-06 1998-09-22 Sumitomo Chem Co Ltd 光学活性アルコールの製造方法
JPH10287634A (ja) 1997-04-11 1998-10-27 Otsuka Pharmaceut Co Ltd ベンゼン誘導体
JPH11130761A (ja) 1997-10-24 1999-05-18 Otsuka Pharmaceut Co Ltd ベンゾチアゾール誘導体
JP2000236883A (ja) 1998-12-21 2000-09-05 Daicel Chem Ind Ltd 新規なカルボニル還元酵素、該酵素の製造方法、該酵素をコードするｄｎａおよびこれを利用したアルコールの製造方法
KR20010102198A (ko) * 1999-02-16 2001-11-15 후루타 타케시 치환 아세틸피리딘 유도체 및 그를 이용하는 광학활성 β3작용제 중간체의 제조 방법
CA2360376C (en) 1999-12-03 2005-04-26 Noriyuki Kizaki Novel carbonyl reductase, gene thereof and method of using the same
DE10037101A1 (de) 2000-07-27 2002-02-07 Degussa Rekombinant hergestellte Enzyme mit verbesserter NAD(H)-Akzeptanz
MXPA03008437A (es) 2001-03-22 2004-01-29 Bristol Myers Squibb Co Reduccion estereoselectiva de acetofenona substituida.
DE10119274A1 (de) 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
JP4630486B2 (ja) 2001-05-28 2011-02-09 ダイセル化学工業株式会社 新規な（ｒ）−２，３−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法
JP2003230398A (ja) 2001-12-07 2003-08-19 Daicel Chem Ind Ltd 光学活性アルコールの製造方法
TW200305645A (en) 2002-03-19 2003-11-01 Mitsubishi Chem Corp Novel carbonyl reductase, gene encoding the same and process for producing optically active alcohols using the same
JP2003289895A (ja) 2002-04-03 2003-10-14 Sumitomo Chem Co Ltd メチレンジオキシフェニル基を有するケトン化合物の不斉還元による光学活性アルコール化合物の製造方法
AU2003235980A1 (en) 2002-04-30 2003-11-17 Kaneka Corporation Novel carbonyl reductase, gene thereof and use of the same
US7056540B2 (en) 2002-10-29 2006-06-06 Council Of Scientific And Industrial Research Enzymatic process for the preparation of optically active alcohols from ketones using tuberous root Daucus carota
JP4366097B2 (ja) 2003-02-28 2009-11-18 住友化学株式会社 還元酵素遺伝子及びその利用
JP4295531B2 (ja) 2003-03-10 2009-07-15 三菱化学株式会社 新規カルボニル還元酵素及びこれをコードするｄｎａ、ならびにこれらを利用した光学活性アルコールの製造方法
DE10315760A1 (de) * 2003-04-07 2004-10-21 Basf Ag L-Carnitin Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von substituierten (S)-Alkanolen
JP2004313033A (ja) 2003-04-14 2004-11-11 Daiichi Fine Chemical Co Ltd 新規なカルボニル還元酵素及びそれをコードする遺伝子並びにその用途
JP4213524B2 (ja) 2003-04-17 2009-01-21 ダイセル化学工業株式会社 新規なカルボニル還元酵素、その酵素をコードするｄｎａを含むポリヌクレオチド、その製造方法、およびこれを利用した光学活性アルコールの製造方法
JP4294382B2 (ja) 2003-06-06 2009-07-08 ダイセル化学工業株式会社 （２ｓ，３ｓ）−２，３−ブタンジオール脱水素酵素
DE10327454A1 (de) 2003-06-18 2005-01-20 Juelich Enzyme Products Gmbh Oxidoreduktase aus Pichia capsulata
JP4205496B2 (ja) 2003-06-19 2009-01-07 三菱化学株式会社 新規カルボニル還元酵素及びこれをコードするｄｎａ、ならびにこれらを利用した光学活性アルコールの製造方法
DE102004037669A1 (de) 2003-08-13 2005-03-10 Juelich Enzyme Products Gmbh (R)- und (S)-1,4-Dichlor-butan-2-ol und Verfahren zu deren Herstellung durch enantioselektive enzymatische Reduktion von 1,4-Dichlor-butan-2-on
SG128683A1 (en) 2003-10-31 2007-01-30 Daiichi Fine Chem Co Ltd Novel plasmids and utilization thereof
DE10354779A1 (de) 2003-11-21 2005-06-23 Juelich Enzyme Products Gmbh Oxidoreduktase aus Metschnikowia zobellii
EP1712630A4 (en) 2004-02-04 2008-04-16 Api Corp PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE ALCOHOL AND OPTICALLY ACTIVE CARBOXYLIC ACID
JP2005218348A (ja) 2004-02-05 2005-08-18 Daicel Chem Ind Ltd 光学活性α−ヒドロキシアミドの製造方法
DE102004022686A1 (de) 2004-05-05 2005-11-24 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
AT413541B (de) 2004-05-10 2006-03-15 Iep Gmbh Verfahren zur herstellung von 2-butanol
JP2007274901A (ja) 2004-05-12 2007-10-25 Taisho Pharmaceut Co Ltd 光学活性プロパルギルアルコールの製造方法
DE102004029112B4 (de) 2004-06-11 2007-06-21 Julich Chiral Solutions Gmbh Alkoholdehydrogenase zur stereoselektiven Gewinnung von Hydroxyverbindungen
WO2006046455A1 (ja) 2004-10-27 2006-05-04 Kaneka Corporation 新規カルボニル還元酵素、その遺伝子、およびその利用法
AT501928B1 (de) 2004-10-27 2010-09-15 Iep Gmbh Verfahren zur herstellung von chiralen alkoholen
DE102004059376A1 (de) 2004-12-09 2006-06-22 Consortium für elektrochemische Industrie GmbH GDH-Mutante mit verbesserter chemischer Stabilität
US20060177913A1 (en) 2005-02-08 2006-08-10 Consortium Fur Elektrochemische Industrie Gmbh Process for enantioselective enzymatic reduction of keto compounds
AT501496B1 (de) 2005-02-21 2007-03-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
US20080038803A1 (en) 2005-02-25 2008-02-14 Akira Iwasaki Process for Producing Optically Active Secondary Alcohol
DE102005010804A1 (de) 2005-03-07 2006-09-14 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
US7598279B2 (en) * 2005-04-22 2009-10-06 Sk Holdings Co., Ltd. Neurotherapeutic azole compounds
US7393667B2 (en) 2005-05-31 2008-07-01 Bristol-Myers Squibb Company Stereoselective reduction process for the preparation of pyrrolotriazine compounds
AT502395B1 (de) 2005-07-27 2007-03-15 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
JP4745762B2 (ja) 2005-09-02 2011-08-10 住友化学株式会社 還元酵素及びその利用
DE102005044736A1 (de) 2005-09-19 2007-03-22 Basf Ag Neue Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von optisch aktiven Alkanolen
AT502185B1 (de) 2005-09-23 2007-02-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
AT503017B1 (de) * 2005-12-19 2007-07-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen
WO2007099764A1 (ja) 2006-02-28 2007-09-07 Kaneka Corporation 新規カルボニル還元酵素、その遺伝子、およびそれらを利用した光学活性アルコールの製造方法
WO2007099994A1 (ja) 2006-03-02 2007-09-07 Kaneka Corporation 新規カルボニル還元酵素、その遺伝子、ベクター、形質転換体、およびそれらを利用した光学活性アルコールの製造方法
DE102006010994A1 (de) 2006-03-09 2007-09-13 Wacker Chemie Ag Verfahren zur enzymatischen Herstellung von chiralen Alkoholen
ATE529507T1 (de) 2006-03-31 2011-11-15 Kaneka Corp Verfahren zur produktion von erythro- oder threo- 2-amino-3-hydroxypropionsäureester, neuartige carbonylreduktase, gen für die reduktase, vektor, transformante und verfahren zur produktion von optisch aktivem alkohol unter verwendung dieser
CN101501202A (zh) 2006-06-05 2009-08-05 大赛璐化学工业株式会社 光学活性醇的制造方法
JP4903512B2 (ja) 2006-07-13 2012-03-28 住友化学株式会社 還元酵素遺伝子を含む発現ベクター
WO2008035187A2 (en) 2006-09-21 2008-03-27 Dow Global Technologies Inc. Alcohol dehydrogenase from agromyces sp. and a method of producing a chiral secondary alcohol using same
DE102006055047A1 (de) 2006-11-22 2008-05-29 Wacker Chemie Ag Verfahren zur Herstellung von Dihydroxy-Verbindungen aus Diketo-Verbindungen durch enzymkatalysierte enantioselektive Reduktion
DE102006056526A1 (de) 2006-11-30 2008-06-05 Archimica Gmbh Verfahren zur stereoselektiven Synthese von chiralen Epoxiden durch ADH-Reduktion von alpha-Abgangsgruppen-substituierten Ketonen und Cyclisierung
AT504542B1 (de) 2006-12-07 2008-09-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten
JP5503534B2 (ja) 2007-06-20 2014-05-28 ビーエーエスエフ ソシエタス・ヨーロピア アゾアルクス（Ａｚｏａｒｃｕｓ）ＳｐＥｂＮ１脱水素酵素を用いる光学活性アルコールの製造方法
TWI601825B (zh) 2007-09-27 2017-10-11 Ｉｅｐ有限公司 對映異構選擇性酶催化還原中間產物之方法
DE102007052112A1 (de) 2007-10-30 2009-05-07 Chiracon Gmbh Pflanzliche Biokatalysatoren zur Herstellung optisch aktiver Hydroxyverbindungen
WO2009070822A2 (en) 2007-12-05 2009-06-11 Angewandte Biokatalyse Kompetenzzentrum Gmbh Recombinant pichia pastoris cell
CN101314787A (zh) 2008-06-24 2008-12-03 江苏华荣生物科技有限公司 用红酵母还原酶制剂制备光学活性手性仲醇的方法
CN101319236A (zh) 2008-07-01 2008-12-10 江南大学 水/离子液体两相体系中生物催化不对称还原羰基化合物的方法
CN101358183B (zh) 2008-09-03 2010-07-14 华东理工大学 红豆羰基还原酶、制备方法和用途
BRPI0924997B1 (pt) * 2009-06-22 2024-01-16 Sk Biopharmaceuticals Co., Ltd Método para preparar um composto de éster do ácido 1-aril-2- tetrazoil etil carbâmico
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester

Also Published As

Publication number Publication date
WO2011046380A3 (en) 2011-10-20
EP2488505A4 (en) 2013-05-01
IL218787A0 (en) 2012-06-28
ES2536488T3 (es) 2015-05-25
US20110111467A1 (en) 2011-05-12
US9434970B2 (en) 2016-09-06
HUE025816T2 (en) 2016-04-28
PL2488505T3 (pl) 2015-10-30
MX2012004055A (es) 2012-08-31
CN102574821B (zh) 2015-03-18
RU2012119801A (ru) 2013-11-20
CN102574821A (zh) 2012-07-11
RU2539983C2 (ru) 2015-01-27
JP2013507911A (ja) 2013-03-07
CL2012000959A1 (es) 2012-10-12
HK1172625A1 (en) 2013-04-26
BR112012008858B1 (pt) 2021-07-20
US8404461B2 (en) 2013-03-26
US9068207B2 (en) 2015-06-30
CA2776743C (en) 2017-03-28
US20140073018A1 (en) 2014-03-13
JP5797656B2 (ja) 2015-10-21
US20150252398A1 (en) 2015-09-10
ZA201202629B (en) 2012-12-27
WO2011046380A2 (en) 2011-04-21
CA2776743A1 (en) 2011-04-21
EP2488505B1 (en) 2015-02-25
EP2488505A2 (en) 2012-08-22
KR20120087124A (ko) 2012-08-06
KR101708437B1 (ko) 2017-02-20
MY162997A (en) 2017-07-31
AU2010307466B2 (en) 2015-02-05
AU2010307466A1 (en) 2012-04-19

Similar Documents

Publication Publication Date Title
BR112012008858A2 (pt) métodos para preparar éster do ácido aril-2-tetrazolil-etil carbânico, e um composto de álcool.
MY155662A (en) Method for preparation of carbamic acid (r)-1-aryl-2-tetrazolyl-ethyl ester
BR112012032166A2 (pt) “composição, método para produzir um extrator e métodos para produzir um produto de álcool”
CL2015002372A1 (es) Un proceso para preparar un compuesto de fórmula (2-g) y (2-h) que comprende llevar a cabo la reducción enantioselectiva para obtener un compuesto de fórmula (3-c). un proceso para preparar un compuesto de fórmula (5-f). un proceso para preparar un compuesto de fórmula (m).
CO6440530A2 (es) Formulaciones de caldo de fermentación
BR112014029994A2 (pt) método e sistema para produção de um bloco dentário personalizado
EP2336347A4 (en) L-amino acid-producing microorganism and method for producing L-amino acid
BRPI1014472A8 (pt) Método para produzir um derivado de ácido graxo, microrganismo engenheirado geneticamente, derivado de ácido graxo e composição de biocombustível
WO2012083189A3 (en) Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
BRPI0917169A2 (pt) método para a produção de álcool concentrado a partir de caldo de fermentação
BRPI0920804A2 (pt) método para preparar alquil ésteres de ácido graxo.
BRPI0923797A2 (pt) Método para produzir um éster.
WO2011057871A3 (de) Verwendung eines zu einem meab-protein homologen proteins zur erhöhung der enzymatischen aktivität einer 3-hydroxycarbonsäure-coa-mutase
EP2669382A4 (en) Cellulosic biomass treatment method, method of producing sugar, alcohol or organic acid from cellulosic biomass
WO2011123854A3 (en) Bioaugmentation of anaerobic digester systems
BRPI0823260A2 (pt) Método de operação de um sistema de gerenciamento de combustível de aeronave.
BR112012003958A2 (pt) método para produzir um l-aminoácido.
AU2009290334A8 (en) Method for acquiring highly unsaturated fatty acid derivatives
BRPI1013673A2 (pt) Microorganismo que produz l-amiácido e método para a produção de l-aminoácido usando o mesmo
MX336787B (es) Microorganismos deseñados geneticamente que comprenden 4-hidroxibenzoil-coa tioesterasas y metodos de uso de los mismos para producir acidos grasos libes y derivados de acidos grasos.
WO2009117498A3 (en) Methods of making cyclododecatriene and methods of making laurolactone
BR112013004988A2 (pt) método para preparação de um composto
BRPI1007069A2 (pt) Método para produzir um l-aminoácido.
MY158474A (en) Multistage cellulose hydrolysis and quench with or without acid
BR112012021230A2 (pt) método para produzir uma glicosidade mutante, composição de enzimas para sacarificação de bikomassa e método para hidrolisar biomassa

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/10/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 12A ANUIDADE.

B24D Patent annual fee: restoration after fee payment