BR0308495A - Composto, formulação farmacêutica, métodos para ativar receptores de 5-ht1f, para inibir o extravasamento de proteìna neuronal, para tratar ou prevenir enxaqueca em um mamìfero e para preparar um composto, uso de um composto, e, processo para preparar um composto - Google Patents

Composto, formulação farmacêutica, métodos para ativar receptores de 5-ht1f, para inibir o extravasamento de proteìna neuronal, para tratar ou prevenir enxaqueca em um mamìfero e para preparar um composto, uso de um composto, e, processo para preparar um composto

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Publication number
BR0308495A
BR0308495A BR0308495-7A BR0308495A BR0308495A BR 0308495 A BR0308495 A BR 0308495A BR 0308495 A BR0308495 A BR 0308495A BR 0308495 A BR0308495 A BR 0308495A
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BR
Brazil
Prior art keywords
compound
alkyl
preparing
hydrogen
substituted
Prior art date
Application number
BR0308495-7A
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English (en)
Other versions
BRPI0308495B8 (pt
BRPI0308495B1 (pt
Inventor
Michael Philip Cohen
Daniel Timothy Kohlman
Sidney Xi Liang
Vincent Mancuso
Frantz Victor
Yao-Chang Xu
Bai-Ping Ying
Deanna Piatt Zacherl
Deyi Zhang
Original Assignee
Lilly Co Eli
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Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR0308495A publication Critical patent/BR0308495A/pt
Publication of BRPI0308495B1 publication Critical patent/BRPI0308495B1/pt
Publication of BRPI0308495B8 publication Critical patent/BRPI0308495B8/pt

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

"COMPOSTO, FORMULAçãO FARMACêUTICA, MéTODOS PARA ATIVAR RECEPTORES DE 5-HT~ 1F~, PARA INIBIR O EXTRAVASAMENTO DE PROTEìNA NEURONAL, PARA TRATAR OU PREVENIR ENXAQUECA EM UM MAMìFERO E PAPA PREPARAR UM COMPOSTO, USO DE UM COMPOSTO, E, PROCESSO PARA PREPARAR UM COMPOSTO". A presente invenção refere-se aos compostos de fórmula I ou sais de adição de ácido farmaceuticamente aceitáveis dos mesmos, na qual R^ 1^ é C~ 1~-C~ 6~-alquila, C~ 1~-C~ 6~-alquila substituída, C~ 3~-C~ 7~ ciclo-alquila, C~ 3~-C~ 7~ cicloalquila substituída, C~ 3~-C~ 7~ ciclo-alquil-C~ 1~-C~ 3~-alquila, C~ 3~-C~ 7~ ciclo-alquil-C~ 1~-C~ 3~alquila substituída, fenila, fenila substituída, heterociclo, ou heterociclo substituído; R^ 2^ é hidrogênio, C~ 1~-C~ 3~-alquila, C~ 3~-C~ 6~ ciclo-alquil-C~ 1~-C~ 3~-alquila, ou um grupo de fórmula II; R^ 3^ é hidrogênio ou C~ 1~-C~ 3~-alquila; R^ 4^ é hidrogênio, halo, ou C~ 1~C~ 3~-alquila; R^ 5^ é hidrogênio ou C~ 1~-C~ 3~-alquila, R^ 6^ é hidrogênio ou C~ 1~-C~ 6~-alquila; e n é um número inteiro de 1 a 6 inclusive. Os compostos da presente invenção são úteis para a ativação de receptores de 5-HTIF, inibição de extravasamento de proteína neuronal, e para o tratamento ou a prevenção de enxaqueca em um mamífero. A presente invenção também se refere a um processo para a síntese de intermediários na sintese de compostos de fórmula I.
BRPI0308495A 2002-03-29 2003-03-27 composto piridinoila útil para a ativação de receptores 5-ht1f, formulação farmacêutica, e, uso de um composto BRPI0308495B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36908802P 2002-03-29 2002-03-29
PCT/US2003/008455 WO2003084949A1 (en) 2002-03-29 2003-03-27 Pyridinoylpiperidines as 5-ht1f agonists

Publications (3)

Publication Number Publication Date
BR0308495A true BR0308495A (pt) 2005-02-01
BRPI0308495B1 BRPI0308495B1 (pt) 2015-07-07
BRPI0308495B8 BRPI0308495B8 (pt) 2021-05-25

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BRPI0308495A BRPI0308495B8 (pt) 2002-03-29 2003-03-27 composto piridinoila útil para a ativação de receptores 5-ht1f, formulação farmacêutica, e, uso de um composto

Country Status (32)

Country Link
US (6) US7423050B2 (pt)
EP (1) EP1492786B1 (pt)
JP (2) JP4493345B2 (pt)
KR (1) KR100985995B1 (pt)
CN (1) CN100352817C (pt)
AR (1) AR039150A1 (pt)
AT (1) ATE341543T1 (pt)
AU (1) AU2003224719B2 (pt)
BR (1) BRPI0308495B8 (pt)
CA (2) CA2478229C (pt)
CR (1) CR7496A (pt)
CY (1) CY1105899T1 (pt)
DE (1) DE60308850T2 (pt)
DK (1) DK1492786T3 (pt)
EA (1) EA007966B1 (pt)
EC (1) ECSP045317A (pt)
EG (1) EG25226A (pt)
ES (1) ES2277074T3 (pt)
HK (1) HK1073464A1 (pt)
HR (1) HRP20040883B1 (pt)
IL (1) IL163928A0 (pt)
MX (1) MXPA04009497A (pt)
MY (1) MY134666A (pt)
NO (1) NO330394B1 (pt)
NZ (1) NZ534952A (pt)
PE (1) PE20030976A1 (pt)
PL (1) PL210019B1 (pt)
PT (1) PT1492786E (pt)
TW (1) TWI263497B (pt)
UA (1) UA77504C2 (pt)
WO (1) WO2003084949A1 (pt)
ZA (1) ZA200407666B (pt)

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