BR0211364A - Composição farmacêutica para tratamento de doenças associadas com redução na massa óssea compreendendo o agonista ep4 como componente ativo - Google Patents

Composição farmacêutica para tratamento de doenças associadas com redução na massa óssea compreendendo o agonista ep4 como componente ativo

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Publication number
BR0211364A
BR0211364A BR0211364-3A BR0211364A BR0211364A BR 0211364 A BR0211364 A BR 0211364A BR 0211364 A BR0211364 A BR 0211364A BR 0211364 A BR0211364 A BR 0211364A
Authority
BR
Brazil
Prior art keywords
bone
agonist
reduction
diseases associated
pharmaceutical composition
Prior art date
Application number
BR0211364-3A
Other languages
English (en)
Inventor
Toru Maruyama
Kaoru Kobayashi
Tohru Kambe
Takayuki Maruyama
Hideyuki Yoshida
Akio Nishiura
Nobutaka Abe
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of BR0211364A publication Critical patent/BR0211364A/pt

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/559—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

"COMPOSIçãO FARMACêUTICA PARA TRATAMENTO DE DOENçAS ASSOCIADAS COM REDUçãO NA MASSA óSSEA COMPREENDENDO O AGONISTA EP~ 4~ COMO COMPONENTE ATIVO". Uma composição farmacêutica para administração tópica para prevenção e/ou tratamento de doenças associadas com a redução na massa óssea compreendendo um agonista EP~ 4~ como um componente ativo. Um agonista EP~ 4~, no qual inclui um composto que apresenta uma estrutura de prostaglandina como um representante, possuindo ação promotora na formação óssea, de forma que é útil na prevenção e/ou tratamento de doenças associadas com a redução da massa óssea (doenças ósseas, tais como osteoporose primária, osteoporose secundária, metástase óssea de câncer, hipercalcemia, doença de Paget, perda óssea e necrose óssea, osteogênese pós-operatória, terapia alteranativa para enxerto ósseo).
BR0211364-3A 2001-07-23 2002-07-22 Composição farmacêutica para tratamento de doenças associadas com redução na massa óssea compreendendo o agonista ep4 como componente ativo BR0211364A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001222148 2001-07-23
JP2001239895 2001-08-07
JP2002056449 2002-03-01
PCT/JP2002/007385 WO2003009872A1 (en) 2001-07-23 2002-07-22 Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient

Publications (1)

Publication Number Publication Date
BR0211364A true BR0211364A (pt) 2004-07-13

Family

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BR0211364-3A BR0211364A (pt) 2001-07-23 2002-07-22 Composição farmacêutica para tratamento de doenças associadas com redução na massa óssea compreendendo o agonista ep4 como componente ativo

Country Status (22)

Country Link
US (3) US7608637B2 (pt)
EP (2) EP1417975B1 (pt)
JP (3) JP4273407B2 (pt)
KR (3) KR100826866B1 (pt)
CN (1) CN101921220B (pt)
AT (1) ATE500218T1 (pt)
AU (1) AU2002318759C1 (pt)
BR (1) BR0211364A (pt)
CA (1) CA2454584C (pt)
DE (1) DE60239343D1 (pt)
DK (1) DK1417975T3 (pt)
HU (1) HU230421B1 (pt)
IL (1) IL159996A0 (pt)
MX (1) MXPA04000757A (pt)
NO (2) NO332625B1 (pt)
NZ (1) NZ530885A (pt)
PL (1) PL367740A1 (pt)
PT (1) PT1417975E (pt)
RU (1) RU2303451C2 (pt)
TW (1) TWI313608B (pt)
WO (1) WO2003009872A1 (pt)
ZA (1) ZA200400493B (pt)

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