MXPA04000757A - Remedios para enfermedades con perdida de masa de hueso que tienen agonistas ep4 como ingrediente activo. - Google Patents

Remedios para enfermedades con perdida de masa de hueso que tienen agonistas ep4 como ingrediente activo.

Info

Publication number
MXPA04000757A
MXPA04000757A MXPA04000757A MXPA04000757A MXPA04000757A MX PA04000757 A MXPA04000757 A MX PA04000757A MX PA04000757 A MXPA04000757 A MX PA04000757A MX PA04000757 A MXPA04000757 A MX PA04000757A MX PA04000757 A MXPA04000757 A MX PA04000757A
Authority
MX
Mexico
Prior art keywords
bone
diseases
mass loss
bone mass
remedies
Prior art date
Application number
MXPA04000757A
Other languages
English (en)
Inventor
Nishiura Akio
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of MXPA04000757A publication Critical patent/MXPA04000757A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/559—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Abstract

Se describe una composicion farmaceutica para la administracion topica para la prevencion y/o tratamiento de enfermedades asociadas con la reduccion en la masa osea, que comprende un agonista EP4 como un ingrediente activo. Un agonista EP4, el cual incluye un compuesto que posee una estructura de prostaglandina como un representativo, que posee accion promotora de la formacion osea, de manera que es util para la prevencion y/o tratamiento de enfermedades asociadas con la reduccion en la masa osea (enfermedades oseas tales como osteoporosis primaria, osteoporosis secundaria, metastasis osea del cancer, hipercalcemia, enfermedad de Paget, perdida osea y necrosis osea, osteogenesis post-operatoria, o terapia alternativa para el injerto oseo).
MXPA04000757A 2001-07-23 2002-07-22 Remedios para enfermedades con perdida de masa de hueso que tienen agonistas ep4 como ingrediente activo. MXPA04000757A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001222148 2001-07-23
JP2001239895 2001-08-07
JP2002056449 2002-03-01
PCT/JP2002/007385 WO2003009872A1 (en) 2001-07-23 2002-07-22 Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient

Publications (1)

Publication Number Publication Date
MXPA04000757A true MXPA04000757A (es) 2004-07-08

Family

ID=27347210

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000757A MXPA04000757A (es) 2001-07-23 2002-07-22 Remedios para enfermedades con perdida de masa de hueso que tienen agonistas ep4 como ingrediente activo.

Country Status (22)

Country Link
US (3) US7608637B2 (es)
EP (2) EP2255829A3 (es)
JP (3) JP4273407B2 (es)
KR (3) KR100826866B1 (es)
CN (1) CN101921220B (es)
AT (1) ATE500218T1 (es)
AU (1) AU2002318759C1 (es)
BR (1) BR0211364A (es)
CA (1) CA2454584C (es)
DE (1) DE60239343D1 (es)
DK (1) DK1417975T3 (es)
HU (1) HU230421B1 (es)
IL (1) IL159996A0 (es)
MX (1) MXPA04000757A (es)
NO (2) NO332625B1 (es)
NZ (1) NZ530885A (es)
PL (1) PL367740A1 (es)
PT (1) PT1417975E (es)
RU (1) RU2303451C2 (es)
TW (1) TWI313608B (es)
WO (1) WO2003009872A1 (es)
ZA (1) ZA200400493B (es)

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