AU2003275838A1 - Pyrrolidin-2-on derivatives as ep4 receptor agonists - Google Patents

Pyrrolidin-2-on derivatives as ep4 receptor agonists

Info

Publication number
AU2003275838A1
AU2003275838A1 AU2003275838A AU2003275838A AU2003275838A1 AU 2003275838 A1 AU2003275838 A1 AU 2003275838A1 AU 2003275838 A AU2003275838 A AU 2003275838A AU 2003275838 A AU2003275838 A AU 2003275838A AU 2003275838 A1 AU2003275838 A1 AU 2003275838A1
Authority
AU
Australia
Prior art keywords
pyrrolidin
derivatives
receptor agonists
agonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003275838A
Other versions
AU2003275838A8 (en
Inventor
Zavier Billot
Mario Girard
Yongxin Han
Marie-Claire Wilson
Robert N. Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Publication of AU2003275838A1 publication Critical patent/AU2003275838A1/en
Publication of AU2003275838A8 publication Critical patent/AU2003275838A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003275838A 2002-10-25 2003-10-23 Pyrrolidin-2-on derivatives as ep4 receptor agonists Abandoned AU2003275838A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42150302P 2002-10-25 2002-10-25
US60/421,503 2002-10-25
PCT/CA2003/001618 WO2004037813A1 (en) 2002-10-25 2003-10-23 Pyrrolidin-2-on derivatives as ep4 receptor agonists

Publications (2)

Publication Number Publication Date
AU2003275838A1 true AU2003275838A1 (en) 2004-05-13
AU2003275838A8 AU2003275838A8 (en) 2004-05-13

Family

ID=32176723

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003275838A Abandoned AU2003275838A1 (en) 2002-10-25 2003-10-23 Pyrrolidin-2-on derivatives as ep4 receptor agonists

Country Status (2)

Country Link
AU (1) AU2003275838A1 (en)
WO (1) WO2004037813A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7547685B2 (en) 2004-11-08 2009-06-16 Allergan, Inc. Therapeutic substituted pyrrolidone compounds
PL1856042T3 (en) * 2005-03-10 2012-11-30 Allergan Inc Substituted gamma lactams as therapeutic agents
AU2012211448B2 (en) * 2005-03-10 2016-01-07 Allergan, Inc. Substituted gamma lactams as therapeutic agents
US7893107B2 (en) 2005-11-30 2011-02-22 Allergan, Inc. Therapeutic methods using prostaglandin EP4 agonist components
UY30121A1 (en) 2006-02-03 2007-08-31 Glaxo Group Ltd NEW COMPOUNDS
US7592364B2 (en) 2006-02-28 2009-09-22 Allergan, Inc. Substituted gamma lactams as therapeutic agents
AU2007226957B2 (en) 2006-03-20 2013-08-15 Allergan, Inc. Substituted gamma lactams as prostaglandin EP2 agonists
EP2049472B1 (en) 2006-06-23 2015-01-21 AbbVie Bahamas Ltd. Cyclopropyl amine derivatives as histamin h3 receptor modulators
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
EP2049467B1 (en) 2006-08-09 2011-03-23 Allergan, Inc. Therapeutic amides and related compounds
WO2008058766A1 (en) 2006-11-16 2008-05-22 Bayer Schering Pharma Aktiengesellschaft Ep2 and ep4 agonists as agents for the treatment of influenza a viral infection
KR20090089868A (en) 2006-12-15 2009-08-24 글락소 그룹 리미티드 Benzamide derivatives as ep4 receptor agonists
ES2404169T3 (en) * 2007-02-15 2013-05-24 Allergan, Inc. Gamma-lactams for the treatment of glaucoma or elevated intraocular pressure
GB0721611D0 (en) 2007-11-02 2007-12-12 Glaxo Group Ltd Novel compounds
PL2291368T3 (en) 2008-04-24 2013-05-31 Allergan Inc Substituted gamma lactams as therapeutic agents
EP2149552A1 (en) 2008-07-30 2010-02-03 Bayer Schering Pharma AG 5,6 substituted benzamide derivatives as modulators of EP2 receptors
EP2149551A1 (en) 2008-07-30 2010-02-03 Bayer Schering Pharma AG N-(indol-3-ylalkyl)-(hetero)arylamid derivatives as modulators of EP2 receptors
EP2149554A1 (en) 2008-07-30 2010-02-03 Bayer Schering Pharma Aktiengesellschaft Indolyamides as modulators for an EP2 receptor
US7985765B2 (en) 2008-08-20 2011-07-26 Allergan, Inc. Therapeutic substituted pyrroles
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
CN107304452A (en) * 2016-04-25 2017-10-31 复旦大学 BK channel proteins are preparing the purposes during osteoblastic proliferation intervenes medicine extremely

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2346706A1 (en) * 1973-09-17 1975-04-03 Hoechst Ag NEW, NON NATURALLY OCCURRING ANALOGS OF PROSTANIC ACIDS AND THE PROCESS FOR THEIR PRODUCTION
PT1339678E (en) * 2000-11-27 2007-11-30 Pfizer Prod Inc Ep4 receptor selective agonists in the treatment of osteoporosis
TWI313608B (en) * 2001-07-23 2009-08-21 Ono Pharmaceutical Co Lower bone mass treating agent containing er4 agonist as active ingredient
JP4547912B2 (en) * 2002-03-05 2010-09-22 小野薬品工業株式会社 8-Azaprostaglandin derivative compound and drug containing the compound as an active ingredient

Also Published As

Publication number Publication date
WO2004037813A1 (en) 2004-05-06
AU2003275838A8 (en) 2004-05-13

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase