EP1682493B8 - Amidoacetonitrile derivatives - Google Patents

Amidoacetonitrile derivatives Download PDF

Info

Publication number
EP1682493B8
EP1682493B8 EP04797665A EP04797665A EP1682493B8 EP 1682493 B8 EP1682493 B8 EP 1682493B8 EP 04797665 A EP04797665 A EP 04797665A EP 04797665 A EP04797665 A EP 04797665A EP 1682493 B8 EP1682493 B8 EP 1682493B8
Authority
EP
European Patent Office
Prior art keywords
amidoacetonitrile derivatives
amidoacetonitrile
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP04797665A
Other languages
German (de)
French (fr)
Other versions
EP1682493B1 (en
EP1682493A1 (en
Inventor
Noëlle GAUVRY
Thomas Goebel
Pierre Ducray
François PAUTRAT
Ronald Kaminsky
Martin Jung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis Pharma GmbH
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP03025290 priority Critical
Priority to GBGB0402677.9A priority patent/GB0402677D0/en
Application filed by Novartis Pharma GmbH, Novartis AG filed Critical Novartis Pharma GmbH
Priority to PCT/EP2004/012559 priority patent/WO2005044784A1/en
Priority to EP04797665A priority patent/EP1682493B8/en
Publication of EP1682493A1 publication Critical patent/EP1682493A1/en
Application granted granted Critical
Publication of EP1682493B1 publication Critical patent/EP1682493B1/en
Publication of EP1682493B8 publication Critical patent/EP1682493B8/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46N-acyl derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/49Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
EP04797665A 2003-11-06 2004-11-05 Amidoacetonitrile derivatives Active EP1682493B8 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03025290 2003-11-06
GBGB0402677.9A GB0402677D0 (en) 2003-11-06 2004-02-06 Organic compounds
PCT/EP2004/012559 WO2005044784A1 (en) 2003-11-06 2004-11-05 Amidoacetonitrile derivatives
EP04797665A EP1682493B8 (en) 2003-11-06 2004-11-05 Amidoacetonitrile derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200431066T SI1682493T1 (en) 2003-11-06 2004-11-05 Amidoacetonitrile derivatives
PL04797665T PL1682493T3 (en) 2003-11-06 2004-11-05 Amidoacetonitrile derivatives
EP04797665A EP1682493B8 (en) 2003-11-06 2004-11-05 Amidoacetonitrile derivatives

Publications (3)

Publication Number Publication Date
EP1682493A1 EP1682493A1 (en) 2006-07-26
EP1682493B1 EP1682493B1 (en) 2009-01-07
EP1682493B8 true EP1682493B8 (en) 2009-11-25

Family

ID=34575667

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04797665A Active EP1682493B8 (en) 2003-11-06 2004-11-05 Amidoacetonitrile derivatives

Country Status (22)

Country Link
US (2) US7494956B2 (en)
EP (1) EP1682493B8 (en)
JP (1) JP4319680B2 (en)
KR (1) KR100793462B1 (en)
CN (1) CN100447130C (en)
AR (1) AR046322A1 (en)
AT (1) AT420066T (en)
AU (1) AU2004287611B2 (en)
BR (1) BRPI0416294B1 (en)
CA (1) CA2544741C (en)
DE (1) DE602004018967D1 (en)
DK (1) DK1682493T3 (en)
ES (1) ES2317070T3 (en)
GB (1) GB0402677D0 (en)
MX (1) MXPA06005036A (en)
NZ (1) NZ546830A (en)
PL (1) PL1682493T3 (en)
PT (1) PT1682493E (en)
RU (1) RU2370485C2 (en)
SI (1) SI1682493T1 (en)
TW (1) TWI342875B (en)
WO (1) WO2005044784A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402677D0 (en) * 2003-11-06 2004-03-10 Novartis Ag Organic compounds
DK1731512T3 (en) 2004-03-05 2015-01-05 Nissan Chemical Ind Ltd Isoxazoline-substituted benzamide AND INSTRUMENTS FOR COMBATING HARMFUL ORGANISMS
EP1812385B1 (en) * 2004-11-09 2012-07-18 Novartis AG Process for the preparation of enantiomers of amidoacetonitrile compounds from their racemates
CN101600687B (en) * 2007-02-09 2012-10-31 辉瑞股份有限公司 Antiparasitic agents
NZ578259A (en) 2007-02-09 2011-12-22 Pfizer Ltd Antiparasitic agents
JP5327876B2 (en) * 2007-02-21 2013-10-30 ゾエティス・ユーケイ・リミテッド Benzofuran antiparasitic agent
AU2008254279B2 (en) 2007-05-15 2013-03-14 Aventis Agriculture Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof
AR066939A1 (en) 2007-06-07 2009-09-23 Divergence Inc ECTOPARASITES CONTROL
TWI556741B (en) 2007-08-17 2016-11-11 英特威特國際股份有限公司 Isoxazoline compositions and their use as antiparasitics
WO2010048191A1 (en) 2008-10-21 2010-04-29 Merial Limited Thioamide compounds, method of making and method of using thereof
TWI516261B (en) 2008-11-14 2016-01-11 龍馬躍有限公司 Enantiomerically enriched aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof
NZ592367A (en) 2008-12-03 2013-05-31 Novartis Ag Amidoacetonitrile compounds and pesticidal composition thereof
GB0905365D0 (en) * 2009-03-27 2009-05-13 Norbrook Lab Ltd A topical parasiticide composition
US20100310726A1 (en) 2009-06-05 2010-12-09 Kraft Foods Global Brands Llc Novel Preparation of an Enteric Release System
US8859003B2 (en) * 2009-06-05 2014-10-14 Intercontinental Great Brands Llc Preparation of an enteric release system
US9968564B2 (en) 2009-06-05 2018-05-15 Intercontinental Great Brands Llc Delivery of functional compounds
US20100307542A1 (en) * 2009-06-05 2010-12-09 Kraft Foods Global Brands Llc Method of Reducing Surface Oil on Encapsulated Material
EP2314292A1 (en) 2009-10-20 2011-04-27 Novartis AG Endoparasiticidal compositions
UY33282A (en) * 2010-03-25 2011-09-30 Novartis Ag Endoparasiticidal compositions
CN104271128A (en) 2011-10-19 2015-01-07 佐蒂斯有限责任公司 Use of aminoacetonitrile derivatives against endoparasites
NZ630807A (en) * 2012-03-23 2016-04-29 Pitney Pharmaceuticals Pty Ltd Kinase inhibitors for the treatment of cancer
US8822689B2 (en) 2012-09-19 2014-09-02 Merial Limited Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof
US8859005B2 (en) 2012-12-03 2014-10-14 Intercontinental Great Brands Llc Enteric delivery of functional ingredients suitable for hot comestible applications
CN103030575B (en) * 2013-01-04 2014-10-01 中国农业大学 Double-cyano acidamide compound, and synthetic method and application of compound
AR094961A1 (en) 2013-03-15 2015-09-09 Lilly Co Eli 1-hydroxy-benzooxaboroles as antiparasitic agents
EP2821412A1 (en) 2013-07-01 2015-01-07 Universität Zürich Organometallic 2-cyano-2-aminobenzoate-propyl derivates and their use as anthelmintics
CN105658056B (en) * 2013-07-01 2018-03-06 苏黎世大学 (trifluoromethyl sulfydryl) heterocyclic carbamate derivatives of N (Methylethyl of 1 cyano group, 2 hydroxyl 1) 4 as nematicide thing
EP3043791B1 (en) * 2013-09-13 2019-04-24 Pitney Pharmaceuticals Pty Limited Anticancer agent comprising aminoacetonitrile compound as active ingredient
EP3049425A1 (en) 2013-09-26 2016-08-03 Universität Zürich Bis-organometallic 2-amino-3-hydroxy-2-methylpropanenitrile derivatives for use as anthelmintics
JP2016533339A (en) * 2013-09-26 2016-10-27 ウニヴェルズィテート チューリッヒ Organometallic N-2-cyano-1-hydroxypropan-2-yl for use as an anthelmintic
MX2016003799A (en) * 2013-09-26 2016-10-05 Universität Zürich Organometallic compounds for use as anthelmintics.
JP2016535014A (en) * 2013-11-01 2016-11-10 ピットニー・ファーマシューティカルズ・ピーティーワイ・リミテッド Medicinal combination for the treatment of cancer
WO2020112374A1 (en) 2018-11-20 2020-06-04 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1441499A (en) 1964-02-14 1966-06-10 Geigy Ag J R New phenyl esters endowed with antimicrobial properties, usable in particular for the protection of organic materials
US4515731A (en) * 1975-08-25 1985-05-07 Monsanto Company Asymmetric catalysis
US6239077B1 (en) * 1998-05-01 2001-05-29 Nihon Nohyaku Co., Ltd. Aminoacetonitrile derivative agricultural and horticultural insecticide containing the same and use thereof
US7700656B2 (en) * 2000-12-20 2010-04-20 Novartis Ag Organic compounds
AR035531A1 (en) 2001-01-22 2004-06-02 Novartis Ag Composition for the control of endoparasitic pests in cattle and domestic animals, a method for their control and the use of said composition for the preparation of medicines
JP4124661B2 (en) * 2001-05-15 2008-07-23 ノバルティス アクチエンゲゼルシャフト Benzamide acetonitrile and its use as an anthelmintic
AR036054A1 (en) * 2001-06-15 2004-08-04 Novartis Ag Use of aminoacetonitrile compounds for pest control, a composition and a process for such control and a pharmaceutical composition against parasites
WO2003004474A1 (en) 2001-07-06 2003-01-16 Syngenta Participations Ag Pesticidally active aminoacetonitriles
RU2296747C2 (en) * 2001-10-04 2007-04-10 Новартис Аг Carbonyloxycyanomethyl compounds, method for their preparing and their using (variants), composition and method for control of parasites
CA2458446A1 (en) * 2001-10-04 2003-04-17 Novartis Ag Cyanoacetyl compounds
TW200300140A (en) * 2001-11-14 2003-05-16 Novartis Ag Organic compounds
TWI261053B (en) * 2001-12-06 2006-09-01 Novartis Ag Amidoacetonitrile compounds, their preparation, compositions and use as pesticides
AR038156A1 (en) * 2002-01-21 2004-12-29 Novartis Ag Amidoacetonitrile compounds, process for their preparation, composition to control parasites, and use of these compounds to prepare a pharmaceutical composition
AR040082A1 (en) 2002-05-22 2005-03-16 Novartis Ag Derivatives of n-acylaminoacetonitrile and their use for the control of parasites
AR040229A1 (en) * 2002-05-22 2005-03-23 Novartis Ag Amidoacetonitriles
AR039961A1 (en) * 2002-06-06 2005-03-09 Novartis Ag Amidoacetonitrile derivatives and their use as a pesticide
AR040149A1 (en) * 2002-06-07 2005-03-16 Novartis Ag Aminoacetonitrile compounds, a process for their preparation, composition, and use of the compound
TW200400932A (en) 2002-06-19 2004-01-16 Novartis Ag Organic compounds
GB0214117D0 (en) * 2002-06-19 2002-07-31 Syngenta Participations Ag N-sulphonylaminoacetonitriles having pesticidal properties
TW200409760A (en) * 2002-09-11 2004-06-16 Novartis Ag Organic compounds
GB0402677D0 (en) * 2003-11-06 2004-03-10 Novartis Ag Organic compounds
AR046757A1 (en) * 2003-12-10 2005-12-21 Novartis Ag Amidoacetonitriles useful as pesticides
TW200613251A (en) * 2004-06-10 2006-05-01 Novartis Ag Organic compounds
EP1812385B1 (en) 2004-11-09 2012-07-18 Novartis AG Process for the preparation of enantiomers of amidoacetonitrile compounds from their racemates

Also Published As

Publication number Publication date
GB0402677D0 (en) 2004-03-10
EP1682493A1 (en) 2006-07-26
WO2005044784A1 (en) 2005-05-19
BRPI0416294B1 (en) 2018-06-05
KR20060088122A (en) 2006-08-03
US7494956B2 (en) 2009-02-24
TWI342875B (en) 2011-06-01
US20070072944A1 (en) 2007-03-29
US20090176868A1 (en) 2009-07-09
DK1682493T3 (en) 2009-04-20
MXPA06005036A (en) 2006-07-06
RU2370485C2 (en) 2009-10-20
TW200528024A (en) 2005-09-01
AU2004287611A1 (en) 2005-05-19
BRPI0416294A (en) 2007-01-23
EP1682493B1 (en) 2009-01-07
AU2004287611B2 (en) 2008-05-15
PL1682493T3 (en) 2009-06-30
CN1902162A (en) 2007-01-24
KR100793462B1 (en) 2008-01-14
RU2006119506A (en) 2007-12-27
NZ546830A (en) 2009-07-31
AT420066T (en) 2009-01-15
JP2007510632A (en) 2007-04-26
DE602004018967D1 (en) 2009-02-26
SI1682493T1 (en) 2009-06-30
PT1682493E (en) 2009-02-12
US7964635B2 (en) 2011-06-21
CA2544741A1 (en) 2005-05-19
ES2317070T3 (en) 2009-04-16
JP4319680B2 (en) 2009-08-26
CN100447130C (en) 2008-12-31
AR046322A1 (en) 2005-11-30
CA2544741C (en) 2012-08-07

Similar Documents

Publication Publication Date Title
IL213984D0 (en) Spiroindolinepiperidine derivatives
EG24050A (en) Heterocylocarboxamide derivatives
AU2003274022A1 (en) 3-heterocyclylpyridine derivatives useful as herbicides
PL374718A1 (en) Azolidinone-vinyl fused-benzene derivatives
SI1551802T1 (en) Indole-3-sulphur derivatives
AU2003255492A1 (en) Heterocyclic derivatives
EP1522540A4 (en) Azaarene derivatives
PL376475A1 (en) N-substituted-2-oxodihydropyridine derivatives
AU2003266949A1 (en) Compounds
AU2003273865A1 (en) Amino-propanol derivatives
AU2003221098A1 (en) Oligofluorenylene compounds
TWI368482B (en) New 2-pyridinylethylbenzamide derivatives
AU2003255831A1 (en) Delayed-gelation solution
ZA200504852B (en) Novel 2-pyridinecarboxamide derivatives
AU2003224111A1 (en) Substituted pyrazolo-pyrimidine-4-ones
AU2003239909A1 (en) Enhanced-service provision
AU2003249738A1 (en) Ostoscope
AU2003297193A1 (en) Meta-web
AU2003273433A1 (en) Cartridge-operated coffee-machine
AU2003217234A1 (en) Modulator- amplifier
AU2003274037A1 (en) 1-phenylpyrrolidine-2-one-3-carboxamides
AU2002335152A1 (en) Robot-phone
AU2003205622A1 (en) Aza-arylpiperazines
AU2003259219A1 (en) Superprimer
WO2003072535A8 (en) Substituted hydroxyethylamines

Legal Events

Date Code Title Description
AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR

17P Request for examination filed

Effective date: 20060606

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20080125

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20090129

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 602004018967

Country of ref document: DE

Date of ref document: 20090226

Kind code of ref document: P

REG Reference to a national code

Ref country code: RO

Ref legal event code: EPE

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20090400637

Country of ref document: GR

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2317070

Country of ref document: ES

Kind code of ref document: T3

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: PL

Ref legal event code: T3

REG Reference to a national code

Ref country code: HU

Ref legal event code: AG4A

Ref document number: E005234

Country of ref document: HU

RAP2 Rights of a patent transferred

Owner name: NOVARTIS PHARMA GMBH

Owner name: NOVARTIS AG

26N No opposition filed

Effective date: 20091008

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: MC

Payment date: 20091028

Year of fee payment: 6

NLT2 Nl: modifications (of names), taken from the european patent patent bulletin

Owner name: NOVARTIS AG

Effective date: 20091209

NLXE Nl: other communications concerning ep-patents (part 3 heading xe)

Free format text: PAT. BUL. 05/2009, PAGE 678: CORR.: NOVARTIS A.G.

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: CY

Payment date: 20091026

Year of fee payment: 6

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101105

REG Reference to a national code

Ref country code: CH

Ref legal event code: PUE

Owner name: NOVARTIS TIERGESUNDHEIT AG, CH

Free format text: FORMER OWNER: NOVARTIS AG, CH

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

Free format text: REGISTERED BETWEEN 20150312 AND 20150318

REG Reference to a national code

Ref country code: EE

Ref legal event code: GB1A

Ref document number: E003106

Country of ref document: EE

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 602004018967

Country of ref document: DE

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, DE

REG Reference to a national code

Ref country code: PT

Ref legal event code: PC4A

Owner name: NOVARTIS TIERGESUNDHEIT AG, CH

Effective date: 20150429

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 602004018967

Country of ref document: DE

Owner name: NOVARTIS TIERGESUNDHEIT AG, CH

Free format text: FORMER OWNER: NOVARTIS AG, BASEL, CH

Effective date: 20150417

Ref country code: DE

Ref legal event code: R082

Ref document number: 602004018967

Country of ref document: DE

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, DE

Effective date: 20150417

Ref country code: DE

Ref legal event code: R082

Ref document number: 602004018967

Country of ref document: DE

Representative=s name: DR. SCHOEN, NEYMEYR & PARTNER MBB, DE

Effective date: 20150417

Ref country code: DE

Ref legal event code: R082

Ref document number: 602004018967

Country of ref document: DE

Representative=s name: OFFICE FREYLINGER S.A., LU

Effective date: 20150417

Ref country code: DE

Ref legal event code: R081

Ref document number: 602004018967

Country of ref document: DE

Owner name: NOVARTIS TIERGESUNDHEIT AG, CH

Free format text: FORMER OWNER: NOVARTIS AG, 4056 BASEL, CH

Effective date: 20150417

Ref country code: DE

Ref legal event code: R081

Ref document number: 602004018967

Country of ref document: DE

Owner name: ELANCO TIERGESUNDHEIT AG, CH

Free format text: FORMER OWNER: NOVARTIS AG, 4056 BASEL, CH

Effective date: 20150417

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 602004018967

Country of ref document: DE

Representative=s name: DR. SCHOEN, NEYMEYR & PARTNER MBB, DE

Ref country code: DE

Ref legal event code: R082

Ref document number: 602004018967

Country of ref document: DE

Representative=s name: OFFICE FREYLINGER S.A., LU

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: E. BLUM AND CO. AG PATENT- UND MARKENANWAELTE , CH

REG Reference to a national code

Ref country code: ES

Ref legal event code: PC2A

Owner name: NOVARTIS TIERGESUNDHEIT AG

Effective date: 20150615

Ref country code: ES

Ref legal event code: PC2A

Owner name: NOVARTIS TIERGESUNDHEIT AG

Effective date: 20150717

REG Reference to a national code

Ref country code: NL

Ref legal event code: SD

Effective date: 20150616

REG Reference to a national code

Ref country code: SK

Ref legal event code: PC4A

Ref document number: E 6049

Country of ref document: SK

Owner name: NOVARTIS TIERGESUNDHEIT AG, BASEL, CH

Free format text: FORMER OWNER: NOVARTIS AG, BASEL, CH

Effective date: 20150604

REG Reference to a national code

Ref country code: SI

Ref legal event code: SP73

Owner name: NOVARTIS TIERGESUNDHEIT AG; CH

Effective date: 20150605

REG Reference to a national code

Ref country code: FR

Ref legal event code: TP

Owner name: NOVARTIS TIERGESUNDHEIT AG, CH

Effective date: 20150820

REG Reference to a national code

Ref country code: HU

Ref legal event code: FH1C

Free format text: FORMER REPRESENTATIVE(S): PARRAGH GABORNE DR., S.B.G & K. SZABADALMI UEGYVIVOEI IRODA, HU

Representative=s name: SBGK SZABADALMI UEGYVIVOEI IRODA, HU

Ref country code: HU

Ref legal event code: GB9C

Owner name: NOVARTIS TIERGESUNDHEIT AG, CH

Free format text: FORMER OWNER(S): NOVARTIS AG, CH

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 12

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 602004018967

Country of ref document: DE

Representative=s name: OFFICE FREYLINGER S.A., LU

REG Reference to a national code

Ref country code: AT

Ref legal event code: PC

Ref document number: 420066

Country of ref document: AT

Kind code of ref document: T

Owner name: NOVARTIS TIERGESUNDHEIT AG, CH

Effective date: 20160705

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 13

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 14

REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Owner name: ELANCO TIERGESUNDHEIT AG, CH

Free format text: FORMER OWNER: NOVARTIS TIERGESUNDHEIT AG, CH

REG Reference to a national code

Ref country code: LU

Ref legal event code: HC

Owner name: ELANCO TIERGESUNDHEIT AG; CH

Free format text: FORMER OWNER: NOVARTIS TIERGESUNDHEIT AG

Effective date: 20171213

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 602004018967

Country of ref document: DE

Representative=s name: OFFICE FREYLINGER S.A., LU

Ref country code: DE

Ref legal event code: R081

Ref document number: 602004018967

Country of ref document: DE

Owner name: ELANCO TIERGESUNDHEIT AG, CH

Free format text: FORMER OWNER: NOVARTIS TIERGESUNDHEIT AG, 4058 BASEL, CH

REG Reference to a national code

Ref country code: ES

Ref legal event code: PC2A

Owner name: ELANCO TIERGESUNDHEIT AG

Effective date: 20180207

REG Reference to a national code

Ref country code: EE

Ref legal event code: HC1A

Ref document number: E003106

Country of ref document: EE

REG Reference to a national code

Ref country code: BE

Ref legal event code: HC

Owner name: ELANCO TIERGESUNDHEIT AG; CH

Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), CHANGEMENT DE NOM DU PROPRIETAIRE, NOM/ADRESSE; FORMER OWNER NAME: NOVARTIS TIERGESUNDHEIT AG

Effective date: 20171214

Ref country code: BE

Ref legal event code: PD

Owner name: NOVARTIS TIERGESUNDHEIT AG; CH

Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), AFFECTATION / CESSION; FORMER OWNER NAME: NOVARTIS AG

Effective date: 20150504

REG Reference to a national code

Ref country code: HU

Ref legal event code: HC9C

Owner name: ELANCO TIERGESUNDHEIT AG, CH

Free format text: FORMER OWNER(S): NOVARTIS AG, CH; NOVARTIS TIERGESUNDHEIT AG, CH

Ref country code: SI

Ref legal event code: SP73

Owner name: ELANCO TIERGESUNDHEIT AG; CH

Effective date: 20180126

REG Reference to a national code

Ref country code: SK

Ref legal event code: TC4A

Ref document number: E 6049

Country of ref document: SK

Owner name: ELANCO TIERGESUNDHEIT AG, BASEL, CH

Effective date: 20180219

REG Reference to a national code

Ref country code: FR

Ref legal event code: CA

Effective date: 20180316

Ref country code: FR

Ref legal event code: CD

Owner name: ELANCO TIERGESUNDHEIT AG, CH

Effective date: 20180316

REG Reference to a national code

Ref country code: NL

Ref legal event code: HC

Owner name: ELANCO TIERGESUNDHEIT AG; CH

Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), CHANGE OF OWNER(S) NAME; FORMER OWNER NAME: NOVARTIS TIERGESUNDHEIT AG

Effective date: 20180731

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 15

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: LU

Payment date: 20181105

Year of fee payment: 15

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: RO

Payment date: 20181017

Year of fee payment: 15

Ref country code: SK

Payment date: 20181023

Year of fee payment: 15

Ref country code: EE

Payment date: 20181105

Year of fee payment: 15

Ref country code: GR

Payment date: 20181026

Year of fee payment: 15

Ref country code: IS

Payment date: 20181011

Year of fee payment: 15

Ref country code: FI

Payment date: 20181026

Year of fee payment: 15

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: BG

Payment date: 20180928

Year of fee payment: 15

Ref country code: SI

Payment date: 20181025

Year of fee payment: 15

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: CZ

Payment date: 20191024

Year of fee payment: 16

Ref country code: HU

Payment date: 20191105

Year of fee payment: 16

Ref country code: DE

Payment date: 20191017

Year of fee payment: 16

Ref country code: IE

Payment date: 20191029

Year of fee payment: 16

Ref country code: SE

Payment date: 20191108

Year of fee payment: 16

Ref country code: PT

Payment date: 20191028

Year of fee payment: 16

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: BE

Payment date: 20191021

Year of fee payment: 16

Ref country code: IT

Payment date: 20191113

Year of fee payment: 16

Ref country code: ES

Payment date: 20191202

Year of fee payment: 16

Ref country code: PL

Payment date: 20191022

Year of fee payment: 16

Ref country code: DK

Payment date: 20191028

Year of fee payment: 16

Ref country code: FR

Payment date: 20191029

Year of fee payment: 16

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: CH

Payment date: 20191028

Year of fee payment: 16

Ref country code: AT

Payment date: 20191028

Year of fee payment: 16

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: GB

Payment date: 20191029

Year of fee payment: 16

REG Reference to a national code

Ref country code: FI

Ref legal event code: MAE

REG Reference to a national code

Ref country code: EE

Ref legal event code: MM4A

Ref document number: E003106

Country of ref document: EE

Effective date: 20191130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191105

Ref country code: EE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191130

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200609

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191105

Ref country code: RO

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191105

REG Reference to a national code

Ref country code: SK

Ref legal event code: MM4A

Ref document number: E 6049

Country of ref document: SK

Effective date: 20191105

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191105

Ref country code: BG

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191106

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: NL

Payment date: 20201015

Year of fee payment: 17

Ref country code: TR

Payment date: 20201103

Year of fee payment: 17

REG Reference to a national code

Ref country code: CH

Ref legal event code: PVP