BG65800B1 - Използване на инхибитори на интерлевкин-18 за потискане на туморни метастази - Google Patents

Използване на инхибитори на интерлевкин-18 за потискане на туморни метастази Download PDF

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Publication number
BG65800B1
BG65800B1 BG106311A BG10631102A BG65800B1 BG 65800 B1 BG65800 B1 BG 65800B1 BG 106311 A BG106311 A BG 106311A BG 10631102 A BG10631102 A BG 10631102A BG 65800 B1 BG65800 B1 BG 65800B1
Authority
BG
Bulgaria
Prior art keywords
cells
hse
adhesion
production
inhibitors
Prior art date
Application number
BG106311A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG106311A (en
Inventor
Charles Dinarello
Original Assignee
Yeda Research And Development Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.
Publication of BG106311A publication Critical patent/BG106311A/xx
Publication of BG65800B1 publication Critical patent/BG65800B1/bg

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG106311A 1999-07-22 2002-01-16 Използване на инхибитори на интерлевкин-18 за потискане на туморни метастази BG65800B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors
PCT/IL2000/000419 WO2001007480A2 (en) 1999-07-22 2000-07-17 Use of interleukin-18 inhibitors to inhibit tumor metastasis

Publications (2)

Publication Number Publication Date
BG106311A BG106311A (en) 2002-08-30
BG65800B1 true BG65800B1 (bg) 2009-12-31

Family

ID=11073044

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106311A BG65800B1 (bg) 1999-07-22 2002-01-16 Използване на инхибитори на интерлевкин-18 за потискане на туморни метастази

Country Status (31)

Country Link
US (1) US7741276B2 (OSRAM)
EP (1) EP1206274B1 (OSRAM)
JP (1) JP4827352B2 (OSRAM)
KR (1) KR100682219B1 (OSRAM)
CN (1) CN1173736C (OSRAM)
AR (1) AR024907A1 (OSRAM)
AT (1) ATE363288T1 (OSRAM)
AU (1) AU782478B2 (OSRAM)
BG (1) BG65800B1 (OSRAM)
BR (1) BR0012675A (OSRAM)
CA (1) CA2380216C (OSRAM)
CY (1) CY1107932T1 (OSRAM)
CZ (1) CZ302114B6 (OSRAM)
DE (2) DE1206274T1 (OSRAM)
DK (1) DK1206274T3 (OSRAM)
EA (1) EA005419B1 (OSRAM)
EE (1) EE04838B1 (OSRAM)
ES (1) ES2186596T3 (OSRAM)
HK (1) HK1048248B (OSRAM)
HU (1) HU228780B1 (OSRAM)
IL (2) IL131047A0 (OSRAM)
MX (1) MXPA02000838A (OSRAM)
NO (1) NO329827B1 (OSRAM)
NZ (1) NZ516535A (OSRAM)
PL (1) PL202477B1 (OSRAM)
PT (1) PT1206274E (OSRAM)
SK (1) SK287522B6 (OSRAM)
TR (1) TR200200169T2 (OSRAM)
UA (1) UA73745C2 (OSRAM)
WO (1) WO2001007480A2 (OSRAM)
ZA (1) ZA200200390B (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0300423A3 (en) 2000-02-10 2008-07-28 Abbott Lab Antibodies that bind human interleukin-18 and methods of making and using
WO2002031115A2 (en) 2000-10-11 2002-04-18 Viron Therapeutics, Inc. Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
EP1425028B1 (en) * 2001-05-16 2009-12-16 Yeda Research And Development Co. Ltd. Use of il-18 inhibitors for the treatement or prevention of sepsis
RU2225720C1 (ru) * 2002-08-12 2004-03-20 Научно-исследовательский институт онкологии Томского научного центра СО РАМН Средство, повышающее противоопухолевую и антиметастатическую активность циклофосфана
BR0315155A (pt) * 2002-10-08 2005-08-16 Ares Trading Sa Uso de citocina capaz de ligar il-18bp e de inibir a atividade de uma segunda citocina
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
PT2267024E (pt) 2005-06-03 2012-06-01 Ares Trading Sa Produção de proteína de ligação a il-18 recombinante
ATE529433T1 (de) 2005-06-10 2011-11-15 Ares Trading Sa Verfahren zur reinigung eines il-18-bindenden proteins
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
US9812033B2 (en) * 2013-03-06 2017-11-07 Venkatesh R. Chari Tactile graphic display
KR20240144422A (ko) 2022-03-15 2024-10-02 컴퓨젠 엘티디. 암 치료의 단독치료법 및 병용치료법에서 il-18bp 길항제 항체 및 이의 용도
KR20250133728A (ko) 2023-01-06 2025-09-08 라센 테라퓨틱스, 인코포레이티드 항-il-18bp 항체
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ256171A (en) * 1992-09-02 1996-12-20 Isis Pharmaceuticals Inc Treating diseases amenable to treatment through modulating intercellular adhesion molecule metabolism or synthesis using oligonucleotides
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
EP0998300A1 (en) * 1997-03-18 2000-05-10 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use

Also Published As

Publication number Publication date
EE200200032A (et) 2003-02-17
AU782478B2 (en) 2005-08-04
HK1048248A1 (en) 2003-03-28
IL131047A0 (en) 2001-01-28
ES2186596T1 (es) 2003-05-16
NO20020153D0 (no) 2002-01-11
NZ516535A (en) 2004-04-30
ATE363288T1 (de) 2007-06-15
CA2380216A1 (en) 2001-02-01
KR100682219B1 (ko) 2007-02-12
CY1107932T1 (el) 2013-09-04
DE60035049T2 (de) 2007-09-27
WO2001007480A3 (en) 2001-05-10
UA73745C2 (en) 2005-09-15
CZ302114B6 (cs) 2010-10-20
IL147675A (en) 2009-05-04
US7741276B2 (en) 2010-06-22
KR20020027493A (ko) 2002-04-13
EP1206274A2 (en) 2002-05-22
BG106311A (en) 2002-08-30
US20080003216A1 (en) 2008-01-03
JP4827352B2 (ja) 2011-11-30
CN1173736C (zh) 2004-11-03
MXPA02000838A (es) 2002-07-30
WO2001007480A2 (en) 2001-02-01
EP1206274B1 (en) 2007-05-30
CA2380216C (en) 2012-01-31
EE04838B1 (et) 2007-06-15
EA005419B1 (ru) 2005-02-24
BRPI0012675B1 (pt) 2001-02-01
NO20020153L (no) 2002-03-11
HUP0202107A3 (en) 2005-01-28
CZ2002195A3 (cs) 2002-06-12
PT1206274E (pt) 2007-07-06
ES2186596T3 (es) 2007-11-16
BR0012675A (pt) 2002-04-09
EA200200189A1 (ru) 2002-12-26
HK1048248B (zh) 2005-04-22
JP2003505472A (ja) 2003-02-12
DE1206274T1 (de) 2002-11-14
BRPI0012675B8 (OSRAM) 2021-05-25
DE60035049D1 (de) 2007-07-12
HUP0202107A2 (en) 2002-10-28
DK1206274T3 (da) 2007-08-13
HU228780B1 (en) 2013-05-28
CN1364086A (zh) 2002-08-14
SK882002A3 (en) 2002-07-02
PL202477B1 (pl) 2009-06-30
SK287522B6 (sk) 2011-01-04
AU5843200A (en) 2001-02-13
PL353732A1 (en) 2003-12-01
ZA200200390B (en) 2003-04-30
NO329827B1 (no) 2011-01-03
TR200200169T2 (tr) 2002-06-21
AR024907A1 (es) 2002-10-30

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