BG64599B1 - Платинов комплекс, метод за получаването му и терапевтичното му приложение - Google Patents
Платинов комплекс, метод за получаването му и терапевтичното му приложение Download PDFInfo
- Publication number
- BG64599B1 BG64599B1 BG104972A BG10497200A BG64599B1 BG 64599 B1 BG64599 B1 BG 64599B1 BG 104972 A BG104972 A BG 104972A BG 10497200 A BG10497200 A BG 10497200A BG 64599 B1 BG64599 B1 BG 64599B1
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- Prior art keywords
- complex
- formula
- carbon atoms
- platinum
- group
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title claims abstract description 59
- 229910052697 platinum Inorganic materials 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims description 5
- 230000001225 therapeutic effect Effects 0.000 title description 4
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 24
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 22
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 11
- 229960004853 betadex Drugs 0.000 claims abstract description 11
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims abstract description 11
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims abstract description 11
- 125000005843 halogen group Chemical group 0.000 claims abstract description 10
- 150000007942 carboxylates Chemical group 0.000 claims abstract description 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 9
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 7
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- 230000009471 action Effects 0.000 claims abstract description 3
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 3
- 201000010099 disease Diseases 0.000 claims abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 3
- 230000008569 process Effects 0.000 claims abstract description 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 230000000771 oncological effect Effects 0.000 claims abstract 2
- 230000003647 oxidation Effects 0.000 claims abstract 2
- 238000007254 oxidation reaction Methods 0.000 claims abstract 2
- 239000013543 active substance Substances 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 8
- -1 3,5-dimethyladamantylamino group Chemical group 0.000 claims description 6
- 125000003282 alkyl amino group Chemical group 0.000 claims description 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 239000008177 pharmaceutical agent Substances 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 2
- 230000001590 oxidative effect Effects 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 2
- 241001440267 Cyclodes Species 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 abstract description 11
- 150000001412 amines Chemical class 0.000 abstract description 2
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 description 80
- 241001465754 Metazoa Species 0.000 description 71
- 206010028980 Neoplasm Diseases 0.000 description 61
- 230000004083 survival effect Effects 0.000 description 55
- 238000011081 inoculation Methods 0.000 description 38
- 241000699670 Mus sp. Species 0.000 description 34
- 230000000259 anti-tumor effect Effects 0.000 description 31
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 24
- 238000012360 testing method Methods 0.000 description 23
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 19
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 16
- 150000003057 platinum Chemical class 0.000 description 15
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 12
- 230000000977 initiatory effect Effects 0.000 description 12
- 239000007787 solid Substances 0.000 description 12
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- 238000011285 therapeutic regimen Methods 0.000 description 10
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 9
- 206010003445 Ascites Diseases 0.000 description 9
- 210000004881 tumor cell Anatomy 0.000 description 9
- 208000007093 Leukemia L1210 Diseases 0.000 description 8
- 239000002552 dosage form Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 238000000692 Student's t-test Methods 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 238000002054 transplantation Methods 0.000 description 6
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 208000032839 leukemia Diseases 0.000 description 5
- 208000025036 lymphosarcoma Diseases 0.000 description 5
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 238000012353 t test Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- 206010002091 Anaesthesia Diseases 0.000 description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 4
- 230000037005 anaesthesia Effects 0.000 description 4
- 239000008346 aqueous phase Substances 0.000 description 4
- 239000007900 aqueous suspension Substances 0.000 description 4
- 230000006793 arrhythmia Effects 0.000 description 4
- 206010003119 arrhythmia Diseases 0.000 description 4
- 210000003567 ascitic fluid Anatomy 0.000 description 4
- 201000008274 breast adenocarcinoma Diseases 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 231100000636 lethal dose Toxicity 0.000 description 4
- 230000002035 prolonged effect Effects 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 206010006187 Breast cancer Diseases 0.000 description 3
- 238000002224 dissection Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000004614 tumor growth Effects 0.000 description 3
- 238000011785 NMRI mouse Methods 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000021736 acetylation Effects 0.000 description 2
- 238000006640 acetylation reaction Methods 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 238000002350 laparotomy Methods 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- OCKGFTQIICXDQW-ZEQRLZLVSA-N 5-[(1r)-1-hydroxy-2-[4-[(2r)-2-hydroxy-2-(4-methyl-1-oxo-3h-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3h-2-benzofuran-1-one Chemical compound C1=C2C(=O)OCC2=C(C)C([C@@H](O)CN2CCN(CC2)C[C@H](O)C2=CC=C3C(=O)OCC3=C2C)=C1 OCKGFTQIICXDQW-ZEQRLZLVSA-N 0.000 description 1
- 208000003468 Ehrlich Tumor Carcinoma Diseases 0.000 description 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 241000289371 Ornithorhynchus anatinus Species 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical group [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 241001041510 Oxytelinae group Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229960004562 carboplatin Drugs 0.000 description 1
- 190000008236 carboplatin Chemical compound 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 239000000824 cytostatic agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 201000005296 lung carcinoma Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000816 toxic dose Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000005760 tumorsuppression Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ19981628A CZ288912B6 (cs) | 1998-05-27 | 1998-05-27 | Komplex platiny v oxidačním čísle IV, způsob přípravy tohoto komplexu, tento komplex jako léčivo a farmaceutická kompozice tento komplex obsahující |
| PCT/CZ1999/000015 WO1999061451A1 (en) | 1998-05-27 | 1999-05-24 | Platinum complex, its preparation and therapeutic application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG104972A BG104972A (en) | 2001-08-31 |
| BG64599B1 true BG64599B1 (bg) | 2005-08-31 |
Family
ID=5463562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104972A BG64599B1 (bg) | 1998-05-27 | 2000-11-21 | Платинов комплекс, метод за получаването му и терапевтичното му приложение |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6503943B1 (uk) |
| EP (1) | EP1082330B1 (uk) |
| JP (1) | JP3575686B2 (uk) |
| CN (1) | CN1124279C (uk) |
| AU (1) | AU741380B2 (uk) |
| BG (1) | BG64599B1 (uk) |
| BR (1) | BR9910669B1 (uk) |
| CA (1) | CA2332054C (uk) |
| CZ (1) | CZ288912B6 (uk) |
| DE (1) | DE69901177T2 (uk) |
| ES (1) | ES2175968T3 (uk) |
| HR (1) | HRP20000791B1 (uk) |
| HU (1) | HU224716B1 (uk) |
| IL (1) | IL139529A (uk) |
| MX (1) | MXPA00011621A (uk) |
| NO (1) | NO328930B1 (uk) |
| PL (1) | PL191132B1 (uk) |
| PT (1) | PT1082330E (uk) |
| RS (1) | RS49738B (uk) |
| RU (1) | RU2200164C2 (uk) |
| SI (1) | SI1082330T1 (uk) |
| SK (1) | SK284436B6 (uk) |
| UA (1) | UA56315C2 (uk) |
| WO (1) | WO1999061451A1 (uk) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ296045B6 (cs) * | 2003-03-31 | 2005-12-14 | Pliva-Lachema A. S. | Farmaceutická kompozice obsahující jako účinnou látku komplex čtyřmocné platiny a způsob její výroby |
| CZ295584B6 (cs) * | 2004-02-12 | 2005-08-17 | Pliva-Lachema A. S. | Farmaceutická kompozice obsahující jako účinnou látku platinový komplex a způsob výroby této kompozice |
| BRPI0408805A (pt) * | 2003-03-31 | 2006-03-28 | Pliva Lachema As | composição farmacêutica contendo complexo de platina e método de fabricação da mesma |
| WO2006002119A2 (en) | 2004-06-18 | 2006-01-05 | Gpc Biotech, Inc. | Kinase inhibitors for treating cancers |
| EP1781230A1 (en) * | 2004-07-14 | 2007-05-09 | GPC Biotech AG | Variable-dose packaging system |
| CZ296169B6 (cs) * | 2004-09-08 | 2006-01-11 | Pliva - Lachema A. S. | Farmaceutická kompozice pro rektální nebo vaginální podání, zpusob její prípravy a tato kompozice pro pouzití jako lécivo |
| CZ296459B6 (cs) * | 2004-09-14 | 2006-03-15 | Pliva-Lachema A. S. | Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo |
| US7977500B2 (en) * | 2004-11-10 | 2011-07-12 | University Of South Florida | Platinum complexes for targeted drug delivery |
| JP5106098B2 (ja) * | 2005-02-28 | 2012-12-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の抗癌剤との新規併用 |
| EP1792622A1 (en) | 2005-11-11 | 2007-06-06 | GPC Biotech AG | Anti-proliferative combination therapy comprising a platinum-based chemotherapeutic agent and EGFR inhibitors or pyrimidine analogues |
| CZ300424B6 (cs) * | 2006-06-20 | 2009-05-13 | Pliva - Lachema A. S. | Farmaceutická kompozice pro perorální podání |
| CZ300120B6 (cs) * | 2006-06-20 | 2009-02-11 | Pliva - Lachema A. S. | Farmaceutická kompozice pro injekcní podání |
| CZ300590B6 (cs) * | 2006-06-20 | 2009-06-24 | Pliva - Lachema A. S. | Farmaceutická kompozice pro injekcní podání |
| KR100829173B1 (ko) * | 2006-09-19 | 2008-05-13 | 광주과학기술원 | 물에 대한 용해도가 우수한 플라틴 복합체의 포접복합체 및그 제조방법 |
| GB2457453B (en) * | 2008-02-12 | 2010-05-12 | Pliva Lachema As | Polymorphic crystalline form III of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV) |
| GB2457454B (en) * | 2008-02-12 | 2010-05-12 | Pliva Lachema As | Polymorphic crystalline form II of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV) |
| GB2457452B (en) * | 2008-02-12 | 2010-05-12 | Pliva Lachema As | Amorphous form of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) amminedichloroplatinum (IV) |
| GB2457455B (en) * | 2008-02-12 | 2010-04-21 | Pliva Lachema As | Polymorphic crystalline form (I) of (OC-6-43)-Bis(Acetato)-1-(Tricyclo[3,3,1,1 (3,7)]Decylamine)Amminedichloroplatinum(IV) |
| WO2010149666A1 (en) | 2009-06-22 | 2010-12-29 | Medexis S.A. | Methods for treating neoplasia |
| WO2011029639A2 (en) | 2009-09-08 | 2011-03-17 | Medexis S.A. | Compounds and methods for treating neoplasia |
| US20130303500A1 (en) | 2010-07-30 | 2013-11-14 | Medexis S.A. | Compounds and methods for treating neoplasia |
| JP6321291B2 (ja) | 2014-09-03 | 2018-05-09 | ブイユーエービー ファーマ エー．エス． | 増加した抗腫瘍効果を有する白金（ｉｖ）錯体 |
| CN104984356A (zh) * | 2015-05-14 | 2015-10-21 | 昆明贵研药业有限公司 | 赛特铂的环糊精复合物及制备方法 |
| RU2613513C2 (ru) * | 2015-07-17 | 2017-03-16 | Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) | Способ получения комплексов платины (IV) с аминонитроксильными радикалами |
| RU2726826C2 (ru) * | 2016-12-27 | 2020-07-15 | Общество с ограниченной ответственностью "Плат-АН" (ООО "Плат-АН") | Композиция на основе аминонитроксильного комплекса платины и доксорубицина и способ лечения опухолей |
| IL291110A (en) * | 2019-09-05 | 2022-07-01 | Vuab Pharma A S | New iv platinum complexes with significantly increased antitumor activity |
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| EP0328274A1 (en) * | 1988-02-02 | 1989-08-16 | Johnson Matthey, Inc., | Pt (IV) complexes |
| EP0423707A2 (en) * | 1989-10-17 | 1991-04-24 | Bristol-Myers Squibb Company | Platinum complexes |
| EP0503830A1 (en) * | 1991-03-09 | 1992-09-16 | Johnson Matthey Public Limited Company | Trans-platinum compounds with anti-tumor activity, process for their preparation and compositions containing them |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10265380A (ja) * | 1997-03-17 | 1998-10-06 | Bristol Myers Squibb Co | 抗ガン剤 |
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1999
- 1999-05-24 MX MXPA00011621A patent/MXPA00011621A/es not_active IP Right Cessation
- 1999-05-24 PT PT99920541T patent/PT1082330E/pt unknown
- 1999-05-24 IL IL13952999A patent/IL139529A/en not_active IP Right Cessation
- 1999-05-24 US US09/700,514 patent/US6503943B1/en not_active Expired - Fee Related
- 1999-05-24 ES ES99920541T patent/ES2175968T3/es not_active Expired - Lifetime
- 1999-05-24 WO PCT/CZ1999/000015 patent/WO1999061451A1/en active IP Right Grant
- 1999-05-24 SK SK1773-2000A patent/SK284436B6/sk not_active IP Right Cessation
- 1999-05-24 AU AU38093/99A patent/AU741380B2/en not_active Ceased
- 1999-05-24 HU HU0102549A patent/HU224716B1/hu not_active IP Right Cessation
- 1999-05-24 UA UA2000116684A patent/UA56315C2/uk unknown
- 1999-05-24 RS YUP-719/00A patent/RS49738B/sr unknown
- 1999-05-24 SI SI9930056T patent/SI1082330T1/xx unknown
- 1999-05-24 PL PL344346A patent/PL191132B1/pl not_active IP Right Cessation
- 1999-05-24 JP JP2000550855A patent/JP3575686B2/ja not_active Expired - Fee Related
- 1999-05-24 DE DE69901177T patent/DE69901177T2/de not_active Expired - Lifetime
- 1999-05-24 EP EP99920541A patent/EP1082330B1/en not_active Expired - Lifetime
- 1999-05-24 BR BRPI9910669-8A patent/BR9910669B1/pt not_active IP Right Cessation
- 1999-05-24 RU RU2000128648/04A patent/RU2200164C2/ru not_active IP Right Cessation
- 1999-05-24 CN CN99806649A patent/CN1124279C/zh not_active Expired - Fee Related
- 1999-05-24 CA CA002332054A patent/CA2332054C/en not_active Expired - Fee Related
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2000
- 2000-11-17 HR HR20000791A patent/HRP20000791B1/xx not_active IP Right Cessation
- 2000-11-21 BG BG104972A patent/BG64599B1/bg unknown
- 2000-11-27 NO NO20005990A patent/NO328930B1/no not_active IP Right Cessation
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0328274A1 (en) * | 1988-02-02 | 1989-08-16 | Johnson Matthey, Inc., | Pt (IV) complexes |
| EP0423707A2 (en) * | 1989-10-17 | 1991-04-24 | Bristol-Myers Squibb Company | Platinum complexes |
| EP0503830A1 (en) * | 1991-03-09 | 1992-09-16 | Johnson Matthey Public Limited Company | Trans-platinum compounds with anti-tumor activity, process for their preparation and compositions containing them |
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