BG64582B1 - Фармацевтичен състав за комбинирана терапия на остеопороза и използване - Google Patents
Фармацевтичен състав за комбинирана терапия на остеопороза и използване Download PDFInfo
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- BG64582B1 BG64582B1 BG102726A BG10272698A BG64582B1 BG 64582 B1 BG64582 B1 BG 64582B1 BG 102726 A BG102726 A BG 102726A BG 10272698 A BG10272698 A BG 10272698A BG 64582 B1 BG64582 B1 BG 64582B1
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- Prior art keywords
- compound
- phenyl
- pharmaceutical composition
- cis
- hydroxy
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Applications Claiming Priority (2)
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| US1241296P | 1996-02-28 | 1996-02-28 | |
| PCT/IB1996/001462 WO1997031640A1 (en) | 1996-02-28 | 1996-12-23 | Combination therapy for osteoporosis |
Publications (2)
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| BG102726A BG102726A (en) | 1999-04-30 |
| BG64582B1 true BG64582B1 (bg) | 2005-08-31 |
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| BG102726A BG64582B1 (bg) | 1996-02-28 | 1998-08-26 | Фармацевтичен състав за комбинирана терапия на остеопороза и използване |
Country Status (45)
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| US5552412A (en) * | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| HN1996000101A (es) * | 1996-02-28 | 1997-06-26 | Inc Pfizer | Terapia combinada para la osteoporosis |
| AR008155A1 (es) * | 1996-09-06 | 1999-12-09 | Smithkline Beecham Corp | Uso de un compuesto de formula i para preparar un medicamento util para tratar y prevenir la enfermedad cardiovascular post menopausica en mujeres. |
| GB2324726A (en) * | 1997-05-01 | 1998-11-04 | Merck & Co Inc | Combination Therapy for the Treatment of Osteoporosis |
| SE9702401D0 (sv) | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
| US6531485B2 (en) | 1997-06-23 | 2003-03-11 | Pfizer Inc. | Prostaglandin agonists |
| SK3402000A3 (en) * | 1997-09-09 | 2000-12-11 | Procter & Gamble | Use of a substance primary activating the osteoblastic protein kinase c/intracellular calcium pathways of a subject |
| UA67754C2 (uk) * | 1997-10-10 | 2004-07-15 | Пфайзер, Інк. | Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти) |
| EP0950417A3 (en) * | 1998-02-23 | 2000-02-23 | Pfizer Products Inc. | Treatment of skeletal disorders |
| PL344699A1 (en) * | 1998-06-03 | 2001-11-19 | Pfizer Prod Inc | 2-aminopyridines containing fused ring substituents as nitric oxide synthase inhibitors |
| ATE265853T1 (de) * | 1998-06-16 | 2004-05-15 | Pfizer Prod Inc | Kombinationstherapeutika, enthaltend einen selektiven östrogenrezeptormodulator und prostaglandin e2 |
| ID26726A (id) * | 1998-06-16 | 2001-02-01 | Pfizer Prod Inc | Kombinasi terapeutik untuk kelemahan muskuloskeletal |
| PA8471201A1 (es) * | 1998-06-16 | 2000-09-29 | Pfizer Prod Inc | Combinaciones terapeuticas que comprenden un modulador del receptor de estrogenos selectivo y hormona paratiroidea |
| AR018869A1 (es) * | 1998-06-16 | 2001-12-12 | Pfizer Prod Inc | Composicion farmaceutica, su uso para la preparacion de medicamentos y estuche que la contiene |
| EP1004306A3 (en) * | 1998-08-06 | 2000-06-07 | Pfizer Products Inc. | Estrogen agonists/antagonists |
| US6414006B1 (en) | 1998-10-15 | 2002-07-02 | Merck Frosst Canada & Co. | Methods for inhibiting bone resorption |
| CA2349338C (en) * | 1998-11-03 | 2005-12-06 | Pfizer Products Inc. | Novel macrolide antibiotics |
| JP2002538122A (ja) * | 1999-03-05 | 2002-11-12 | ザ プロクター アンド ギャンブル カンパニー | 天然に存在しないｆｐ選択的アゴニストおよび骨吸収抑制化合物を用いる骨体積の増加方法 |
| GB9913649D0 (en) * | 1999-06-11 | 1999-08-11 | Karobio Ab | Estrogen receptor |
| EP1113007A1 (en) * | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists |
| CO5251465A1 (es) | 2000-01-26 | 2003-02-28 | Pfizer Prod Inc | Composiciones y procedimientos para tratar la osteoporosis y reducir el colesterol |
| CN1400897A (zh) * | 2000-06-01 | 2003-03-05 | 沃特森药物公司 | Lasofoxifene的经皮转运 |
| EP1192945A3 (en) * | 2000-09-21 | 2004-03-03 | Pfizer Products Inc. | Use of an estrogen agonist/antagonist for treating osteoarthritis |
| TWI303990B (en) * | 2000-10-17 | 2008-12-11 | Pfizer Prod Inc | New use of estrogen agonists/antagonists for improving vascular health |
| EP1210951B1 (en) * | 2000-11-30 | 2005-02-02 | Pfizer Products Inc. | Composition containing estrogen agonists/antagonists and testosterone for treating a decline in the level of the hormone testosterone |
| CN1599606A (zh) * | 2001-07-31 | 2005-03-23 | 辉瑞产品公司 | 包含雌激素激动剂/拮抗剂、雌激素与孕激素组合的药物组合物、试剂盒和方法 |
| UY28089A1 (es) | 2002-11-26 | 2004-06-30 | Smithkline Beecham Corp | Compuestos calciliticos |
| WO2011159769A2 (en) | 2010-06-17 | 2011-12-22 | Aragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
| US9421180B2 (en) | 2011-09-30 | 2016-08-23 | Perio Sciences, Llc | Antioxidant compositions for treatment of inflammation or oxidative damage |
| CN103142644B (zh) * | 2013-03-21 | 2014-07-23 | 青岛正大海尔制药有限公司 | 骨化三醇和氟化钠的混悬颗粒及其制备方法 |
| CA3040266A1 (en) | 2016-10-11 | 2018-05-24 | Duke University | Lasofoxifene treatment of er+ breast cancer |
| US11497730B2 (en) | 2018-04-10 | 2022-11-15 | Duke University | Lasofoxifene treatment of breast cancer |
| CN112384634B (zh) * | 2018-04-24 | 2024-04-16 | 深圳华大生命科学研究院 | 骨质疏松生物标志物及其用途 |
| CN110412289B (zh) * | 2019-07-25 | 2022-08-02 | 北京美迪阿姆科技发展有限公司 | 抑制性t细胞及筛选方法和抑制自身免疫反应中的应用 |
| GB202116903D0 (en) | 2021-11-18 | 2022-01-05 | Sermonix Pharmaceuticals Inc | Lasofoxifene treatment of aromatase-resistant er+ cancer |
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1996
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- 1996-12-20 TW TW085115770A patent/TW464496B/zh not_active IP Right Cessation
- 1996-12-23 CN CNA2003101202356A patent/CN1515317A/zh active Pending
- 1996-12-23 PL PL35998796A patent/PL187962B1/pl not_active IP Right Cessation
- 1996-12-23 RU RU98117620/14A patent/RU2190395C2/ru not_active IP Right Cessation
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- 1996-12-23 AT AT96941153T patent/ATE405273T1/de not_active IP Right Cessation
- 1996-12-23 CN CNA2003101202341A patent/CN1515316A/zh active Pending
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1999
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5254594A (en) * | 1991-04-09 | 1993-10-19 | Klinge Pharma Gmbh | Remedies for bone diseases |
| WO1994006750A1 (en) * | 1992-09-11 | 1994-03-31 | Merck & Co., Inc. | Prostaglandin analog for treating osteoporosis |
| EP0605193A1 (en) * | 1992-12-22 | 1994-07-06 | Eli Lilly And Company | Use of benzothiophenes for treatment of hypercholesterolaemia |
| EP0635270A1 (en) * | 1993-07-22 | 1995-01-25 | Eli Lilly And Company | Parathyroid hormone and raloxifene for increasing bone mass |
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